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Data on clinical, endocrine, and surgical outcomes were collected and analyzed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The cohort included 3 pituicytomas (PCs), 8 granular cell tumors (GCTs), and 8 spindle cell oncocytomas (SCOs) patients, with a female predominance (58%) and a mean age of 57.2\u2009\u00b1\u200913.2 years. Symptoms leading to diagnosis were headache (31.6%), visual impairment (21%), and sexual dysfunction (10.5%). GCT patients had higher preoperative BMI (34.49\u2009\u00b1\u20095.72) compared to PC (22.12\u2009\u00b1\u20092.40) and SCO (24.74\u2009\u00b1\u20094.24) patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Postoperative BMI increased across all groups, with GCTs patients showing the steepest rise (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Endocrine dysfunction largely persisted or worsened after surgery, with limited recovery at follow-up. Surgical approaches included transsphenoidal (48%) and transcranial (52%), achieving gross total resection in 58% of cases. Tumor recurrence occurred in 16% of patients, all requiring adjuvant radiation therapy. Tumor-specific survival at 5 years was 100% with an overall survival rate of 80% where non-tumor-related comorbidities accounted for the observed mortality.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>PPTs are rare tumors with significant endocrine and metabolic consequences. While surgical management is associated with favorable tumor-specific survival, persistent endocrine dysfunction and postoperative progressive BMI underscore the need for long-term follow-up and targeted interventions. These findings contribute to the understanding of PPT biology and support the development of optimized management strategies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s11102-025-01518-z","type":"journal-article","created":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T02:49:37Z","timestamp":1743907777000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical, surgical, and endocrine outcome following treatment of posterior pituitary tumors: a retrospective cohort study"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6082-6617","authenticated-orcid":false,"given":"Natalia","family":"Kremenevski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Schnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Coras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Buchfelder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirjhar","family":"Hore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,5]]},"reference":[{"issue":"6","key":"1518_CR1","doi-asserted-by":"publisher","first-page":"e220188","DOI":"10.1530\/EC-22-0188","volume":"11","author":"N Qiao","year":"2022","unstructured":"Qiao N, Cheng H, Zhang Z, Ye H, Shen M, Shou X, Cao X, Chen H, Zhou X, Wang Y, Zhao Y (2022) Recommendation to improve the WHO classification of posterior pituitary tumors as a unique entity: evidence from a large case series. 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