{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:55:56Z","timestamp":1789430156725,"version":"build-2803163510"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,1,5]],"date-time":"2014-01-05T00:00:00Z","timestamp":1388880000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatr Q"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1007\/s11126-013-9281-3","type":"journal-article","created":{"date-parts":[[2014,1,4]],"date-time":"2014-01-04T07:43:26Z","timestamp":1388821406000},"page":"177-185","source":"Crossref","is-referenced-by-count":8,"title":["N-Acetylcysteine and Metabotropic Glutamate Receptors: Implications for the Treatment of Schizophrenia: A Literature review"],"prefix":"10.1007","volume":"85","author":[{"given":"Adam Daniel","family":"Zavodnick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rizwan","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,1,5]]},"reference":[{"issue":"1","key":"9281_CR1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/npp.2011.181","volume":"37","author":"B Moghaddam","year":"2012","unstructured":"Moghaddam B, Javitt D: From revolution to evolution: The glutamate hypothesis of schizophrenia and its implication for treatment. Neuropsychopharmacology 37(1):4\u201315, 2012.","journal-title":"Neuropsychopharmacology."},{"key":"9281_CR2","unstructured":"Coyle J, Leski M, Morrison J, et al.: The diverse roles of l-glutamic acid in brain signal transduction. In: Davis K, Charney D, Coyle J, Nemeroff C (Eds) Neuropsychopharmacology (The Fifth Generation of Progress). Philadelphia: Lippincott, Williams & Wilkins, pp. 71\u201390, 2002."},{"issue":"1","key":"9281_CR3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/schbul\/sbr133","volume":"38","author":"A Adell","year":"2012","unstructured":"Adell A, Jim\u00e9nez-S\u00e1nchez L, L\u00f3pez-Gil X, Rom\u00f3n T: Is the acute NMDA receptor hypofunction a valid model of schizophrenia? Schizophrenia Bulletin 38(1):9\u201314, 2012.","journal-title":"Schizophrenia Bulletin"},{"issue":"9","key":"9281_CR4","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1176\/appi.ajp.158.9.1367","volume":"158","author":"DC Goff","year":"2001","unstructured":"Goff DC, Coyle JT: The emerging role of glutamate in the pathophysiology and treatment of schizophrenia. American Journal of Psychiatry 158(9):1367\u20131377, 2001.","journal-title":"American Journal of Psychiatry"},{"issue":"1","key":"9281_CR5","first-page":"10","volume":"8","author":"RA Sansone","year":"2011","unstructured":"Sansone RA, Sansone LA: Getting a knack for NAC: N-acetyl-cysteine. Innovations in Clinical Neuroscience 8(1):10\u201314, 2011.","journal-title":"Innovations in Clinical Neuroscience"},{"issue":"2","key":"9281_CR6","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1503\/jpn.100057","volume":"36","author":"O Dean","year":"2011","unstructured":"Dean O, Giorlando F, Berk M: N-acetylcysteine in psychiatry: Current therapeutic evidence and potential mechanisms of action. Journal of Psychiatry & Neuroscience 36(2):78\u201386, 2011.","journal-title":"Journal of Psychiatry & Neuroscience"},{"issue":"3","key":"9281_CR7","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1124\/pr.110.003889","volume":"64","author":"R Bridges","year":"2012","unstructured":"Bridges R, Lutgen V, Lobner D, Baker DA: Thinking outside the cleft to understand synaptic activity: Contribution of the cystine-glutamate antiporter (System xc-) to normal and pathological glutamatergic signaling. Pharmacological Reviews 64(3):780\u2013802, 2012.","journal-title":"Pharmacological Reviews"},{"issue":"6","key":"9281_CR8","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1093\/schbul\/sbq112","volume":"37","author":"KV Sathyasaikumar","year":"2011","unstructured":"Sathyasaikumar KV, Stachowski EK, Wonodi I, Roberts RC, Rassoulpour A, McMahon RP, Schwarcz R: Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia. Schizophrenia Bulletin 37(6):1147\u20131156, 2011.","journal-title":"Schizophrenia Bulletin"},{"issue":"4","key":"9281_CR9","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.pbb.2011.04.015","volume":"100","author":"MF Olive","year":"2012","unstructured":"Olive MF, Cleva RM, Kalivas PW, Malcolm RJ: Glutamatergic medications for the treatment of drug and behavioral addictions. Pharmacology Biochemistry and Behavior 100(4):801\u2013810, 2012.","journal-title":"Pharmacology Biochemistry and Behavior"},{"issue":"1\u20133","key":"9281_CR10","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ejphar.2010.01.028","volume":"639","author":"MR Stefani","year":"2010","unstructured":"Stefani MR, Moghaddam B: Activation of type 5 metabotropic glutamate receptors attenuates deficits in cognitive flexibility induced by NMDA receptor blockade. European Journal of Pharmacology 639(1\u20133):26\u201332, 2010.","journal-title":"European Journal of Pharmacology"},{"issue":"1\u20133","key":"9281_CR11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ejphar.2010.02.058","volume":"639","author":"GJ Marek","year":"2010","unstructured":"Marek GJ: Metabotropic glutamate2\/3 (mGlu2\/3) receptors, schizophrenia and cognition. European Journal of Pharmacology 639(1\u20133):81\u201390, 2010.","journal-title":"European Journal of Pharmacology"},{"issue":"1\u20133","key":"9281_CR12","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ejphar.2009.12.041","volume":"639","author":"S Chaki","year":"2010","unstructured":"Chaki S: Group II metabotropic glutamate receptor agonists as a potential drug for schizophrenia. European Journal of Pharmacology 639(1\u20133):59\u201366, 2010.","journal-title":"European Journal of Pharmacology"},{"issue":"1\u20133","key":"9281_CR13","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ejphar.2010.02.059","volume":"639","author":"RM O\u2019Connor","year":"2010","unstructured":"O\u2019Connor RM, Finger BC, Flor PJ, Cryan JF: Metabotropic glutamate receptor 7: At the interface of cognition and emotion. European Journal of Pharmacology 639(1\u20133):123\u2013131, 2010.","journal-title":"European Journal of Pharmacology"},{"issue":"27","key":"9281_CR14","doi-asserted-by":"crossref","first-page":"6389","DOI":"10.1523\/JNEUROSCI.1007-05.2005","volume":"25","author":"MM Moran","year":"2005","unstructured":"Moran MM, McFarland K, Melendez RI, Kalivas PW, Seamans JK: Cystine\/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking. The Journal of Neuroscience 25(27):6389\u20136393.","journal-title":"The Journal of Neuroscience"},{"issue":"40","key":"9281_CR15","doi-asserted-by":"crossref","first-page":"9080","DOI":"10.1523\/JNEUROSCI.2220-05.2005","volume":"25","author":"JA Wolf","year":"2005","unstructured":"Wolf JA, Moyer JT, Lazarewicz MT, Contreras D, Benoit-Marand M, O\u2019Donnell P, Finkel LH: NMDA\/AMPA ratio impacts state transitions and entrainment to oscillations in a computational model of the nucleus accumbens medium spiny projection neuron. The Journal of Neuroscience 25(40):9080\u20139095, 2005.","journal-title":"The Journal of Neuroscience"},{"issue":"24","key":"9281_CR16","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1056\/NEJM198812153192401","volume":"319","author":"MJ Smilkstein","year":"1988","unstructured":"Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH: Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985). The New England Journal of Medicine 319(24):1557\u20131562, 1988.","journal-title":"The New England Journal of Medicine"},{"issue":"19","key":"9281_CR17","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1056\/NEJMoa1101214","volume":"365","author":"E Nguyen-Khac","year":"2011","unstructured":"Nguyen-Khac E, Thevenot T, Piquet MA, Benferhat S, Goria O, Chatelain D, Tramier B, Dewaele F, Ghrib S, Rudler M, Carbonell N, Tossou H, Bental A, Bernard-Chabert B, Dupas JL; AAH-NAC Study Group: Glucocorticoids plus N-acetylcysteine in severe alcoholic hepatitis. The New England Journal of Medicine 365(19):1781\u20131789, 2011.","journal-title":"The New England Journal of Medicine"},{"issue":"26","key":"9281_CR18","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1056\/NEJMoa054209","volume":"354","author":"G Marenzi","year":"2006","unstructured":"Marenzi G, Assanelli E, Marana I, Lauri G, Campodonico J, Grazi M, De Metrio M, Galli S, Fabbiocchi F, Montorsi P, Veglia F, Bartorelli AL: N-acetylcysteine and contrast-induced nephropathy in primary angioplasty. The New England Journal of Medicine 354(26):2773\u20132782, 2006.","journal-title":"The New England Journal of Medicine"},{"issue":"2","key":"9281_CR19","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2174\/157015911795596595","volume":"9","author":"M Bo\u0161kovi\u0107","year":"2011","unstructured":"Bo\u0161kovi\u0107 M, Vovk T, Kores Plesni\u010dar B, Grabnar I: Oxidative stress in schizophrenia. Current Neuropharmacology 9(2):301\u2013312, 2011.","journal-title":"Current Neuropharmacology"},{"issue":"42","key":"9281_CR20","doi-asserted-by":"crossref","first-page":"16621","DOI":"10.1073\/pnas.0706778104","volume":"104","author":"R Gysin","year":"2007","unstructured":"Gysin R, Kraftsik R, Sandell J, Bovet P, Chappuis C, Conus P, Deppen P, Preisig M, Ruiz V, Steullet P, Tosic M, Werge T, Cu\u00e9nod M, Do KQ: Impaired glutathione synthesis in schizophrenia: Convergent genetic and functional evidence. Proceedings of the National Academy of Sciences of the United States of America 104(42):16621\u201316666, 2007.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"11","key":"9281_CR21","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.biopsych.2012.03.025","volume":"71","author":"DC Shungu","year":"2012","unstructured":"Shungu DC: N-acetylcysteine for the treatment of glutathione deficiency and oxidative stress in schizophrenia. Biological Psychiatry 71(11):937\u2013938, 2012.","journal-title":"Biological Psychiatry"},{"issue":"7","key":"9281_CR22","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1038\/sj.npp.1301532","volume":"33","author":"DA Baker","year":"2008","unstructured":"Baker DA, Madayag A, Kristiansen LV, Meador-Woodruff JH, Haroutunian V, Raju I: Contribution of cystine-glutamate antiporters to the psychotomimetic effects of phencyclidine. Neuropsychopharmacology 33(7):1760\u20131772, 2008.","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"9281_CR23","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.brainres.2004.04.072","volume":"1016","author":"G Fukami","year":"2004","unstructured":"Fukami G, Hashimoto K, Koike K, Okamura N, Shimizu E, Iyo M: Effect of antioxidant N-acetyl-l-cysteine on behavioral changes and neurotoxicity in rats after administration of methamphetamine. Brain Research 1016(1):90\u201395, 2004.","journal-title":"Brain Research"},{"issue":"4 Pt 2","key":"9281_CR24","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1080\/15622970903144004","volume":"10","author":"M Bulut","year":"2009","unstructured":"Bulut M, Savas HA, Altindag A, Virit O, Dalkilic A: Beneficial effects of N-acetylcysteine in treatment resistant schizophrenia. The World Journal of Biological Psychiatry 10(4 Pt 2):626\u2013628, 2009.","journal-title":"The World Journal of Biological Psychiatry"},{"issue":"9","key":"9281_CR25","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1038\/sj.npp.1301624","volume":"33","author":"S Lavoie","year":"2008","unstructured":"Lavoie S, Murray MM, Deppen P, Knyazeva MG, Berk M, Boulat O, Bovet P, Bush AI, Conus P, Copolov D, Fornari E, Meuli R, Solida A, Vianin P, Cu\u00e9nod M, Buclin T, Do KQ: Glutathione precursor, N-acetyl-cysteine, improves mismatch negativity in schizophrenia patients. Neuropsychopharmacology 33(9):2187\u20132199, 2008.","journal-title":"Neuropsychopharmacology"},{"issue":"5","key":"9281_CR26","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.biopsych.2008.03.004","volume":"64","author":"M Berk","year":"2008","unstructured":"Berk M, Copolov D, Dean O, Lu K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Judd F, Katz F, Katz P, Ording-Jespersen S, Little J, Conus P, Cuenod M, Do KQ, Bush AI: N-acetyl cysteine as a glutathione precursor for schizophrenia: A double-blind, randomized, placebo-controlled trial. Biological Psychiatry 64(5):361\u2013368, 2008.","journal-title":"Biological Psychiatry"},{"issue":"11","key":"9281_CR27","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.biopsych.2011.09.031","volume":"71","author":"H Gunduz-Bruce","year":"2012","unstructured":"Gunduz-Bruce H, Reinhart RM, Roach BJ, Gueorguieva R, Oliver S, D\u2019Souza DC, Ford JM, Krystal JH, Mathalon DH: Glutamatergic modulation of auditory information processing in the human brain. Biological Psychiatry 71(11):969\u2013977, 2012.","journal-title":"Biological Psychiatry"},{"issue":"1\u20133","key":"9281_CR28","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.jad.2011.06.005","volume":"135","author":"M Berk","year":"2011","unstructured":"Berk M, Dean O, Cotton SM, Gama CS, Kapczinski F, Fernandes BS, Kohlmann K, Jeavons S, Hewitt K, Allwang C, Cobb H, Bush AI, Schapkaitz I, Dodd S, Malhi GS: The efficacy of N-acetylcysteine as an adjunctive treatment in bipolar depression: An open label trial. Journal of Affective Disorders 135(1\u20133):389\u2013394, 2011.","journal-title":"Journal of Affective Disorders"}],"container-title":["Psychiatric Quarterly"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11126-013-9281-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11126-013-9281-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11126-013-9281-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T07:24:57Z","timestamp":1559373897000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11126-013-9281-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,5]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["9281"],"URL":"https:\/\/doi.org\/10.1007\/s11126-013-9281-3","relation":{},"ISSN":["0033-2720","1573-6709"],"issn-type":[{"value":"0033-2720","type":"print"},{"value":"1573-6709","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,5]]}}}