{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T19:20:51Z","timestamp":1788981651838,"version":"build-2803163510"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T00:00:00Z","timestamp":1544400000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31501772"],"award-info":[{"award-number":["31501772"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010010","name":"Shanxi Province Science Foundation for Youths","doi-asserted-by":"crossref","award":["201601D021097"],"award-info":[{"award-number":["201601D021097"]}],"id":[{"id":"10.13039\/501100010010","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Plant Mol Biol"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1007\/s11103-018-0807-9","type":"journal-article","created":{"date-parts":[[2018,12,9]],"date-time":"2018-12-09T22:27:37Z","timestamp":1544394457000},"page":"123-134","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Characterization of the O-acetylserine(thiol)lyase gene family in Solanum lycopersicum L."],"prefix":"10.1007","volume":"99","author":[{"given":"Danmei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8428-3399","authenticated-orcid":false,"given":"Yanxi","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,12,10]]},"reference":[{"key":"807_CR1","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1104\/pp.109.147975","volume":"152","author":"C Alvarez","year":"2010","unstructured":"Alvarez C, Calo L, Romero LC, Garcia I, Gotor C (2010) An O-acetylserine(thiol)lyase homolog with l-cysteine desulfhydrase activity regulates cysteine homeostasis in Arabidopsis. Plant Physiol 152:656\u2013669","journal-title":"Plant Physiol"},{"key":"807_CR2","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/j.1469-8137.2011.03889.x","volume":"193","author":"C Alvarez","year":"2012","unstructured":"Alvarez C, Bermudez MA, Romero LC, Gotor C, Garcia I (2012) Cysteine homeostasis plays an essential role in plant immunity. New Phytol 193:165\u2013177","journal-title":"New Phytol"},{"key":"807_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0014-5793(95)00255-8","volume":"363","author":"C Barroso","year":"1995","unstructured":"Barroso C, Vega JM, Gotor C (1995) A new member of the cytosolic O-acetylserine(thiol)lyase gene family in Arabidopsis thaliana. FEBS Lett 363:1\u20135","journal-title":"FEBS Lett"},{"key":"807_CR4","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1105\/tpc.109.071985","volume":"22","author":"MA Bermudez","year":"2010","unstructured":"Bermudez MA, Paez-Ochoa MA, Gotor C, Romero LC (2010) Arabidopsis S-sulfocysteine synthase activity is essential for chloroplast function and long-day light-dependent redox control. Plant Cell 22:403\u2013416","journal-title":"Plant Cell"},{"key":"807_CR5","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1104\/pp.112.201491","volume":"160","author":"MA Bermudez","year":"2012","unstructured":"Bermudez MA, Galmes J, Moreno I, Mullineaux PM, Gotor C, Romero LC (2012) Photosynthetic adaptation to length of day is dependent on S-sulfocysteine synthase activity in the thylakoid lumen. Plant Physiol 160:274\u2013288","journal-title":"Plant Physiol"},{"key":"807_CR6","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1042\/BJ20120038","volume":"445","author":"H Birke","year":"2012","unstructured":"Birke H, Haas FH, De Kok LJ, Balk J, Wirtz M, Hell R (2012) Cysteine biosynthesis, in concert with a novel mechanism, contributes to sulfide detoxification in mitochondria of Arabidopsis thaliana. Biochem J 445:275\u2013283","journal-title":"Biochem J"},{"key":"807_CR7","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1104\/pp.113.221200","volume":"163","author":"H Birke","year":"2013","unstructured":"Birke H, Heeg C, Wirtz M, Hell R (2013) Successful fertilization requires the presence of at least one major O-acetylserine(thiol)lyase for cysteine synthesis in pollen of Arabidopsis. Plant Physiol 163:959\u2013972","journal-title":"Plant Physiol"},{"key":"807_CR8","doi-asserted-by":"publisher","first-page":"38803","DOI":"10.1074\/jbc.M505313200","volume":"280","author":"ER Bonner","year":"2005","unstructured":"Bonner ER, Cahoon RE, Knapke SM, Jez JM (2005) Molecular basis of cysteine biosynthesis in plants: structural and functional analysis of O-acetylserine sulfhydrylase from Arabidopsis thaliana. J Biol Chem 280:38803\u201338813","journal-title":"J Biol Chem"},{"key":"807_CR9","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1016\/j.bbapap.2015.02.013","volume":"1854","author":"B Campanini","year":"2015","unstructured":"Campanini B, Benoni R, Bettati S, Beck CM, Hayes CS, Mozzarelli A (2015) Moonlighting O-acetylserine sulfhydrylase: new functions for an old protein. Biochim Biophys Acta 1854:1184\u20131193","journal-title":"Biochim Biophys Acta"},{"key":"807_CR10","doi-asserted-by":"publisher","first-page":"8315","DOI":"10.1021\/bi602603c","volume":"46","author":"A Chattopadhyay","year":"2007","unstructured":"Chattopadhyay A et al (2007) Structure, mechanism, and conformational dynamics of O-acetylserine sulfhydrylase from Salmonella typhimurium: comparison of A and B isozymes. Biochemistry 46:8315\u20138330","journal-title":"Biochemistry"},{"key":"807_CR11","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1046\/j.1432-1327.1998.2550235.x","volume":"255","author":"M Droux","year":"1998","unstructured":"Droux M, Ruffet ML, Douce R, Job D (1998) Interactions between serine acetyltransferase and O-acetylserine (thiol) lyase in higher plants\u2013structural and kinetic properties of the free and bound enzymes. Eur J Biochem 255:235\u2013245","journal-title":"Eur J Biochem"},{"key":"807_CR12","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/1471-2229-8-131","volume":"8","author":"M Exposito-Rodriguez","year":"2008","unstructured":"Exposito-Rodriguez M, Borges AA, Borges-Perez A, Perez JA (2008) Selection of internal control genes for quantitative real-time RT-PCR studies during tomato development process. BMC Plant Biol 8:131","journal-title":"BMC Plant Biol"},{"key":"807_CR13","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.jmb.2008.08.075","volume":"386","author":"A Feldman-Salit","year":"2009","unstructured":"Feldman-Salit A, Wirtz M, Hell R, Wade RC (2009) A mechanistic model of the cysteine synthase complex. J Mol Biol 386:37\u201359","journal-title":"J Mol Biol"},{"key":"807_CR14","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1105\/tpc.107.056747","volume":"20","author":"C Heeg","year":"2008","unstructured":"Heeg C, Kruse C, Jost R, Gutensohn M, Ruppert T, Wirtz M, Hell R (2008) Analysis of the Arabidopsis O-acetylserine(thiol)lyase gene family demonstrates compartment-specific differences in the regulation of cysteine synthesis. Plant Cell 20:168\u2013185","journal-title":"Plant Cell"},{"key":"807_CR15","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/0014-5793(94)00872-8","volume":"351","author":"R Hell","year":"1994","unstructured":"Hell R, Bork C, Bogdanova N, Frolov I, Hauschild R (1994) Isolation and characterization of two cDNAs encoding for compartment specific isoforms of O-acetylserine (thiol) lyase from Arabidopsis thaliana. FEBS Lett 351:257\u2013262","journal-title":"FEBS Lett"},{"key":"807_CR16","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/BF01321531","volume":"16","author":"H Hesse","year":"1999","unstructured":"Hesse H, Lipke J, Altmann T, Hofgen R (1999) Molecular cloning and expression analyses of mitochondrial and plastidic isoforms of cysteine synthase (O-acetylserine(thiol)lyase) from Arabidopsis thaliana. Amino Acids 16:113\u2013131","journal-title":"Amino Acids"},{"key":"807_CR17","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1023\/A:1022349623951","volume":"51","author":"JR Howarth","year":"2003","unstructured":"Howarth JR, Dominguez-Solis JR, Gutierrez-Alcala G, Wray JL, Romero LC, Gotor C (2003) The serine acetyltransferase gene family in Arabidopsis thaliana and the regulation of its expression by cadmium. Plant Mol Biol 51:589\u2013598","journal-title":"Plant Mol Biol"},{"key":"807_CR18","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s11104-017-3335-5","volume":"419","author":"ZP Jin","year":"2017","unstructured":"Jin ZP et al (2017) Hydrogen sulfide mediates ion fluxes inducing stomatal closure in response to drought stress in Arabidopsis thaliana. Plant Soil 419:141\u2013152","journal-title":"Plant Soil"},{"key":"807_CR19","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S0378-1119(00)00261-4","volume":"253","author":"R Jost","year":"2000","unstructured":"Jost R, Berkowitz O, Wirtz M, Hopkins L, Hawkesford MJ, Hell R (2000) Genomic and functional characterization of the oas gene family encoding O-acetylserine (thiol) lyases, enzymes catalyzing the final step in cysteine biosynthesis in Arabidopsis thaliana. Gene 253:237\u2013247","journal-title":"Gene"},{"key":"807_CR20","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.jhazmat.2017.05.009","volume":"337","author":"R Khare","year":"2017","unstructured":"Khare R, Kumar S, Shukla T, Ranjan A, Trivedi PK (2017) Differential sulphur assimilation mechanism regulates response of Arabidopsis thaliana natural variation towards arsenic stress under limiting sulphur condition. J Hazard Mater 337:198\u2013207","journal-title":"J Hazard Mater"},{"key":"807_CR21","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1007\/s11103-016-0438-y","volume":"91","author":"A Koprivova","year":"2016","unstructured":"Koprivova A, Kopriva S (2016) Hormonal control of sulfate uptake and assimilation. Plant Mol Biol 91:617\u2013627","journal-title":"Plant Mol Biol"},{"key":"807_CR22","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1093\/molbev\/msw054","volume":"33","author":"S Kumar","year":"2016","unstructured":"Kumar S, Stecher G, Tamura K (2016) MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets. Mol Biol Evol 33:1870\u20131874","journal-title":"Mol Biol Evol"},{"key":"807_CR23","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1093\/jxb\/ern343","volume":"60","author":"KW Lai","year":"2009","unstructured":"Lai KW, Yau CP, Tse YC, Jiang L, Yip WK (2009) Heterologous expression analyses of rice OsCAS in Arabidopsis and in yeast provide evidence for its roles in cyanide detoxification rather than in cysteine synthesis in vivo. J Exp Bot 60:993\u20131008","journal-title":"J Exp Bot"},{"key":"807_CR24","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1105\/tpc.110.082230","volume":"23","author":"J Lee","year":"2011","unstructured":"Lee J, Lee H, Kim J, Lee S, Kim DH, Kim S, Hwang I (2011) Both the hydrophobicity and a positively charged region flanking the C-terminal region of the transmembrane domain of signal-anchored proteins play critical roles in determining their targeting specificity to the endoplasmic reticulum or endosymbiotic organelles in Arabidopsis cells. Plant Cell 23:1588\u20131607","journal-title":"Plant Cell"},{"key":"807_CR25","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1111\/tpj.12387","volume":"77","author":"D Liu","year":"2014","unstructured":"Liu D et al (2014) The SEPALLATA MADS-box protein SLMBP21 forms protein complexes with JOINTLESS and MACROCALYX as a transcription activator for development of the tomato flower abscission zone. Plant J 77:284\u2013296","journal-title":"Plant J"},{"key":"807_CR26","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method. Methods 25:402\u2013408","journal-title":"Methods"},{"key":"807_CR27","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1104\/pp.108.117408","volume":"147","author":"MC Lopez-Martin","year":"2008","unstructured":"Lopez-Martin MC, Becana M, Romero LC, Gotor C (2008) Knocking out cytosolic cysteine synthesis compromises the antioxidant capacity of the cytosol to maintain discrete concentrations of hydrogen peroxide in Arabidopsis. Plant Physiol 147:562\u2013572","journal-title":"Plant Physiol"},{"key":"807_CR28","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1016\/j.jmb.2010.09.027","volume":"404","author":"SM Marino","year":"2010","unstructured":"Marino SM, Gladyshev VN (2010) Cysteine function governs its conservation and degeneration and restricts its utilization on protein surfaces. J Mol Biol 404:902\u2013916","journal-title":"J Mol Biol"},{"key":"807_CR29","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1111\/j.1365-313X.2007.03212.x","volume":"51","author":"BK Nelson","year":"2007","unstructured":"Nelson BK, Cai X, Nebenfuhr A (2007) A multicolored set of in vivo organelle markers for co-localization studies in Arabidopsis and other plants. Plant J 51:1126\u20131136","journal-title":"Plant J"},{"key":"807_CR30","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1002\/cfg.405","volume":"5","author":"E Palmer","year":"2004","unstructured":"Palmer E, Freeman T (2004) Investigation into the use of C- and N-terminal GFP fusion proteins for subcellular localization studies using reverse transfection microarrays. Comp Funct Genom 5:342\u2013353","journal-title":"Comp Funct Genom"},{"key":"807_CR31","doi-asserted-by":"publisher","first-page":"26803","DOI":"10.1074\/jbc.R400001200","volume":"279","author":"WM Rabeh","year":"2004","unstructured":"Rabeh WM, Cook PF (2004) Structure and mechanism of O-acetylserine sulfhydrylase. J Biol Chem 279:26803\u201326806","journal-title":"J Biol Chem"},{"key":"807_CR32","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.plaphy.2005.04.001","volume":"43","author":"A Riemenschneider","year":"2005","unstructured":"Riemenschneider A, Nikiforova V, Hoefgen R, De Kok LJ, Papenbrock J (2005a) Impact of elevated H(2)S on metabolite levels, activity of enzymes and expression of genes involved in cysteine metabolism. Plant Physiol Biochem 43:473\u2013483","journal-title":"Plant Physiol Biochem"},{"key":"807_CR33","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1104\/pp.104.057125","volume":"137","author":"A Riemenschneider","year":"2005","unstructured":"Riemenschneider A, Riedel K, Hoefgen R, Papenbrock J, Hesse H (2005b) Impact of reduced O-acetylserine(thiol)lyase isoform contents on potato plant metabolism. Plant Physiol 137:892\u2013900","journal-title":"Plant Physiol"},{"key":"807_CR34","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1093\/mp\/sst168","volume":"7","author":"LC Romero","year":"2014","unstructured":"Romero LC, Aroca MA, Laureano-Marin AM, Moreno I, Garcia I, Gotor C (2014) Cysteine and cysteine-related signaling pathways in Arabidopsis thaliana. Molecular plant 7:264\u2013276","journal-title":"Molecular plant"},{"key":"807_CR35","doi-asserted-by":"publisher","first-page":"318","DOI":"10.2144\/98242pf02","volume":"24","author":"VK Singh","year":"1998","unstructured":"Singh VK, Mangalam AK, Dwivedi S, Naik S (1998) Primer premier: program for design of degenerate primers from a protein sequence. Biotechniques 24:318\u2013319","journal-title":"Biotechniques"},{"key":"807_CR36","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.jmb.2010.02.044","volume":"398","author":"O Spiegelhauer","year":"2010","unstructured":"Spiegelhauer O, Mende S, Dickert F, Knauer SH, Ullmann GM, Dobbek H (2010) Cysteine as a modulator residue in the active site of xenobiotic reductase A: a structural, thermodynamic and kinetic study. J Mol Biol 398:66\u201382","journal-title":"J Mol Biol"},{"key":"807_CR37","first-page":"3","volume":"2","author":"JD Thompson","year":"2002","unstructured":"Thompson JD, Gibson TJ, Higgins DG (2002) Multiple sequence alignment using ClustalW and ClustalX. Curr Protocols Bioinform 2:3","journal-title":"Curr Protocols Bioinform"},{"key":"807_CR38","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1016\/j.cub.2016.06.008","volume":"26","author":"P Wang","year":"2016","unstructured":"Wang P, Richardson C, Hawes C, Hussey PJ (2016) Arabidopsis NAP1 regulates the formation of autophagosomes. Curr Biol 26:2060\u20132069","journal-title":"Curr Biol"},{"key":"807_CR39","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.jplph.2005.11.013","volume":"163","author":"M Wirtz","year":"2006","unstructured":"Wirtz M, Hell R (2006) Functional analysis of the cysteine synthase protein complex from plants: structural, biochemical and regulatory properties. J Plant Physiol 163:273\u2013286","journal-title":"J Plant Physiol"},{"key":"807_CR40","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1093\/jxb\/erh201","volume":"55","author":"M Wirtz","year":"2004","unstructured":"Wirtz M, Droux M, Hell R (2004) O-acetylserine (thiol) lyase: an enigmatic enzyme of plant cysteine biosynthesis revisited in Arabidopsis thaliana. J Exp Bot 55:1785\u20131798","journal-title":"J Exp Bot"},{"key":"807_CR41","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s11103-009-9507-9","volume":"71","author":"C Xiao","year":"2009","unstructured":"Xiao C, Chen F, Yu X, Lin C, Fu YF (2009) Over-expression of an AT-hook gene, AHL22, delays flowering and inhibits the elongation of the hypocotyl in Arabidopsis thaliana. Plant Mol Biol 71:39\u201350","journal-title":"Plant Mol Biol"},{"key":"807_CR42","doi-asserted-by":"publisher","first-page":"4168","DOI":"10.1016\/j.jmb.2016.08.011","volume":"428","author":"M Xu","year":"2016","unstructured":"Xu M, Marsh HM, Sevier CS (2016) A conserved cysteine within the ATPase domain of the endoplasmic reticulum chaperone BiP is necessary for a complete complement of BiP activities. J Mol Biol 428:4168\u20134184","journal-title":"J Mol Biol"},{"key":"807_CR43","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1093\/pcp\/41.4.465","volume":"41","author":"Y Yamaguchi","year":"2000","unstructured":"Yamaguchi Y, Nakamura T, Kusano T, Sano H (2000) Three Arabidopsis genes encoding proteins with differential activities for cysteine synthase and beta-cyanoalanine synthase. Plant Cell Physiol 41:465\u2013476","journal-title":"Plant Cell Physiol"},{"key":"807_CR44","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1046\/j.1365-313X.1993.04050759.x","volume":"4","author":"S Youssefian","year":"1993","unstructured":"Youssefian S, Nakamura M, Sano H (1993) Tobacco plants transformed with the O-acetylserine (thiol) lyase gene of wheat are resistant to toxic levels of hydrogen sulphide gas. Plant J 4:759\u2013769","journal-title":"Plant J"}],"container-title":["Plant Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11103-018-0807-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11103-018-0807-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11103-018-0807-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T19:08:41Z","timestamp":1575918521000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11103-018-0807-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,10]]},"references-count":44,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["807"],"URL":"https:\/\/doi.org\/10.1007\/s11103-018-0807-9","relation":{},"ISSN":["0167-4412","1573-5028"],"issn-type":[{"value":"0167-4412","type":"print"},{"value":"1573-5028","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,10]]},"assertion":[{"value":"11 April 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}