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We examined outcomes and time points following transsphenoidal surgery for pituitary adenoma to identify reporting heterogeneity within the literature.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A systematic review of studies that reported outcomes for transsphenoidal surgery for pituitary adenoma 1990\u20132021 were examined. The protocol was registered a priori and adhered to the PRISMA statement. Studies in English with\u2009&gt;\u200910 patients (prospective) or\u2009&gt;\u2009500 patients (retrospective) were included.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>178 studies comprising 427,659 patients were included. 91 studies reported 2 or more adenoma pathologies within the same study; 53 studies reported a single pathology. The most common adenomas reported were growth hormone-secreting (n\u2009=\u2009106), non-functioning (n\u2009=\u2009101), and ACTH-secreting (n\u2009=\u200995); 27 studies did not state a pathology. Surgical complications were the most reported outcome (n\u2009=\u2009116, 65%). Other domains included endocrine (n\u2009=\u2009104, 58%), extent of resection (n\u2009=\u200981, 46%), ophthalmic (n\u2009=\u200966, 37%), recurrence (n\u2009=\u200949, 28%), quality of life (n\u2009=\u200925, 19%); and nasal (n\u2009=\u200918, 10%). Defined follow up time points were most reported for endocrine (n\u2009=\u200956, 31%), extent of resection (n\u2009=\u200939, 22%), and recurrence (n\u2009=\u200928, 17%). There was heterogeneity in the follow up reported for all outcomes at different time points: discharge (n\u2009=\u20099),\u2009&lt;\u200930\u00a0days (n\u2009=\u200923),\u2009&lt;\u20096\u00a0months (n\u2009=\u200964),\u2009&lt;\u20091\u00a0year (n\u2009=\u200923), and\u2009&gt;\u20091\u00a0year (n\u2009=\u200969).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Outcomes and follow up reported for transsphenoidal surgical resection of pituitary adenoma are heterogenous over the last 30\u00a0years. This study highlights the necessity to develop a robust, consensus-based, minimum, core outcome set. The next step is to develop a Delphi survey of essential outcomes, followed by a consensus meeting of interdisciplinary experts. Patient representatives should also be included. An agreed core outcome set will enable homogeneous reporting and meaningful research synthesis, ultimately improving patient care.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11102-023-01303-w","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T08:02:46Z","timestamp":1677744166000},"page":"171-181","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Reported outcomes in transsphenoidal surgery for pituitary adenomas: a systematic review"],"prefix":"10.1007","volume":"26","author":[{"given":"Hugo","family":"Layard Horsfall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwin","family":"Venkatesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan T. 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