{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:03:51Z","timestamp":1791090231078,"version":"4.1.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006095","name":"Helse S\u00f8r-\u00d8st RHF","doi-asserted-by":"publisher","award":["HS\u00d8 2020081"],"award-info":[{"award-number":["HS\u00d8 2020081"]}],"id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006095","name":"Helse S\u00f8r-\u00d8st RHF","doi-asserted-by":"publisher","award":["2019054, 2019055, 2022046"],"award-info":[{"award-number":["2019054, 2019055, 2022046"]}],"id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG 263024513"],"award-info":[{"award-number":["DFG 263024513"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013263","name":"Nasjonalforeningen for Folkehelsen","doi-asserted-by":"publisher","award":["16154"],"award-info":[{"award-number":["16154"]}],"id":[{"id":"10.13039\/501100013263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016242","name":"Barnekreftforeningen","doi-asserted-by":"publisher","award":["19008"],"award-info":[{"award-number":["19008"]}],"id":[{"id":"10.13039\/501100016242","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013609","name":"EEA Grants\/Norway Grants","doi-asserted-by":"publisher","award":["TA\u010cR TARIMAD TO100078"],"award-info":[{"award-number":["TA\u010cR TARIMAD TO100078"]}],"id":[{"id":"10.13039\/501100013609","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges forskningsr\u00e5d","doi-asserted-by":"crossref","award":["295910 NAPI, 327571 PETABC"],"award-info":[{"award-number":["295910 NAPI, 327571 PETABC"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100012538","name":"Swedish Cancer Foundation","doi-asserted-by":"publisher","award":["190157 Fk"],"award-info":[{"award-number":["190157 Fk"]}],"id":[{"id":"10.13039\/100012538","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish government and county councils","award":["ALF-agreement"],"award-info":[{"award-number":["ALF-agreement"]}]},{"DOI":"10.13039\/501100005366","name":"University of Oslo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005366","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005366","name":"University of Oslo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005366","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pituitary"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Transforming growth factor-beta receptor 3-like (TGFBR3L) is a pituitary enriched membrane protein selectively detected in gonadotroph cells. TGFBR3L is named after transforming growth factor-beta receptor 3 (TGFBR3), an inhibin A co-receptor in mice, due to sequence identity to the C-terminal region. We aimed to characterize TGFBR3L detection in a well-characterized, prospectively collected cohort of non-functioning pituitary neuroendocrine tumours (NF-PitNETs) and correlate it to clinical data.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>144 patients operated for clinically NF-PitNETs were included. Clinical, radiological and biochemical data were recorded. Immunohistochemical (IHC) staining for FSH\u03b2 and LH\u03b2 was scored using the immunoreactive score (IRS), TGFBR3L and TGFBR3 were scored by the percentage of positive stained cells.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>TGFBR3L staining was selectively present in 52% of gonadotroph tumours. TGFBR3L was associated to IRS of LH\u03b2 (median 2 [IQR 0\u20133] in TGFBR3L negative and median 6 [IQR 3\u20139] in TGFBR3L positive tumours, p\u2009&lt;\u20090.001), but not to the IRS of FSH\u03b2 (p\u2009=\u20090.32). The presence of TGFBR3L was negatively associated with plasma gonadotropin concentrations in males (P-FSH median 5.5 IU\/L [IQR 2.9\u20139.6] and median 3.0 [IQR 1.8\u20135.6] in TGFBR3L negative and positive tumours respectively, p\u2009=\u20090.008) and P-LH (median 2.8 IU\/L [IQR 1.9\u20133.7] and median 1.8 [IQR 1.1-3.0] in TGFBR3L negative and positive tumours respectively, p\u2009=\u20090.03). TGFBR3 stained positive in 22% (n\u2009=\u200925) of gonadotroph tumours with no correlation to TGFBR3L.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>TGFBR3L was selectively detected in half (52%) of gonadotroph NF-PitNETs. The association to LH\u03b2 staining and plasma gonadotropins suggests that TGFBR3L may be involved in hormone production in gonadotroph NF-PitNETs.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11102-023-01310-x","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T08:03:28Z","timestamp":1679558608000},"page":"227-236","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["TGFBR3L is associated with gonadotropin production in non-functioning gonadotroph pituitary neuroendocrine tumours"],"prefix":"10.1007","volume":"26","author":[{"given":"Anders Jensen","family":"Kolnes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin Astrid Berland","family":"\u00d8ystese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelina","family":"Sj\u00f6stedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoleta Cristina","family":"Olarescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansgar","family":"Heck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Pahnke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Dahlberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Berg-Johnsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geir","family":"Ringstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivera","family":"Casar-Borota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Bollerslev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders Palmstr\u00f8m","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"1310_CR1","unstructured":"Lloyd RVOR, Kl\u00f6ppel G, Rosai J (2017) WHO Classification of Tumours of Endocrine Organs. 4th Edition. ;Volume 10"},{"issue":"4","key":"1310_CR2","doi-asserted-by":"publisher","first-page":"C5","DOI":"10.1530\/ERC-17-0004","volume":"24","author":"SL Asa","year":"2017","unstructured":"Asa SL, Casar-Borota O, Chanson P, Delgrange E, Earls P, Ezzat S et al (2017) From pituitary adenoma to pituitary neuroendocrine tumor (PitNET): an International Pituitary Pathology Club proposal. Endocrine-related Cancer 24(4):C5\u2013C8","journal-title":"Endocrine-related Cancer"},{"issue":"4","key":"1310_CR3","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s12022-015-9398-z","volume":"26","author":"H Nishioka","year":"2015","unstructured":"Nishioka H, Inoshita N, Mete O, Asa SL, Hayashi K, Takeshita A et al (2015) The complementary role of transcription factors in the Accurate diagnosis of clinically nonfunctioning pituitary adenomas. Endocr Pathol 26(4):349\u2013355","journal-title":"Endocr Pathol"},{"issue":"1","key":"1310_CR4","doi-asserted-by":"publisher","first-page":"G1","DOI":"10.1530\/EJE-17-0796","volume":"178","author":"G Raverot","year":"2018","unstructured":"Raverot G, Burman P, McCormack A, Heaney A, Petersenn S, Popovic V et al (2018) European Society of Endocrinology Clinical Practice Guidelines for the management of aggressive pituitary tumours and carcinomas. Eur J Endocrinol\/Eur Fed Endocr Soc 178(1):G1\u2013G24","journal-title":"Eur J Endocrinol\/Eur Fed Endocr Soc"},{"issue":"10","key":"1310_CR5","doi-asserted-by":"publisher","first-page":"3717","DOI":"10.1210\/jc.2008-0643","volume":"93","author":"OM Dekkers","year":"2008","unstructured":"Dekkers OM, Pereira AM, Romijn JA (2008) Treatment and follow-up of clinically nonfunctioning pituitary macroadenomas. J Clin Endocrinol Metab 93(10):3717\u20133726","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"1310_CR6","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1530\/EJE-20-1273","volume":"184","author":"NF Lenders","year":"2021","unstructured":"Lenders NF, Wilkinson AC, Wong SJ, Shein TT, Harvey RJ, Inder WJ et al (2021) Transcription factor immunohistochemistry in the diagnosis of pituitary tumours. Eur J Endocrinol\/Eur Fed Endocr Soc 184(6):891\u2013901","journal-title":"Eur J Endocrinol\/Eur Fed Endocr Soc"},{"issue":"12","key":"1310_CR7","doi-asserted-by":"publisher","first-page":"4423","DOI":"10.1210\/jc.2014-2362","volume":"99","author":"G Ntali","year":"2014","unstructured":"Ntali G, Capatina C, Grossman A, Karavitaki N (2014) Clinical review: functioning gonadotroph adenomas. J Clin Endocrinol Metab 99(12):4423\u20134433","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"1310_CR8","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1227\/NEU.0000000000001188","volume":"79","author":"DJ Cote","year":"2016","unstructured":"Cote DJ, Smith TR, Sandler CN, Gupta T, Bale TA, Bi WL et al (2016) Functional Gonadotroph Adenomas: Case Series and Report of Literature. Neurosurgery 79(6):823\u2013831","journal-title":"Neurosurgery"},{"issue":"4","key":"1310_CR9","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1210\/edrv-6-4-552","volume":"6","author":"PJ Snyder","year":"1985","unstructured":"Snyder PJ (1985) Gonadotroph cell adenomas of the pituitary. Endocr Rev 6(4):552\u2013563","journal-title":"Endocr Rev"},{"issue":"4","key":"1310_CR10","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1210\/jcem-70-4-859","volume":"70","author":"DS Oppenheim","year":"1990","unstructured":"Oppenheim DS, Kana AR, Sangha JS, Klibanski A (1990) Prevalence of alpha-subunit hypersecretion in patients with pituitary tumors: clinically nonfunctioning and somatotroph adenomas. J Clin Endocrinol Metab 70(4):859\u2013864","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"1310_CR11","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1210\/jcem-68-6-1128","volume":"68","author":"DJ Kwekkeboom","year":"1989","unstructured":"Kwekkeboom DJ, de Jong FH, Lamberts SW (1989) Gonadotropin release by clinically nonfunctioning and gonadotroph pituitary adenomas in vivo and in vitro: relation to sex and effects of thyrotropin-releasing hormone, gonadotropin-releasing hormone, and bromocriptine. J Clin Endocrinol Metab 68(6):1128\u20131135","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"1310_CR12","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/S0046-8177(97)90005-8","volume":"28","author":"DM Ho","year":"1997","unstructured":"Ho DM, Hsu CY, Ting LT, Chiang H (1997) The clinicopathological characteristics of gonadotroph cell adenoma: a study of 118 cases. Hum Pathol 28(8):905\u2013911","journal-title":"Hum Pathol"},{"issue":"5","key":"1310_CR13","first-page":"1352","volume":"77","author":"L Daneshdoost","year":"1993","unstructured":"Daneshdoost L, Gennarelli TA, Bashey HM, Savino PJ, Sergott RC, Bosley TM et al (1993) Identification of gonadotroph adenomas in men with clinically nonfunctioning adenomas by the luteinizing hormone beta subunit response to thyrotropin-releasing hormone. J Clin Endocrinol Metab 77(5):1352\u20131355","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"1310_CR14","first-page":"1343","volume":"74","author":"L Katznelson","year":"1992","unstructured":"Katznelson L, Alexander JM, Bikkal HA, Jameson JL, Hsu DW, Klibanski A (1992) Imbalanced follicle-stimulating hormone beta-subunit hormone biosynthesis in human pituitary adenomas. J Clin Endocrinol Metab 74(6):1343\u20131351","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"1310_CR15","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1210\/jcem-62-5-1011","volume":"62","author":"SL Asa","year":"1986","unstructured":"Asa SL, Gerrie BM, Singer W, Horvath E, Kovacs K, Smyth HS (1986) Gonadotropin secretion in vitro by human pituitary null cell adenomas and oncocytomas. J Clin Endocrinol Metab 62(5):1011\u20131019","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"1310_CR16","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1210\/clinem\/dgaa281","volume":"105","author":"AJ Kolnes","year":"2020","unstructured":"Kolnes AJ, \u00d8ystese KAB, Olarescu NC, Ringstad G, Berg-Johnsen J, Casar-Borota O et al (2020) FSH levels are related to E-cadherin expression and subcellular location in nonfunctioning pituitary tumors. J Clin Endocrinol Metab 105(8):2587\u20132594","journal-title":"J Clin Endocrinol Metab"},{"issue":"1\u20132","key":"1310_CR17","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.mce.2004.02.010","volume":"225","author":"LM Bilezikjian","year":"2004","unstructured":"Bilezikjian LM, Blount AL, Leal AM, Donaldson CJ, Fischer WH, Vale WW (2004) Autocrine\/paracrine regulation of pituitary function by activin, inhibin and follistatin. Mol Cell Endocrinol 225(1\u20132):29\u201336","journal-title":"Mol Cell Endocrinol"},{"key":"1310_CR18","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.mce.2017.10.015","volume":"463","author":"GA Stamatiades","year":"2018","unstructured":"Stamatiades GA, Kaiser UB (2018) Gonadotropin regulation by pulsatile GnRH: signaling and gene expression. Mol Cell Endocrinol 463:131\u2013141","journal-title":"Mol Cell Endocrinol"},{"issue":"2","key":"1310_CR19","doi-asserted-by":"publisher","first-page":"T41","DOI":"10.1530\/JOE-15-0113","volume":"226","author":"TM Plant","year":"2015","unstructured":"Plant TM (2015) 60 YEARS OF NEUROENDOCRINOLOGY: the hypothalamo-pituitary-gonadal axis. J Endocrinol 226(2):T41\u201354","journal-title":"J Endocrinol"},{"issue":"12","key":"1310_CR20","doi-asserted-by":"publisher","first-page":"3910","DOI":"10.1210\/en.2018-00750","volume":"159","author":"LYM Cheung","year":"2018","unstructured":"Cheung LYM, George AS, McGee SR, Daly AZ, Brinkmeier ML, Ellsworth BS et al (2018) Single-cell RNA sequencing reveals novel markers of male pituitary stem cells and hormone-producing cell types. Endocrinology 159(12):3910\u20133924","journal-title":"Endocrinology"},{"key":"1310_CR21","doi-asserted-by":"publisher","first-page":"623","DOI":"10.3389\/fendo.2019.00623","volume":"10","author":"PA Fletcher","year":"2019","unstructured":"Fletcher PA, Smiljanic K, Maso Previde R, Iben JR, Li T, Rokic MB et al (2019) Cell type- and sex-dependent transcriptome profiles of rat anterior pituitary cells. Front Endocrinol (Lausanne) 10:623","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"1310_CR22","doi-asserted-by":"publisher","first-page":"5275","DOI":"10.1038\/s41467-020-19012-4","volume":"11","author":"S Zhang","year":"2020","unstructured":"Zhang S, Cui Y, Ma X, Yong J, Yan L, Yang M et al (2020) Single-cell transcriptomics identifies divergent developmental lineage trajectories during human pituitary development. Nat Commun 11(1):5275","journal-title":"Nat Commun"},{"issue":"51","key":"1310_CR23","doi-asserted-by":"publisher","first-page":"eabl4391","DOI":"10.1126\/sciadv.abl4391","volume":"7","author":"E Br\u00fbl\u00e9","year":"2021","unstructured":"Br\u00fbl\u00e9 E, Wang Y, Li Y, Lin YF, Zhou X, Ongaro L et al (2021) TGFBR3L is an inhibin B co-receptor that regulates female fertility. Sci Adv 7(51):eabl4391","journal-title":"Sci Adv"},{"key":"1310_CR24","unstructured":"Tissue expression of TGFBR3L- The Human Protein Atlas (2022) Available at https:\/\/www.proteinatlasorg\/ENSG00000260001-TGFBR3L\/tissue.Accessed"},{"issue":"1","key":"1310_CR25","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.tem.2019.08.014","volume":"31","author":"DJ Bernard","year":"2020","unstructured":"Bernard DJ, Smith CL, Br\u00fbl\u00e9 E (2020) A tale of two proteins: Betaglycan, IGSF1, and the Continuing search for the Inhibin B receptor. Trends Endocrinol Metab 31(1):37\u201345","journal-title":"Trends Endocrinol Metab"},{"key":"1310_CR26","doi-asserted-by":"crossref","unstructured":"Sj\u00f6stedt E, Kolnes AJ, Olarescu NC, Mitsios N, Hikmet F, Sivertsson \u00c3 et al (2020) TGFBR3L-An uncharacterised Pituitary Specific membrane protein detected in the Gonadotroph cells in non-neoplastic and Tumour tissue. Cancers (Basel).; 13(1)","DOI":"10.3390\/cancers13010114"},{"issue":"2","key":"1310_CR27","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s12020-018-1679-0","volume":"62","author":"KAB Oystese","year":"2018","unstructured":"Oystese KAB, Berg JP, Normann KR, Zucknick M, Casar-Borota O, Bollerslev J (2018) The role of E and N-cadherin in the postoperative course of gonadotroph pituitary tumours. Endocrine 62(2):351\u2013360","journal-title":"Endocrine"},{"issue":"4","key":"1310_CR28","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1210\/jc.2008-2075","volume":"94","author":"MS Elston","year":"2009","unstructured":"Elston MS, Gill AJ, Conaglen JV, Clarkson A, Cook RJ, Little NS et al (2009) Nuclear accumulation of e-cadherin correlates with loss of cytoplasmic membrane staining and invasion in pituitary adenomas. J Clin Endocrinol Metab 94(4):1436\u20131442","journal-title":"J Clin Endocrinol Metab"},{"issue":"23","key":"1310_CR29","doi-asserted-by":"publisher","first-page":"3756","DOI":"10.1007\/s00018-008-8281-1","volume":"65","author":"F van Roy","year":"2008","unstructured":"van Roy F, Berx G (2008) The cell-cell adhesion molecule E-cadherin. Cell Mol Life Sci 65(23):3756\u20133788","journal-title":"Cell Mol Life Sci"},{"issue":"8","key":"1310_CR30","doi-asserted-by":"publisher","first-page":"E1237","DOI":"10.1210\/jc.2010-3040","volume":"96","author":"W Zhou","year":"2011","unstructured":"Zhou W, Song Y, Xu H, Zhou K, Zhang W, Chen J et al (2011) In nonfunctional pituitary adenomas, estrogen receptors and slug contribute to development of invasiveness. J Clin Endocrinol Metab 96(8):E1237\u2013E1245","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"1310_CR31","first-page":"138","volume":"8","author":"W Remmele","year":"1987","unstructured":"Remmele W, Stegner HE (1987) [Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue]. Pathologe 8(3):138\u2013140","journal-title":"Pathologe"},{"issue":"4","key":"1310_CR32","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.maturitas.2011.09.011","volume":"70","author":"B Gjelsvik","year":"2011","unstructured":"Gjelsvik B, Rosvold EO, Straand J, Dalen I, Hunskaar S (2011) Symptom prevalence during menopause and factors associated with symptoms and menopausal age. Results from the norwegian Hordaland Women\u2019s Cohort study. Maturitas 70(4):383\u2013390","journal-title":"Maturitas"},{"key":"1310_CR33","doi-asserted-by":"crossref","unstructured":"Knosp E, Steiner E, Kitz K, Matula C (1993) Pituitary adenomas with invasion of the cavernous sinus space: a magnetic resonance imaging classification compared with surgical findings. Neurosurgery. ; 33(4):610\u20137; discussion 7\u20138","DOI":"10.1227\/00006123-199310000-00008"},{"issue":"4","key":"1310_CR34","doi-asserted-by":"publisher","first-page":"803","DOI":"10.3171\/2014.12.JNS141083","volume":"122","author":"AS Micko","year":"2015","unstructured":"Micko AS, Wohrer A, Wolfsberger S, Knosp E (2015) Invasion of the cavernous sinus space in pituitary adenomas: endoscopic verification and its correlation with an MRI-based classification. J Neurosurg 122(4):803\u2013811","journal-title":"J Neurosurg"},{"key":"1310_CR35","doi-asserted-by":"crossref","unstructured":"Ilie MD, Vasiljevic A, Louvet C, Jouanneau E, Raverot G (2020) Gonadotroph Tumors Show subtype differences that might have implications for Therapy. Cancers (Basel). ; 12(4)","DOI":"10.3390\/cancers12041012"},{"key":"1310_CR36","doi-asserted-by":"crossref","unstructured":"Nishioka H, Inoshita N (2018) New WHO classification of pituitary adenomas (4th edition): assessment of pituitary transcription factors and the prognostic histological factors. Brain Tumor Pathol. ; 35(2):57\u201361","DOI":"10.1007\/s10014-017-0307-7"},{"issue":"5","key":"1310_CR37","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1530\/eje.0.1450561","volume":"145","author":"SJ Meachem","year":"2001","unstructured":"Meachem SJ, Nieschlag E, Simoni M (2001) Inhibin B in male reproduction: pathophysiology and clinical relevance. Eur J Endocrinol\/Eur Fed Endocr Soc 145(5):561\u2013571","journal-title":"Eur J Endocrinol\/Eur Fed Endocr Soc"},{"issue":"5","key":"1310_CR38","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1210\/er.2014-1003","volume":"35","author":"Y Makanji","year":"2014","unstructured":"Makanji Y, Zhu J, Mishra R, Holmquist C, Wong WP, Schwartz NB et al (2014) Inhibin at 90: from discovery to clinical application, a historical review. Endocr Rev 35(5):747\u2013794","journal-title":"Endocr Rev"},{"issue":"3","key":"1310_CR39","doi-asserted-by":"publisher","first-page":"3739","DOI":"10.1007\/s13277-015-4192-6","volume":"37","author":"Y Jin","year":"2016","unstructured":"Jin Y, Wang H, Han W, Lu J, Chu P, Han S et al (2016) Single nucleotide polymorphism rs11669203 in TGFBR3L is associated with the risk of neuroblastoma in a chinese population. Tumour Biol 37(3):3739\u20133747","journal-title":"Tumour Biol"},{"issue":"12","key":"1310_CR40","doi-asserted-by":"publisher","first-page":"4077","DOI":"10.1210\/en.2018-00770","volume":"159","author":"Y Li","year":"2018","unstructured":"Li Y, Fortin J, Ongaro L, Zhou X, Boehm U, Schneyer A et al (2018) Betaglycan (TGFBR3) functions as an Inhibin A, but not Inhibin B, Coreceptor in Pituitary Gonadotrope cells in mice. Endocrinology 159(12):4077\u20134091","journal-title":"Endocrinology"},{"issue":"6776","key":"1310_CR41","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/35006129","volume":"404","author":"KA Lewis","year":"2000","unstructured":"Lewis KA, Gray PC, Blount AL, MacConell LA, Wiater E, Bilezikjian LM et al (2000) Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. Nature 404(6776):411\u2013414","journal-title":"Nature"},{"issue":"2","key":"1310_CR42","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1210\/mend.16.2.0783","volume":"16","author":"DJ Bernard","year":"2002","unstructured":"Bernard DJ, Chapman SC, Woodruff TK (2002) Inhibin binding protein (InhBP\/p120), betaglycan, and the continuing search for the inhibin receptor. Mol Endocrinol (Baltimore Md) 16(2):207\u2013212","journal-title":"Mol Endocrinol (Baltimore Md)"},{"issue":"4","key":"1310_CR43","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1210\/mend.15.4.0630","volume":"15","author":"DJ Bernard","year":"2001","unstructured":"Bernard DJ, Woodruff TK (2001) Inhibin binding protein in rats: alternative transcripts and regulation in the pituitary across the estrous cycle. Mol Endocrinol (Baltimore Md) 15(4):654\u2013667","journal-title":"Mol Endocrinol (Baltimore Md)"}],"container-title":["Pituitary"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-023-01310-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11102-023-01310-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-023-01310-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T03:32:57Z","timestamp":1686195177000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11102-023-01310-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,23]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["1310"],"URL":"https:\/\/doi.org\/10.1007\/s11102-023-01310-x","relation":{},"ISSN":["1386-341X","1573-7403"],"issn-type":[{"value":"1386-341X","type":"print"},{"value":"1573-7403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,23]]},"assertion":[{"value":"6 March 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Regional Ethics Committee (REK number 2014\/1680 approved 23.10.2014) and hospital authority. All patients agreed to participate in the study and provided written informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}