{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:58:57Z","timestamp":1793325537255,"version":"4.5.0"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pituitary"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s11102-022-01256-6","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T15:02:54Z","timestamp":1658502174000},"page":"780-794","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Determinants of skeletal fragility in acromegaly: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8545-7381","authenticated-orcid":false,"given":"Cl\u00e1udia","family":"Ribeiro de Moura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3888-5938","authenticated-orcid":false,"given":"Sara","family":"Campos Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9820-1940","authenticated-orcid":false,"given":"Ana Margarida","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"issue":"11","key":"1256_CR1","doi-asserted-by":"publisher","first-page":"3933","DOI":"10.1210\/jc.2014-2700","volume":"99","author":"L Katznelson","year":"2014","unstructured":"Katznelson L, Laws ER, Melmed S, Molitch ME, Murad MH, Utz A et al (2014) Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 99(11):3933\u20133951. https:\/\/doi.org\/10.1210\/jc.2014-2700","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"1256_CR2","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1007\/s11102-016-0772-8","volume":"20","author":"L Vilar","year":"2017","unstructured":"Vilar L, Vilar CF, Lyra R, Lyra R, Naves LA (2017) Acromegaly: clinical features at diagnosis. Pituitary 20(1):22\u201332. https:\/\/doi.org\/10.1007\/s11102-016-0772-8","journal-title":"Pituitary"},{"issue":"4","key":"1256_CR3","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1530\/EJE-10-1005","volume":"164","author":"MJE Wassenaar","year":"2011","unstructured":"Wassenaar MJE, Biermasz NR, Hamdy NAT, Zillikens MC, Van Meurs JBJ, Rivadeneira F et al (2011) High prevalence of vertebral fractures despite normal bone mineral density in patients with long-term controlled acromegaly. Eur J Endocrinol 164(4):475\u2013483. https:\/\/doi.org\/10.1530\/EJE-10-1005","journal-title":"Eur J Endocrinol"},{"issue":"12","key":"1256_CR4","doi-asserted-by":"publisher","first-page":"4649","DOI":"10.1210\/jc.2008-0791","volume":"93","author":"G Mazziotti","year":"2008","unstructured":"Mazziotti G, Bianchi A, Bonadonna S, Cimino V, Patelli I, Fusco A et al (2008) Prevalence of vertebral fractures in men with acromegaly. J Clin Endocrinol Metab 93(12):4649\u20134655. https:\/\/doi.org\/10.1210\/jc.2008-0791","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"1256_CR5","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1210\/er.2007-0036","volume":"29","author":"A Giustina","year":"2008","unstructured":"Giustina A, Mazziotti G, Canalis E (2008) Growth hormone, insulin-like growth factors, and the skeleton. Endocr Rev 29(5):535\u2013559. https:\/\/doi.org\/10.1210\/er.2007-0036","journal-title":"Endocr Rev"},{"issue":"5","key":"1256_CR6","first-page":"621","volume":"28","author":"W Zgliczynski","year":"2007","unstructured":"Zgliczynski W, Kochman M, Misiorowski W, Zdunowski P (2007) In acromegaly, increased bone mineral density (BMD) is determined by GH-excess, gonadal function and gender. Neuroendocrinol Lett 28(5):621\u2013628","journal-title":"Neuroendocrinol Lett"},{"issue":"6","key":"1256_CR7","doi-asserted-by":"publisher","first-page":"R213","DOI":"10.1530\/EJE-18-0991","volume":"180","author":"C Eller-Vainicher","year":"2019","unstructured":"Eller-Vainicher C, Falchetti A, Gennari L, Cairoli E, Bertoldo F, Vescini F et al (2019) Diagnosis of endocrine disease: evaluation of bone fragility in endocrine disorders. Eur J Endocrinol 180(6):R213\u2013R232. https:\/\/doi.org\/10.1530\/EJE-18-0991","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"1256_CR8","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1046\/j.1365-2265.2001.01280.x","volume":"55","author":"H Kaji","year":"2001","unstructured":"Kaji H, Sugimoto T, Nakaoka D, Okimura Y, Kaji H, Abe H et al (2001) Bone metabolism and body composition in Japanese patients with active acromegaly. Clin Endocrinol (Oxf) 55(2):175\u2013181. https:\/\/doi.org\/10.1046\/j.1365-2265.2001.01280.x","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4","key":"1256_CR9","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.tem.2020.01.011","volume":"31","author":"A Giustina","year":"2020","unstructured":"Giustina A (2020) Acromegaly and vertebral fractures: facts and questions. Trends Endocrinol Metab 31(4):274\u2013275. https:\/\/doi.org\/10.1016\/j.tem.2020.01.011","journal-title":"Trends Endocrinol Metab"},{"issue":"4","key":"1256_CR10","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1210\/er.2018-00005","volume":"39","author":"G Mazziotti","year":"2018","unstructured":"Mazziotti G, Frara S, Giustina A (2018) Pituitary diseases and bone. Endocr Rev 39(4):440\u2013488. https:\/\/doi.org\/10.1210\/er.2018-00005","journal-title":"Endocr Rev"},{"key":"1256_CR11","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6284269","author":"YL Liu","year":"2018","unstructured":"Liu YL, Hsu JT, Shih TY, Luzhbin D, Tu CY, Wu J (2018) Quantification of volumetric bone mineral density of proximal femurs using a two-compartment model and computed tomography images. Biomed Res Int. https:\/\/doi.org\/10.1155\/2018\/6284269","journal-title":"Biomed Res Int"},{"key":"1256_CR12","doi-asserted-by":"publisher","first-page":"121","DOI":"10.33549\/physiolres.934303","volume":"68","author":"M Ku\u017ema","year":"2019","unstructured":"Ku\u017ema M, Killinger Z, Jackuliak P, Va\u00f2uga P, Hans D, Binkley N et al (2019) Pathophysiology of growth hormone secretion disorders and their impact on bone microstructure as measured by trabecular bone score. Physiol Res 68:121\u2013129. https:\/\/doi.org\/10.33549\/physiolres.934303","journal-title":"Physiol Res"},{"issue":"7412","key":"1256_CR13","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"J Higgins","year":"2003","unstructured":"Higgins J, Thompson S, Deeks J, Altman D (2003) Measuring inconsistency in meta-analyses. BMJ 327(7412):557\u2013560. https:\/\/doi.org\/10.1136\/bmj.327.7414.557","journal-title":"BMJ"},{"key":"1256_CR14","unstructured":"Higgins J, Li T, Deeks J (2020) Chapter 6\u2014choosing effect measures and computing estimates of effects. Cochrane. https:\/\/training.cochrane.org\/handbook\/current\/chapter-06. Accessed 20 July 2020"},{"issue":"5","key":"1256_CR15","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1111\/j.1398-9995.2009.01973.x","volume":"64","author":"JL Brozek","year":"2009","unstructured":"Brozek JL, Akl EA, Alonso-Coello P, Lang D, Jaeschke R, Williams JW, Phillips B, Lelgemann M, Lethaby A, Bousquet J, Guyatt GH, Sch\u00fcnemann HJ, GRADE Working Group (2009) Grading quality of evidence and strength of recommendations in clinical practice guidelines. Part 1 of 3. An overview of the GRADE approach and grading quality of evidence about interventions. Allergy 64(5):669\u2013677. https:\/\/doi.org\/10.1111\/j.1398-9995.2009.01973.x","journal-title":"Allergy"},{"issue":"3","key":"1256_CR16","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/0009-8981(79)90285-7","volume":"93","author":"J \u0160t\u011bp\u00e1n","year":"1979","unstructured":"\u0160t\u011bp\u00e1n J, Marek J, Havr\u00e1nek T, Dole\u017eal V, Pacovsk\u00fd V (1979) Bone isoenzyme of serum alkaline phosphatase in acromegaly. Clin Chim Acta 93(3):355\u2013363. https:\/\/doi.org\/10.1016\/0009-8981(79)90285-7","journal-title":"Clin Chim Acta"},{"issue":"1","key":"1256_CR17","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/BF02555167","volume":"43","author":"C de la Piedra","year":"1988","unstructured":"de la Piedra C, Larra\u00f1aga J, Castro N, Horcajada C, Rapado A, Herrera Pombo JL, Carb\u00f3 E (1988) Correlation among plasma osteocalcin, growth hormone, and somatomedin C in acromegaly. Calcif Tissue Int 43(1):44\u201345. https:\/\/doi.org\/10.1007\/BF02555167","journal-title":"Calcif Tissue Int"},{"issue":"7","key":"1256_CR18","doi-asserted-by":"publisher","first-page":"567","DOI":"10.7326\/0003-4819-111-7-567","volume":"111","author":"T Diamond","year":"1989","unstructured":"Diamond T, Nery L, Posen S (1989) Spinal and peripheral bone mineral densities in acromegaly: the effects of excess growth hormone and hypogonadism. Ann Intern Med 111(7):567\u2013573. https:\/\/doi.org\/10.7326\/0003-4819-111-7-567","journal-title":"Ann Intern Med"},{"issue":"9","key":"1256_CR19","first-page":"1608","volume":"33","author":"PJ Ho","year":"1992","unstructured":"Ho PJ, Fig LM, Barkan AL, Shapiro B (1992) Bone mineral density of the axial skeleton in acromegaly. J Nucl Med 33(9):1608\u20131612","journal-title":"J Nucl Med"},{"issue":"6","key":"1256_CR20","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/BF00571329","volume":"52","author":"M Marazuela","year":"1993","unstructured":"Marazuela M, Astigarraga B, Tabuenca MJ, Estrada J, Mar\u00edn F, Lucas T (1993) Serum bone Gla protein as a marker of bone turnover in acromegaly. Calcif Tissue Int 52(6):419\u2013421. https:\/\/doi.org\/10.1007\/BF00571329","journal-title":"Calcif Tissue Int"},{"issue":"4","key":"1256_CR21","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/S0011-393X(05)80195-X","volume":"53","author":"P Legovini","year":"1993","unstructured":"Legovini P, De Menis E, Doroldi C, Carteri A, Billeci D, Roiter I et al (1993) Parathormone levels during treatment of acromegaly with octreotide: one-year follow-up. Curr Ther Res 53(4):360\u2013366. https:\/\/doi.org\/10.1016\/S0011-393X(05)80195-X","journal-title":"Curr Ther Res"},{"issue":"4","key":"1256_CR22","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1002\/jbmr.5650080410","volume":"8","author":"H Kotzmann","year":"1993","unstructured":"Kotzmann H, Bernecker P, H\u00fcbsch P, Pietschmann P, Woloszczuk W, Svoboda T et al (1993) Bone mineral density and parameters of bone metabolism in patients with acromegaly. J Bone Miner Res 8(4):459\u2013465. https:\/\/doi.org\/10.1002\/jbmr.5650080410","journal-title":"J Bone Miner Res"},{"issue":"5","key":"1256_CR23","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1055\/s-2007-1001672","volume":"26","author":"A Piovesan","year":"1994","unstructured":"Piovesan A, Terzolo M, Reimondo G, Pia A, Codegone A, Osella G et al (1994) Biochemical markers of bone and collagen turnover in acromegaly or Cushing\u2019s syndrome. Horm Metab Res 26(5):234\u2013237. https:\/\/doi.org\/10.1055\/s-2007-1001672","journal-title":"Horm Metab Res"},{"issue":"10","key":"1256_CR24","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1359\/jbmr.1997.12.10.1729","volume":"12","author":"A Scillitani","year":"1997","unstructured":"Scillitani A, Chiodini I, Carnevale V, Giannatempo GM, Frusciante V, Villella M et al (1997) Skeletal involvement in female acromegalic subjects: the effects of growth hormone excess in amenorrheal and menstruating patients. J Bone Miner Res 12(10):1729\u20131736. https:\/\/doi.org\/10.1359\/jbmr.1997.12.10.1729","journal-title":"J Bone Miner Res"},{"issue":"10","key":"1256_CR25","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1007\/BF03350799","volume":"21","author":"S Longobardi","year":"1998","unstructured":"Longobardi S, Di Somma C, Di Rella F, Angelillo N, Ferone D, Colao A et al (1998) Bone mineral density and circulating cytokines in patients with acromegaly. J Endocrinol Investig 21(10):688\u2013693. https:\/\/doi.org\/10.1007\/BF03350799","journal-title":"J Endocrinol Investig"},{"issue":"8","key":"1256_CR26","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/s1076-6332(00)80573-5","volume":"7","author":"M Bolanowski","year":"2000","unstructured":"Bolanowski M, Wielgus W, Milewicz A, Marciniak R (2000) Axial bone mineral density in patients with acromegaly. Acad Radiol 7(8):592\u2013594. https:\/\/doi.org\/10.1016\/s1076-6332(00)80573-5","journal-title":"Acad Radiol"},{"issue":"6","key":"1256_CR27","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1530\/eje.0.1450685","volume":"145","author":"T Ueland","year":"2001","unstructured":"Ueland T, Bollerslev J, Godang K, M\u00fcller F, Fr\u00f8land SS, Aukrust P (2001) Increased serum osteoprotegerin in disorders characterized by persistent immune activation or glucocorticoid excess\u2014possible role in bone homeostasis. Eur J Endocrinol 145(6):685\u2013690. https:\/\/doi.org\/10.1530\/eje.0.1450685","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"1256_CR28","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s001980200009","volume":"13","author":"S Minisola","year":"2002","unstructured":"Minisola S, Dionisi S, Pacitti MT, Paglia F, Carnevale V, Scillitani A et al (2002) Gender differences in serum markers of bone resorption in healthy subjects and patients with disorders affecting bone. Osteoporos Int 13(2):171\u2013175. https:\/\/doi.org\/10.1007\/s001980200009","journal-title":"Osteoporos Int"},{"issue":"2","key":"1256_CR29","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1046\/j.1365-2362.2002.00944.x","volume":"32","author":"T Ueland","year":"2002","unstructured":"Ueland T, Ebbesen EN, Thomsen JS, Mosekilde L, Brixen K, Flyvbjerg A et al (2002) Decreased trabecular bone biomechanical competence, apparent density, IGF-II and IGFBP-5 content in acromegaly. Eur J Clin Investig 32(2):122\u2013128. https:\/\/doi.org\/10.1046\/j.1365-2362.2002.00944.x","journal-title":"Eur J Clin Investig"},{"issue":"4","key":"1256_CR30","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s001980200030","volume":"13","author":"M Bolanowski","year":"2002","unstructured":"Bolanowski M, J\u0229drzejuk D, Milewicz A, Arkowska A (2002) Quantitative ultrasound of the heel and some parameters of bone turnover in patients with acromegaly. Osteoporos Int 13(4):303\u2013308. https:\/\/doi.org\/10.1007\/s001980200030","journal-title":"Osteoporos Int"},{"issue":"6","key":"1256_CR31","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1046\/j.1365-2265.2003.01777.x","volume":"58","author":"A Scillitani","year":"2003","unstructured":"Scillitani A, Battista C, Chiodini I, Carnevale V, Fusilli S, Ciccarelli E et al (2003) Bone mineral density in acromegaly: the effect of gender, disease activity and gonadal status. Clin Endocrinol (Oxf) 58(6):725\u2013731. https:\/\/doi.org\/10.1046\/j.1365-2265.2003.01777.x","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2","key":"1256_CR32","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s007740300015","volume":"21","author":"J Matsuyama","year":"2003","unstructured":"Matsuyama J, Eshima N, Fukunaga T, Hori S, Kobayashi H, Isono M (2003) Various risks of osteoporosis in patients with pituitary adenomas. J Bone Miner Metab 21(2):91\u201397. https:\/\/doi.org\/10.1007\/s007740300015","journal-title":"J Bone Miner Metab"},{"issue":"12","key":"1256_CR33","doi-asserted-by":"publisher","first-page":"5650","DOI":"10.1210\/jc.2003-030772","volume":"88","author":"C Parkinson","year":"2003","unstructured":"Parkinson C, Kassem M, Heickendorff L, Flyvbjerg A, Trainer PJ (2003) Pegvisomant-induced serum insulin-like growth factor-I normalization in patients with acromegaly returns elevated markers of bone turnover to normal. J Clin Endocrinol Metab 88(12):5650\u20135655. https:\/\/doi.org\/10.1210\/jc.2003-030772","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"1256_CR34","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1055\/s-2004-820913","volume":"112","author":"NB T\u00fct\u00fcnc\u00fc","year":"2004","unstructured":"T\u00fct\u00fcnc\u00fc NB, Erba\u015f T (2004) Factors associated with bone metabolism in acromegalic patients: hypogonadism and female gender. Exp Clin Endocrinol Diabetes 112(6):328\u2013332. https:\/\/doi.org\/10.1055\/s-2004-820913","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"10","key":"1256_CR35","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1359\/JBMR.050603","volume":"20","author":"S Bonadonna","year":"2005","unstructured":"Bonadonna S, Mazziotti G, Nuzzo M, Bianchi A, Fusco A, De Marinis L et al (2005) Increased prevalence of radiological spinal deformities in active acromegaly: a cross-sectional study in postmenopausal women. J Bone Miner Res 20(10):1837\u20131844. https:\/\/doi.org\/10.1359\/JBMR.050603","journal-title":"J Bone Miner Res"},{"issue":"1","key":"1256_CR36","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1530\/eje.1.01820","volume":"152","author":"NR Biermasz","year":"2005","unstructured":"Biermasz NR, Hamdy NAT, Pereira AM, Romijn JA, Roelfsema F (2005) Long-term maintenance of the anabolic effects of GH on the skeleton in successful treated patients with acromegaly. Eur J Endocrinol 152(1):53\u201360. https:\/\/doi.org\/10.1530\/eje.1.01820","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"1256_CR37","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/s00774-005-0649-9","volume":"24","author":"M Bolanowski","year":"2006","unstructured":"Bolanowski M, Daroszewski J, M\u0229dra\u015b M, Zadrozna-\u015aliwka B (2006) Bone mineral density and turnover in patients with acromegaly in relation to sex, disease activity, and gonadal function. J Bone Miner Metab 24(1):72\u201378. https:\/\/doi.org\/10.1007\/s00774-005-0649-9","journal-title":"J Bone Miner Metab"},{"issue":"3","key":"1256_CR38","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1210\/jc.2005-1602","volume":"91","author":"HD White","year":"2006","unstructured":"White HD, Ahmad AM, Durham BH, Chandran S, Patwala A, Fraser WD et al (2006) Effect of active acromegaly and its treatment on parathyroid circadian rhythmicity and parathyroid target-organ sensitivity. J Clin Endocrinol Metab 91(3):913\u2013919. https:\/\/doi.org\/10.1210\/jc.2005-1602","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"1256_CR39","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1530\/eje.1.02285","volume":"155","author":"T Ueland","year":"2006","unstructured":"Ueland T, Fougner SL, Godang K, Schreiner T, Bollerslev J (2006) Serum GH and IGF-I are significant determinants of bone turnover but not bone mineral density in active acromegaly: a prospective study of more than 70 consecutive patients. Eur J Endocrinol 155(5):709\u2013715. https:\/\/doi.org\/10.1530\/eje.1.02285","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"1256_CR40","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.ultrasmedbio.2005.10.003","volume":"32","author":"M Bolanowski","year":"2006","unstructured":"Bolanowski M, Pluskiewicz W, Adamczyk P, Daroszewski J (2006) Quantitative ultrasound at the hand phalanges in patients with acromegaly. Ultrasound Med Biol 32(2):191\u2013195. https:\/\/doi.org\/10.1016\/j.ultrasmedbio.2005.10.003","journal-title":"Ultrasound Med Biol"},{"issue":"3","key":"1256_CR41","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.jocd.2007.03.103","volume":"10","author":"D Kastelan","year":"2007","unstructured":"Kastelan D, Dusek T, Kraljevic I, Polasek O, Perkovic Z, Kardum I et al (2007) Bone properties in patients with acromegaly: quantitative ultrasound of the heel. J Clin Densitom 10(3):327\u2013331. https:\/\/doi.org\/10.1016\/j.jocd.2007.03.103","journal-title":"J Clin Densitom"},{"issue":"5","key":"1256_CR42","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1097\/TEN.0b013e3181b66096","volume":"19","author":"M Sasaki","year":"2009","unstructured":"Sasaki M, Okazaki R, Inoue D, Nakashima M, Ide F, Nakaguchi H et al (2009) Preoperative elevated serum growth hormone is preventive of osteopenia in postsurgical patients with pituitary somatotroph adenomas: comparison with clinically nonfunctioning adenomas. Endocrinologist 19(5):208\u2013210","journal-title":"Endocrinologist"},{"issue":"3","key":"1256_CR43","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1111\/j.1365-2265.2008.03322.x","volume":"70","author":"C Battista","year":"2009","unstructured":"Battista C, Chiodini I, Muscarella S, Guglielmi G, Mascia ML, Carnevale V et al (2009) Spinal volumetric trabecular bone mass in acromegalic patients: a longitudinal study. Clin Endocrinol (Oxf) 70(3):378\u2013382. https:\/\/doi.org\/10.1111\/j.1365-2265.2008.03322.x","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"10","key":"1256_CR44","doi-asserted-by":"publisher","first-page":"3889","DOI":"10.1210\/jc.2009-0474","volume":"94","author":"N Sucunza Alfonso","year":"2009","unstructured":"Sucunza Alfonso N, Barahona MJ, Resmini E, Fern\u00e1ndez-Real JM, Ricart W, Farrerons J et al (2009) A link between bone mineral density and serum adiponectin and visfatin levels in acromegaly. J Clin Endocrinol Metab 94(10):3889\u20133896. https:\/\/doi.org\/10.1210\/jc.2009-0474","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"1256_CR45","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1007\/s00198-009-1165-x","volume":"21","author":"M Madeira","year":"2010","unstructured":"Madeira M, Neto LV, De Lima GAB, Moreira RO, De Mendon\u00e7a LMC, Gadelha MR et al (2010) Effects of GH-IGF-I excess and gonadal status on bone mineral density and body composition in patients with acromegaly. Osteoporos Int 21(12):2019\u20132025. https:\/\/doi.org\/10.1007\/s00198-009-1165-x","journal-title":"Osteoporos Int"},{"issue":"3","key":"1256_CR46","first-page":"37","volume":"8","author":"G Padova","year":"2011","unstructured":"Padova G, Borz\u00ec G, Incorvaia L, Siciliano G, Migliorino V, Vetri M et al (2011) Prevalence of osteoporosis and vertebral fractures in acromegalic patients. Clin Cases Miner Bone Metab 8(3):37\u201343","journal-title":"Clin Cases Miner Bone Metab"},{"issue":"4","key":"1256_CR47","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1210\/jc.2012-4073","volume":"98","author":"M Madeira","year":"2013","unstructured":"Madeira M, Neto LV, De Paula Paranhos Neto F, Lima ICB, De Mendon\u00e7a LMC, Gadelha MR et al (2013) Acromegaly has a negative influence on trabecular bone, but not on cortical bone, as assessed by high-resolution peripheral quantitative computed tomography. J Clin Endocrinol Metab 98(4):1734\u20131741. https:\/\/doi.org\/10.1210\/jc.2012-4073","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"1256_CR48","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.jocd.2012.06.002","volume":"16","author":"M Madeira","year":"2013","unstructured":"Madeira M, Neto LV, Torres CH, de Mendon\u00e7a LMC, Gadelha MR, de Farias MLF (2013) Vertebral fracture assessment in acromegaly. J Clin Densitom 16(2):238\u2013243. https:\/\/doi.org\/10.1016\/j.jocd.2012.06.002","journal-title":"J Clin Densitom"},{"issue":"8","key":"1256_CR49","doi-asserted-by":"publisher","first-page":"3402","DOI":"10.1210\/jc.2013-1460","volume":"98","author":"G Mazziotti","year":"2013","unstructured":"Mazziotti G, Bianchi A, Porcelli T, Mormando M, Maffezzoni F, Cristiano A et al (2013) Vertebral fractures in patients with acromegaly: a 3-year prospective study. J Clin Endocrinol Metab 98(8):3402\u20133410. https:\/\/doi.org\/10.1210\/jc.2013-1460","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"1256_CR50","doi-asserted-by":"publisher","first-page":"42","DOI":"10.4274\/tjem.2687","volume":"19","author":"H Serins\u00f6z","year":"2015","unstructured":"Serins\u00f6z H, Ert\u00f6rer ME, Ba\u015fc\u0131l S, Bak\u0131ner O, Bozk\u0131rl\u0131 E, T\u00fct\u00fcnc\u00fc NB (2015) Low prevalence of periodontitis in acromegaly: growth hormone may exert a protective effect. Turkish J Endocrinol Metab 19(2):42\u201348","journal-title":"Turkish J Endocrinol Metab"},{"issue":"2","key":"1256_CR51","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1007\/s12020-016-1078-3","volume":"54","author":"F Maffezzoni","year":"2016","unstructured":"Maffezzoni F, Maddalo M, Frara S, Mezzone M, Zorza I, Baruffaldi F et al (2016) High-resolution-cone beam tomography analysis of bone microarchitecture in patients with acromegaly and radiological vertebral fractures. Endocrine 54(2):532\u2013542. https:\/\/doi.org\/10.1007\/s12020-016-1078-3","journal-title":"Endocrine"},{"issue":"3","key":"1256_CR52","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1007\/s00198-015-3344-2","volume":"27","author":"AR Hong","year":"2016","unstructured":"Hong AR, Kim JH, Kim SW, Kim SY, Shin CS (2016) Trabecular bone score as a skeletal fragility index in acromegaly patients. Osteoporos Int 27(3):1123\u20131129. https:\/\/doi.org\/10.1007\/s00198-015-3344-2","journal-title":"Osteoporos Int"},{"issue":"3","key":"1256_CR53","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1007\/s12020-016-0945-2","volume":"53","author":"E Valassi","year":"2016","unstructured":"Valassi E, Crespo I, Malouf J, Vilades D, Leta R, Llauger J et al (2016) Epicardial fat is a negative predictor of spine volumetric bone mineral density and trabecular bone score in acromegaly. Endocrine 53(3):860\u2013864. https:\/\/doi.org\/10.1007\/s12020-016-0945-2","journal-title":"Endocrine"},{"issue":"8","key":"1256_CR54","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1007\/s00393-016-0171-6","volume":"76","author":"S Tuzcu","year":"2017","unstructured":"Tuzcu S, Durmaz A, Carl\u0131o\u011flu A, Demircan Z, Tuzcu A, Beyaz C et al (2017) The effects of high serum growth hormone and IGF-1 levels on bone mineral density in acromegaly. Z Rheumatol 76(8):716\u2013722. https:\/\/doi.org\/10.1007\/s00393-016-0171-6","journal-title":"Z Rheumatol"},{"issue":"8","key":"1256_CR55","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.1007\/s00198-017-4054-8","volume":"28","author":"F Malgo","year":"2017","unstructured":"Malgo F, Hamdy NAT, Papapoulos SE, Appelman-Dijkstra NM (2017) Bone material strength index as measured by impact microindentation is low in patients with fractures irrespective of fracture site. Osteoporos Int 28(8):2433\u20132437. https:\/\/doi.org\/10.1007\/s00198-017-4054-8","journal-title":"Osteoporos Int"},{"issue":"7","key":"1256_CR56","doi-asserted-by":"publisher","first-page":"2416","DOI":"10.1210\/jc.2016-3693","volume":"102","author":"T Constantin","year":"2017","unstructured":"Constantin T, Tangpricha V, Shah R, Oyesiku NM, Ioachimescu OC, Ritchie J et al (2017) Calcium and bone turnover markers in acromegaly: a prospective, controlled study. J Clin Endocrinol Metab 102(7):2416\u20132424. https:\/\/doi.org\/10.1210\/jc.2016-3693","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"1256_CR57","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1530\/EJE-17-0468","volume":"177","author":"PPB Silva","year":"2017","unstructured":"Silva PPB, Amlashi FG, Yu EW, Pulaski-liebert KJ, Gerweck AV, Fazeli K et al (2017) Bone microarchitecture and estimated bone strength in men with active acromegaly. Eur J Endocrinol 177(5):409\u2013420. https:\/\/doi.org\/10.1530\/EJE-17-0468","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"1256_CR58","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s12020-017-1391-5","volume":"59","author":"S Chiloiro","year":"2018","unstructured":"Chiloiro S, Mormando M, Bianchi A, Giampietro A, Milardi D, Bima C et al (2018) Prevalence of morphometric vertebral fractures in \u201cdifficult\u201d patients with acromegaly with different biochemical outcomes after multimodal treatment. Endocrine 59(2):449\u2013453. https:\/\/doi.org\/10.1007\/s12020-017-1391-5","journal-title":"Endocrine"},{"issue":"1","key":"1256_CR59","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s11102-017-0847-1","volume":"21","author":"LD Carbonare","year":"2018","unstructured":"Carbonare LD, Micheletti V, Cosaro E, Valenti MT, Mottes M, Francia G et al (2018) Bone histomorphometry in acromegaly patients with fragility vertebral fractures. Pituitary 21(1):56\u201364. https:\/\/doi.org\/10.1007\/s11102-017-0847-1","journal-title":"Pituitary"},{"issue":"3","key":"1256_CR60","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1530\/ERC-17-0523","volume":"25","author":"MT Valenti","year":"2018","unstructured":"Valenti MT, Mottes M, Cheri S, Deiana M, Micheletti V, Cosaro E et al (2018) Runx2 overexpression compromises bone quality in acromegalic patients. Endocr Relat Cancer 25(3):269\u2013277. https:\/\/doi.org\/10.1530\/ERC-17-0523","journal-title":"Endocr Relat Cancer"},{"issue":"7","key":"1256_CR61","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1055\/a-0630-1529","volume":"50","author":"FF Ozer","year":"2018","unstructured":"Ozer FF, Dagdelen S, Erbas T (2018) Relation of RANKL and OPG levels with bone resorption in patients with acromegaly and prolactinoma. Horm Metab Res 50(7):562\u2013567. https:\/\/doi.org\/10.1055\/a-0630-1529","journal-title":"Horm Metab Res"},{"key":"1256_CR62","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/21012566","author":"L Qin","year":"2019","unstructured":"Qin L, Guo X, Gao L, Wang Z, Feng C, Deng K et al (2019) Preoperative and postoperative bone mineral density change and risk factor analysis in patients with a GH-secreting pituitary adenoma. Int J Endocrinol. https:\/\/doi.org\/10.1155\/2019\/21012566","journal-title":"Int J Endocrinol"},{"issue":"12","key":"1256_CR63","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10240","volume":"3","author":"K Godang","year":"2019","unstructured":"Godang K, Lekva T, Normann KR, Olarescu NC, \u00d8ystese KAB, Kolnes A et al (2019) Hip structure analyses in acromegaly: decrease of cortical bone thickness after treatment: a longitudinal cohort study. JBMR Plus 3(12):e10240. https:\/\/doi.org\/10.1002\/jbm4.10240","journal-title":"JBMR Plus"},{"issue":"3","key":"1256_CR64","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1530\/EJE-18-0881","volume":"180","author":"M Ku\u017ema","year":"2019","unstructured":"Ku\u017ema M, Va\u0148uga P, S\u00e1gova I, P\u00e1vai D, Jackuliak P, Killinger Z et al (2019) Non-invasive DXA-derived bone structure assessment of acromegaly patients: a cross-sectional study. Eur J Endocrinol 180(3):201\u2013211. https:\/\/doi.org\/10.1530\/EJE-18-0881","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"1256_CR65","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1530\/EC-18-0482","volume":"8","author":"E Valassi","year":"2019","unstructured":"Valassi E, Garc\u00eda-Giralt N, Malouf J, Crespo I, Llauger J, D\u00edez-P\u00e9rez A et al (2019) Circulating mir-103a-3p and mir-660-5p are associated with bone parameters in patients with controlled acromegaly. Endocr Connect 8(1):39\u201349. https:\/\/doi.org\/10.1530\/EC-18-0482","journal-title":"Endocr Connect"},{"issue":"3","key":"1256_CR66","doi-asserted-by":"publisher","first-page":"dgz054","DOI":"10.1210\/clinem\/dgz054","volume":"105","author":"S Chiloiro","year":"2019","unstructured":"Chiloiro S, Giampietro A, Stefano F, Chiara B, Frederico D, Fleseriu M et al (2019) Effects of pegvisomant and pasireotide LAR on vertebral fractures in acromegaly resistant to first-generation SRLs. J Clin Endocrinol Metab 105(3):dgz054. https:\/\/doi.org\/10.1210\/clinem\/dgz054","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"1256_CR67","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1530\/EJE-20-0415","volume":"183","author":"ICM Pelsma","year":"2020","unstructured":"Pelsma ICM, Biermasz NR, Pereira AM, van Furth WR, Appelman-Dijkstra NM, Kloppenburg M et al (2020) Progression of vertebral fractures in long-term controlled acromegaly: a 9-year follow-up study. Eur J Endocrinol 183(4):427\u2013437. https:\/\/doi.org\/10.1530\/EJE-20-0415","journal-title":"Eur J Endocrinol"},{"issue":"9","key":"1256_CR68","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1007\/s40618-020-01221-9","volume":"43","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Liu M, Chen H, Zhu K, Feng W, Zhu D et al (2020) Associations between circulating bone-derived hormones lipocalin 2, osteocalcin, and glucose metabolism in acromegaly. J Endocrinol Investig 43(9):1309\u20131316. https:\/\/doi.org\/10.1007\/s40618-020-01221-9","journal-title":"J Endocrinol Investig"},{"issue":"2","key":"1256_CR69","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1007\/s12020-020-02358-6","volume":"69","author":"DO de Castro","year":"2020","unstructured":"de Castro DO, de Azevedo BP, Dytz MG, Barbosa BA, J\u00fanior AJ, Reggatieri NAT et al (2020) Entropy and uniformity as additional parameters to optimize the effectiveness of bone CT in the evaluation of acromegalic patients. Endocrine 69(2):368\u2013376. https:\/\/doi.org\/10.1007\/s12020-020-02358-6","journal-title":"Endocrine"},{"issue":"114","key":"1256_CR70","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.bone.2018.06.006","volume":"2018","author":"K Mys","year":"2017","unstructured":"Mys K, Stockmans F, Vereecke E, van Lenthe GH (2017) Quantification of bone microstructure in the wrist using cone-beam computed tomography. Bone 2018(114):206\u2013214. https:\/\/doi.org\/10.1016\/j.bone.2018.06.006","journal-title":"Bone"},{"issue":"6","key":"1256_CR71","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/S8756-3282(02)00735-4","volume":"30","author":"AM Parfitt","year":"2002","unstructured":"Parfitt AM (2002) Misconceptions (2): turnover is always higher in cancellous than in cortical bone. Bone 30(6):807\u2013809. https:\/\/doi.org\/10.1016\/S8756-3282(02)00735-4","journal-title":"Bone"},{"issue":"12","key":"1256_CR72","doi-asserted-by":"publisher","first-page":"4808","DOI":"10.1210\/jc.2013-2695","volume":"98","author":"KMJA Claessen","year":"2013","unstructured":"Claessen KMJA, Kroon HM, Pereira AM, Appelman-Dijkstra NM, Verstegen MJ, Kloppenburg M et al (2013) Progression of vertebral fractures despite long-term biochemical control of acromegaly: a prospective follow-up study. J Clin Endocrinol Metab 98(12):4808\u20134815. https:\/\/doi.org\/10.1210\/jc.2013-2695","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"1256_CR73","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1159\/000489672","volume":"47","author":"SM Ott","year":"2018","unstructured":"Ott SM (2018) Cortical or trabecular bone: what\u2019s the difference? Am J Nephrol 47(6):373\u2013375. https:\/\/doi.org\/10.1159\/000489672","journal-title":"Am J Nephrol"},{"issue":"3","key":"1256_CR74","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1530\/EJE-08-0845","volume":"160","author":"MJE Wassenaar","year":"2009","unstructured":"Wassenaar MJE, Biermasz NR, van Duinen N, van der Klaauw AA, Pereira AM, Roelfsena F et al (2009) High prevalence of arthropathy, according to the definitions of radiological and clinical osteoarthritis, in patients with long-term cure of acromegaly: a case\u2013control study. Eur J Endocrinol 160(3):357\u2013365. https:\/\/doi.org\/10.1530\/EJE-08-0845","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"1256_CR75","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1530\/EJE-13-0102","volume":"169","author":"C Eller-Vainicher","year":"2013","unstructured":"Eller-Vainicher C, Cairoli E, Zhukouskaya VV, Morelli V, Palmieri S, Scillitani A et al (2013) Prevalence of subclinical contributors to low bone mineral density and\/or fragility fracture. Eur J Endocrinol 169(2):225\u2013237. https:\/\/doi.org\/10.1530\/EJE-13-0102","journal-title":"Eur J Endocrinol"},{"issue":"4","key":"1256_CR76","doi-asserted-by":"publisher","first-page":"dgz096","DOI":"10.1210\/clinem\/dgz096","volume":"105","author":"A Giustina","year":"2020","unstructured":"Giustina A, Barkan A, Beckers A, Biermasz N, Biller B, Boguszewski C et al (2020) A consensus on the diagnosis and treatment of acromegaly comorbidities: an uptade. J Clin Endocrinol Metab 105(4):dgz096. https:\/\/doi.org\/10.1210\/clinem\/dgz096","journal-title":"J Clin Endocrinol Metab"},{"key":"1256_CR77","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa363","author":"G Mazziotti","year":"2020","unstructured":"Mazziotti G, Battista C, Maffezzoni F, Chiloiro S, Ferrante E, Prencipe N et al (2020) Treatment of acromegalic osteopathy in real-life clinical practice: the BAAC (Bone Active Drugs in Acromegaly) Study. J Clin Endocrinol Metab. https:\/\/doi.org\/10.1210\/clinem\/dgaa363","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"1256_CR78","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1210\/er.2018-00097","volume":"39","author":"RS Hardy","year":"2018","unstructured":"Hardy RS, Zhou H, Seibel MJ, Cooper MS (2018) Glucocorticoids and bone: consequences of endogenous and exogenous excess and replacement therapy. Endocr Rev 39(5):519\u2013548. https:\/\/doi.org\/10.1210\/er.2018-00097","journal-title":"Endocr Rev"},{"key":"1256_CR79","doi-asserted-by":"publisher","first-page":"4438","DOI":"10.1210\/jc.2014-2670","volume":"99","author":"Mercado M, Gonzalez B, Vargas G, Ramirez C, de los Monteros AL, Sosa E, Jervis P, Roldan P, Mendoza V, L\u00f3pez-F\u00e9lix B, Guinto G","year":"2014","unstructured":"Mercado M, Gonzalez B, Vargas G, Ramirez C, de los Monteros AL, Sosa E, Jervis P, Roldan P, Mendoza V, L\u00f3pez-F\u00e9lix B, Guinto G (2014) Successful mortality reduction and control of comorbidities in patients with acromegaly followed at a highly specialized multidisciplinary clinic. J Clin Endocrinol Metab 99:4438\u20134446. https:\/\/doi.org\/10.1210\/jc.2014-2670","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"1256_CR80","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1055\/s-0042-103933","volume":"48","author":"F Ceccato","year":"2016","unstructured":"Ceccato F, Lizzul L, Zilio M, Barbot M, Denaro L, Emanuelli E, Alessio L, Rolma G, Manara R, Saller A, Boscaro M, Scaroni C (2016) Medical treatment for acromegaly does not increase the risk of central adrenal insufficiency: a long-term follow-up study. Horm Metab Res 48(8):514\u2013519","journal-title":"Horm Metab Res"},{"key":"1256_CR81","doi-asserted-by":"publisher","first-page":"4216","DOI":"10.1210\/jc.2009-1097","volume":"94","author":"M Sherlock","year":"2009","unstructured":"Sherlock M, Reulen RC, Alonso AA, Ayuk J, Clayton RN, Sheppard MC, Hawkins MM, Bates AS, Stewart PM (2009) ACTH deficiency, higher doses of hydrocortisone replacement, and radiotherapy are independent predictors of mortality in patients with acromegaly. J Clin Endocrinol Metab 94:4216\u20134223. https:\/\/doi.org\/10.1210\/jc.2009-1097","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"1256_CR82","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1530\/EJE-15-1096","volume":"174","author":"J Schulz","year":"2016","unstructured":"Schulz J, Frey KR, Cooper MS et al (2016) Reduction in daily hydrocortisone dose improves bone health in primary adrenal insufficiency. Eur J Endocrinol 174(4):531\u2013538. https:\/\/doi.org\/10.1530\/EJE-15-1096","journal-title":"Eur J Endocrinol"},{"key":"1256_CR83","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s11102-010-0273-0","volume":"14","author":"A Krzentowska-Korek","year":"2011","unstructured":"Krzentowska-Korek A, Go\u0142kowski F, Ba\u0142dys-Walig\u00f3rska A, Hubalewska-Dydejczyk A (2011) Efficacy and complications of neurosurgical treatment of acromegaly. Pituitary 14:157\u2013162. https:\/\/doi.org\/10.1007\/s11102-010-0273-0","journal-title":"Pituitary"},{"key":"1256_CR84","doi-asserted-by":"publisher","first-page":"4114","DOI":"10.1210\/jc.2010-0670","volume":"95","author":"L Katznelson","year":"2010","unstructured":"Katznelson L (2010) Approach to the patient with persistent acromegaly after pituitary surgery. J Clin Endocrinol Metab 95:4114\u20134123. https:\/\/doi.org\/10.1210\/jc.2010-0670","journal-title":"J Clin Endocrinol Metab"},{"key":"1256_CR85","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1007\/s007010100015","volume":"143","author":"G Minniti","year":"2001","unstructured":"Minniti G, Jaffrain-Rea ML, Esposito V, Santoro A, Moroni C, Lenzi J, Tamburrano G, Cassone R, Cantore G (2001) Surgical treatment and clinical outcome of GH-secreting adenomas in elderly patients. Acta Neurochir 143:1205\u20131211. https:\/\/doi.org\/10.1007\/s007010100015","journal-title":"Acta Neurochir"}],"container-title":["Pituitary"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-022-01256-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11102-022-01256-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-022-01256-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T21:37:26Z","timestamp":1668893846000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11102-022-01256-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,22]]},"references-count":85,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["1256"],"URL":"https:\/\/doi.org\/10.1007\/s11102-022-01256-6","relation":{},"ISSN":["1386-341X","1573-7403"],"issn-type":[{"value":"1386-341X","type":"print"},{"value":"1573-7403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,22]]},"assertion":[{"value":"8 July 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have nothing to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study followed the recommended guidelines for good clinical practice and ethics. The research protocol was submitted and approved by the Ethics Committee for Health of Hospital de Braga and the Ethics Committee for Life and Health Sciences of University of Minho. The protocol was registered with the International Prospective Register of Systematic Reviews (Registration No. CRD42021230349) in February 2021.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}