{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T10:48:19Z","timestamp":1784026099503,"version":"3.55.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pituitary"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s11102-025-01550-z","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T05:46:20Z","timestamp":1750916780000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Weight gain reversibility and BMI following treatment for Cushing\u2019s syndrome: long-term outcomes and potential predictors"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7175-7742","authenticated-orcid":false,"given":"Liat","family":"Sasson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3344-3006","authenticated-orcid":false,"given":"Laura","family":"Dery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Stern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9188-3894","authenticated-orcid":false,"given":"Ilan","family":"Shimon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3220-6321","authenticated-orcid":false,"given":"Yaron","family":"Rudman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0551-4759","authenticated-orcid":false,"given":"Idit","family":"Dotan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2359-5249","authenticated-orcid":false,"given":"Shiri","family":"Kushnir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7576-8327","authenticated-orcid":false,"given":"Tzipora","family":"Shochat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9284-6289","authenticated-orcid":false,"given":"Maria","family":"Fleseriu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9376-344X","authenticated-orcid":false,"given":"Amit","family":"Akirov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"1550_CR1","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1001\/jama.2023.11305","volume":"330","author":"M Reincke","year":"2023","unstructured":"Reincke M, Fleseriu M (2023) Cushing syndrome: A review. JAMA 330:170\u2013181. https:\/\/doi.org\/10.1001\/jama.2023.11305","journal-title":"JAMA"},{"key":"1550_CR2","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.1016\/S0140-6736(23)01961-X","volume":"402","author":"M Gadelha","year":"2023","unstructured":"Gadelha M, Gatto F, Wildemberg LE, Fleseriu M (2023) Cushing\u2019s syndrome. Lancet 402:2237\u20132252. https:\/\/doi.org\/10.1016\/S0140-6736(23)01961-X","journal-title":"Lancet"},{"key":"1550_CR3","doi-asserted-by":"publisher","first-page":"e3723","DOI":"10.1210\/clinem\/dgac379","volume":"107","author":"LT Braun","year":"2022","unstructured":"Braun LT, Vogel F, Zopp S et al (2022) Whom should we screen for Cushing syndrome?? The endocrine society practice guideline recommendations 2008 revisited. J Clin Endocrinol Metab 107:e3723\u2013e3730. https:\/\/doi.org\/10.1210\/clinem\/dgac379","journal-title":"J Clin Endocrinol Metab"},{"key":"1550_CR4","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/S2213-8587(16)00086-3","volume":"4","author":"R Pivonello","year":"2016","unstructured":"Pivonello R, Isidori AM, De Martino MC et al (2016) Complications of cushing\u2019s syndrome: state of the Art. Lancet Diabetes Endocrinol 4:611\u2013629. https:\/\/doi.org\/10.1016\/S2213-8587(16)00086-3","journal-title":"Lancet Diabetes Endocrinol"},{"key":"1550_CR5","doi-asserted-by":"publisher","first-page":"2377","DOI":"10.1210\/clinem\/dgac265","volume":"107","author":"P Limumpornpetch","year":"2022","unstructured":"Limumpornpetch P, Morgan AW, Tiganescu A et al (2022) The effect of endogenous Cushing syndrome on All-cause and Cause-specific mortality. J Clin Endocrinol Metab 107:2377\u20132388. https:\/\/doi.org\/10.1210\/clinem\/dgac265","journal-title":"J Clin Endocrinol Metab"},{"key":"1550_CR6","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/S2213-8587(21)00235-7","volume":"9","author":"M Fleseriu","year":"2021","unstructured":"Fleseriu M, Auchus R, Bancos I et al (2021) Consensus on diagnosis and management of cushing\u2019s disease: a guideline update. Lancet Diabetes Endocrinol 9:847\u2013875. https:\/\/doi.org\/10.1016\/S2213-8587(21)00235-7","journal-title":"Lancet Diabetes Endocrinol"},{"key":"1550_CR7","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1210\/jc.2008-0125","volume":"93","author":"LK Nieman","year":"2008","unstructured":"Nieman LK, Biller BMK, Findling JW et al (2008) The diagnosis of cushing\u2019s syndrome: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 93:1526\u20131540. https:\/\/doi.org\/10.1210\/jc.2008-0125","journal-title":"J Clin Endocrinol Metab"},{"key":"1550_CR8","doi-asserted-by":"publisher","first-page":"101380","DOI":"10.1016\/j.beem.2020.101380","volume":"34","author":"M Barbot","year":"2020","unstructured":"Barbot M, Zilio M, Scaroni C (2020) Cushing\u2019s syndrome: overview of clinical presentation, diagnostic tools and complications. Best Pract Res Clin Endocrinol Metab 34:101380. https:\/\/doi.org\/10.1016\/j.beem.2020.101380","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"1550_CR9","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s12020-016-0984-8","volume":"56","author":"R Pivonello","year":"2017","unstructured":"Pivonello R, De Martino MC, De Leo M et al (2017) Cushing\u2019s disease: the burden of illness. Endocrine 56:10\u201318. https:\/\/doi.org\/10.1007\/s12020-016-0984-8","journal-title":"Endocrine"},{"key":"1550_CR10","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1111\/j.1365-2265.2011.04055.x","volume":"75","author":"R Giordano","year":"2011","unstructured":"Giordano R, Picu A, Marinazzo E et al (2011) Metabolic and cardiovascular outcomes in patients with cushing\u2019s syndrome of different aetiologies during active disease and 1 year after remission. Clin Endocrinol (Oxf) 75:354\u2013360. https:\/\/doi.org\/10.1111\/j.1365-2265.2011.04055.x","journal-title":"Clin Endocrinol (Oxf)"},{"key":"1550_CR11","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1093\/ejendo\/lvae145","volume":"191","author":"C Morbach","year":"2024","unstructured":"Morbach C, Detomas M, Sahiti F et al (2024) Cardiovascular status in endogenous cortisol excess: the prospective CV-CORT-EX study. Eur J Endocrinol 191:604\u2013613. https:\/\/doi.org\/10.1093\/ejendo\/lvae145","journal-title":"Eur J Endocrinol"},{"key":"1550_CR12","doi-asserted-by":"publisher","first-page":"e13114","DOI":"10.1111\/jne.13114","volume":"34","author":"E Valassi","year":"2022","unstructured":"Valassi E (2022) Clinical presentation and etiology of cushing\u2019s syndrome: data from ERCUSYN. J Neuroendocrinol 34:e13114. https:\/\/doi.org\/10.1111\/jne.13114","journal-title":"J Neuroendocrinol"},{"key":"1550_CR13","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1159\/000486002","volume":"49","author":"F Ferra\u00f9","year":"2018","unstructured":"Ferra\u00f9 F, Korbonits M (2018) Metabolic syndrome in cushing\u2019s syndrome patients. Front Horm Res 49:85\u2013103. https:\/\/doi.org\/10.1159\/000486002","journal-title":"Front Horm Res"},{"key":"1550_CR14","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1210\/jc.2011-3123","volume":"97","author":"EB Geer","year":"2012","unstructured":"Geer EB, Shen W, Strohmayer E et al (2012) Body composition and cardiovascular risk markers after remission of cushing\u2019s disease: a prospective study using whole-body MRI. J Clin Endocrinol Metab 97:1702\u20131711. https:\/\/doi.org\/10.1210\/jc.2011-3123","journal-title":"J Clin Endocrinol Metab"},{"key":"1550_CR15","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1007\/s11102-022-01258-4","volume":"25","author":"A Coulden","year":"2022","unstructured":"Coulden A, Hamblin R, Wass J, Karavitaki N (2022) Cardiovascular health and mortality in cushing\u2019s disease. Pituitary 25:750\u2013753. https:\/\/doi.org\/10.1007\/s11102-022-01258-4","journal-title":"Pituitary"},{"key":"1550_CR16","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/S2213-8587(16)30005-5","volume":"4","author":"RN Clayton","year":"2016","unstructured":"Clayton RN, Jones PW, Reulen RC et al (2016) Mortality in patients with cushing\u2019s disease more than 10 years after remission: a multicentre, multinational, retrospective cohort study. Lancet Diabetes Endocrinol 4:569\u2013576. https:\/\/doi.org\/10.1016\/S2213-8587(16)30005-5","journal-title":"Lancet Diabetes Endocrinol"},{"key":"1550_CR17","doi-asserted-by":"publisher","first-page":"2664","DOI":"10.1210\/jcem.84.8.5896","volume":"84","author":"A Colao","year":"1999","unstructured":"Colao A, Pivonello R, Spiezia S et al (1999) Persistence of increased cardiovascular risk in patients with cushing\u2019s disease after five years of successful cure. J Clin Endocrinol Metab 84:2664\u20132672. https:\/\/doi.org\/10.1210\/jcem.84.8.5896","journal-title":"J Clin Endocrinol Metab"},{"key":"1550_CR18","doi-asserted-by":"publisher","first-page":"3365","DOI":"10.1210\/jc.2009-0766","volume":"94","author":"M-J Barahona","year":"2009","unstructured":"Barahona M-J, Sucunza N, Resmini E et al (2009) Persistent body fat mass and inflammatory marker increases after long-term cure of cushing\u2019s syndrome. J Clin Endocrinol Metab 94:3365\u20133371. https:\/\/doi.org\/10.1210\/jc.2009-0766","journal-title":"J Clin Endocrinol Metab"},{"key":"1550_CR19","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1080\/07853890.2016.1252055","volume":"49","author":"R Lupoli","year":"2017","unstructured":"Lupoli R, Ambrosino P, Tortora A et al (2017) Markers of atherosclerosis in patients with cushing\u2019s syndrome: a meta-analysis of literature studies. Ann Med 49:206\u2013216. https:\/\/doi.org\/10.1080\/07853890.2016.1252055","journal-title":"Ann Med"},{"key":"1550_CR20","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1093\/ejendo\/lvae098","volume":"191","author":"Y Rudman","year":"2024","unstructured":"Rudman Y, Fleseriu M, Dery L et al (2024) Endogenous cushing\u2019s syndrome and cancer risk. Eur J Endocrinol 191:223\u2013231. https:\/\/doi.org\/10.1093\/ejendo\/lvae098","journal-title":"Eur J Endocrinol"},{"key":"1550_CR21","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s11102-024-01399-8","volume":"27","author":"L Dery","year":"2024","unstructured":"Dery L, Stern J, Shimon I et al (2024) Impact of etiology, sex, diabetes mellitus and remission status on erythrocytic profile in patients with cushing\u2019s syndrome: a large population database study. Pituitary 27:389\u2013402. https:\/\/doi.org\/10.1007\/s11102-024-01399-8","journal-title":"Pituitary"},{"key":"1550_CR22","doi-asserted-by":"publisher","unstructured":"Garvey WT, Mechanick JI, Brett EM et al (2016) American association of clinical endocrinologists and American college of endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity. Endocr Pract Off J Am Coll Endocrinol Am Assoc Clin Endocrinol 22 Suppl 31\u2013203. https:\/\/doi.org\/10.4158\/EP161365.GL","DOI":"10.4158\/EP161365.GL"},{"key":"1550_CR23","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1089\/lap.2014.0430","volume":"25","author":"T Kang","year":"2015","unstructured":"Kang T, Gridley A, Richardson WS (2015) Long-term outcomes of laparoscopic adrenalectomy for adrenal masses. J Laparoendosc Adv Surg Tech A 25:182\u2013186. https:\/\/doi.org\/10.1089\/lap.2014.0430","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"1550_CR24","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.3390\/biomedicines10092328","volume":"10","author":"F de Fatima Silva","year":"2022","unstructured":"de Fatima Silva F, Komino ACM, Andreotti S et al (2022) Dexamethasone-Induced adipose tissue redistribution and metabolic changes: is gene expression the main factor?? An animal model of chronic hypercortisolism. Biomedicines 10:2328. https:\/\/doi.org\/10.3390\/biomedicines10092328","journal-title":"Biomedicines"},{"key":"1550_CR25","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.beem.2009.06.001","volume":"23","author":"X Bertagna","year":"2009","unstructured":"Bertagna X, Guignat L, Groussin L, Bertherat J (2009) Cushing\u2019s disease. Best Pract Res Clin Endocrinol Metab 23:607\u2013623. https:\/\/doi.org\/10.1016\/j.beem.2009.06.001","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"1550_CR26","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1038\/s41467-023-36541-w","volume":"14","author":"N Othonos","year":"2023","unstructured":"Othonos N, Pofi R, Arvaniti A et al (2023) 11\u03b2-HSD1 Inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial. Nat Commun 14:1025. https:\/\/doi.org\/10.1038\/s41467-023-36541-w","journal-title":"Nat Commun"},{"key":"1550_CR27","doi-asserted-by":"publisher","first-page":"l5584","DOI":"10.1136\/bmj.l5584","volume":"367","author":"C Chen","year":"2019","unstructured":"Chen C, Ye Y, Zhang Y et al (2019) Weight change across adulthood in relation to all cause and cause specific mortality: prospective cohort study. BMJ 367:l5584. https:\/\/doi.org\/10.1136\/bmj.l5584","journal-title":"BMJ"},{"key":"1550_CR28","doi-asserted-by":"publisher","first-page":"e158451","DOI":"10.1172\/JCI158451","volume":"132","author":"AK Palmer","year":"2022","unstructured":"Palmer AK, Jensen MD (2022) Metabolic changes in aging humans: current evidence and therapeutic strategies. J Clin Invest 132:e158451. https:\/\/doi.org\/10.1172\/JCI158451","journal-title":"J Clin Invest"},{"key":"1550_CR29","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1210\/jc.2012-2893","volume":"98","author":"JK Lambert","year":"2013","unstructured":"Lambert JK, Goldberg L, Fayngold S et al (2013) Predictors of mortality and long-term outcomes in treated cushing\u2019s disease: a study of 346 patients. J Clin Endocrinol Metab 98:1022\u20131030. https:\/\/doi.org\/10.1210\/jc.2012-2893","journal-title":"J Clin Endocrinol Metab"},{"key":"1550_CR30","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/S2213-8587(24)00316-4","volume":"13","author":"F Rubino","year":"2025","unstructured":"Rubino F, Cummings DE, Eckel RH et al (2025) Definition and diagnostic criteria of clinical obesity. Lancet Diabetes Endocrinol 13:221\u2013262. https:\/\/doi.org\/10.1016\/S2213-8587(24)00316-4","journal-title":"Lancet Diabetes Endocrinol"}],"container-title":["Pituitary"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-025-01550-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11102-025-01550-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-025-01550-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T03:58:56Z","timestamp":1756267136000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11102-025-01550-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,26]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["1550"],"URL":"https:\/\/doi.org\/10.1007\/s11102-025-01550-z","relation":{},"ISSN":["1386-341X","1573-7403"],"issn-type":[{"value":"1386-341X","type":"print"},{"value":"1573-7403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,26]]},"assertion":[{"value":"16 June 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"78"}}