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The essential oils (EOs) of\n                    <jats:italic>Eucalyptus camaldulensis<\/jats:italic>\n                    ,\n                    <jats:italic>E. ficifolia<\/jats:italic>\n                    F. Muell.,\n                    <jats:italic>E. citriodora<\/jats:italic>\n                    Hook,\n                    <jats:italic>E. globulus<\/jats:italic>\n                    Labill,\n                    <jats:italic>E. sideroxylon<\/jats:italic>\n                    Cunn. ex Woolls, and\n                    <jats:italic>E. torquata<\/jats:italic>\n                    Luehm. were investigated for its antiviral activity against SARS-CoV-2. The EOs phytochemical composition was determined using GC\/MS analysis. Correlation with the explored antiviral activity was also studied using multi-variate data analysis and Pearson\u2019s correlation. The antiviral MTT and cytopathic effect inhibition assays revealed very potent and promising anti SARS-CoV-2 potential for\n                    <jats:italic>E. citriodora<\/jats:italic>\n                    EO (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u20090.00019\u00a0\u00b5g\/mL and SI\u2009=\u200926.27). The multivariate analysis revealed\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -pinene,\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -terpinyl acetate, globulol, \u03b3 -terpinene, and pinocarvone were the main biomarkers for\n                    <jats:italic>E. citriodora<\/jats:italic>\n                    oil. Pearson\u2019s correlation revealed that globulol is the top positively correlated compound in\n                    <jats:italic>E. citriodora<\/jats:italic>\n                    oil to its newly explored potent anti SARS-CoV-2 potential. A molecular simulation was performed on globulol\n                    <jats:italic>via<\/jats:italic>\n                    docking in the main active sites of both SARS-CoV-2 viral main protease (Mpro) and spike protein (S).\n                    <jats:italic>In silico<\/jats:italic>\n                    predictive ADMET study was also developed to investigate the pharmacokinetic profile and predict globulol toxicity. The obtained\n                    <jats:italic>in silico<\/jats:italic>\n                    , in vitro and Pearson\u2019s correlation results were aligned showing promising SARS-CoV-2 inhibitory activity of\n                    <jats:italic>E. citriodora<\/jats:italic>\n                    and globulol. This study is a first record for\n                    <jats:italic>E. citriodora<\/jats:italic>\n                    EO as a novel lead exhibiting potent in vitro, and\n                    <jats:italic>in silico<\/jats:italic>\n                    anti SARS-CoV-2 potential and suggesting its component globulol as a promising candidate for further extensive\n                    <jats:italic>in silico<\/jats:italic>\n                    , in vitro and in vivo anti-COVID studies.\n                  <\/jats:p>","DOI":"10.1007\/s11130-024-01159-w","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T08:01:33Z","timestamp":1710576093000},"page":"410-416","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Eucalyptus Oils Phytochemical Composition in Correlation with Their Newly Explored Anti-SARS-CoV-2 Potential: in Vitro and in Silico Approaches"],"prefix":"10.1007","volume":"79","author":[{"given":"Riham A.","family":"El-Shiekh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona M.","family":"Okba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa A.","family":"Mandour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omnia","family":"Kutkat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Elshimy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany A.","family":"Nagaty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab M.","family":"Ashour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,16]]},"reference":[{"issue":"4","key":"1159_CR1","doi-asserted-by":"publisher","first-page":"3136","DOI":"10.1111\/1541-4337.12773","volume":"20","author":"D Galvan","year":"2021","unstructured":"Galvan D, Effting L, Torres Neto L, Conte-Junior CA (2021) An overview of research of essential oils by self\u2010organizing maps: a novel approach for meta\u2010analysis study. 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