{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:31:17Z","timestamp":1791433877418,"version":"4.3.3"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pituitary"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1007\/s11102-023-01368-7","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T14:02:43Z","timestamp":1704290563000},"page":"160-168","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prediction of adrenal insufficiency after pituitary surgery: a retrospective study using beckman access cortisol assay"],"prefix":"10.1007","volume":"27","author":[{"given":"Maria Francesca","family":"Birtolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Giannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Antonini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Lavezzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Lasio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Da Rin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gherardo","family":"Mazziotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea G.","family":"Lania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,3]]},"reference":[{"issue":"10","key":"1368_CR1","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1056\/NEJMra1810772","volume":"382","author":"S Melmed","year":"2020","unstructured":"Melmed S (2020) Pituitary-tumor endocrinopathies. N Engl J Med 382(10):937\u2013950","journal-title":"N Engl J Med"},{"key":"1368_CR2","doi-asserted-by":"crossref","unstructured":"Ostrom QT et al (2020) CBTRUS Statistical Report: primary brain and other Central Nervous System tumors diagnosed in the United States in 2013\u20132017. Neuro Oncol 22(12 Suppl 2):iv1\u2013iv96","DOI":"10.1093\/neuonc\/noaa200"},{"issue":"3","key":"1368_CR3","doi-asserted-by":"publisher","first-page":"P1","DOI":"10.1530\/EJE-21-0977","volume":"186","author":"R Cozzi","year":"2022","unstructured":"Cozzi R et al (2022) Italian Association of Clinical Endocrinologists (AME) and international chapter of clinical endocrinology (ICCE). Position statement for clinical practice: prolactin-secreting tumors. Eur J Endocrinol 186(3):P1\u2013P33","journal-title":"Eur J Endocrinol"},{"issue":"4","key":"1368_CR4","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1210\/jc.2010-1048","volume":"96","author":"PU Freda","year":"2011","unstructured":"Freda PU et al (2011) Pituitary incidentaloma: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 96(4):894\u2013904","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"1368_CR5","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.ecl.2020.05.011","volume":"49","author":"WR van Furth","year":"2020","unstructured":"van Furth WR et al (2020) Endoscopic surgery for pituitary tumors. Endocrinol Metab Clin North Am 49(3):487\u2013503","journal-title":"Endocrinol Metab Clin North Am"},{"key":"1368_CR6","doi-asserted-by":"publisher","first-page":"e1007","DOI":"10.1016\/j.wneu.2021.05.030","volume":"151","author":"A Goyal-Honavar","year":"2021","unstructured":"Goyal-Honavar A et al (2021) Impact of experience on outcomes after endoscopic transsphenoidal surgery for acromegaly. World Neurosurg 151:e1007\u2013e1015","journal-title":"World Neurosurg"},{"key":"1368_CR7","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.3171\/2017.12.JNS172318","volume":"130","author":"MS Agam","year":"2018","unstructured":"Agam MS et al (2018) Complications associated with microscopic and endoscopic transsphenoidal pituitary surgery: experience of 1153 consecutive cases treated at a single tertiary care pituitary center. J Neurosurg 130:1576\u20131583","journal-title":"J Neurosurg"},{"issue":"4","key":"1368_CR8","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s11102-013-0502-4","volume":"17","author":"A Paluzzi","year":"2014","unstructured":"Paluzzi A et al (2014) Endoscopic endonasal approach for pituitary adenomas: a series of 555 patients. Pituitary 17(4):307\u2013319","journal-title":"Pituitary"},{"issue":"5","key":"1368_CR9","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1001\/jama.1988.03720050044021","volume":"259","author":"NB Watts","year":"1988","unstructured":"Watts NB, Tindall GT (1988) Rapid assessment of corticotropin reserve after pituitary surgery. JAMA 259(5):708\u2013711","journal-title":"JAMA"},{"issue":"7","key":"1368_CR10","doi-asserted-by":"publisher","first-page":"E1163","DOI":"10.1210\/jc.2010-2673","volume":"96","author":"AM Burgers","year":"2011","unstructured":"Burgers AM et al (2011) Low incidence of adrenal insufficiency after transsphenoidal surgery in patients with acromegaly: a long-term follow-up study. J Clin Endocrinol Metab 96(7):E1163\u2013E1170","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"1368_CR11","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1210\/jcem.87.6.8547","volume":"87","author":"WJ Inder","year":"2002","unstructured":"Inder WJ, Hunt PJ (2002) Glucocorticoid replacement in pituitary surgery: guidelines for perioperative assessment and management. J Clin Endocrinol Metab 87(6):2745\u20132750","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"1368_CR12","doi-asserted-by":"publisher","first-page":"3888","DOI":"10.1210\/jc.2016-2118","volume":"101","author":"M Fleseriu","year":"2016","unstructured":"Fleseriu M et al (2016) Hormonal replacement in hypopituitarism in adults: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 101(11):3888\u20133921","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"1368_CR13","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s11102-022-01218-y","volume":"25","author":"X He","year":"2022","unstructured":"He X, Findling JW, Auchus RJ (2022) Glucocorticoid withdrawal syndrome following treatment of endogenous cushing syndrome. Pituitary 25(3):393\u2013403","journal-title":"Pituitary"},{"issue":"11","key":"1368_CR14","doi-asserted-by":"publisher","first-page":"e2242221","DOI":"10.1001\/jamanetworkopen.2022.42221","volume":"5","author":"X Guo","year":"2022","unstructured":"Guo X et al (2022) Safety of withholding perioperative hydrocortisone for patients with pituitary adenomas with an intact hypothalamus-pituitary-adrenal axis: a randomized clinical trial. JAMA Netw Open 5(11):e2242221","journal-title":"JAMA Netw Open"},{"issue":"5","key":"1368_CR15","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1007\/BF03346486","volume":"32","author":"R Cozzi","year":"2009","unstructured":"Cozzi R et al (2009) Perioperative cortisol can predict hypothalamus-pituitary-adrenal status in clinically non-functioning pituitary adenomas. J Endocrinol Invest 32(5):460\u2013464","journal-title":"J Endocrinol Invest"},{"issue":"4","key":"1368_CR16","doi-asserted-by":"publisher","first-page":"531","DOI":"10.33549\/physiolres.932875","volume":"64","author":"V Hana Jr","year":"2015","unstructured":"Hana V Jr. et al (2015) Prediction of adrenocortical insufficiency after pituitary adenoma Surgery using postoperative basal cortisol levels. Physiol Res 64(4):531\u2013536","journal-title":"Physiol Res"},{"issue":"7","key":"1368_CR17","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1159\/000509092","volume":"111","author":"N Prencipe","year":"2021","unstructured":"Prencipe N et al (2021) Second-day morning cortisol levels after transsphenoidal Surgery are accurate predictors of secondary adrenal insufficiency with diagnostic cut-offs similar to those in non-stressed conditions. Neuroendocrinology 111(7):639\u2013649","journal-title":"Neuroendocrinology"},{"issue":"3","key":"1368_CR18","doi-asserted-by":"publisher","first-page":"540","DOI":"10.3171\/2008.12.JNS081265","volume":"111","author":"NF Marko","year":"2009","unstructured":"Marko NF et al (2009) Use of morning serum cortisol level after transsphenoidal resection of pituitary adenoma to predict the need for long-term glucocorticoid supplementation. J Neurosurg 111(3):540\u2013544","journal-title":"J Neurosurg"},{"issue":"3","key":"1368_CR19","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s11102-010-0227-6","volume":"13","author":"NF Marko","year":"2010","unstructured":"Marko NF, Hamrahian AH, Weil RJ (2010) Immediate postoperative cortisol levels accurately predict postoperative hypothalamic-pituitary-adrenal axis function after transsphenoidal Surgery for pituitary tumors. Pituitary 13(3):249\u2013255","journal-title":"Pituitary"},{"issue":"8","key":"1368_CR20","doi-asserted-by":"publisher","first-page":"949","DOI":"10.4158\/EP171861.OR","volume":"23","author":"T Struja","year":"2017","unstructured":"Struja T et al (2017) Diagnostic accuracy of basal cortisol level to predict adrenal insufficiency in cosyntropin Testing: results from an observational cohort study with 804 patients. Endocr Pract 23(8):949\u2013961","journal-title":"Endocr Pract"},{"issue":"1","key":"1368_CR21","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s12020-019-02094-6","volume":"67","author":"F de Vries","year":"2020","unstructured":"de Vries F et al (2020) Early postoperative HPA-axis testing after pituitary tumor Surgery: reliability and safety of basal cortisol and CRH test. Endocrine 67(1):161\u2013171","journal-title":"Endocrine"},{"issue":"11","key":"1368_CR22","doi-asserted-by":"publisher","first-page":"5316","DOI":"10.1210\/jc.2019-00406","volume":"104","author":"R Pofi","year":"2019","unstructured":"Pofi R et al (2019) Recovery of the hypothalamo-pituitary-adrenal axis after transsphenoidal adenomectomy for Non-ACTH-Secreting Macroadenomas. J Clin Endocrinol Metab 104(11):5316\u20135324","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"1368_CR23","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1373\/clinchem.2008.117374","volume":"55","author":"CN Jayasena","year":"2009","unstructured":"Jayasena CN et al (2009) Day 5 morning serum cortisol predicts hypothalamic-pituitary-adrenal function after transsphenoidal surgery for pituitary tumors. Clin Chem 55(5):972\u2013977","journal-title":"Clin Chem"},{"issue":"7","key":"1368_CR24","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1530\/EC-21-0155","volume":"10","author":"I Staby","year":"2021","unstructured":"Staby I et al (2021) Pituitary function after transsphenoidal Surgery including measurement of basal morning cortisol as predictor of adrenal insufficiency. Endocr Connect 10(7):750\u2013757","journal-title":"Endocr Connect"},{"issue":"3","key":"1368_CR25","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1530\/EJE-10-0229","volume":"163","author":"Z Karaca","year":"2010","unstructured":"Karaca Z et al (2010) Can basal cortisol measurement be an alternative to the insulin tolerance test in the assessment of the hypothalamic-pituitary-adrenal axis before and after pituitary surgery? Eur J Endocrinol 163(3):377\u2013382","journal-title":"Eur J Endocrinol"},{"issue":"4","key":"1368_CR26","doi-asserted-by":"publisher","first-page":"bvab022","DOI":"10.1210\/jendso\/bvab022","volume":"5","author":"BR Javorsky","year":"2021","unstructured":"Javorsky BR et al (2021) New cutoffs for the biochemical diagnosis of adrenal insufficiency after ACTH stimulation using specific cortisol assays. J Endocr Soc 5(4):bvab022","journal-title":"J Endocr Soc"},{"issue":"8","key":"1368_CR27","doi-asserted-by":"publisher","first-page":"bvab112","DOI":"10.1210\/jendso\/bvab112","volume":"5","author":"I Jialal","year":"2021","unstructured":"Jialal I, Sood A (2021) Letter to the editor from jialal and sood: new cutoffs for the biochemical diagnosis of adrenal insufficiency after ACTH stimulation using specific cortisol assays. J Endocr Soc 5(8):bvab112","journal-title":"J Endocr Soc"},{"issue":"4","key":"1368_CR28","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1210\/jc.2017-02602","volume":"103","author":"GA Ueland","year":"2018","unstructured":"Ueland GA et al (2018) The short cosyntropin test revisited: new normal reference range using LC\u2013MS\/MS. J Clin Endocrinol Metab 103(4):1696\u20131703","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"1368_CR29","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1111\/cen.12039","volume":"78","author":"N El-Farhan","year":"2013","unstructured":"El-Farhan N et al (2013) Method-specific serum cortisol responses to the adrenocorticotrophin test: comparison of gas chromatography-mass spectrometry and five automated immunoassays. Clin Endocrinol (Oxf) 78(5):673\u2013680","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"1368_CR30","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s42000-020-00185-y","volume":"19","author":"G Grassi","year":"2020","unstructured":"Grassi G et al (2020) Minding the gap between cortisol levels measured with second-generation assays and current diagnostic thresholds for the diagnosis of adrenal insufficiency: a single-center experience. Horm (Athens) 19(3):425\u2013431","journal-title":"Horm (Athens)"},{"issue":"4","key":"1368_CR31","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/BF02340051","volume":"2","author":"VY Fujimoto","year":"1986","unstructured":"Fujimoto VY et al (1986) Increased adrenocortical responsiveness to exogenous ACTH in oral contraceptive users. Adv Contracept 2(4):343\u2013353","journal-title":"Adv Contracept"},{"issue":"5","key":"1368_CR32","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1111\/cen.13559","volume":"88","author":"AS Cross","year":"2018","unstructured":"Cross AS et al (2018) International survey on high- and low-dose synacthen test and assessment of accuracy in preparing low-dose synacthen. Clin Endocrinol (Oxf) 88(5):744\u2013751","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"1368_CR33","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/MED.0000000000000473","volume":"26","author":"N Burgos","year":"2019","unstructured":"Burgos N, Ghayee HK, Singh-Ospina N (2019) Pitfalls in the interpretation of the cosyntropin stimulation test for the diagnosis of adrenal insufficiency. Curr Opin Endocrinol Diabet Obes 26(3):139\u2013145","journal-title":"Curr Opin Endocrinol Diabet Obes"},{"issue":"2","key":"1368_CR34","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1210\/jc.2015-1700","volume":"101","author":"NS Ospina","year":"2016","unstructured":"Ospina NS et al (2016) ACTH Stimulation tests for the diagnosis of adrenal insufficiency: systematic review and meta-analysis. J Clin Endocrinol Metab 101(2):427\u2013434","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"1368_CR35","doi-asserted-by":"publisher","first-page":"4245","DOI":"10.1210\/jc.2008-0710","volume":"93","author":"R Kazlauskaite","year":"2008","unstructured":"Kazlauskaite R et al (2008) Corticotropin tests for hypothalamic-pituitary- adrenal insufficiency: a metaanalysis. J Clin Endocrinol Metab 93(11):4245\u20134253","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"1368_CR36","doi-asserted-by":"publisher","first-page":"194","DOI":"10.7326\/0003-4819-139-3-200308050-00009","volume":"139","author":"RI Dorin","year":"2003","unstructured":"Dorin RI, Qualls CR, Crapo LM (2003) Diagnosis of adrenal insufficiency. Ann Intern Med 139(3):194\u2013204","journal-title":"Ann Intern Med"},{"issue":"3","key":"1368_CR37","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1177\/2042018816687240","volume":"8","author":"A Prete","year":"2017","unstructured":"Prete A, Corsello SM, Salvatori R (2017) Current best practice in the management of patients after pituitary surgery. Ther Adv Endocrinol Metab 8(3):33\u201348","journal-title":"Ther Adv Endocrinol Metab"},{"key":"1368_CR38","doi-asserted-by":"publisher","first-page":"117955142210933","DOI":"10.1177\/11795514221093316","volume":"15","author":"R Ravindran","year":"2022","unstructured":"Ravindran R et al (2022) Pre-test cortisol levels in predicting short synacthen test outcome: a retrospective analysis. Clin Med Insights Endocrinol Diabet 15:11795514221093316","journal-title":"Clin Med Insights Endocrinol Diabet"}],"container-title":["Pituitary"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-023-01368-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11102-023-01368-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-023-01368-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T08:32:36Z","timestamp":1712910756000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11102-023-01368-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,3]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["1368"],"URL":"https:\/\/doi.org\/10.1007\/s11102-023-01368-7","relation":{},"ISSN":["1386-341X","1573-7403"],"issn-type":[{"value":"1386-341X","type":"print"},{"value":"1573-7403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,3]]},"assertion":[{"value":"27 November 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have nothing to disclose.\u00a0The Authors declare no competing non-financial interests but the following competing financial interests: Dr. Mazziotti received consultancy fees from Novartis, Ipsen, Eli Lilly and lecture fees from Amgen and Abiogen, outside the submitted work; Dr. Lania received grants from Pfizer and consultancy fees from Ipsen, outside the submitted work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}