{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:00:15Z","timestamp":1793293215403,"version":"4.5.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pituitary"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s11102-025-01508-1","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T21:17:01Z","timestamp":1741900621000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical and prognostic implications of pituitary macroadenomas (PitNets) grading: a monocentric experience"],"prefix":"10.1007","volume":"28","author":[{"given":"F.","family":"Ferra\u00f9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Giuffrida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Casablanca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ylenia","family":"Alessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Tuccari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. R.","family":"Cotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. F.","family":"Angileri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Cannav\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"issue":"12 Suppl 2","key":"1508_CR1","doi-asserted-by":"publisher","first-page":"iii1","DOI":"10.1093\/neuonc\/noab200","volume":"23","author":"QT Ostrom","year":"2021","unstructured":"Ostrom QT, Cioffi G, Waite K et al (2021) CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the united States in 2014\u20132018. Neuro-Oncol 23(12 Suppl 2):iii1\u2013iii105","journal-title":"Neuro-Oncol"},{"key":"1508_CR2","volume-title":"Aggressive pituitary tumors and pituitary carcinomas. 2022, 5","author":"SMC De Sousa","year":"2000","unstructured":"De Sousa SMC, McCormack AI (2000) In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E et al (eds) Aggressive pituitary tumors and pituitary carcinomas. 2022, 5. MDText.com, Inc., South Dartmouth (MA)"},{"issue":"8","key":"1508_CR3","doi-asserted-by":"publisher","first-page":"e230021","DOI":"10.1530\/ERC-23-0021","volume":"30","author":"C Villa","year":"2023","unstructured":"Villa C, Baussart B, Assi G, Raverot G, Roncaroli F (2023) The world health organization classifications of pituitary neuroendocrine tumours: a clinico-pathological appraisal. Endocr Relat Cancer 30(8):e230021. https:\/\/doi.org\/10.1530\/ERC-23-0021Print 2023 Aug 1","journal-title":"Endocr Relat Cancer"},{"issue":"6","key":"1508_CR4","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1007\/s11596-022-2673-6","volume":"42","author":"X Wan","year":"2022","unstructured":"Wan X, Chen J, Wang J, Liu Y, Shu K, Lei T (2022) Overview of the 2022 WHO classification of pituitary adenomas\/pituitary neuroendocrine tumors: clinical practices, controversies, and perspectives. Curr Med Sci 42(6):1111\u20131118. https:\/\/doi.org\/10.1007\/s11596-022-2673-6Epub 2022 Dec 22","journal-title":"Curr Med Sci"},{"issue":"7","key":"1508_CR5","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1007\/s40618-019-01178-4","volume":"43","author":"TM Vicchio","year":"2020","unstructured":"Vicchio TM, Aliqu\u00f2 F, Ruggeri RM, Ragonese M, Giuffrida G, Cotta OR et al (2020) MicroRNAs expression in pituitary tumors: differences related to functional status, pathological features, and clinical behavior. J Endocrinol Invest 43(7):947\u2013958","journal-title":"J Endocrinol Invest"},{"key":"1508_CR6","doi-asserted-by":"publisher","first-page":"841118","DOI":"10.3389\/fendo.2022.841118","volume":"13","author":"G Giuffrida","year":"2022","unstructured":"Giuffrida G, D\u2019Argenio V, Ferra\u00f9 F, Lasorsa VA, Polito F, Aliqu\u00f2 F et al (2022) Aguennouz M. Methylome analysis in nonfunctioning and GH-Secreting pituitary adenomas. Front Endocrinol (Lausanne) 13:841118","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"1508_CR7","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s00401-013-1084-y","volume":"126","author":"J Trouillas","year":"2013","unstructured":"Trouillas J, Roy P, Sturm N, Dantony E, Cortet-Rudelli C, Viennet G et al (2013) A new prognostic clinicopathological classification of pituitary adenomas: a multicentric case-control study of 410 patients with 8 years post-operative follow-up. Acta Neuropathol 126(1):123\u2013135","journal-title":"Acta Neuropathol"},{"issue":"2","key":"1508_CR8","doi-asserted-by":"publisher","first-page":"514","DOI":"10.3390\/cancers12020514","volume":"12","author":"J Trouillas","year":"2020","unstructured":"Trouillas J, Jaffrain-Rea ML, Vasiljevic A, Raverot G, Roncaroli F, Villa C (2020) How to classify the pituitary neuroendocrine tumors (PitNET)s in 2020. Cancers (Basel) 12(2):514","journal-title":"Cancers (Basel)"},{"issue":"3","key":"1508_CR9","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1530\/EJE-17-0933","volume":"178","author":"A McCormack","year":"2018","unstructured":"McCormack A, Dekkers OM, Petersenn S, Popovic V, Trouillas J, Raverot G, Burman P (2018) ESE survey collaborators. Treatment of aggressive pituitary tumours and carcinomas: results of a European society of endocrinology (ESE) survey 2016. Eur J Endocrinol 178(3):265\u2013227","journal-title":"Eur J Endocrinol"},{"issue":"9","key":"1508_CR10","doi-asserted-by":"publisher","first-page":"3368","DOI":"10.1210\/jc.2017-00773","volume":"102","author":"G Raverot","year":"2017","unstructured":"Raverot G et al (2017) Risk of recurrence in pituitary neuroendocrine tumors: A prospective study using a Five-Tiered classification. J Clin Endocrinol Metab 102(9):3368\u20133374","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"1508_CR11","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1530\/EJE-18-0749","volume":"180","author":"S Asioli","year":"2019","unstructured":"Asioli S, Righi A, Iommi M, Baldovini C, Ambrosi F, Guaraldi F, Zoli M et al (2019) Validation of a clinicopathological score for the prediction of post-surgical evolution of pituitary adenoma: retrospective analysis on 566 patients from a tertiary care centre. Eur J Endocrinol 180(2):127\u2013134","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"1508_CR12","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1530\/EJE-22-0812","volume":"187","author":"N Sahakian","year":"2022","unstructured":"Sahakian N, Appay R, Resseguier N et al (2022) Real-life clinical impact of a five-tiered classification of pituitary tumors. Eur J Endocrinol 187(6):893\u2013904. https:\/\/doi.org\/10.1530\/EJE-22-0812Print 2022 Dec 1.\u00f9","journal-title":"Eur J Endocrinol"},{"issue":"4","key":"1508_CR13","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1007\/s11102-023-01319-2","volume":"26","author":"C Peixe","year":"2023","unstructured":"Peixe C, Alexandre MI, Gomes AR et al (2023) Usefulness of a clinicopathological classification in predicting treatment-related outcomes and multimodal therapeutic approaches in pituitary adenoma patients: retrospective analysis on a Portuguese cohort of 129 patients from a tertiary pituitary center. Pituitary 26(4):352\u2013363. https:\/\/doi.org\/10.1007\/s11102-023-01319-2Epub 2023 Apr 18","journal-title":"Pituitary"},{"issue":"11","key":"1508_CR14","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1007\/s00234-023-03162-5","volume":"65","author":"R Calandrelli","year":"2023","unstructured":"Calandrelli R, Pilato F, D\u2019Apolito G et al (2023) MRI and Trouillas\u2019 grading system of pituitary tumors: the usefulness of T2 signal intensity volumetric values. Neuroradiology 65(11):1567\u20131578 Epub 2023 May 26","journal-title":"Neuroradiology"},{"key":"1508_CR15","doi-asserted-by":"publisher","first-page":"3933","DOI":"10.1210\/jc.2014-2700","volume":"99","author":"L Katznelson","year":"2014","unstructured":"Katznelson L, Laws ER Jr, Melmed S et al (2014) Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 99:3933\u20133951","journal-title":"J Clin Endocrinol Metab"},{"key":"1508_CR16","doi-asserted-by":"publisher","first-page":"5593","DOI":"10.1210\/jc.2003-030871","volume":"88","author":"G Arnaldi","year":"2003","unstructured":"Arnaldi G, Angeli A, Atkinson AB, Bertahna X, Cavagnini F, Chrousos GP et al (2003) Diagnosis and complications of Cushing\u2019s syndrome: a consensus statement. J Clin Endocrinol Metab 88:5593\u20135602","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"1508_CR17","doi-asserted-by":"publisher","first-page":"101278","DOI":"10.1016\/j.beem.2019.05.002","volume":"33","author":"WA Bashari","year":"2019","unstructured":"Bashari WA, Senanayake R, Fern\u00e1ndez-Pombo A, Gillett D, Koulouri O, Powlson AS et al (2019) Modern imaging of pituitary adenomas. Best Pract Res Clin Endocrinol Metab 33(2):101278","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"4","key":"1508_CR18","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1007\/s00401-017-1769-8","volume":"134","author":"MBS Lopes","year":"2017","unstructured":"Lopes MBS (2017) The 2017 world health organization classification of tumors of the pituitary gland: a summary. Acta Neuropathol 134(4):521\u2013535","journal-title":"Acta Neuropathol"},{"issue":"119","key":"1508_CR19","doi-asserted-by":"publisher","first-page":"2464","DOI":"10.3390\/jcm11092464","volume":"27","author":"L Lu","year":"2022","unstructured":"Lu L, Wan X, Xu Y, Chen J, Shu K, Lei T (2022) Classifying pituitary adenoma invasiveness based on radiological, surgical and histological features: A retrospective assessment of 903 cases. J Clin Med 27(119):2464","journal-title":"J Clin Med"},{"issue":"9","key":"1508_CR20","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1038\/s41379-021-00820-y","volume":"34","author":"SL Asa","year":"2021","unstructured":"Asa SL, Meter O, Cusimano MD et al (2021) Attendees of the 15th meeting of the international pituitary pathology club, Instanbul October 2019. pituitary neuroendocrine tumors: a model for neuroendocrine tumor classification. Mod Pathol 34(9):1634\u20131650","journal-title":"Mod Pathol"},{"issue":"12","key":"1508_CR21","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.3390\/cancers11121936","volume":"11","author":"S Serioli","year":"2019","unstructured":"Serioli S, Doglietto F, Fiorindi A, Biroli A, Mattavelli D, Buffoli B, Ferrari M, Cornali C, Rodella L, Maroldi R, Gasparotti R, Nicolai P, Fontanella MM, Poliani PL (2019) Pituitary adenomas and invasiveness from Anatomo-Surgical, radiological, and histological perspectives: A systematic literature review. Cancers (Basel) 11(12):1936","journal-title":"Cancers (Basel)"}],"container-title":["Pituitary"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-025-01508-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11102-025-01508-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-025-01508-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T08:48:17Z","timestamp":1746521297000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11102-025-01508-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,13]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["1508"],"URL":"https:\/\/doi.org\/10.1007\/s11102-025-01508-1","relation":{},"ISSN":["1386-341X","1573-7403"],"issn-type":[{"value":"1386-341X","type":"print"},{"value":"1573-7403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,13]]},"assertion":[{"value":"17 February 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"41"}}