{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:51:28Z","timestamp":1781052688525,"version":"3.54.1"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"BAP Research Project , Recep Tayyip Erdogan University, Turkey","award":["1662"],"award-info":[{"award-number":["1662"]}]},{"name":"Italian Minitry of University and Research","award":["PRIN 2017S55RXB"],"award-info":[{"award-number":["PRIN 2017S55RXB"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pituitary"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1007\/s11102-024-01394-z","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T17:01:52Z","timestamp":1716829312000},"page":"370-380","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["High prevalence of morphometric vertebral fractures opportunistically detected on thoracic radiograms in patients with non-functioning pituitary adenoma"],"prefix":"10.1007","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1308-5598","authenticated-orcid":false,"given":"Stefano","family":"Frara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6569-8142","authenticated-orcid":false,"given":"Meliha Melin","family":"Uygur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Bolamperti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"di Filippo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Doga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7810-8247","authenticated-orcid":false,"given":"Marco","family":"Losa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2320-2281","authenticated-orcid":false,"given":"Pietro","family":"Mortini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6783-3398","authenticated-orcid":false,"given":"Andrea","family":"Giustina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"1394_CR1","volume-title":"WHO classification of tumours of endocrine organs","author":"R Lloyd","year":"2017","unstructured":"Lloyd R, Osamura R, Kl\u00f6ppel G, Rosai J (2017) WHO classification of tumours of endocrine organs. IARC, New Delhi"},{"issue":"6","key":"1394_CR2","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1210\/endrev\/bnac010","volume":"43","author":"S Melmed","year":"2022","unstructured":"Melmed S, Kaiser UB, Lopes MB, Bertherat J, Syro LV, Raverot G et al (2022) Clinical biology of the pituitary adenoma. Endocrine Rev 43(6):1003\u20131037. https:\/\/doi.org\/10.1210\/endrev\/bnac010","journal-title":"Endocrine Rev"},{"issue":"1","key":"1394_CR3","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/s12020-017-1458-3","volume":"59","author":"P Mortini","year":"2018","unstructured":"Mortini P, Barzaghi LR, Albano L, Panni P, Losa M (2018) Microsurgical therapy of pituitary adenomas. Endocrine 59(1):72\u201381. https:\/\/doi.org\/10.1007\/s12020-017-1458-3","journal-title":"Endocrine"},{"issue":"4","key":"1394_CR4","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.tem.2023.01.006","volume":"34","author":"MM Uygur","year":"2023","unstructured":"Uygur MM, Frara S, di Filippo L, Giustina A (2023) New tools for bone health assessment in secreting pituitary adenomas. Trends Endocrinol Metab 34(4):231\u2013242. https:\/\/doi.org\/10.1016\/j.tem.2023.01.006","journal-title":"Trends Endocrinol Metab"},{"key":"1394_CR5","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-022-01252-w","author":"S Frara","year":"2022","unstructured":"Frara S, di Filippo L, Doga M, Loli P, Casanueva FF, Giustina A (2022) Novel approaches to bone comorbidity in cushing\u2019s disease: an update. Pituitary. https:\/\/doi.org\/10.1007\/s11102-022-01252-w","journal-title":"Pituitary"},{"issue":"8","key":"1394_CR6","doi-asserted-by":"publisher","first-page":"3402","DOI":"10.1210\/jc.2013-1460","volume":"98","author":"G Mazziotti","year":"2013","unstructured":"Mazziotti G, Bianchi A, Porcelli T, Mormando M, Maffezzoni F, Cristiano A et al (2013) Vertebral fractures in patients with acromegaly: a 3-year prospective study. J Clin Endocrinol Metabol 98(8):3402\u20133410. https:\/\/doi.org\/10.1210\/jc.2013-1460","journal-title":"J Clin Endocrinol Metabol"},{"issue":"4","key":"1394_CR7","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1359\/jbmr.060112","volume":"21","author":"G Mazziotti","year":"2006","unstructured":"Mazziotti G, Bianchi A, Bonadonna S, Nuzzo M, Cimino V, Fusco A et al (2006) Increased prevalence of radiological spinal deformities in adult patients with GH deficiency: influence of GH replacement therapy. J Bone Miner Res 21(4):520\u2013528. https:\/\/doi.org\/10.1359\/jbmr.060112","journal-title":"J Bone Miner Res"},{"issue":"1","key":"1394_CR8","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1530\/EJE-10-0125","volume":"163","author":"G Mazziotti","year":"2010","unstructured":"Mazziotti G, Porcelli T, Bianchi A, Cimino V, Patelli I, Mejia C et al (2010) Glucocorticoid replacement therapy and vertebral fractures in hypopituitary adult males with GH deficiency. Eur J Endocrinol 163(1):15. https:\/\/doi.org\/10.1530\/EJE-10-0125","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"1394_CR9","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1530\/EJE-14-0097","volume":"170","author":"G Mazziotti","year":"2014","unstructured":"Mazziotti G, Mormando M, Cristiano A, Bianchi A, Porcelli T, Giampietro A et al (2014) Association between l-thyroxine treatment, GH deficiency, and radiological vertebral fractures in patients with adult-onset hypopituitarism. Eur J Endocrinol 170(6):893\u2013899. https:\/\/doi.org\/10.1530\/EJE-14-0097","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"1394_CR10","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1210\/jc.2014-2937","volume":"100","author":"G Mazziotti","year":"2015","unstructured":"Mazziotti G, Biagioli E, Maffezzoni F, Spinello M, Serra V, Maroldi R et al (2015) Bone turnover, bone mineral density, and fracture risk in acromegaly: a meta-analysis. J Clin Endocrinol Metab 100(2):384\u2013394. https:\/\/doi.org\/10.1210\/jc.2014-2937","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"1394_CR11","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1210\/er.2018-00005","volume":"39","author":"G Mazziotti","year":"2018","unstructured":"Mazziotti G, Frara S, Giustina A (2018) Pituitary diseases and bone. Endocr Rev 39(4):440\u2013488. https:\/\/doi.org\/10.1210\/er.2018-00005","journal-title":"Endocr Rev"},{"issue":"1","key":"1394_CR12","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s12020-015-0738-z","volume":"52","author":"G Mazziotti","year":"2016","unstructured":"Mazziotti G, Doga M, Frara S, Maffezzoni F, Porcelli T, Cerri L et al (2016) Incidence of morphometric vertebral fractures in adult patients with growth hormone deficiency. Endocrine 52(1):103\u2013110. https:\/\/doi.org\/10.1007\/s12020-015-0738-z","journal-title":"Endocrine"},{"issue":"7","key":"1394_CR13","doi-asserted-by":"publisher","first-page":"e2843","DOI":"10.1210\/clinem\/dgac183","volume":"107","author":"S Frara","year":"2022","unstructured":"Frara S, Melin Uygur M, di Filippo L, Doga M, Losa M, Santoro S et al (2022) High prevalence of vertebral fractures associated with preoperative gh levels in patients with recent diagnosis of acromegaly. J Clin Endocrinol Metab 107(7):e2843\u2013e2850. https:\/\/doi.org\/10.1210\/clinem\/dgac183","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"1394_CR14","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/j.amjmed.2010.02.028","volume":"123","author":"G Mazziotti","year":"2010","unstructured":"Mazziotti G, Canalis E, Giustina A (2010) Drug-induced osteoporosis: mechanisms and clinical implications. Am J Med 123(10):877\u2013884. https:\/\/doi.org\/10.1016\/j.amjmed.2010.02.028","journal-title":"Am J Med"},{"issue":"2","key":"1394_CR15","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1210\/jc.2015-1710","volume":"101","author":"SR Bornstein","year":"2016","unstructured":"Bornstein SR, Allolio B, Arlt W, Barthel A, Don-Wauchope A, Hammer GD et al (2016) Diagnosis and treatment of primary adrenal insufficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 101(2):364\u2013389. https:\/\/doi.org\/10.1210\/jc.2015-1710","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"1394_CR16","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.juro.2018.03.115","volume":"200","author":"JP Mulhall","year":"2018","unstructured":"Mulhall JP, Trost LW, Brannigan RE, Kurtz EG, Redmon JB, Chiles KA et al (2018) Evaluation and management of testosterone deficiency: AUA guideline. J Urol 200(2):423\u2013432. https:\/\/doi.org\/10.1016\/j.juro.2018.03.115","journal-title":"J Urol"},{"issue":"12","key":"1394_CR17","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/s41574-023-00886-5","volume":"19","author":"S Petersenn","year":"2023","unstructured":"Petersenn S, Fleseriu M, Casanueva FF, Giustina A, Biermasz N, Biller BMK et al (2023) Diagnosis and management of prolactin-secreting pituitary adenomas: a pituitary society international consensus statement. Nat Rev Endocrinol 19(12):722\u2013740. https:\/\/doi.org\/10.1038\/s41574-023-00886-5","journal-title":"Nat Rev Endocrinol"},{"issue":"4","key":"1394_CR18","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s11102-006-0410-y","volume":"9","author":"M Doga","year":"2006","unstructured":"Doga M, Bonadonna S, Gola M, Mazziotti G, Giustina A (2006) Growth hormone deficiency in the adult. Pituitary 9(4):305\u2013311. https:\/\/doi.org\/10.1007\/s11102-006-0410-y","journal-title":"Pituitary"},{"issue":"9","key":"1394_CR19","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1007\/BF03349263","volume":"31","author":"A Giustina","year":"2008","unstructured":"Giustina A, Barkan A, Chanson P, Grossman A, Hoffman A, Ghigo E et al (2008) Guidelines for the treatment of growth hormone excess and growth hormone deficiency in adults. J Endocrinol Invest 31(9):820\u2013838. https:\/\/doi.org\/10.1007\/BF03349263","journal-title":"J Endocrinol Invest"},{"issue":"11","key":"1394_CR20","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.4158\/GL-2019-0405","volume":"25","author":"KC Yuen","year":"2019","unstructured":"Yuen KC, Biller BM, Radovick S, Carmichael JD, Jasim S, Pantalone KM et al (2019) American association of clinical endocrinologists and american college of endocrinology guidelines for management of growth hormone deficiency in adults and patients transitioning from pediatric to adult care. Endocr Pract 25(11):1191\u20131232. https:\/\/doi.org\/10.4158\/GL-2019-0405","journal-title":"Endocr Pract"},{"issue":"12","key":"1394_CR21","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/s2213-8587(21)00235-7","volume":"9","author":"M Fleseriu","year":"2021","unstructured":"Fleseriu M, Auchus R, Bancos I, Ben-Shlomo A, Bertherat J, Biermasz NR et al (2021) Consensus on diagnosis and management of cushing\u2019s disease: a guideline update. Lancet Diabet Endocrinol 9(12):847\u2013875. https:\/\/doi.org\/10.1016\/s2213-8587(21)00235-7","journal-title":"Lancet Diabet Endocrinol"},{"issue":"1","key":"1394_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4081\/reumatismo.2016.870","volume":"68","author":"M Rossini","year":"2016","unstructured":"Rossini M, Adami S, Bertoldo F, Diacinti D, Gatti D, Giannini S et al (2016) Guidelines for the diagnosis, prevention and management of osteoporosis. Reumatismo 68(1):1\u201339. https:\/\/doi.org\/10.4081\/reumatismo.2016.870","journal-title":"Reumatismo"},{"issue":"9","key":"1394_CR23","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1002\/jbmr.5650080915","volume":"8","author":"HK Genant","year":"1993","unstructured":"Genant HK, Wu CY, van Kuijk C, Nevitt MC (1993) Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 8(9):1137\u20131148. https:\/\/doi.org\/10.1002\/jbmr.5650080915","journal-title":"J Bone Miner Res"},{"issue":"3","key":"1394_CR24","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1023\/a:1015362822901","volume":"4","author":"A Faggiano","year":"2001","unstructured":"Faggiano A, Pivonello R, Filippella M, Di Somma C, Orio F Jr, Lombard G et al (2001) Spine abnormalities and damage in patients cured from cushing\u2019s disease. Pituitary 4(3):153\u2013161. https:\/\/doi.org\/10.1023\/a:1015362822901","journal-title":"Pituitary"},{"issue":"9","key":"1394_CR25","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1210\/js.2018-00091","volume":"2","author":"S Frara","year":"2018","unstructured":"Frara S, Losa M, Doga M, Formenti AM, Mortini P, Mazziotti G et al (2018) High prevalence of radiological vertebral fractures in patients with TSH-secreting pituitary adenoma. J Endocr Soc. 2(9):1089\u20131099. https:\/\/doi.org\/10.1210\/js.2018-00091","journal-title":"J Endocr Soc."},{"issue":"2","key":"1394_CR26","doi-asserted-by":"publisher","first-page":"189","DOI":"10.23736\/S2724-6507.21.03515-6","volume":"47","author":"T Somma","year":"2022","unstructured":"Somma T, Rosa ADE, Mastantuoni C, Esposito F, Meglio V, Romano F et al (2022) Multidisciplinary management of osteoporotic vertebral fractures. Minerva Endocrinol (Torino). 47(2):189\u2013202. https:\/\/doi.org\/10.23736\/S2724-6507.21.03515-6","journal-title":"Minerva Endocrinol (Torino)."},{"issue":"6","key":"1394_CR27","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1359\/jbmr.2003.18.6.1139","volume":"18","author":"LJ Melton III","year":"2003","unstructured":"Melton LJ III (2003) Adverse outcomes of osteoporotic fractures in the general population. J Bone Miner Res 18(6):1139\u20131141. https:\/\/doi.org\/10.1359\/jbmr.2003.18.6.1139","journal-title":"J Bone Miner Res"},{"issue":"2","key":"1394_CR28","doi-asserted-by":"publisher","first-page":"e602","DOI":"10.1210\/clinem\/dgaa738","volume":"106","author":"L di Filippo","year":"2021","unstructured":"di Filippo L, Formenti AM, Doga M, Pedone E, Rovere-Querini P, Giustina A (2021) Radiological thoracic vertebral fractures are highly prevalent in COVID-19 and predict disease outcomes. J Clin Endocrinol Metabol 106(2):e602\u2013e614. https:\/\/doi.org\/10.1210\/clinem\/dgaa738","journal-title":"J Clin Endocrinol Metabol"},{"issue":"3","key":"1394_CR29","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1007\/s11102-020-01041-3","volume":"23","author":"L di Filippo","year":"2020","unstructured":"di Filippo L, Doga M, Resmini E, Giustina A (2020) Hyperprolactinemia and bone. Pituitary 23(3):314\u2013321. https:\/\/doi.org\/10.1007\/s11102-020-01041-3","journal-title":"Pituitary"},{"issue":"4","key":"1394_CR30","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s11102-011-0293-4","volume":"14","author":"G Mazziotti","year":"2011","unstructured":"Mazziotti G, Mancini T, Mormando M, De Menis E, Bianchi A, Doga M et al (2011) High prevalence of radiological vertebral fractures in women with prolactin-secreting pituitary adenomas. Pituitary 14(4):299\u2013306. https:\/\/doi.org\/10.1007\/s11102-011-0293-4","journal-title":"Pituitary"},{"issue":"3","key":"1394_CR31","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1007\/s12020-011-9462-5","volume":"39","author":"G Mazziotti","year":"2011","unstructured":"Mazziotti G, Porcelli T, Mormando M, De Menis E, Bianchi A, Mejia C et al (2011) Vertebral fractures in males with prolactinoma. Endocrine 39(3):288\u2013293. https:\/\/doi.org\/10.1007\/s12020-011-9462-5","journal-title":"Endocrine"},{"key":"1394_CR32","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s11657-015-0244-1","volume":"10","author":"ZE Belaya","year":"2015","unstructured":"Belaya ZE, Hans D, Rozhinskaya LY, Dragunova NV, Sasonova NI, Solodovnikov AG et al (2015) The risk factors for fractures and trabecular bone-score value in patients with endogenous cushing\u2019s syndrome. Arch Osteoporos 10:44. https:\/\/doi.org\/10.1007\/s11657-015-0244-1","journal-title":"Arch Osteoporos"},{"issue":"3","key":"1394_CR33","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s11154-019-09507-x","volume":"20","author":"AM Formenti","year":"2019","unstructured":"Formenti AM, Tecilazich F, Giubbini R, Giustina A (2019) Risk of vertebral fractures in hypoparathyroidism. Rev Endocr Metab Disord 20(3):295\u2013302. https:\/\/doi.org\/10.1007\/s11154-019-09507-x","journal-title":"Rev Endocr Metab Disord"},{"issue":"1","key":"1394_CR34","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1136\/ard.2008.092775","volume":"68","author":"TA van Geel","year":"2009","unstructured":"van Geel TA, van Helden S, Geusens PP, Winkens B, Dinant GJ (2009) Clinical subsequent fractures cluster in time after first fractures. Ann Rheum Dis 68(1):99\u2013102. https:\/\/doi.org\/10.1136\/ard.2008.092775","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"1394_CR35","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1002\/jbmr.5650110719","volume":"11","author":"TW O'Neill","year":"1996","unstructured":"O\u2019Neill TW, Felsenberg D, Varlow J, Cooper C, Kanis JA, Silman AJ (1996) The prevalence of vertebral deformity in european men and women: the European Vertebral Osteoporosis Study. J Bone Miner Res 11(7):1010\u20131018. https:\/\/doi.org\/10.1002\/jbmr.5650110719","journal-title":"J Bone Miner Res"},{"issue":"4","key":"1394_CR36","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.bone.2003.11.026","volume":"34","author":"E Canalis","year":"2004","unstructured":"Canalis E, Bilezikian JP, Angeli A, Giustina A (2004) Perspectives on glucocorticoid-induced osteoporosis. Bone 34(4):593\u2013598. https:\/\/doi.org\/10.1016\/j.bone.2003.11.026","journal-title":"Bone"},{"key":"1394_CR37","unstructured":"Division UNDoEaSAP.(2022) World population prospects 2022: Summary of results. https:\/\/www.un.org\/development\/desa\/pd\/sites\/www.un.org.development.desa.pd\/files\/wpp2022_summary_of_results.pdf"},{"issue":"1","key":"1394_CR38","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s11657-020-0706-y","volume":"15","author":"F Borgstrom","year":"2020","unstructured":"Borgstrom F, Karlsson L, Ortsater G, Norton N, Halbout P, Cooper C et al (2020) Fragility fractures in Europe: burden, management and opportunities. Arch Osteoporos 15(1):59. https:\/\/doi.org\/10.1007\/s11657-020-0706-y","journal-title":"Arch Osteoporos"},{"issue":"2","key":"1394_CR39","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1017\/cjn.2015.301","volume":"43","author":"K Al-Dahmani","year":"2016","unstructured":"Al-Dahmani K, Mohammad S, Imran F, Theriault C, Doucette S, Zwicker D et al (2016) Sellar masses: an epidemiological study. Can J Neurol Sci 43(2):291\u2013297. https:\/\/doi.org\/10.1017\/cjn.2015.301","journal-title":"Can J Neurol Sci"},{"issue":"2","key":"1394_CR40","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1530\/eje.1.02334","volume":"156","author":"OM Dekkers","year":"2007","unstructured":"Dekkers OM, Hammer S, de Keizer RJ, Roelfsema F, Schutte PJ, Smit JW et al (2007) The natural course of non-functioning pituitary macroadenomas. Eur J Endocrinol 156(2):217\u2013224. https:\/\/doi.org\/10.1530\/eje.1.02334","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"1394_CR41","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1111\/cen.12879","volume":"84","author":"N Lenders","year":"2016","unstructured":"Lenders N, Ikeuchi S, Russell AW, Ho KK, Prins JB, Inder WJ (2016) Longitudinal evaluation of the natural history of conservatively managed nonfunctioning pituitary adenomas. Clin Endocrinol 84(2):222\u2013228. https:\/\/doi.org\/10.1111\/cen.12879","journal-title":"Clin Endocrinol"},{"issue":"6","key":"1394_CR42","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1111\/j.1365-2265.2007.02990.x","volume":"67","author":"N Karavitaki","year":"2007","unstructured":"Karavitaki N, Collison K, Halliday J, Byrne JV, Price P, Cudlip S et al (2007) What is the natural history of nonoperated nonfunctioning pituitary adenomas? Clin Endocrinol 67(6):938\u2013943. https:\/\/doi.org\/10.1111\/j.1365-2265.2007.02990.x","journal-title":"Clin Endocrinol"},{"issue":"6","key":"1394_CR43","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1530\/eje.1.02298","volume":"155","author":"E Ferrante","year":"2006","unstructured":"Ferrante E, Ferraroni M, Castrignano T, Menicatti L, Anagni M, Reimondo G et al (2006) Non-functioning pituitary adenoma database: a useful resource to improve the clinical management of pituitary tumors. Eur J Endocrinol 155(6):823\u2013829. https:\/\/doi.org\/10.1530\/eje.1.02298","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"1394_CR44","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.tem.2020.12.004","volume":"32","author":"AM Formenti","year":"2021","unstructured":"Formenti AM, Dalla Volta A, di Filippo L, Berruti A, Giustina A (2021) Effects of medical treatment of prostate cancer on bone health. Trends Endocrinol Metabol TEM 32(3):135\u2013158. https:\/\/doi.org\/10.1016\/j.tem.2020.12.004","journal-title":"Trends Endocrinol Metabol TEM"},{"key":"1394_CR45","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.bone.2017.01.013","volume":"97","author":"R Pedersini","year":"2017","unstructured":"Pedersini R, Monteverdi S, Mazziotti G, Amoroso V, Roca E, Maffezzoni F et al (2017) Morphometric vertebral fractures in breast cancer patients treated with adjuvant aromatase inhibitor therapy: a cross-sectional study. Bone 97:147\u2013152. https:\/\/doi.org\/10.1016\/j.bone.2017.01.013","journal-title":"Bone"},{"key":"1394_CR46","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-015-0421-5","author":"G Iolascon","year":"2015","unstructured":"Iolascon G, Frizzi L, Bianco M, Gimigliano F, Palumbo V, Sinisi AM et al (2015) Bone involvement in males with kallmann disease. Aging Clin Exp Res. https:\/\/doi.org\/10.1007\/s40520-015-0421-5","journal-title":"Aging Clin Exp Res"},{"issue":"12","key":"1394_CR47","doi-asserted-by":"publisher","first-page":"4649","DOI":"10.1210\/jc.2008-0791","volume":"93","author":"G Mazziotti","year":"2008","unstructured":"Mazziotti G, Bianchi A, Bonadonna S, Cimino V, Patelli I, Fusco A et al (2008) Prevalence of vertebral fractures in men with acromegaly. J Clin Endocrinol Metab 93(12):4649\u20134655. https:\/\/doi.org\/10.1210\/jc.2008-0791","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"1394_CR48","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1530\/EJE-10-1005","volume":"164","author":"M Wassenaar","year":"2011","unstructured":"Wassenaar M, Biermasz N, Hamdy N, Zillikens M, Van Meurs J, Rivadeneira F et al (2011) High prevalence of vertebral fractures despite normal bone mineral density in patients with long-term controlled acromegaly. Eur J Endocrinol 164(4):475-483. https:\/\/doi.org\/10.1530\/EJE-10-1005","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"1394_CR49","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s12020-017-1391-5","volume":"59","author":"S Chiloiro","year":"2018","unstructured":"Chiloiro S, Mormando M, Bianchi A, Giampietro A, Milardi D, Bima C et al (2018) Prevalence of morphometric vertebral fractures in \u201cdifficult\u201d patients with acromegaly with different biochemical outcomes after multimodal treatment. Endocrine 59(2):449\u2013453. https:\/\/doi.org\/10.1007\/s12020-017-1391-5","journal-title":"Endocrine"},{"issue":"3","key":"1394_CR50","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s12020-021-02751-9","volume":"73","author":"MM Uygur","year":"2021","unstructured":"Uygur MM, Bu\u011fdayc\u0131 O, Yavuz DG (2021) Prevalence of vertebral fractures and serum sclerostin levels in acromegaly. Endocrine 73(3):67\u2013673. https:\/\/doi.org\/10.1007\/s12020-021-02751-9","journal-title":"Endocrine"},{"issue":"3","key":"1394_CR51","doi-asserted-by":"publisher","first-page":"449","DOI":"10.3390\/jcm10030530","volume":"10","author":"K Shigehara","year":"2021","unstructured":"Shigehara K, Izumi K, Kadono Y, Mizokami A (2021) Testosterone and bone health in men: a narrative review. J Clin Med 10(3):530. https:\/\/doi.org\/10.3390\/jcm10030530","journal-title":"J Clin Med"},{"issue":"12","key":"1394_CR52","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.1007\/s40618-022-01859-7","volume":"45","author":"AM Isidori","year":"2022","unstructured":"Isidori AM, Aversa A, Calogero A, Ferlin A, Francavilla S, Lanfranco F et al (2022) Adult- and late-onset male hypogonadism: the clinical practice guidelines of the italian society of andrology and sexual medicine (SIAMS) and the Italian society of endocrinology (SIE). J Endocrinol Invest 45(12):2385\u20132403. https:\/\/doi.org\/10.1007\/s40618-022-01859-7","journal-title":"J Endocrinol Invest"},{"issue":"3","key":"1394_CR53","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1210\/jc.2017-01986","volume":"103","author":"G Mazziotti","year":"2018","unstructured":"Mazziotti G, Formenti AM, Frara S, Olivetti R, Banfi G, Memo M et al (2018) High prevalence of radiological vertebral fractures in women on thyroid-stimulating hormone-suppressive therapy for thyroid carcinoma. J Clin Endocrinol Metabol 103(3):956\u2013964. https:\/\/doi.org\/10.1210\/jc.2017-01986","journal-title":"J Clin Endocrinol Metabol"},{"issue":"11","key":"1394_CR54","doi-asserted-by":"publisher","first-page":"3888","DOI":"10.1210\/jc.2016-2118","volume":"101","author":"M Fleseriu","year":"2016","unstructured":"Fleseriu M, Hashim IA, Karavitaki N, Melmed S, Murad MH, Salvatori R et al (2016) Hormonal replacement in hypopituitarism in adults: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 101(11):3888\u20133921. https:\/\/doi.org\/10.1210\/jc.2016-2118","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"1394_CR55","doi-asserted-by":"publisher","first-page":"R231","DOI":"10.1530\/eje-17-0154","volume":"177","author":"G Mazziotti","year":"2017","unstructured":"Mazziotti G, Formenti AM, Frara S, Roca E, Mortini P, Berruti A et al (2017) Management of endocrine disease: risk of overtreatment in patients with adrenal insufficiency: current and emerging aspects. Eur J Endocrinol 177(5):R231\u2013R248. https:\/\/doi.org\/10.1530\/eje-17-0154","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"1394_CR56","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1530\/EJE-10-0043","volume":"163","author":"D Rendina","year":"2010","unstructured":"Rendina D, Gianfrancesco F, De Filippo G, Merlotti D, Esposito T, Mingione A et al (2010) FSHR gene polymorphisms influence bone mineral density and bone turnover in postmenopausal women. Eur J Endocrinol 163(1):165\u2013172. https:\/\/doi.org\/10.1530\/EJE-10-0043","journal-title":"Eur J Endocrinol"},{"issue":"5","key":"1394_CR57","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1210\/jc.2009-0659","volume":"95","author":"MR Sowers","year":"2010","unstructured":"Sowers MR, Zheng H, Jannausch ML, McConnell D, Nan B, Harlow S et al (2010) Amount of bone loss in relation to time around the final menstrual period and follicle-stimulating hormone staging of the transmenopause. J Clin Endocrinol Metabol 95(5):2155\u20132162. https:\/\/doi.org\/10.1210\/jc.2009-0659","journal-title":"J Clin Endocrinol Metabol"},{"issue":"1","key":"1394_CR58","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1210\/jc.2012-2778","volume":"98","author":"U Omodei","year":"2013","unstructured":"Omodei U, Mazziotti G, Donarini G, Gola M, Guella V, Pagani F et al (2013) Effects of recombinant follicle-stimulating hormone on bone turnover markers in infertile women undergoing in vitro fertilization procedure. J Clin Endocrinol Metabol 98(1):330\u2013336. https:\/\/doi.org\/10.1210\/jc.2012-2778","journal-title":"J Clin Endocrinol Metabol"},{"issue":"2","key":"1394_CR59","doi-asserted-by":"publisher","first-page":"137","DOI":"10.23736\/S0391-1977.18.02946-2","volume":"44","author":"C Lamas","year":"2019","unstructured":"Lamas C, Garcia-Martinez A, Camara R, Fajardo-Montanana C, Viguera L, Aranda I (2019) Silent somatotropinomas. Minerva Endocrinol 44(2):137\u2013142. https:\/\/doi.org\/10.23736\/S0391-1977.18.02946-2","journal-title":"Minerva Endocrinol"},{"issue":"2","key":"1394_CR60","doi-asserted-by":"publisher","first-page":"101515","DOI":"10.1016\/j.beem.2021.101515","volume":"35","author":"S Frara","year":"2021","unstructured":"Frara S, Allora A, di Filippo L, Formenti AM, Loli P, Polizzi E et al (2021) Osteopathy in mild adrenal cushing\u2019s syndrome and cushing disease. Best Pract Res Clin Endocrinol Metabol 35(2):101515. https:\/\/doi.org\/10.1016\/j.beem.2021.101515","journal-title":"Best Pract Res Clin Endocrinol Metabol"},{"issue":"4","key":"1394_CR61","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1007\/s11154-021-09693-7","volume":"22","author":"JP Bilezikian","year":"2021","unstructured":"Bilezikian JP, Formenti AM, Adler RA, Binkley N, Bouillon R, Lazaretti-Castro M et al (2021) Vitamin D: dosing, levels, form, and route of administration: does one approach fit all? Rev Endocr Metabol Disord 22(4):1201\u20131218. https:\/\/doi.org\/10.1007\/s11154-021-09693-7","journal-title":"Rev Endocr Metabol Disord"},{"issue":"4","key":"1394_CR62","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/s41574-023-00942-0","volume":"20","author":"A Giustina","year":"2024","unstructured":"Giustina A, Lazaretti-Castro M, Martineau AR, Mason RS, Rosen CJ, Schoenmakers I (2024) A view on vitamin D: a pleiotropic factor? Nat Rev Endocrinol 20(4):202\u2013208. https:\/\/doi.org\/10.1038\/s41574-023-00942-0","journal-title":"Nat Rev Endocrinol"},{"key":"1394_CR63","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad493","author":"S Chiloiro","year":"2023","unstructured":"Chiloiro S, Frara S, Gagliardi I, Bianchi A, Giampietro A, Medici M et al (2023) Cholecalciferol use is associated with a decreased risk of incident morphometric vertebral fractures in acromegaly. Journal Clin Endocrinol Metabol. https:\/\/doi.org\/10.1210\/clinem\/dgad493","journal-title":"Journal Clin Endocrinol Metabol"},{"issue":"1","key":"1394_CR64","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1210\/jcem-68-1-120","volume":"68","author":"A Giustina","year":"1989","unstructured":"Giustina A, Romanelli G, Candrina R, Giustina G (1989) Growth hormone deficiency in patients with idiopathic adrenocorticotropin deficiency resolves during glucocorticoid replacement. J Clin Endocrinol Metab 68(1):120\u2013124. https:\/\/doi.org\/10.1210\/jcem-68-1-120","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"1394_CR65","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.ecl.2020.05.010","volume":"49","author":"S Frara","year":"2020","unstructured":"Frara S, Rodriguez-Carnero G, Formenti AM, Martinez-Olmos MA, Giustina A, Casanueva FF (2020) Pituitary tumors centers of excellence. Endocrinol Metab Clin North Am 49(3):553\u2013564. https:\/\/doi.org\/10.1016\/j.ecl.2020.05.010","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"5","key":"1394_CR66","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s11102-023-01345-0","volume":"26","author":"A Giustina","year":"2023","unstructured":"Giustina A, Uygur MM, Frara S, Barkan A, Biermasz NR, Chanson P et al (2023) Pilot study to define criteria for pituitary tumors centers of excellence (PTCOE): results of an audit of leading international centers. Pituitary 26(5):583\u2013596. https:\/\/doi.org\/10.1007\/s11102-023-01345-0","journal-title":"Pituitary"},{"issue":"5","key":"1394_CR67","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1007\/s11102-022-01252-w","volume":"25","author":"S Frara","year":"2022","unstructured":"Frara S, di Filippo L, Doga M, Loli P, Casanueva FF, Giustina A (2022) Novel approaches to bone comorbidity in cushing\u2019s disease: an update. Pituitary 25(5):754\u2013759. https:\/\/doi.org\/10.1007\/s11102-022-01252-w","journal-title":"Pituitary"},{"key":"1394_CR68","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz096","author":"A Giustina","year":"2020","unstructured":"Giustina A, Barkan A, Beckers A, Biermasz N, Biller BMK, Boguszewski C et al (2020) A Consensus on the diagnosis and treatment of acromegaly comorbidities: an update. J Clin Endocrinol Metab. https:\/\/doi.org\/10.1210\/clinem\/dgz096","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Pituitary"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-024-01394-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11102-024-01394-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-024-01394-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T13:17:53Z","timestamp":1722345473000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11102-024-01394-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,27]]},"references-count":68,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["1394"],"URL":"https:\/\/doi.org\/10.1007\/s11102-024-01394-z","relation":{},"ISSN":["1386-341X","1573-7403"],"issn-type":[{"value":"1386-341X","type":"print"},{"value":"1573-7403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,27]]},"assertion":[{"value":"22 April 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"SF received research grant to Institution from Abiogen Pharma, consultancy, and speaker fees from Ipsen, Novartis and Pfizer, took part in advisory boards from Recordati and Novo Nordisk. AG received grants\/scientific consultancy from Abiogen, Chiasma, Ipsen, Pfizer, Recordati and research grants to Institution from Abiogen, Ipsen, Novartis, Pfizer, and Takeda. The other Authors declare that they have no conflicts of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}