{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:54:33Z","timestamp":1787068473045,"version":"build-2736575974"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88882.375434\/2019-01"],"award-info":[{"award-number":["88882.375434\/2019-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["313727\/2020-1"],"award-info":[{"award-number":["313727\/2020-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Plant Foods Hum Nutr"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s11130-021-00921-8","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T03:08:59Z","timestamp":1632798539000},"page":"466-471","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Hypoglycemic and Vasorelaxant Effect of Passiflora edulis Fruit Peel By-Product"],"prefix":"10.1007","volume":"76","author":[{"given":"B\u00e1rbara","family":"Cabral","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul Hernandes","family":"Bortolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tays Amanda Felisberto","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla Maria Pereira","family":"Maciel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alinne Villar","family":"de Arruda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais Gomes","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kahlile Youssef","family":"Abboud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovelina Samara Ferreira","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucimara M. C.","family":"Cordeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isac Almeida","family":"de Medeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Augusto","family":"de Rezende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana Maria","family":"Zucolotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,28]]},"reference":[{"key":"921_CR1","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1016\/S0140-6736(14)60685-1","volume":"383","author":"E Rapsomaniki","year":"2014","unstructured":"Rapsomaniki E, Timmis A, George J, Pujades-Rodriguez M, Shah AD, Denaxas S, Branco IR, Caulfield MJ, Deanfield JE, Smeeth L, Williams B, Hingorani A, Hemingway H (2014) Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years llost, and age-specific associations in 1.25 million people. Lancet 383:1899\u20131911","journal-title":"Lancet"},{"key":"921_CR2","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1053\/j.ackd.2014.03.003","volume":"21","author":"R P\u00e1lsson","year":"2014","unstructured":"P\u00e1lsson R, Patel UD (2014) Cardiovascular complications of diabetic kidney disease. Adv Chronic Kidney Dis 21:273\u2013280","journal-title":"Adv Chronic Kidney Dis"},{"key":"921_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2296-7-50","volume":"7","author":"CD MacLean","year":"2006","unstructured":"MacLean CD, Littenberg B, Kennedy AG (2006) Limitations of diabetes pharmacotherapy: results from the Vermont Diabetes Information System Study. BMC Fam Pract 7:1\u20136","journal-title":"BMC Fam Pract"},{"key":"921_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40885-018-0104-6","volume":"25","author":"EA Gebreyohannes","year":"2019","unstructured":"Gebreyohannes EA, Bhagavathula AS, Abebe TB, Tefera YG, Abegaz TM (2019) Adverse effects and non-adherence to antihypertensive medications in University of Gondar Comprehensive Specialized Hospital. Clin Hypertens 25:1\u20139","journal-title":"Clin Hypertens"},{"key":"921_CR5","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.15419\/bmrat.v5i8.463","volume":"5","author":"B Moradi","year":"2018","unstructured":"Moradi B, Abbaszadeh S, Shahsavari S, Alizadeh M, Beyranvand F (2018) The most useful medicinal herbs to treat diabetes. Biomed Res Ther 5:2538\u20132551","journal-title":"Biomed Res Ther"},{"key":"921_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15406\/japlr.2017.05.00134","volume":"5","author":"P Landazuri","year":"2017","unstructured":"Landazuri P, Chamorro NL, Cortes BR (2017) Medicinal plants used in the management hypertension. J Anal Pharm Res 5:1\u20133","journal-title":"J Anal Pharm Res"},{"key":"921_CR7","first-page":"170","volume":"2","author":"K Devaki","year":"2011","unstructured":"Devaki K, Beulah U, Akila G, Sunitha M, Gopalakrishnan VK (2011) Hypoglycemic activity of Passiflora edulis sims leaf extract in Wistar albino rats. Int Res J Pharm 2:170\u2013172","journal-title":"Int Res J Pharm"},{"key":"921_CR8","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1271\/bbb.70.718","volume":"70","author":"T Ichimura","year":"2006","unstructured":"Ichimura T, Yamanaka A, Ichiba T, Toyokawa T, Kamada Y, Tamamura T, Maruyama S (2006) Antihypertensive effect of an extract of Passiflora edulis Rind in spontaneously hypertensive rats. Biosci Biotechnol Biochem 70:718\u2013721","journal-title":"Biosci Biotechnol Biochem"},{"key":"921_CR9","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1590\/S0101-20612010000300034","volume":"30","author":"JM Salgado","year":"2010","unstructured":"Salgado JM, Bombarde TAD, Mansi DN, Piedade SMS, Meletti LMM (2010) Effects of different concentrations of passion fruit peel (Passiflora edulis) on the glicemic control in diabetic mice. J Food Sci Technol 30:784\u2013789","journal-title":"J Food Sci Technol"},{"key":"921_CR10","doi-asserted-by":"publisher","first-page":"5561","DOI":"10.1016\/j.biortech.2007.10.058","volume":"99","author":"ER Pinheiro","year":"2008","unstructured":"Pinheiro ER, Silva IMDA, Gonzaga LV, Amante ER, Te\u00f3filo RF, Ferreira MMC, Amboni RDMC (2008) Optimization of extraction of high-ester pectin from passion fruit eel (Passiflora edulis Flavicarpa) with citric acid by using response surface methodology. Bioresour Technol 99:5561\u20135566","journal-title":"Bioresour Technol"},{"key":"921_CR11","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.jff.2016.08.020","volume":"26","author":"CBB Cazarin","year":"2016","unstructured":"Cazarin CBB, Rodriguez-Nogales A, Francesca A, Utrilla MP, Rodr\u00edguez-Cabezas ME, Garrido-Mesa J, Guerra-Hern\u00e1ndez E, Braga PAC, Reyes FGR, Mar\u00f3stica MR, G\u00e1lvez J (2016) Intestinal anti-inflammatory effects of Passiflora edulis peel in the dextran sodium sulphate model of mouse colitis. J Funct Foods 26:565\u2013576","journal-title":"J Funct Foods"},{"key":"921_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12986-015-0057-7","volume":"12","author":"R Vinayagam","year":"2015","unstructured":"Vinayagam R, Xu B (2015) Antidiabetic properties of dietary flavonoids: a cellular mechanism review. Nutr Metab 12:1\u201320","journal-title":"Nutr Metab"},{"key":"921_CR13","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.coph.2019.04.014","volume":"45","author":"D Maalik","year":"2019","unstructured":"Maalik D, Shaito AA, Pintus G, El-Yazbi A, Eid AH (2019) Flavonoids in hypertension: a brief review of the underlying mechanisms. Curr Opin Pharmacol 45:57\u201365","journal-title":"Curr Opin Pharmacol"},{"key":"921_CR14","doi-asserted-by":"crossref","unstructured":"Sorensen CM, Giese I, Braunstein TH, Holstein-Rathlou NH, Salomonsson M (2011) closure of multiple types of K+ channels is necessary to induce changes in renal vascular resistance in vivo in rats. Pflugers Arch 5:655\u2013667","DOI":"10.1007\/s00424-011-1018-2"},{"key":"921_CR15","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1590\/0103-8478cr20131437","volume":"44","author":"CBB Cazarin","year":"2014","unstructured":"Cazarin CBB, Silva JK, Colomeu TC, Zollner RL, Marostica MR (2014) Antioxidant capacity and chemical composition of passion fruit peel (Passiflora edulis)\/capacidade antioxidante e composicao quimica da casca de maracuja (Passiflora edulis). Cienc Rural 44:1699\u20131704","journal-title":"Cienc Rural"},{"key":"921_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2020.00001","volume":"11","author":"X He","year":"2020","unstructured":"He X, Luan F, Yang Y, Wang Z, Zhao Z, Fang J, Wang M, Zuo M, Li Y (2020) Passiflora edulis: an insight into current researches on phytochemistry and pharmacology. Front Pharmacol 11:1\u201316","journal-title":"Front Pharmacol"},{"key":"921_CR17","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1248\/bpb.28.37","volume":"28","author":"XC Fu","year":"2005","unstructured":"Fu XC, Wang MW, Li SP, Zhang Y, Wang HL (2005) Vasodilatation produced by orientin and its mechanism study. Biol Pharm Bull 28:37\u201341","journal-title":"Biol Pharm Bull"},{"key":"921_CR18","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1586\/ecp.12.34","volume":"5","author":"HJ Woerdenbag","year":"2012","unstructured":"Woerdenbag HJ, Nguyen TM, Vu DV, Tran H, Nguyen DT, Tran TV (2012) Vietnamese traditional medicine from a pharmacista [euro] [TM]s perspective. Expert Rev Clin Pharmacol 5:459\u2013477","journal-title":"Expert Rev Clin Pharmacol"},{"key":"921_CR19","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1055\/s-0029-1185536","volume":"75","author":"SM Zucolotto","year":"2009","unstructured":"Zucolotto SM, Goulart S, Montanher AB, Reginatto FH, Schenkel EP, Fr\u00f6de TS (2009) Bioassay-guided isolation of anti-inflammatory C-glucosylflavones from Passiflora edulis. Planta Med 75:1221\u20131226","journal-title":"Planta Med"},{"key":"921_CR20","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.2147\/DDDT.S176698","volume":"13","author":"A Malik","year":"2019","unstructured":"Malik A, Jamil U, Butt TT, Waquar S, Gan SH, Shafique H, Jafar TH (2019) In silico and in vitro studies of lupeol and iso-orientin as potential antidiabetic agents in a rat model. Drug Des Devel Ther 13:1501\u20131513","journal-title":"Drug Des Devel Ther"},{"key":"921_CR21","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.jff.2019.02.003","volume":"54","author":"KY Abboud","year":"2019","unstructured":"Abboud KY, Luz BB, Dallazen JL, Werner MFP, Cazarin CBB, Mar\u00f3stica JMR, Iacomini M, Cordeiro LMC (2019) Gastroprotective effect of soluble dietary fibres from yellow passion fruit (Passiflora edulis f. flavicarpa) peel against ethanol-induced ulcer in rats. J Funct Foods 54:552\u2013558","journal-title":"J Funct Foods"},{"key":"921_CR22","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1089\/jmf.2010.0220","volume":"14","author":"DC Silva","year":"2011","unstructured":"Silva DC, Freitas A, Pessoa C, Paula R, Mesquita J, Leal L, Brito G, Goncalves D, Viana G (2011) Pectin from Passiflora edulis shows antiinflammatory action as well as hypoglycemic and hypotriglyceridemic properties in diabetic rats. J Med Food 14:1118\u20131126","journal-title":"J Med Food"},{"key":"921_CR23","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1159\/000480395","volume":"42","author":"N Sibiya","year":"2017","unstructured":"Sibiya N, Ngubane P, Mabandla M (2017) The ameliorative effect of pectin insulin patch on renal injury in streptozotocin-induced diabetic rats. Kidney Blood Press Res 42:530\u2013540","journal-title":"Kidney Blood Press Res"},{"key":"921_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/4827461","volume":"2018","author":"KS Assis","year":"2018","unstructured":"Assis KS, Ara\u00fajo IGA, Azevedo FLAA, Maciel PMP, Machado-Calzerra NT, Silva TAF, Assis VL, Vasconcelos AP, Santos CAG, Meireles BRLA, Cordeiro AMTM, Ara\u00fajo DAM, Ribeiro TP, Medeiros IA (2018) Potassium channel activation is involved in the cardiovascular effects induced by freeze dried Syzygium jambolanum (Lam.) DC fruit juice. Biomed Res Int 2018:1\u201312","journal-title":"Biomed Res Int"},{"key":"921_CR25","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s11130-021-00891-x","volume":"76","author":"RS Soumya","year":"2021","unstructured":"Soumya RS, Raj KB, Abraham A (2021) Passiflora edulis (var. Flavicarpa) juice supplementation mitigates isoproterenol-induced myocardial infarction in rats. Plant Foods Hum Nutr 76:189\u2013195","journal-title":"Plant Foods Hum Nutr"},{"key":"921_CR26","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1590\/S0102-695X2010000200009","volume":"20","author":"A Braga","year":"2010","unstructured":"Braga A, Medeiros TP, Araujo BV (2010) Investigation of antihyperglycemic activity of Passiflora edulis sims, Passifloraceae, in alloxan-induced diabetic rats. Braz J Pharmacog 20:186\u2013191","journal-title":"Braz J Pharmacog"},{"key":"921_CR27","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1039\/c004698c","volume":"27","author":"AK Verma","year":"2010","unstructured":"Verma AK, Pratap R (2010) The biological potential of flavones. Nat Prod Rep 27:1571\u20131593","journal-title":"Nat Prod Rep"}],"container-title":["Plant Foods for Human Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11130-021-00921-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11130-021-00921-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11130-021-00921-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T12:08:49Z","timestamp":1638274129000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11130-021-00921-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,28]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["921"],"URL":"https:\/\/doi.org\/10.1007\/s11130-021-00921-8","relation":{},"ISSN":["0921-9668","1573-9104"],"issn-type":[{"value":"0921-9668","type":"print"},{"value":"1573-9104","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,28]]},"assertion":[{"value":"31 August 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}