{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:30:18Z","timestamp":1789695018215,"version":"4.0.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pituitary"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s11102-022-01277-1","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T03:02:51Z","timestamp":1666148571000},"page":"982-987","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Idiopathic central diabetes insipidus in a large cohort of patients: the hypopituitarism ENEA rare observational (HEROS) study"],"prefix":"10.1007","volume":"25","author":[{"given":"H. Masri","family":"Iraqi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Pigarova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Zacharieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Colao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Baraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Tsoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Doknic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ricci Bitti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Barbot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Akirov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Witek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Serebro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. K.","family":"Auer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"T\u00f3th","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Shimon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,19]]},"reference":[{"key":"1277_CR1","doi-asserted-by":"publisher","DOI":"10.4158\/EP161555.OR","author":"H Masri-Iraqi","year":"2017","unstructured":"Masri-Iraqi H, Hirsch D, Herzberg D, Lifshitz A, Tsvetov G, Benbassat C, Shimon I (2017) Central diabetes insipidus: clinical characteristics and long-term course in a large cohort of adults. Endocr Pract. https:\/\/doi.org\/10.4158\/EP161555.OR","journal-title":"Endocr Pract"},{"issue":"10","key":"1277_CR2","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1056\/NEJM199309023291002","volume":"329","author":"H Imura","year":"1993","unstructured":"Imura H, Nakao K, Shimatsu A, Ogawa Y, Sando T, Fujisawa I, Yamabe H (1993) Lymphocytic infundibuloneurohypophysitis as a cause of central diabetes insipidus. N Engl J Med 329(10):683\u2013689","journal-title":"N Engl J Med"},{"issue":"4","key":"1277_CR3","first-page":"349","volume":"78","author":"H Arima","year":"2016","unstructured":"Arima H, Azuma Y, Morishita Y, Hagiwara D (2016) Central diabetes insipidus. Nagoya J Med Sci 78(4):349\u2013357","journal-title":"Nagoya J Med Sci"},{"issue":"1","key":"1277_CR4","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/cen.13866","volume":"90","author":"A Garrahy","year":"2019","unstructured":"Garrahy A, Moran C, Thompson CJ (2019) Diagnosis and management of central diabetes insipidus in adults. Clin Endocrinol 90(1):23\u201330","journal-title":"Clin Endocrinol"},{"key":"1277_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2020.101398","author":"J Refardt","year":"2020","unstructured":"Refardt J (2020) Diagnosis and differential diagnosis of diabetes insipidus: update. Best Pract Res Clin Endocrinol Metab. https:\/\/doi.org\/10.1016\/j.beem.2020.101398","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"5","key":"1277_CR6","doi-asserted-by":"publisher","first-page":"600","DOI":"10.4158\/EP161555.OR","volume":"23","author":"H Masri-Iraqi","year":"2017","unstructured":"Masri-Iraqi H, Hirsch D, Herzberg D, Lifshitz A, Tsvetov G, Benbassat C, Shimon I (2017) Central diabetes insipidus: clinical characteristics and long-term course in a large cohort of adults. Endocr Pract 23(5):600\u2013604","journal-title":"Endocr Pract"},{"issue":"14","key":"1277_CR7","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1056\/NEJM200010053431403","volume":"343","author":"M Maghnie","year":"2000","unstructured":"Maghnie M, Cosi G, Genovese E, Manca-Bitti ML, Cohen A, Zecca S, Tinelli C, Gallucci M, Bernasconi S, Boscherini B, Severi F, Aric\u00f2 M (2000) Central diabetes insipidus in children and young adults. N Engl J Med 343(14):998\u20131007","journal-title":"N Engl J Med"},{"issue":"4","key":"1277_CR8","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1210\/jc.2013-3724","volume":"99","author":"N Di Iorgi","year":"2014","unstructured":"Di Iorgi N, Allegri AEM, Napoli F, Calcagno A, Calandra E, Fratangeli N, Vannati M, Rossi A, Bagnasco F, Haupt R, Maghnie M (2014) Central diabetes insipidus in children and young adults: etiological diagnosis and long-term outcome of idiopathic cases. J Clin Endocrinol Metab 99(4):1264\u20131272","journal-title":"J Clin Endocrinol Metab"},{"issue":"5807","key":"1277_CR9","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1136\/bmj.2.5807.210","volume":"2","author":"TDR Hockaday","year":"1972","unstructured":"Hockaday TDR (1972) Diabetes insipidus. BMJ 2(5807):210\u2013213","journal-title":"BMJ"},{"issue":"8","key":"1277_CR10","doi-asserted-by":"publisher","first-page":"3825","DOI":"10.1210\/jcem.87.8.8757","volume":"87","author":"A De Bellis","year":"2002","unstructured":"De Bellis A, Colao A, Bizzarro A, Di Salle F, Coronella C, Solimeno S, Vetrano A, Pivonello R, Pisano G, Lombardi G, Bellastella A (2002) Longitudinal study of vasopressin-cell antibodies and of hypothalamic-pituitary region on magnetic resonance imaging in patients with autoimmune and idiopathic complete central diabetes insipidus. J Clin Endocrinol Metab 87(8):3825\u20133829","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"1277_CR11","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1210\/jc.2002-020791","volume":"88","author":"R Pivonello","year":"2003","unstructured":"Pivonello R, De Bellis A, Faggiano A, Di Salle F, Petretta M, Di Somma C, Perrino S, Altucci P, Bizzarro A, Bellastella A, Lombardi G, Colao A (2003) Central diabetes insipidus and autoimmunity: relationship between the occurrence of antibodies to arginine vasopressin-secreting cells and clinical, immunological, and radiological features in a large cohort of patients with central diabetes insipidus of. J Clin Endocrinol Metab 88(4):1629\u20131636","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"1277_CR12","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1111\/j.1365-2265.2006.02616.x","volume":"65","author":"M Maghnie","year":"2006","unstructured":"Maghnie M, Ghirardello S, De Bellis A, Di Iorgi N, Ambrosini L, Secco A, De Amici M, Tinelli C, Bellastella A, Lorini R (2006) Idiopathic central diabetes insipidus in children and young adults is commonly associated with vasopressin-cell antibodies and markers of autoimmunity. Clin Endocrinol 65(4):470\u2013478","journal-title":"Clin Endocrinol"},{"key":"1277_CR13","doi-asserted-by":"crossref","unstructured":"Czernichow P, Garel C, L\u00e9ger J (2000) Thickened pituitary stalk on magnetic resonance imaging in children with central diabetes insipidus. In: Hormone research, vol 53. S. Karger AG, Basel, pp 61\u201364.","DOI":"10.1159\/000023536"},{"issue":"1","key":"1277_CR14","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s00431-006-0206-0","volume":"166","author":"J De Buyst","year":"2007","unstructured":"De Buyst J, Massa G, Christophe C, Tenoutasse S, Heinrichs C (2007) Clinical, hormonal and imaging findings in 27 children with central diabetes insipidus. Eur J Pediatr 166(1):43\u201349","journal-title":"Eur J Pediatr"},{"issue":"5","key":"1277_CR15","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.anpedi.2018.05.002","volume":"90","author":"B Corredor Andr\u00e9s","year":"2019","unstructured":"Corredor Andr\u00e9s B, Mu\u00f1oz Calvo MT, L\u00f3pez Pino M\u00c1, M\u00e1rquez Rivera M, Travieso Su\u00e1rez L, Pozo Rom\u00e1n J, Argente J (2019) Thickening of the pituitary stalk in children and adolescents with central diabetes insipidus: causes and consequences. Anal Pediatr 90(5):293\u2013300","journal-title":"Anal Pediatr"},{"issue":"2","key":"1277_CR16","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1159\/000336333","volume":"77","author":"N di Iorgi","year":"2012","unstructured":"di Iorgi N, Napoli F, Allegri AEM, Olivieri I, Bertelli E, Gallizia A, Rossi A, Maghnie M (2012) Diabetes insipidus: diagnosis and management. Horm Res Paediatr 77(2):69\u201384","journal-title":"Horm Res Paediatr"},{"issue":"12","key":"1277_CR17","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1136\/adc.61.12.1222","volume":"61","author":"MC Sherwood","year":"1986","unstructured":"Sherwood MC, Stanhope R, Preece MA, Grant DB (1986) Diabetes insipidus and occult intracranial tumours. Arch Dis Child 61(12):1222\u20131224","journal-title":"Arch Dis Child"},{"issue":"5","key":"1277_CR18","first-page":"1362","volume":"82","author":"SL Mootha","year":"1997","unstructured":"Mootha SL, Barkovich AJ, Grumbach MM, Edwards MS, Gitelman SE, Kaplan SL, Conte FA (1997) Idiopathic hypothalamic diabetes insipidus, pituitary stalk thickening, and the occult intracranial germinoma in children and adolescents. J Clin Endocrinol Metab 82(5):1362\u20131367","journal-title":"J Clin Endocrinol Metab"},{"issue":"9171","key":"1277_CR19","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1016\/S0140-6736(99)00317-7","volume":"353","author":"E Charmandari","year":"1999","unstructured":"Charmandari E, Brook CGD (1999) 20 years of experience in idiopathic central diabetes insipidus. Lancet 353(9171):2212\u20132213","journal-title":"Lancet"},{"key":"1277_CR20","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6365830","author":"W Liu","year":"2016","unstructured":"Liu W, Wang L, Liu M, Li G (2016) Pituitary morphology and function in 43 children with central diabetes insipidus. Int J Endocrinol. https:\/\/doi.org\/10.1155\/2016\/6365830","journal-title":"Int J Endocrinol"},{"key":"1277_CR21","doi-asserted-by":"crossref","unstructured":"Maghnie M (2003) Diabete\u015b insipidus. In: Hormone research, vol 59. S. Karger AG, Basel, pp 42\u201354","DOI":"10.1159\/000067844"},{"issue":"5","key":"1277_CR22","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1111\/j.1365-2265.2011.04270.x","volume":"76","author":"MJ Hannon","year":"2012","unstructured":"Hannon MJ, Orr C, Moran C, Behan LA, Agha A, Ball SG, Thompson CJ (2012) Anterior hypopituitarism is rare and autoimmune disease is common in adults with idiopathic central diabetes insipidus. Clin Endocrinol 76(5):725\u2013728","journal-title":"Clin Endocrinol"},{"issue":"4","key":"1277_CR23","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1111\/j.1365-2265.1986.tb01707.x","volume":"25","author":"WA Scherbaum","year":"1986","unstructured":"Scherbaum WA, Wass JAH, Besser GM, Bottazzo GF, Doniach D (1986) Autoimmune cranial diabetes insipidus: its association with other endocrine diseases and with histiocytosis X. Clin Endocrinol 25(4):411\u2013420","journal-title":"Clin Endocrinol"}],"container-title":["Pituitary"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-022-01277-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11102-022-01277-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-022-01277-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T19:44:08Z","timestamp":1779565448000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11102-022-01277-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,19]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["1277"],"URL":"https:\/\/doi.org\/10.1007\/s11102-022-01277-1","relation":{},"ISSN":["1386-341X","1573-7403"],"issn-type":[{"value":"1386-341X","type":"print"},{"value":"1573-7403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,19]]},"assertion":[{"value":"22 September 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2026","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Incorrect tagging of first name and family name of author S. Ricci Bitti has been corrected.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no competing interests to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of study formal consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}