{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:49:22Z","timestamp":1790304562606,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pituitary"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s11102-025-01613-1","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T06:11:05Z","timestamp":1765260665000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Validation and modification of the PANOMEN 3 classification for predicting long-term recurrence\/progression and quality of life in patients with pituitary adenomas: a multicentre retrospective cohort study"],"prefix":"10.1007","volume":"29","author":[{"given":"Yuhui","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianshun","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shousen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"issue":"11","key":"1613_CR1","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1038\/nrc926","volume":"2","author":"SL Asa","year":"2002","unstructured":"Asa SL, Ezzat S (2002) The pathogenesis of pituitary tumours. Nat Rev Cancer 2(11):836\u2013849. https:\/\/doi.org\/10.1038\/nrc926","journal-title":"Nat Rev Cancer"},{"issue":"10","key":"1613_CR2","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1056\/NEJMra1810772","volume":"382","author":"S Melmed","year":"2020","unstructured":"Melmed S (2020) Pituitary-tumor endocrinopathies. N Engl J Med 382(10):937\u2013950. https:\/\/doi.org\/10.1056\/NEJMra1810772","journal-title":"N Engl J Med"},{"issue":"16","key":"1613_CR3","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1001\/jama.2023.5444","volume":"329","author":"NA Tritos","year":"2023","unstructured":"Tritos NA, Miller KK (2023) Diagnosis and management of pituitary adenomas: a review. JAMA 329(16):1386\u20131398. https:\/\/doi.org\/10.1001\/jama.2023.5444","journal-title":"JAMA"},{"key":"1613_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.793337","volume":"12","author":"Y Chen","year":"2021","unstructured":"Chen Y, Cai F, Cao J et al (2021) Analysis of related factors of tumor recurrence or progression after transnasal sphenoidal surgical treatment of large and giant pituitary adenomas and establish a nomogram to predict tumor prognosis. Front Endocrinol (Lausanne) 12:793337. https:\/\/doi.org\/10.3389\/fendo.2021.793337","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"1613_CR5","doi-asserted-by":"publisher","first-page":"525","DOI":"10.3171\/JNS\/2008\/108\/3\/0525","volume":"108","author":"M Losa","year":"2008","unstructured":"Losa M, Mortini P, Barzaghi R et al (2008) Early results of surgery in patients with nonfunctioning pituitary adenoma and analysis of the risk of tumor recurrence. J Neurosurg 108(3):525\u2013532. https:\/\/doi.org\/10.3171\/JNS\/2008\/108\/3\/0525","journal-title":"J Neurosurg"},{"issue":"3","key":"1613_CR6","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1530\/EJE-17-0965","volume":"178","author":"J Lelotte","year":"2018","unstructured":"Lelotte J, Mourin A, Fomekong E, Michotte A, Raftopoulos C, Maiter D (2018) Both invasiveness and proliferation criteria predict recurrence of non-functioning pituitary macroadenomas after surgery: a retrospective analysis of a monocentric cohort of 120 patients. Eur J Endocrinol 178(3):237\u2013246. https:\/\/doi.org\/10.1530\/EJE-17-0965","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"1613_CR7","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1210\/endrev\/bnac010","volume":"43","author":"S Melmed","year":"2022","unstructured":"Melmed S, Kaiser UB, Lopes MB et al (2022) Clinical biology of the pituitary adenoma. Endocr Rev 43(6):1003\u20131037. https:\/\/doi.org\/10.1210\/endrev\/bnac010","journal-title":"Endocr Rev"},{"issue":"1","key":"1613_CR8","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s12022-022-09703-7","volume":"33","author":"SL Asa","year":"2022","unstructured":"Asa SL, Mete O, Perry A, Osamura RY (2022) Overview of the 2022 WHO classification of pituitary tumors. Endocr Pathol 33(1):6\u201326. https:\/\/doi.org\/10.1007\/s12022-022-09703-7","journal-title":"Endocr Pathol"},{"issue":"4","key":"1613_CR9","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1227\/00006123-199310000-00008","volume":"33","author":"E Knosp","year":"1993","unstructured":"Knosp E, Steiner E, Kitz K, Matula C (1993) Pituitary adenomas with invasion of the cavernous sinus space: a magnetic resonance imaging classification compared with surgical findings. Neurosurgery 33(4):610\u20137. https:\/\/doi.org\/10.1227\/00006123-199310000-00008","journal-title":"Neurosurgery"},{"issue":"1","key":"1613_CR10","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s00401-013-1084-y","volume":"126","author":"J Trouillas","year":"2013","unstructured":"Trouillas J, Roy P, Sturm N et al (2013) A new prognostic clinicopathological classification of pituitary adenomas: a multicentric case-control study of 410 patients with 8 years post-operative follow-up. Acta Neuropathol 126(1):123\u2013135. https:\/\/doi.org\/10.1007\/s00401-013-1084-y","journal-title":"Acta Neuropathol"},{"issue":"1","key":"1613_CR11","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.13299","volume":"35","author":"C Villa","year":"2025","unstructured":"Villa C, Birtolo MF, Perez-Rivas LG et al (2025) Grading and staging for pituitary neuroendocrine tumors. Brain Pathol 35(1):e13299. https:\/\/doi.org\/10.1111\/bpa.13299","journal-title":"Brain Pathol"},{"issue":"11","key":"1613_CR12","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/s41574-023-00883-8","volume":"19","author":"KKY Ho","year":"2023","unstructured":"Ho KKY, Kaiser UB, Chanson P et al (2023) Pituitary adenoma or neuroendocrine tumour: the need for an integrated prognostic classification. Nat Rev Endocrinol 19(11):671\u2013678. https:\/\/doi.org\/10.1038\/s41574-023-00883-8","journal-title":"Nat Rev Endocrinol"},{"issue":"2","key":"1613_CR13","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1007\/s12022-021-09678-x","volume":"32","author":"SL Asa","year":"2021","unstructured":"Asa SL (2021) Challenges in the diagnosis of pituitary neuroendocrine tumors. Endocr Pathol 32(2):222\u2013227. https:\/\/doi.org\/10.1007\/s12022-021-09678-x","journal-title":"Endocr Pathol"},{"issue":"5","key":"1613_CR14","doi-asserted-by":"publisher","first-page":"e1408","DOI":"10.1210\/clinem\/dgad567","volume":"109","author":"PM Stewart","year":"2024","unstructured":"Stewart PM (2024) Clinical practice and nomenclature of pituitary neoplasms: common sense must prevail. J Clin Endocrinol Metab 109(5):e1408\u2013e1409. https:\/\/doi.org\/10.1210\/clinem\/dgad567","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"1613_CR15","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/S2213-8587(23)00382-0","volume":"12","author":"KKY Ho","year":"2024","unstructured":"Ho KKY, Fleseriu M, Wass J et al (2024) A proposed clinical classification for pituitary neoplasms to guide therapy and prognosis. The Lancet Diabetes & Endocrinology 12(3):209\u2013214. https:\/\/doi.org\/10.1016\/S2213-8587(23)00382-0","journal-title":"The Lancet Diabetes & Endocrinology"},{"issue":"8","key":"1613_CR16","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-23-0021","volume":"30","author":"C Villa","year":"2023","unstructured":"Villa C, Baussart B, Assi\u00e9 G, Raverot G, Roncaroli F (2023) The World Health Organization classifications of pituitary neuroendocrine tumours: a clinico-pathological appraisal. Endocr Relat Cancer 30(8):e230021. https:\/\/doi.org\/10.1530\/ERC-23-0021","journal-title":"Endocr Relat Cancer"},{"key":"1613_CR17","doi-asserted-by":"publisher","first-page":"dgaf252","DOI":"10.1210\/clinem\/dgaf252","volume":"25","author":"M Araujo-Castro","year":"2025","unstructured":"Araujo-Castro M, Men\u00e9ndez Torre E, Aida CL et al (2025) Validation and limitations of the PANOMEN-3 predictive model for tumor recurrence and progression in pituitary tumors. J Clin Endocrinol Metab 25:dgaf252. https:\/\/doi.org\/10.1210\/clinem\/dgaf252","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"1613_CR18","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/0168-8510(90)90421-9","volume":"16","author":"EuroQol Group","year":"1990","unstructured":"EuroQol Group (1990) Euroqol \u2013 a new facility for the measurement of health-related quality of life. Health Policy 16(3):199\u2013208. https:\/\/doi.org\/10.1016\/0168-8510(90)90421-9","journal-title":"Health Policy"},{"issue":"1","key":"1613_CR19","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1093\/ejendo\/lvaf122","volume":"193","author":"P Fookeerah","year":"2025","unstructured":"Fookeerah P, Varikatt W, Shingde M et al (2025) Assessing the clinical application of the PANOMEN 3 classification in a large cohort of pituitary tumors. Eur J Endocrinol 193(1):56\u201364. https:\/\/doi.org\/10.1093\/ejendo\/lvaf122","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"1613_CR20","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1007\/s12020-025-04292-x","volume":"89","author":"A Mondin","year":"2025","unstructured":"Mondin A, Bovo G, Barbot M et al (2025) PANOMEN-3 grading score is reliable in predicting pituitary adenoma behavior and prognosis: a single center cohort study. Endocrine 89(3):834\u2013845. https:\/\/doi.org\/10.1007\/s12020-025-04292-x","journal-title":"Endocrine"},{"issue":"5","key":"1613_CR21","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s11102-025-01562-9","volume":"28","author":"S Chiloiro","year":"2025","unstructured":"Chiloiro S, Giampietro A, Migliore R et al (2025) The clinicopathological PANOMEN-3 classification predicts pituitary adenoma prognosis: a real-world retrospective single center study of a surgically treated cohort. Pituitary 28(5):97. https:\/\/doi.org\/10.1007\/s11102-025-01562-9","journal-title":"Pituitary"},{"issue":"1","key":"1613_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/neurolint17010005","volume":"17","author":"A Pala","year":"2025","unstructured":"Pala A, Gr\u00fcbel N, Mayer B et al (2025) Endocrine outcome and quality of life after transsphenoidal resection of pituitary adenoma-a prospective randomized single-blinded study comparing endoscopic versus microscopic resection. Neurol Int 17(1):5. https:\/\/doi.org\/10.3390\/neurolint17010005","journal-title":"Neurol Int"},{"issue":"8","key":"1613_CR23","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1007\/s00520-025-09745-7","volume":"33","author":"X Shen","year":"2025","unstructured":"Shen X, Jin M, Wang Y et al (2025) Fatigue trajectory and its associated factors in patients after pituitary adenoma surgery: a longitudinal study. Support Care Cancer 33(8):702. https:\/\/doi.org\/10.1007\/s00520-025-09745-7","journal-title":"Support Care Cancer"},{"key":"1613_CR24","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s40478-015-0229-8","volume":"3","author":"CP Miermeister","year":"2015","unstructured":"Miermeister CP, Petersenn S, Buchfelder M et al (2015) Histological criteria for atypical pituitary adenomas \u2013 data from the German pituitary adenoma registry suggests modifications. Acta Neuropathol Commun 3:50. https:\/\/doi.org\/10.1186\/s40478-015-0229-8","journal-title":"Acta Neuropathol Commun"},{"issue":"6","key":"1613_CR25","doi-asserted-by":"publisher","first-page":"R45","DOI":"10.1093\/ejendo\/lvaf100","volume":"192","author":"G Raverot","year":"2025","unstructured":"Raverot G, Burman P, Abreu AP et al (2025) Revised European society of endocrinology clinical practice guideline for the management of aggressive pituitary tumours and pituitary carcinomas. Eur J Endocrinol 192(6):R45\u2013R78. https:\/\/doi.org\/10.1093\/ejendo\/lvaf100","journal-title":"Eur J Endocrinol"},{"issue":"10","key":"1613_CR26","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1016\/j.humpath.2011.12.003","volume":"43","author":"A Righi","year":"2012","unstructured":"Righi A, Agati P, Sisto A et al (2012) A classification tree approach for pituitary adenomas. Hum Pathol 43(10):1627\u20131637. https:\/\/doi.org\/10.1016\/j.humpath.2011.12.003","journal-title":"Hum Pathol"},{"issue":"11","key":"1613_CR27","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/s41574-021-00550-w","volume":"17","author":"G Raverot","year":"2021","unstructured":"Raverot G, Ilie MD, Lasolle H et al (2021) Aggressive pituitary tumours and pituitary carcinomas. Nat Rev Endocrinol 17(11):671\u2013684. https:\/\/doi.org\/10.1038\/s41574-021-00550-w","journal-title":"Nat Rev Endocrinol"}],"container-title":["Pituitary"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-025-01613-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11102-025-01613-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-025-01613-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:38:20Z","timestamp":1773682700000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11102-025-01613-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,9]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["1613"],"URL":"https:\/\/doi.org\/10.1007\/s11102-025-01613-1","relation":{},"ISSN":["1386-341X","1573-7403"],"issn-type":[{"value":"1386-341X","type":"print"},{"value":"1573-7403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,9]]},"assertion":[{"value":"10 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the tenets of the Declaration of Helsinki and was approved by the Ethics Committee of Fuzong Clinical Medical College of Fujian Medical University (approval No. 2024-011), which waived the requirement for informed consent given the retrospective design, in accordance with national regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"10"}}