{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:54:48Z","timestamp":1789584888282,"version":"build-2803163510"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pituitary"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1007\/s11102-023-01302-x","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T16:48:59Z","timestamp":1677170939000},"page":"209-220","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Predicting tumor consistency and extent of resection in non-functioning pituitary tumors"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4550-3675","authenticated-orcid":false,"given":"Giorgio","family":"Fiore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio Andrea","family":"Bertani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Conte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Ferrante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Tariciotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letterio","family":"Runza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Pluderi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Borsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Caroli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Sala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Platania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Kremenova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Ferrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Maria","family":"Triulzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Mantovani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Locatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"key":"1302_CR1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab106","author":"DN Louis","year":"2021","unstructured":"Louis DN, Perry A, Wesseling P et al (2021) The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol. https:\/\/doi.org\/10.1093\/neuonc\/noab106","journal-title":"Neuro Oncol"},{"key":"1302_CR2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noz150","author":"QT Ostrom","year":"2019","unstructured":"Ostrom QT, Cioffi G, Gittleman H et al (2019) CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2012\u20132016. Neuro Oncol. https:\/\/doi.org\/10.1093\/neuonc\/noz150","journal-title":"Neuro Oncol"},{"key":"1302_CR3","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1549005","author":"KA Smith","year":"2015","unstructured":"Smith KA, Leever JD, Chamoun RB (2015) Prediction of consistency of pituitary adenomas by magnetic resonance imaging. J Neurol Surgery Part B Skull Base. https:\/\/doi.org\/10.1055\/s-0035-1549005","journal-title":"J Neurol Surgery Part B Skull Base"},{"key":"1302_CR4","doi-asserted-by":"publisher","DOI":"10.1177\/1179551420932921","author":"MH AlMalki","year":"2020","unstructured":"AlMalki MH, Ahmad MM, Brema I et al (2020) Contemporary management of clinically non-functioning pituitary adenomas: a clinical review. Clin Med Insights Endocrinol Diabetes. https:\/\/doi.org\/10.1177\/1179551420932921","journal-title":"Clin Med Insights Endocrinol Diabetes"},{"key":"1302_CR5","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-019-00960-0","author":"D Esposito","year":"2019","unstructured":"Esposito D, Olsson DS, Ragnarsson O et al (2019) Non-functioning pituitary adenomas: indications for pituitary surgery and post-surgical management. Pituitary. https:\/\/doi.org\/10.1007\/s11102-019-00960-0","journal-title":"Pituitary"},{"key":"1302_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/s42000-021-00302-5","author":"A Acitores Cancela","year":"2021","unstructured":"Acitores Cancela A, Rodr\u00edguez Berrocal V, Pian H et al (2021) Clinical relevance of tumor consistency in pituitary adenoma. Hormones. https:\/\/doi.org\/10.1007\/s42000-021-00302-5","journal-title":"Hormones"},{"key":"1302_CR7","doi-asserted-by":"publisher","DOI":"10.1007\/s007010050179","author":"T Iuchi","year":"1998","unstructured":"Iuchi T, Saeki N, Tanaka M et al (1998) MRI prediction of fibrous pituitary adenomas. Acta Neurochir (Wien). https:\/\/doi.org\/10.1007\/s007010050179","journal-title":"Acta Neurochir (Wien)"},{"key":"1302_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuchi.2017.06.003","author":"AK Thotakura","year":"2017","unstructured":"Thotakura AK, Patibandla MR, Panigrahi MK, Mahadevan A (2017) Is it really possible to predict the consistency of a pituitary adenoma preoperatively? Neurochirurgie. https:\/\/doi.org\/10.1016\/j.neuchi.2017.06.003","journal-title":"Neurochirurgie"},{"key":"1302_CR9","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-019-02211-2","author":"A Zeynalova","year":"2019","unstructured":"Zeynalova A, Kocak B, Durmaz ES et al (2019) Preoperative evaluation of tumour consistency in pituitary macroadenomas: a machine learning-based histogram analysis on conventional T2-weighted MRI. Neuroradiology. https:\/\/doi.org\/10.1007\/s00234-019-02211-2","journal-title":"Neuroradiology"},{"key":"1302_CR10","doi-asserted-by":"publisher","DOI":"10.3171\/2014.12.JNS141083","author":"ASG Micko","year":"2015","unstructured":"Micko ASG, W\u00f6hrer A, Wolfsberger S, Knosp E (2015) Invasion of the cavernous sinus space in pituitary adenomas: endoscopic verification and its correlation with an MRI-based classification. J Neurosurg. https:\/\/doi.org\/10.3171\/2014.12.JNS141083","journal-title":"J Neurosurg"},{"key":"1302_CR11","volume-title":"Paranasal Sinuses","author":"AS Alsaied","year":"2017","unstructured":"Alsaied AS (2017) Paranasal sinus anatomy: what the surgeon needs to know. Paranasal Sinuses. InTech, London"},{"key":"1302_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.807040","author":"M Araujo-Castro","year":"2022","unstructured":"Araujo-Castro M, Acitores Cancela A, Vior C et al (2022) Radiological Knosp, Revised-Knosp, and Hardy-Wilson classifications for the prediction of surgical outcomes in the endoscopic endonasal surgery of pituitary adenomas: study of 228 cases. Front Oncol. https:\/\/doi.org\/10.3389\/fonc.2021.807040","journal-title":"Front Oncol"},{"key":"1302_CR13","doi-asserted-by":"publisher","DOI":"10.1093\/ons\/opy401","author":"MA Mooney","year":"2019","unstructured":"Mooney MA, Sarris CE, Zhou JJ et al (2019) Proposal and validation of a simple grading scale (TRANSSPHER Grade) for predicting gross total resection of nonfunctioning pituitary macroadenomas after transsphenoidal surgery. Oper Neurosurg. https:\/\/doi.org\/10.1093\/ons\/opy401","journal-title":"Oper Neurosurg"},{"key":"1302_CR14","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-020-02502-z","author":"R Cuocolo","year":"2020","unstructured":"Cuocolo R, Ugga L, Solari D et al (2020) Prediction of pituitary adenoma surgical consistency: radiomic data mining and machine learning on T2-weighted MRI. Neuroradiology. https:\/\/doi.org\/10.1007\/s00234-020-02502-z","journal-title":"Neuroradiology"},{"key":"1302_CR15","doi-asserted-by":"publisher","DOI":"10.3171\/2015.12.FOCUS15564","author":"C Serra","year":"2016","unstructured":"Serra C, Burkhardt JK, Esposito G et al (2016) Pituitary surgery and volumetric assessment of extent of resection: a paradigm shift in the use of intraoperative magnetic resonance imaging. Neurosurg Focus. https:\/\/doi.org\/10.3171\/2015.12.FOCUS15564","journal-title":"Neurosurg Focus"},{"key":"1302_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.05.077","author":"JD Hughes","year":"2018","unstructured":"Hughes JD, Koeller K, Rinaldo L et al (2018) Beyond gross total and subtotal: does volumetric resection matter in nonfunctioning pituitary macroadenomas? World Neurosurg. https:\/\/doi.org\/10.1016\/j.wneu.2018.05.077","journal-title":"World Neurosurg"},{"key":"1302_CR17","volume-title":"The Pituitary Body and Its Disorders","author":"H Cushing","year":"1912","unstructured":"Cushing H (1912) The Pituitary Body and Its Disorders. J.B. Lippincott, Philadelphia & London"},{"key":"1302_CR18","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6463\/ab06ec","author":"N Fang","year":"2019","unstructured":"Fang N, Wu Z, Jiang C et al (2019) Prediction of the consistency of pituitary adenomas based on multiphoton microscopy. J Phys D Appl Phys. https:\/\/doi.org\/10.1088\/1361-6463\/ab06ec","journal-title":"J Phys D Appl Phys"},{"key":"1302_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2019.03.013","author":"B Hu","year":"2019","unstructured":"Hu B, Mao Z, Du Q et al (2019) miR-93\u20135p targets Smad7 to regulate the transforming growth factor-\u03b21\/Smad3 pathway and mediate fibrosis in drug-resistant prolactinoma. Brain Res Bull. https:\/\/doi.org\/10.1016\/j.brainresbull.2019.03.013","journal-title":"Brain Res Bull"},{"key":"1302_CR20","doi-asserted-by":"publisher","DOI":"10.1080\/02688690802617046","author":"H Wang","year":"2009","unstructured":"Wang H, Li W, Shi D et al (2009) Expression of TGF\u03b21 and pituitary adenoma fibrosis. Br J Neurosurg. https:\/\/doi.org\/10.1080\/02688690802617046","journal-title":"Br J Neurosurg"},{"key":"1302_CR21","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-008-9647-9","author":"H Wang","year":"2008","unstructured":"Wang H, Li WS, Shi DJ et al (2008) Correlation of MMP1 and TIMP1 expression with pituitary adenoma fibrosis. J Neurooncol. https:\/\/doi.org\/10.1007\/s11060-008-9647-9","journal-title":"J Neurooncol"},{"key":"1302_CR22","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-020-01469-y","author":"W Ding","year":"2021","unstructured":"Ding W, Huang Z, Zhou G et al (2021) Diffusion-weighted imaging for predicting tumor consistency and extent of resection in patients with pituitary adenoma. Neurosurg Rev. https:\/\/doi.org\/10.1007\/s10143-020-01469-y","journal-title":"Neurosurg Rev"},{"key":"1302_CR23","doi-asserted-by":"publisher","DOI":"10.1080\/02688690601000717","author":"B Bahuleyan","year":"2006","unstructured":"Bahuleyan B, Raghuram L, Rajshekhar V, Chacko AG (2006) To assess the ability of MRI to predict consistency of pituitary macroadenomas. Br J Neurosurg. https:\/\/doi.org\/10.1080\/02688690601000717","journal-title":"Br J Neurosurg"},{"key":"1302_CR24","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2383042204","author":"A Pierallini","year":"2006","unstructured":"Pierallini A, Caramia F, Falcone C et al (2006) Pituitary macroadenomas: preoperative evaluation of consistency with diffusion-weighted MR imaging - initial experience. Radiology. https:\/\/doi.org\/10.1148\/radiol.2383042204","journal-title":"Radiology"},{"key":"1302_CR25","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.6.1318","author":"LO Wahlund","year":"2001","unstructured":"Wahlund LO, Barkhof F, Fazekas F et al (2001) A new rating scale for age-related white matter changes applicable to MRI and CT. Stroke. https:\/\/doi.org\/10.1161\/01.STR.32.6.1318","journal-title":"Stroke"},{"key":"1302_CR26","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001140","author":"JM Wardlaw","year":"2015","unstructured":"Wardlaw JM, Vald\u00e9s Hern\u00e1ndez MC, Mu\u00f1oz-Maniega S (2015) What are white matter hyperintensities made of\u202f? Relevance to vascular cognitive impairment. J Am Heart Assoc. https:\/\/doi.org\/10.1161\/JAHA.114.001140","journal-title":"J Am Heart Assoc"},{"key":"1302_CR27","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.33.81","author":"S Chakrabortty","year":"1993","unstructured":"Chakrabortty S, Oi S, Yamaguchi M et al (1993) Growth Hormone producing pituitary adenomas: MR characteristics and pre- and postoperative evaluation. Neurol Med Chir (Tokyo). https:\/\/doi.org\/10.2176\/nmc.33.81","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"1302_CR28","doi-asserted-by":"publisher","DOI":"10.3171\/JNS\/2008\/108\/4\/0736","author":"EF Chang","year":"2008","unstructured":"Chang EF, Zada G, Kim S et al (2008) Long-term recurrence and mortality after surgery and adjuvant radiotherapy for nonfunctional pituitary adenomas. J Neurosurg. https:\/\/doi.org\/10.3171\/JNS\/2008\/108\/4\/0736","journal-title":"J Neurosurg"},{"key":"1302_CR29","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2552","author":"OM Dekkers","year":"2006","unstructured":"Dekkers OM, Pereira AM, Roelfsema F et al (2006) Observation alone after transsphenoidal surgery for nonfunctioning pituitary macroadenoma. J Clin Endocrinol Metab. https:\/\/doi.org\/10.1210\/jc.2005-2552","journal-title":"J Clin Endocrinol Metab"},{"key":"1302_CR30","doi-asserted-by":"publisher","DOI":"10.3171\/JNS\/2008\/108\/3\/0525","author":"M Losa","year":"2008","unstructured":"Losa M, Mortini P, Barzaghi R et al (2008) Early results of surgery in patients with nonfunctioning pituitary adenoma and analysis of the risk of tumor recurrence. J Neurosurg. https:\/\/doi.org\/10.3171\/JNS\/2008\/108\/3\/0525","journal-title":"J Neurosurg"},{"key":"1302_CR31","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-014-0560-2","author":"PT Sylvester","year":"2015","unstructured":"Sylvester PT, Evans JA, Zipfel GJ et al (2015) Combined high-field intraoperative magnetic resonance imaging and endoscopy increase extent of resection and progression-free survival for pituitary adenomas. Pituitary. https:\/\/doi.org\/10.1007\/s11102-014-0560-2","journal-title":"Pituitary"},{"key":"1302_CR32","doi-asserted-by":"publisher","DOI":"10.3171\/2020.4.JNS193288","author":"MJ Rutkowski","year":"2021","unstructured":"Rutkowski MJ, Chang KE, Cardinal T et al (2021) Development and clinical validation of a grading system for pituitary adenoma consistency. J Neurosurg. https:\/\/doi.org\/10.3171\/2020.4.JNS193288","journal-title":"J Neurosurg"},{"key":"1302_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2020.12.020","author":"C P\u00e9rez-L\u00f3pez","year":"2021","unstructured":"P\u00e9rez-L\u00f3pez C, Palp\u00e1n AJ, Saez-Alegre M et al (2021) volumetric study of nonfunctioning pituitary adenomas: predictors of gross total resection. World Neurosurg. https:\/\/doi.org\/10.1016\/j.wneu.2020.12.020","journal-title":"World Neurosurg"}],"container-title":["Pituitary"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-023-01302-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11102-023-01302-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-023-01302-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T03:32:28Z","timestamp":1686195148000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11102-023-01302-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,20]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["1302"],"URL":"https:\/\/doi.org\/10.1007\/s11102-023-01302-x","relation":{},"ISSN":["1386-341X","1573-7403"],"issn-type":[{"value":"1386-341X","type":"print"},{"value":"1573-7403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,20]]},"assertion":[{"value":"8 February 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no competing interests to declare that are relevant to the content of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}