{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T14:31:50Z","timestamp":1793457110001,"version":"4.5.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Erciyes University Research Foundation","award":["TTU\u2013 2016-6976"],"award-info":[{"award-number":["TTU\u2013 2016-6976"]}],"id":[{"id":"https:\/\/ror.org\/047g8vk19","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pituitary"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s11102-026-01754-x","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T12:08:13Z","timestamp":1787400493000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of endothelial dysfunction in women with prolactinoma"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8000-5220","authenticated-orcid":false,"given":"Mehmet Cagri","family":"Unal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8325-2796","authenticated-orcid":false,"given":"Osman Onur","family":"Daloglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5644-751X","authenticated-orcid":false,"given":"Ugur","family":"Karabiyik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihat","family":"Kalay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kursad","family":"Unluhizarci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuleyha","family":"Karaca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,22]]},"reference":[{"issue":"16","key":"1754_CR1","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1001\/jama.2023.5444","volume":"329","author":"NA Tritos","year":"2023","unstructured":"Tritos NA, Miller KK (2023) Diagnosis and Management of Pituitary Adenomas: A Review. JAMA 329(16):1386\u20131398","journal-title":"JAMA"},{"issue":"4","key":"1754_CR2","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.mehy.2015.01.024","volume":"84","author":"M Medic-Stojanoska","year":"2015","unstructured":"Medic-Stojanoska M, Icin T, Pletikosic I, Bajkin I, Novakovic-Paro J, Stokic E et al (2015) Risk factors for accelerated atherosclerosis in young women with hyperprolactinemia. Med Hypotheses 84(4):321\u2013326","journal-title":"Med Hypotheses"},{"issue":"3","key":"1754_CR3","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1530\/eje.0.1490187","volume":"149","author":"D Yavuz","year":"2003","unstructured":"Yavuz D, Deyneli O, Akpinar I, Yildiz E, G\u00f6z\u00fc H, Sezgin O et al (2003) Endothelial function, insulin sensitivity and inflammatory markers in hyperprolactinemic pre-menopausal women. Eur J Endocrinol 149(3):187\u2013193","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"1754_CR4","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s11102-010-0277-9","volume":"14","author":"K Berinder","year":"2011","unstructured":"Berinder K, Nystr\u00f6m T, H\u00f6ybye C, Hall K, Hulting AL (2011) Insulin sensitivity and lipid profile in prolactinoma patients before and after normalization of prolactin by dopamine agonist therapy. Pituitary 14(3):199\u2013207","journal-title":"Pituitary"},{"issue":"1","key":"1754_CR5","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1161\/HYPERTENSIONAHA.109.132100","volume":"54","author":"GA Georgiopoulos","year":"2009","unstructured":"Georgiopoulos GA, Stamatelopoulos KS, Lambrinoudaki I, Lykka M, Kyrkou K, Rizos D et al (2009) Prolactin and preclinical atherosclerosis in menopausal women with cardiovascular risk factors. Hypertension 54(1):98\u2013105","journal-title":"Hypertension"},{"issue":"5","key":"1754_CR6","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1046\/j.1365-2125.2000.00277.x","volume":"50","author":"OT Raitakari","year":"2000","unstructured":"Raitakari OT, Celermajer DS (2000) Flow-mediated dilatation. Br J Clin Pharmacol 50(5):397\u2013404","journal-title":"Br J Clin Pharmacol"},{"issue":"2","key":"1754_CR7","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1161\/01.STR.27.2.224","volume":"27","author":"DH O\u2019Leary","year":"1996","unstructured":"O\u2019Leary DH, Polak JF, Kronmal RA, Savage PJ, Borhani NO, Kittner SJ et al (1996) Thickening of the carotid wall. A marker for atherosclerosis in the elderly? Cardiovascular Health Study Collaborative Research Group. Stroke 27(2):224\u2013231","journal-title":"Stroke"},{"issue":"3","key":"1754_CR8","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1007\/s11102-013-0495-z","volume":"17","author":"XB Jiang","year":"2014","unstructured":"Jiang XB, Li CL, He DS, Mao ZG, Liu DH, Fan X et al (2014) Increased carotid intima media thickness is associated with prolactin levels in subjects with untreated prolactinoma: a pilot study. Pituitary 17(3):232\u2013239","journal-title":"Pituitary"},{"issue":"6","key":"1754_CR9","first-page":"440","volume":"16","author":"BA Do\u011fan","year":"2016","unstructured":"Do\u011fan BA, Ardu\u00e7 A, Tuna MM, Nas\u0131ro\u011flu NI, I\u015f\u0131k S, Berker D et al (2016) Evaluation of atherosclerosis after cessation of cabergoline therapy in patients with prolactinoma. Anatol J Cardiol 16(6):440\u20137","journal-title":"Anatol J Cardiol"},{"issue":"1","key":"1754_CR10","doi-asserted-by":"publisher","first-page":"55","DOI":"10.25179\/tjem.2019-72018","volume":"24","author":"MC Unal","year":"2020","unstructured":"Unal MC, Karaca Z, Unluhizarci K, Kelestemur F (2020) Evaluation of Hyperandrogenemia in Women with Prolactinoma. Endocrinol Res Pract 24(1):55\u201362","journal-title":"Endocrinol Res Pract"},{"issue":"3","key":"1754_CR11","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1210\/jc.2011-2590","volume":"97","author":"CR Oliveira","year":"2012","unstructured":"Oliveira CR, Salvatori R, Barreto-Filho JA, Rocha IE, Mari A, Pereira RM et al (2012) Insulin sensitivity and \u03b2-cell function in adults with lifetime, untreated isolated growth hormone deficiency. J Clin Endocrinol Metab 97(3):1013\u20131019","journal-title":"J Clin Endocrinol Metab"},{"key":"1754_CR12","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1159\/000486000","volume":"49","author":"M Andersen","year":"2018","unstructured":"Andersen M, Glintborg D (2018) Metabolic Syndrome in Hyperprolactinemia. Front Horm Res 49:29\u201347","journal-title":"Front Horm Res"},{"issue":"2","key":"1754_CR13","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1517\/14656560903501544","volume":"11","author":"R Scranton","year":"2010","unstructured":"Scranton R, Cincotta A (2010) Bromocriptine\u2013unique formulation of a dopamine agonist for the treatment of type 2 diabetes. Expert Opin Pharmacother 11(2):269\u2013279","journal-title":"Expert Opin Pharmacother"},{"issue":"2","key":"1754_CR14","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1089\/met.2023.0174","volume":"22","author":"M Elleuch","year":"2024","unstructured":"Elleuch M, Ben Bnina M, Loukil F, Hadj Kacem F, Boujelben K, Mnif M et al (2024) Metabolic disorders during prolactinomas. Metab Syndr Relat Disord 22(2):85\u20139","journal-title":"Metab Syndr Relat Disord"},{"issue":"1","key":"1754_CR15","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3904\/kjim.1993.8.1.8","volume":"8","author":"SY Kim","year":"1993","unstructured":"Kim SY, Sung YA, Ko KS, Cho BY, Lee HK, Koh CS et al (1993) Direct relationship between elevated free testosterone and insulin resistance in hyperprolactinemic women. Korean J Intern Med 8(1):8\u201314","journal-title":"Korean J Intern Med"},{"key":"1754_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1018090","volume":"13","author":"A Glezer","year":"2022","unstructured":"Glezer A, Santana MR, Bronstein MD, Donato J Jr., Jallad RS (2022) The interplay between prolactin and cardiovascular disease. Front Endocrinol (Lausanne) 13:1018090","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1754_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-319-12114-7_1","volume":"846","author":"N Ben-Jonathan","year":"2015","unstructured":"Ben-Jonathan N, Hugo E (2015) Prolactin (PRL) in adipose tissue: regulation and functions. Adv Exp Med Biol 846:1\u201335","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"1754_CR18","first-page":"175","volume":"41","author":"BA Dogan","year":"2016","unstructured":"Dogan BA, Berker D, Arduc A, Tuna MM, Nasiroglu NI, Karakili\u00e7 E et al (2016) Insulin resistance and androgen levels in eugonadic and hypogonadic women with prolactinoma. Minerva Endocrinol 41(2):175\u2013182","journal-title":"Minerva Endocrinol"},{"issue":"5","key":"1754_CR19","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/1043-2760(93)90103-L","volume":"4","author":"SE Walker","year":"1993","unstructured":"Walker SE, Allen SH, McMurray RW (1993) Prolactin and autoimmune disease. Trends Endocrinol Metab 4(5):147\u2013151","journal-title":"Trends Endocrinol Metab"},{"issue":"4","key":"1754_CR20","doi-asserted-by":"publisher","first-page":"789","DOI":"10.2337\/dc11-0064","volume":"34","author":"RA Defronzo","year":"2011","unstructured":"Defronzo RA (2011) Bromocriptine: a sympatholytic, d2-dopamine agonist for the treatment of type 2 diabetes. Diabetes Care 34(4):789\u2013794","journal-title":"Diabetes Care"},{"issue":"10","key":"1754_CR21","doi-asserted-by":"publisher","first-page":"R1193","DOI":"10.1152\/ajpregu.00256.2015","volume":"309","author":"J Triebel","year":"2015","unstructured":"Triebel J, Bertsch T, Bollheimer C, Rios-Barrera D, Pearce CF, H\u00fcfner M et al (2015) Principles of the prolactin\/vasoinhibin axis. Am J Physiol Regul Integr Comp Physiol 309(10):R1193\u2013R1203","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"6","key":"1754_CR22","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1111\/cen.12204","volume":"79","author":"A Ciresi","year":"2013","unstructured":"Ciresi A, Amato MC, Guarnotta V, Lo Castro F, Giordano C (2013) Higher doses of cabergoline further improve metabolic parameters in patients with prolactinoma regardless of the degree of reduction in prolactin levels. Clin Endocrinol (Oxf) 79(6):845\u201352","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"9","key":"1754_CR23","volume":"13","author":"G Khalil","year":"2021","unstructured":"Khalil G, Khan FA, Jamal QM, Saleem A, Masroor H, Abbas K (2021) Change in insulin sensitivity and lipid profile after dopamine agonist therapy in patients with prolactinoma. Cureus 13(9):e17824","journal-title":"Cureus"},{"key":"1754_CR24","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s13098-015-0094-4","volume":"7","author":"NA Pala","year":"2015","unstructured":"Pala NA, Laway BA, Misgar RA, Dar RA (2015) Metabolic abnormalities in patients with prolactinoma: response to treatment with cabergoline. Diabetol Metab Syndr 7:99","journal-title":"Diabetol Metab Syndr"},{"issue":"2","key":"1754_CR25","doi-asserted-by":"publisher","first-page":"207","DOI":"10.2215\/CJN.06840711","volume":"7","author":"JJ Carrero","year":"2012","unstructured":"Carrero JJ, Kyriazis J, Sonmez A, Tzanakis I, Qureshi AR, Stenvinkel P et al (2012) Prolactin levels, endothelial dysfunction, and the risk of cardiovascular events and mortality in patients with CKD. Clin J Am Soc Nephrol 7(2):207\u2013215","journal-title":"Clin J Am Soc Nephrol"},{"issue":"3","key":"1754_CR26","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1080\/07435800.2025.2511845","volume":"50","author":"DB Keti","year":"2025","unstructured":"Keti DB, Mammadov M, Goksuluk MB, Hacioglu A, Okcesiz I, Karaca Z et al (2025) The effect of hyperprolactinemia and its treatment on oxidative stress. Endocr Res 50(3):184\u2013189","journal-title":"Endocr Res"},{"issue":"8","key":"1754_CR27","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/jhh.2017.15","volume":"31","author":"G Georgiopoulos","year":"2017","unstructured":"Georgiopoulos G, Lambrinoudaki I, Athanasouli F, Armeni E, Koliviras A, Augoulea A et al (2017) Prolactin as a predictor of endothelial dysfunction and arterial stiffness progression in menopause. J Hum Hypertens 31(8):520\u2013524","journal-title":"J Hum Hypertens"},{"issue":"1","key":"1754_CR28","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1186\/s12902-025-02079-9","volume":"25","author":"A Hac\u0131\u00f6mero\u011flu","year":"2025","unstructured":"Hac\u0131\u00f6mero\u011flu A, G\u00fcng\u00fcne\u015f A, Yal\u00e7\u0131n S, Tekin E (2025) Endocan levels in patients with hyperprolactinemia. BMC Endocr Disord 25(1):253","journal-title":"BMC Endocr Disord"},{"issue":"4","key":"1754_CR29","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1111\/j.1365-2265.2011.04075.x","volume":"75","author":"N Friedrich","year":"2011","unstructured":"Friedrich N, Schneider HJ, Spielhagen C, Markus MR, Haring R, Grabe HJ et al (2011) The association of serum prolactin concentration with inflammatory biomarkers - cross-sectional findings from the population-based Study of Health in Pomerania. Clin Endocrinol (Oxf) 75(4):561\u2013566","journal-title":"Clin Endocrinol (Oxf)"}],"container-title":["Pituitary"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-026-01754-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11102-026-01754-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11102-026-01754-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T14:11:49Z","timestamp":1793455909000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11102-026-01754-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,22]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["1754"],"URL":"https:\/\/doi.org\/10.1007\/s11102-026-01754-x","relation":{},"ISSN":["1386-341X","1573-7403"],"issn-type":[{"value":"1386-341X","type":"print"},{"value":"1573-7403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,22]]},"assertion":[{"value":"4 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study has been approved by the Erciyes University Faculty of Medicine Ethics Committee (approval ID: 2016\/447, Date 29\/07\/2016). All patients provided written consent for tests.","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"149"}}