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The meta-analysis included studies retrieved from PubMed, Embase and PsycINFO that reported risk of psychopathology in acromegaly compared to NFPA or healthy controls, using a random effects model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study population comprised 105 acromegaly and 211 NFPA patients, with similar sex distributions. Patients with acromegaly presented with smaller pituitary adenomas (17.9 (SD: 9.9) mm vs. 22.9 (SD: 10.6) mm, p\u2009&lt;\u20090.001), more frequent pituitary surgery (89.1 vs. 60.2%, p\u2009&lt;\u20090.001) and hormone replacement therapy (25.7 vs. 16.1%, p\u2009=\u20090.042). Acromegaly patients had higher risk of depression (RR: 1.9, CI95% [1.2\u20133.2], p\u2009=\u20090.009), and increased need of admissions to the psychiatric ward (5.7 vs. 0.5%, p\u2009=\u20090.006). The relative risk of anxiety was 1.4 (CI95% [0.5\u20134.4], p\u2009=\u20090.53). Daily opioid use was higher in acromegaly patients with psychiatric morbidity which was associated with a diagnosis of arthropathy (p\u2009=\u20090.009). From the meta-analysis (8 studies, 1387 patients) an increased risk of depression (RR:1.8, CI95% [1.3\u20132.5]) and anxiety (RR:1.9, CI95% [1.1\u20133.2]) was observed in acromegaly compared to NFPAs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study reveals a higher risk of psychiatric disorders in acromegaly, particularly depression and anxiety. Consequently, a need for increased psychiatric awareness in acromegaly is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11102-025-01509-0","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T17:16:51Z","timestamp":1741886211000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Psychiatric morbidity in acromegaly: a cohort study and meta-analysis of the literature"],"prefix":"10.1007","volume":"28","author":[{"given":"Astrid Thaarup","family":"Matthesen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Rosendal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma H.","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helga","family":"Beckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5627-598X","authenticated-orcid":false,"given":"Frederik \u00d8stergaard","family":"Klit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0237-3620","authenticated-orcid":false,"given":"Amar","family":"Nikontovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2290-1048","authenticated-orcid":false,"given":"Gustav","family":"Bizik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9046-2967","authenticated-orcid":false,"given":"Peter","family":"Vestergaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0610-7867","authenticated-orcid":false,"given":"Jakob","family":"Dal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"1509_CR1","doi-asserted-by":"publisher","unstructured":"Ben-Shlomo A., Melmed S (2008) Acromegaly. 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