{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:41:41Z","timestamp":1791423701580,"version":"4.3.3"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pituitary"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11102-025-01586-1","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T16:34:00Z","timestamp":1761410040000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence and evolution of hypertension in a large Iberian cohort of patients with acromegaly"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0519-0072","authenticated-orcid":false,"given":"Marta","family":"Araujo-Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogelio","family":"Garc\u00eda-Centeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ema","family":"Lacerda Nobre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"de Grin\u00e9 Severino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Goi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Mar\u00eda","family":"P\u00e9rez Pena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edelmiro","family":"Men\u00e9ndez Torre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Lozano Aida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ir\u00eda","family":"Novoa-Testa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Cordido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"S\u00e1nch\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Guerrero-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Oliva Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Rodr\u00edguez-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Dolores","family":"Ollero Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Irigaray Echarri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreu","family":"Sim\u00f3-Servat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Dolores","family":"Moure Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Novo-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Calatayud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Villar-Taibo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Bernab\u00e9u","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Tenorio-Jimen\u00e9z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Gonz\u00e1lez Molero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Iglesias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Vidal-Ostos De Lara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Aulinas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Queralt","family":"Asla Roca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Paja Fano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Rivera Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds Miguel","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Giustina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Marazuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"Puig-Domingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8837-4343","authenticated-orcid":false,"given":"Betina","family":"Biagetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,25]]},"reference":[{"key":"1586_CR1","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1023\/A:1020798430884","volume":"4","author":"M Bondanelli","year":"2001","unstructured":"Bondanelli M, Ambrosio MR, degli Uberti EC (2001) Pathogenesis and prevalence of hypertension in acromegaly. Pituitary 4:239\u2013249. https:\/\/doi.org\/10.1023\/A:1020798430884","journal-title":"Pituitary"},{"key":"1586_CR2","first-page":"779","volume":"48","author":"S Puglisi","year":"2019","unstructured":"Puglisi S, Terzolo M (2019) Hypertens Acromegaly 48:779\u2013793","journal-title":"Hypertens Acromegaly"},{"key":"1586_CR3","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1111\/J.1365-2265.2005.02370.X","volume":"63","author":"G Vitale","year":"2005","unstructured":"Vitale G, Pivonello R, Auriemma RS, Guerra E, Milone F, Savastano S et al (2005) Hypertension in acromegaly and in the normal population: prevalence and determinants. Clin Endocrinol (Oxf) 63:470\u2013476. https:\/\/doi.org\/10.1111\/J.1365-2265.2005.02370.X","journal-title":"Clin Endocrinol (Oxf)"},{"key":"1586_CR4","doi-asserted-by":"publisher","unstructured":"Vila G, Luger A, van der Lely AJ, Neggers SJCMM, Webb SM, Biller BMK et al (2020) Hypertension in acromegaly in relationship to biochemical control and mortality: global ACROSTUDY outcomes. Front Endocrinol (Lausanne) 11. https:\/\/doi.org\/10.3389\/FENDO.2020.577173","DOI":"10.3389\/FENDO.2020.577173"},{"key":"1586_CR5","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1210\/ER.2013-1071","volume":"35","author":"P Kamenick\u00fd","year":"2014","unstructured":"Kamenick\u00fd P, Mazziotti G, Lomb\u00e8s M, Giustina A, Chanson P (2014) Growth hormone, insulin-like growth factor-1, and the kidney: pathophysiological and clinical implications. Endocr Rev 35:234\u2013281. https:\/\/doi.org\/10.1210\/ER.2013-1071","journal-title":"Endocr Rev"},{"key":"1586_CR6","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.ando.2020.03.010","volume":"82","author":"P Kamenick\u00fd","year":"2021","unstructured":"Kamenick\u00fd P, Maione L, Chanson P (2021) Cardiovascular complications of acromegaly. Ann Endocrinol (Paris) 82:206\u2013209. https:\/\/doi.org\/10.1016\/j.ando.2020.03.010","journal-title":"Ann Endocrinol (Paris)"},{"key":"1586_CR7","doi-asserted-by":"publisher","first-page":"3933","DOI":"10.1210\/jc.2014-2700","volume":"99","author":"L Katznelson","year":"2014","unstructured":"Katznelson L, Laws ER, Melmed S, Molitch ME, Murad MH, Utz A et al (2014) Acromegaly: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 99:3933\u20133951. https:\/\/doi.org\/10.1210\/jc.2014-2700","journal-title":"J Clin Endocrinol Metab"},{"key":"1586_CR8","doi-asserted-by":"publisher","first-page":"E937","DOI":"10.1210\/CLINEM\/DGZ096","volume":"105","author":"A Giustina","year":"2020","unstructured":"Giustina A, Barkan A, Beckers A, Biermasz N, Biller BMK, Boguszewski C et al (2020) A consensus on the diagnosis and treatment of acromegaly comorbidities: an update. J Clin Endocrinol Metab 105:E937\u2013E946. https:\/\/doi.org\/10.1210\/CLINEM\/DGZ096","journal-title":"J Clin Endocrinol Metab"},{"key":"1586_CR9","doi-asserted-by":"publisher","first-page":"3912","DOI":"10.1093\/EURHEARTJ\/EHAE178","volume":"45","author":"CP McCarthy","year":"2024","unstructured":"McCarthy CP, Bruno RM, Brouwers S, Canavan MD, Ceconi C, Christodorescu RM et al (2024) 2024 ESC guidelines for the management of elevated blood pressure and hypertension: developed by the task force on the management of elevated blood pressure and hypertension of the European society of cardiology (ESC) and endorsed by the European society of endocrinology (ESE) and the European stroke organisation (ESO). Eur Heart J 45:3912\u20134018. https:\/\/doi.org\/10.1093\/EURHEARTJ\/EHAE178","journal-title":"Eur Heart J"},{"key":"1586_CR10","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/S11154-020-09588-Z","volume":"21","author":"A Giustina","year":"2020","unstructured":"Giustina A, Barkhoudarian G, Beckers A, Ben-Shlomo A, Biermasz N, Biller B et al (2020) Multidisciplinary management of acromegaly: a consensus. Rev Endocr Metab Disord 21:667\u2013678. https:\/\/doi.org\/10.1007\/S11154-020-09588-Z","journal-title":"Rev Endocr Metab Disord"},{"key":"1586_CR11","doi-asserted-by":"publisher","first-page":"R173","DOI":"10.1530\/ERC-17-0036","volume":"24","author":"GK Dimitriadis","year":"2017","unstructured":"Dimitriadis GK, Angelousi A, Weickert MO, Randeva HS, Kaltsas G, Grossman A (2017) Paraneoplastic endocrine syndromes. Endocr Relat Cancer 24:R173\u2013R190. https:\/\/doi.org\/10.1530\/ERC-17-0036","journal-title":"Endocr Relat Cancer"},{"key":"1586_CR12","doi-asserted-by":"publisher","first-page":"2639","DOI":"10.1210\/JC.2008-0299","volume":"93","author":"A Colao","year":"2008","unstructured":"Colao A, Pivonello R, Galderisi M, Cappabianca P, Auriemma RS, Galdiero M et al (2008) Impact of treating acromegaly first with surgery or somatostatin analogs on cardiomyopathy. J Clin Endocrinol Metab 93:2639\u20132646. https:\/\/doi.org\/10.1210\/JC.2008-0299","journal-title":"J Clin Endocrinol Metab"},{"key":"1586_CR13","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1007\/S12020-018-1797-8","volume":"63","author":"C Briet","year":"2019","unstructured":"Briet C, Ilie MD, Kuhn E, Maione L, Brailly-Tabard S, Salenave S et al (2019) Changes in metabolic parameters and cardiovascular risk factors after therapeutic control of acromegaly vary with the treatment modality. Data from the Bic\u00eatre cohort, and review of the literature. Endocrine 63:348\u2013360. https:\/\/doi.org\/10.1007\/S12020-018-1797-8","journal-title":"Endocrine"},{"key":"1586_CR14","first-page":"443","volume":"175","author":"C Sardella","year":"2016","unstructured":"Sardella C, Cappellani D, Urbani C, Manetti L, Marconcini G, Tomisti L et al (2016) Disease Activity Lifestyle Influence Comorbidities Cardiovasc Events Patients Acromegaly 175:443\u2013453","journal-title":"Disease Activity Lifestyle Influence Comorbidities Cardiovasc Events Patients Acromegaly"},{"key":"1586_CR15","doi-asserted-by":"publisher","DOI":"10.1159\/000545875","author":"A Abreu-Lomba","year":"2025","unstructured":"Abreu-Lomba A, Aristiz\u00e1bal-Colorado D, Sierra-Castillo S, Weir-Restrepo D, G\u00f3mez-Mercado CA, Trujillo DAV et al (2025) Prevalence and characteristics of heart disease in patients with acromegaly in Colombia (RAPACO HEART Study). Cardiol. https:\/\/doi.org\/10.1159\/000545875","journal-title":"Cardiol"},{"key":"1586_CR16","doi-asserted-by":"publisher","unstructured":"Araujo-Castro M, Biagetti B, Menendez Torre E, Novoa-Testa I, Cordido F, Pascual-Corrales E RB V. Differences between GH and PRL co-secreting and GH-secreting pituitary adenomas. A series of 604 cases 2024. https:\/\/doi.org\/10.1210\/clinem\/dgae126","DOI":"10.1210\/clinem\/dgae126"},{"key":"1586_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11102-020-01091-7","volume":"24","author":"M Fleseriu","year":"2021","unstructured":"Fleseriu M, Biller BMK, Freda PU, Gadelha MR, Giustina A, Katznelson L et al (2021) A pituitary society update to acromegaly management guidelines. Pituitary 24:1\u201313. https:\/\/doi.org\/10.1007\/s11102-020-01091-7","journal-title":"Pituitary"},{"key":"1586_CR18","doi-asserted-by":"publisher","DOI":"10.1530\/EC-25-0103","author":"M Araujo-Castro","year":"2025","unstructured":"Araujo-Castro M, Biagetti B, Men\u00e9ndez E, Novoa-Testa I, Cordido F, Rodr\u00edguez Berrocal V et al (2025) Predictors of therapeutic failure in co-secreting GH and prolactin pituitary adenomas. Endocr Connect. https:\/\/doi.org\/10.1530\/EC-25-0103","journal-title":"Endocr Connect"},{"key":"1586_CR19","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1210\/jc.85.2.526","volume":"85","author":"A Giustina","year":"2000","unstructured":"Giustina A, Barkan A, Casanueva FF, Cavagnini F, Frohman L, Ho K et al (2000) Criteria for cure of acromegaly: A consensus statement. J Clin Endocrinol Metab 85:526\u2013529. https:\/\/doi.org\/10.1210\/jc.85.2.526","journal-title":"J Clin Endocrinol Metab"},{"key":"1586_CR20","doi-asserted-by":"publisher","DOI":"10.1080\/08037051.2018.1530564","author":"SE Kjeldsen","year":"2018","unstructured":"Kjeldsen SE, Narkiewicz K, Burnier M, Oparil S (2018) 2018 practice guidelines for the management of arterial hypertension of the European society of hypertension. Blood Press. https:\/\/doi.org\/10.1080\/08037051.2018.1530564","journal-title":"Blood Press"},{"key":"1586_CR21","doi-asserted-by":"publisher","unstructured":"Mancia(Chairperson G, Kreutz(Co-Chair) R, Brunstr\u00f6m M, Burnier M, Grassi G, Januszewicz A et al (2023) 2023 ESH guidelines for the management of arterial hypertension the task force for the management of arterial hypertension of the European society of hypertension endorsed by the European renal association (ERA) and the international society of hypertensi. Vol Publish Ah. https:\/\/doi.org\/10.1097\/hjh.0000000000003480","DOI":"10.1097\/hjh.0000000000003480"},{"key":"1586_CR22","doi-asserted-by":"publisher","DOI":"10.1210\/CLINEM\/DGAF338","author":"P Wolf","year":"2025","unstructured":"Wolf P, Maione L, Kamenick\u00fd P, Chanson P (2025) Cardiomyopathy in patients with acromegaly \u2013 not truly a concern anymore? J Clin Endocrinol Metab. https:\/\/doi.org\/10.1210\/CLINEM\/DGAF338","journal-title":"J Clin Endocrinol Metab"},{"key":"1586_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/J.BEEM.2019.02.001","author":"L Maione","year":"2019","unstructured":"Maione L, Chanson P (2019) National acromegaly registries. Best Pract Res Clin Endocrinol Metab. https:\/\/doi.org\/10.1016\/J.BEEM.2019.02.001","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"1586_CR24","doi-asserted-by":"publisher","unstructured":"Fauchier G, Laurent E, Maione L, Lecuyer AI, Herbert J, Pierre-Renoult P et al (2024) Acromegaly: Incidence, patient characteristics and treatment patterns in a 10-year nationwide retrospective hospital cohort study. Ann Endocrinol (Paris) 85. https:\/\/doi.org\/10.1016\/j.ando.2024.09.002","DOI":"10.1016\/j.ando.2024.09.002"},{"key":"1586_CR25","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1507\/ENDOCRJ.EJ20-0129","volume":"67","author":"K Matsubayashi","year":"2020","unstructured":"Matsubayashi K, Kawakami K (2020) Prevalence, incidence, comorbidities, and treatment patterns among Japanese patients with acromegaly: a descriptive study using a nationwide claims database. Endocr J 67:997\u20131006. https:\/\/doi.org\/10.1507\/ENDOCRJ.EJ20-0129","journal-title":"Endocr J"},{"key":"1586_CR26","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/J.RECESP.2024.03.002","volume":"77","author":"JR Banegas","year":"2024","unstructured":"Banegas JR, S\u00e1nchez-Mart\u00ednez M, Gij\u00f3n-Conde T, L\u00f3pez-Garc\u00eda E, Graciani A, Guallar-Castill\u00f3n P et al (2024) Cifras e impacto de La hipertensi\u00f3n arterial En Espa\u00f1a. Rev Esp Cardiol 77:767\u2013778. https:\/\/doi.org\/10.1016\/J.RECESP.2024.03.002","journal-title":"Rev Esp Cardiol"},{"key":"1586_CR27","doi-asserted-by":"publisher","DOI":"10.1007\/S11060-025-05041-W","author":"C Mo","year":"2025","unstructured":"Mo C, Liu X, Guo Y, Liang D, Wang Y, Liu H et al (2025) Clinical characteristics and pathological features of growth hormone-secreting pituitary adenoma combined with hyperprolactinemia. J Neurooncol. https:\/\/doi.org\/10.1007\/S11060-025-05041-W","journal-title":"J Neurooncol"},{"key":"1586_CR28","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1530\/EJE-11-1119","volume":"166","author":"M Wang","year":"2012","unstructured":"Wang M, Mou C, Jiang M, Han L, Fan S, Huan C et al (2012) The characteristics of acromegalic patients with hyperprolactinemia and the differences in patients with merely GH-secreting adenomas: clinical analysis of 279 cases. Eur J Endocrinol 166:797\u2013802. https:\/\/doi.org\/10.1530\/EJE-11-1119","journal-title":"Eur J Endocrinol"},{"key":"1586_CR29","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1210\/JC.2018-00325","volume":"103","author":"B Gonz\u00e1lez","year":"2018","unstructured":"Gonz\u00e1lez B, Vargas G, De Los Monteros ALE, Mendoza V, Mercado M (2018) Persistence of diabetes and hypertension after multimodal treatment of acromegaly. J Clin Endocrinol Metab 103:2369\u20132375. https:\/\/doi.org\/10.1210\/JC.2018-00325","journal-title":"J Clin Endocrinol Metab"},{"key":"1586_CR30","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1016\/J.EPRAC.2024.09.014","volume":"30","author":"RPV Sherin","year":"2024","unstructured":"Sherin RPV, Vietor NO, Usman A, Hoang TD, Shakir MKM (2024) Cardiovascular disorders associated with acromegaly: an update. Endocr Pract 30:1212\u20131219. https:\/\/doi.org\/10.1016\/J.EPRAC.2024.09.014","journal-title":"Endocr Pract"},{"key":"1586_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/JCM14061906","author":"P Iglesias","year":"2025","unstructured":"Iglesias P (2025) Acromegaly and cardiovascular disease: associated cardiovascular risk factors, cardiovascular prognosis, and therapeutic impact. J Clin Med. https:\/\/doi.org\/10.3390\/JCM14061906","journal-title":"J Clin Med"},{"key":"1586_CR32","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-1191-3","author":"AM Ramos-Lev\u00ed","year":"2017","unstructured":"Ramos-Lev\u00ed AM, Marazuela M (2017) Cardiovascular comorbidities in acromegaly: an update on their diagnosis and management. Endocrine. https:\/\/doi.org\/10.1007\/s12020-016-1191-3","journal-title":"Endocrine"},{"key":"1586_CR33","doi-asserted-by":"publisher","DOI":"10.3389\/FENDO.2019.00120","author":"AM Ramos-Lev\u00ed","year":"2019","unstructured":"Ramos-Lev\u00ed AM, Marazuela M (2019) Bringing cardiovascular comorbidities in acromegaly to an update. How should we diagnose and manage them? Front Endocrinol. https:\/\/doi.org\/10.3389\/FENDO.2019.00120","journal-title":"Front Endocrinol"},{"key":"1586_CR34","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1007\/S11102-021-01198-5","volume":"25","author":"M Fleseriu","year":"2022","unstructured":"Fleseriu M, Barkan A, del Pilar Schneider M, Darhi Y, de Pierrefeu A, Ribeiro-Oliveira A et al (2022) Prevalence of comorbidities and concomitant medication use in acromegaly: analysis of real-world data from the united States. Pituitary 25:296\u2013307. https:\/\/doi.org\/10.1007\/S11102-021-01198-5","journal-title":"Pituitary"},{"key":"1586_CR35","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1111\/J.1365-2265.2008.03258.X","volume":"69","author":"A Colao","year":"2008","unstructured":"Colao A, Terzolo M, Bondanelli M, Galderisi M, Vitale G, Reimondo G et al (2008) GH and IGF-I excess control contributes to blood pressure control: results of an observational, retrospective, multicentre study in 105 hypertensive acromegalic patients on hypertensive treatment. Clin Endocrinol (Oxf) 69:613\u2013620. https:\/\/doi.org\/10.1111\/J.1365-2265.2008.03258.X","journal-title":"Clin Endocrinol (Oxf)"},{"key":"1586_CR36","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1210\/JC.2011-0078","volume":"96","author":"P Kamenicky","year":"2011","unstructured":"Kamenicky P, Blanchard A, Frank M, Salenave S, Letierce A, Azizi M et al (2011) Body fluid expansion in acromegaly is related to enhanced epithelial sodium channel (ENaC) activity. J Clin Endocrinol Metab 96:2127\u20132135. https:\/\/doi.org\/10.1210\/JC.2011-0078","journal-title":"J Clin Endocrinol Metab"},{"key":"1586_CR37","doi-asserted-by":"publisher","first-page":"147","DOI":"10.2176\/NMC.OA.2017-0215","volume":"58","author":"M Yonenaga","year":"2018","unstructured":"Yonenaga M, Fujio S, Habu M, Arimura H, Hiwatari T, Tanaka S et al (2018) Postoperative changes in metabolic parameters of patients with surgically controlled acromegaly: assessment of new stringent cure criteria. Neurol Med Chir (Tokyo) 58:147\u2013155. https:\/\/doi.org\/10.2176\/NMC.OA.2017-0215","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"1586_CR38","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1046\/J.1365-2265.2001.01343.X","volume":"55","author":"G Minniti","year":"2001","unstructured":"Minniti G, Moroni C, Jaffrain-Rea ML, Esposito V, Santoro A, Affricano C et al (2001) Marked improvement in cardiovascular function after successful transsphenoidal surgery in acromegalic patients. Clin Endocrinol (Oxf) 55:307\u2013313. https:\/\/doi.org\/10.1046\/J.1365-2265.2001.01343.X","journal-title":"Clin Endocrinol (Oxf)"},{"key":"1586_CR39","doi-asserted-by":"publisher","first-page":"4124","DOI":"10.1210\/JC.2014-2259","volume":"99","author":"C Reyes-Vidal","year":"2014","unstructured":"Reyes-Vidal C, Fernandez JC, Bruce JN, Crisman C, Conwell IM, Kostadinov J et al (2014) Prospective study of surgical treatment of acromegaly: effects on ghrelin, weight, adiposity, and markers of CV risk. J Clin Endocrinol Metab 99:4124\u20134132. https:\/\/doi.org\/10.1210\/JC.2014-2259","journal-title":"J Clin Endocrinol Metab"},{"key":"1586_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/07435800.2021.1931298","volume":"47","author":"M Heydari","year":"2022","unstructured":"Heydari M, Hashemi-Madani N, Emami Z, Khajavi A, Ghorbani M, Malek M et al (2022) Post-treatment heterogeneity of cardiometabolic risk in patients with acromegaly: the impact of GH and IGF-1. Endocr Res 47:1\u20137. https:\/\/doi.org\/10.1080\/07435800.2021.1931298","journal-title":"Endocr Res"},{"key":"1586_CR41","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1210\/JC.2006-2547","volume":"92","author":"P Maison","year":"2007","unstructured":"Maison P, Tropeano AI, Macquin-Mavier I, Giustina A, Chanson P (2007) Impact of somatostatin analogs on the heart in acromegaly: a metaanalysis. J Clin Endocrinol Metab 92:1743\u20131747. https:\/\/doi.org\/10.1210\/JC.2006-2547","journal-title":"J Clin Endocrinol Metab"},{"key":"1586_CR42","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1210\/JC.2006-1587","volume":"92","author":"R Pivonello","year":"2007","unstructured":"Pivonello R, Galderisi M, Auriemma RS, De Martino MC, Galdiero M, Ciccarelli A et al (2007) Treatment with growth hormone receptor antagonist in acromegaly: effect on cardiac structure and performance. J Clin Endocrinol Metab 92:476\u2013482. https:\/\/doi.org\/10.1210\/JC.2006-1587","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"1586_CR43","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.1007\/S00701-021-04846-8","volume":"163","author":"S Berkmann","year":"2021","unstructured":"Berkmann S, Brun J, Schuetz P, Christ E, Mariani L, Mueller B (2021) Prevalence and outcome of comorbidities associated with acromegaly. Acta Neurochir (Wien) 163(11):3171\u20133180. https:\/\/doi.org\/10.1007\/S00701-021-04846-8","journal-title":"Acta Neurochir (Wien)"},{"key":"1586_CR44","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1016\/J.IJCARD.2012.11.109","volume":"167","author":"S Mosca","year":"2013","unstructured":"Mosca S, Paolillo S, Colao A, Bossone E, Cittadini A, Iudice F, Lo et al (2013) Cardiovascular involvement in patients affected by acromegaly: an appraisal. Int J Cardiol 167:1712\u20131718. https:\/\/doi.org\/10.1016\/J.IJCARD.2012.11.109","journal-title":"Int J Cardiol"},{"key":"1586_CR45","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/S12020-014-0327-6","volume":"48","author":"J Isgaard","year":"2015","unstructured":"Isgaard J, Arcopinto M, Karason K, Cittadini A (2015) GH and the cardiovascular system: an update on a topic at heart. Endocrine 48:25\u201335. https:\/\/doi.org\/10.1007\/S12020-014-0327-6","journal-title":"Endocrine"},{"key":"1586_CR46","doi-asserted-by":"publisher","DOI":"10.1093\/EURHEARTJ\/EHAE178","author":"JW McEvoy","year":"2024","unstructured":"McEvoy JW, McCarthy CP, Bruno RM, Brouwers S, Canavan MD, Ceconi C et al (2024) 2024 ESC guidelines for the management of elevated blood pressure and hypertension. Eur Heart J. https:\/\/doi.org\/10.1093\/EURHEARTJ\/EHAE178","journal-title":"Eur Heart J"}],"container-title":["Pituitary"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-025-01586-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11102-025-01586-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-025-01586-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:47:12Z","timestamp":1765961232000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11102-025-01586-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,25]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1586"],"URL":"https:\/\/doi.org\/10.1007\/s11102-025-01586-1","relation":{},"ISSN":["1386-341X","1573-7403"],"issn-type":[{"value":"1386-341X","type":"print"},{"value":"1573-7403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,25]]},"assertion":[{"value":"23 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Patient consent was waived due to the retrospective nature of the study. Informed consent was requested only for patients who continued follow-up or who were prospectively included.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Ethics Committee of the Hospital Universitario Ram\u00f3n y Cajal. Madrid. Spain (approval date: 2nd June 2023, code: ACTA 454) and in each collaborating center.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional review board statement"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"119"}}