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However, histological correlates of intraoperative consistency remain inconsistently defined. This study evaluated the relationship between intraoperative tumor consistency and collagen content using digital image analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Biopsy samples from patients undergoing surgery for pituitary adenomas\/PitNets were included. Tumor consistency was assessed intraoperatively by the same neurosurgeon and classified as soft, firm, or fibrous. Histological sections were stained with Masson\u2019s trichrome, and digital image analysis was performed using QuPath software. A trained pixel classifier artificial neural network differentiated collagen, tumor tissue, and background. Collagen content, as a surrogate marker of fibrosis, was quantified as a percentage of total tumor area. All analyses were conducted blinded to intraoperative assessments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 69 tumors were analyzed: 30 soft (43.5%), 22 firm (31.9%), and 17 fibrous (24.6%). Median collagen content increased progressively across groups (6.3%, 8.3%, and 22.0%, respectively). Fibrous tumors demonstrated significantly higher collagen content compared with soft and firm tumors (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), while no significant difference was observed between soft and firm tumors. Collagen content was not associated with tumor subtype or patient age, and its deposition was heterogeneous between paired tissue blocks (CV\u2009=\u200959.83%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Digital collagen quantification provides an objective histological correlate of intraoperative tumor consistency, validating the distinction between soft and fibrous tumors, and establishing a reference standard for future studies aimed at developing preoperative predictive models.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11102-026-01703-8","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T19:53:07Z","timestamp":1779565987000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of intratumoral collagen in pituitary neuroendocrine tumors (pituitary adenomas\/PitNets) via digital pathology and its correlation with intraoperative consistency"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0729-7201","authenticated-orcid":false,"given":"Acitores Cancela","family":"A.","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9001-6386","authenticated-orcid":false,"given":"Ayuso-Cerezo","family":"H.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodr\u00edguez Berrocal","family":"V.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1986-2965","authenticated-orcid":false,"given":"Carretero-Barrio","family":"I.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2298-4683","authenticated-orcid":false,"given":"Ruz-Caracuel","family":"I.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pian","family":"H.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00edez Juan","family":"J.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iglesias","family":"P.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"1703_CR1","doi-asserted-by":"publisher","first-page":"IV1","DOI":"10.1093\/neuonc\/noad149","volume":"25","author":"QT Ostrom","year":"2023","unstructured":"Ostrom QT, Price M, Neff C, Cioffi G, Waite KA, Kruchko C, Barnholtz-Sloan JS (2023) CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2016\u20132020. 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