{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T18:15:24Z","timestamp":1785608124211,"version":"3.56.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:00:00Z","timestamp":1718409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:00:00Z","timestamp":1718409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Postgraduate Research and Innovation Project of Central South University","award":["1053320222467"],"award-info":[{"award-number":["1053320222467"]}]},{"name":"Postgraduate Research and Innovation Project of Central South University","award":["1053320221648"],"award-info":[{"award-number":["1053320221648"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073556"],"award-info":[{"award-number":["82073556"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Plant Foods Hum Nutr"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1007\/s11130-024-01199-2","type":"journal-article","created":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T20:01:49Z","timestamp":1718481709000},"page":"607-616","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Sesamol Alleviates Sarcopenia via Activating AKT\/mTOR\/FoxO1 Signal Pathway in Aged Obese Mice"],"prefix":"10.1007","volume":"79","author":[{"given":"Jinxin","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yansong","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoya","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingmiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,15]]},"reference":[{"issue":"4","key":"1199_CR1","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.jamda.2011.01.003","volume":"12","author":"RA Fielding","year":"2011","unstructured":"Fielding RA, Vellas B, Evans WJ et al (2011) Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc 12(4):249\u201356. https:\/\/doi.org\/10.1016\/j.jamda.2011.01.003","journal-title":"J Am Med Dir Assoc"},{"key":"1199_CR2","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.exger.2016.01.008","volume":"76","author":"A Buch","year":"2016","unstructured":"Buch A, Carmeli E, Boker LK et al (2016) Muscle function and fat content in relation to sarcopenia, obesity and frailty of old age\u2013 an overview. Exp Gerontol 76:25\u201332. https:\/\/doi.org\/10.1016\/j.exger.2016.01.008","journal-title":"Exp Gerontol"},{"key":"1199_CR3","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.jep.2017.10.022","volume":"212","author":"KY Kim","year":"2018","unstructured":"Kim KY, Ku SK, Lee KW et al (2018) Muscle-protective effects of Schisandrae Fructus extracts in old mice after chronic forced exercise. J Ethnopharmacol 212:175\u2013187. https:\/\/doi.org\/10.1016\/j.jep.2017.10.022","journal-title":"J Ethnopharmacol"},{"key":"1199_CR4","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3389\/fphys.2019.00313","volume":"10","author":"F Naro","year":"2019","unstructured":"Naro F, Venturelli M, Monaco L et al (2019) Skeletal muscle fiber size and gene expression in the oldest-old With differing degrees of mobility. Front Physiol 10:313. https:\/\/doi.org\/10.3389\/fphys.2019.00313","journal-title":"Front Physiol"},{"issue":"1","key":"1199_CR5","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1002\/jcsm.12846","volume":"13","author":"N Jaiswal","year":"2022","unstructured":"Jaiswal N, Gavin M, Loro E et al (2022) AKT controls protein synthesis and oxidative metabolism via combined mTORC1 and FOXO1 signalling to govern muscle physiology. J Cachexia Sarcopenia Muscle 13(1):495\u2013514. https:\/\/doi.org\/10.1002\/jcsm.12846","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"16","key":"1199_CR6","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1101\/gad.1212704","volume":"18","author":"N Hay","year":"2004","unstructured":"Hay N, Sonenberg N (2004) Upstream and downstream of mTOR. Genes Dev 18(16):1926\u20131945. https:\/\/doi.org\/10.1101\/gad.1212704","journal-title":"Genes Dev"},{"issue":"2","key":"1199_CR7","doi-asserted-by":"publisher","first-page":"213","DOI":"10.22038\/AJP.2022.21403","volume":"13","author":"Z Beheshtimanesh","year":"2023","unstructured":"Beheshtimanesh Z, Rajaei Z (2023) Neuroprotective effects of sesamol against LPS-induced spatial learning and memory deficits are mediated via anti-inflammatory and antioxidant activities in the rat brain. Avicenna J Phytomed 13(2):213\u201322. https:\/\/doi.org\/10.22038\/AJP.2022.21403","journal-title":"Avicenna J Phytomed"},{"key":"1199_CR8","doi-asserted-by":"publisher","unstructured":"Liou CJ, Chen YL, Yu MC et al (2020) Sesamol alleviates airway hyperresponsiveness and oxidative stress in asthmatic mice. Antioxidants (Basel) 9(4):295. https:\/\/doi.org\/10.3390\/antiox9040295","DOI":"10.3390\/antiox9040295"},{"key":"1199_CR9","doi-asserted-by":"publisher","first-page":"115299","DOI":"10.1016\/j.bcp.2022.115299","volume":"206","author":"X Ma","year":"2022","unstructured":"Ma X, Hu X, Zhu Y et al (2022) Sesamol inhibits proliferation, migration and invasion of triple negative breast cancer via inactivating Wnt\/beta-catenin signaling. Biochem Pharmacol 206:115299. https:\/\/doi.org\/10.1016\/j.bcp.2022.115299","journal-title":"Biochem Pharmacol"},{"key":"1199_CR10","doi-asserted-by":"publisher","first-page":"109091","DOI":"10.1016\/j.apradiso.2020.109091","volume":"159","author":"M Majdaeen","year":"2020","unstructured":"Majdaeen M, Banaei A, Abedi-Firouzjah R et al (2020) Investigating the radioprotective effect of sesamol oral consumption against gamma irradiation in mice by micronucleus and alkaline comet assays. Appl Radiat Isot 159:109091. https:\/\/doi.org\/10.1016\/j.apradiso.2020.109091","journal-title":"Appl Radiat Isot"},{"issue":"10","key":"1199_CR11","doi-asserted-by":"publisher","first-page":"3099","DOI":"10.1021\/acs.jafc.9b07598","volume":"68","author":"B Ren","year":"2020","unstructured":"Ren B, Yuan T, Zhang X et al (2020) Protective effects of sesamol on systemic inflammation and cognitive impairment in aging mice. J Agric Food Chem 68(10):3099\u20133111. https:\/\/doi.org\/10.1021\/acs.jafc.9b07598","journal-title":"J Agric Food Chem"},{"issue":"7","key":"1199_CR12","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1021\/acs.jafc.1c08036","volume":"70","author":"MM Hu","year":"2022","unstructured":"Hu MM, Zheng WY, Cheng MH et al (2022) Sesamol reverses myofiber-type conversion in obese states via activating the SIRT1\/AMPK signal pathway. J Agric Food Chem 70(7):2253\u20132264. https:\/\/doi.org\/10.1021\/acs.jafc.1c08036","journal-title":"J Agric Food Chem"},{"issue":"4","key":"1199_CR13","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1007\/s11130-023-01108-z","volume":"78","author":"W Zheng","year":"2023","unstructured":"Zheng W, Yang J, Zhang Q et al (2023) Sesamol alleviates high-fat diet-induced hepatic insulin resistance in C57BL\/6 J mice through AMPK activation mediated by adipose adiponectin. Plant Foods Hum Nutr 78(4):720\u2013727. https:\/\/doi.org\/10.1007\/s11130-023-01108-z","journal-title":"Plant Foods Hum Nutr"},{"key":"1199_CR14","doi-asserted-by":"publisher","first-page":"793088","DOI":"10.3389\/fcell.2021.793088","volume":"9","author":"Y He","year":"2021","unstructured":"He Y, Xie W, Li H et al (2021) (2021) Cellular senescence in sarcopenia: possible mechanisms and therapeutic potential. Front Cell Dev Biol 9:793088. https:\/\/doi.org\/10.3389\/fcell.2021.793088","journal-title":"Front Cell Dev Biol"},{"key":"1199_CR15","doi-asserted-by":"publisher","first-page":"645593","DOI":"10.3389\/fcell.2021.645593","volume":"9","author":"R Kumari","year":"2021","unstructured":"Kumari R, Jat P (2021) Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype. Front Cell Dev Biol 9:645593. https:\/\/doi.org\/10.3389\/fcell.2021.645593","journal-title":"Front Cell Dev Biol"},{"key":"1199_CR16","doi-asserted-by":"publisher","unstructured":"Mijit M, Caracciolo V, Melillo A et al (2023) Role of p53 in the regulation of cellular senescence. Biomolecules 10(3):420. https:\/\/doi.org\/10.3390\/biom10030420","DOI":"10.3390\/biom10030420"},{"key":"1199_CR17","doi-asserted-by":"publisher","first-page":"821904","DOI":"10.3389\/fragi.2021.821904","volume":"2","author":"SD Guzman","year":"2022","unstructured":"Guzman SD, Judge J, Shigdar SM et al (2022) Removal of p16 (INK4) expressing cells in late life has moderate beneficial effects on skeletal muscle function in male mice. Front Aging 2:821904. https:\/\/doi.org\/10.3389\/fragi.2021.821904","journal-title":"Front Aging"},{"issue":"1","key":"1199_CR18","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1002\/jcsm.13112","volume":"14","author":"Y Huang","year":"2023","unstructured":"Huang Y, Wang B, Hassounah F et al (2023) The impact of senescence on muscle wasting in chronic kidney disease. J Cachexia Sarcopenia Muscle 14(1):126\u2013141. https:\/\/doi.org\/10.1002\/jcsm.13112","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"1","key":"1199_CR19","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/nrd4467","volume":"14","author":"S Cohen","year":"2015","unstructured":"Cohen S, Nathan JA, Goldberg AL (2015) Muscle wasting in disease: molecular mechanisms and promising therapies. Nat Rev Drug Discov 14(1):58\u201374. https:\/\/doi.org\/10.1038\/nrd4467","journal-title":"Nat Rev Drug Discov"},{"issue":"22","key":"1199_CR20","doi-asserted-by":"publisher","first-page":"6214","DOI":"10.1021\/acs.jafc.1c00699","volume":"69","author":"DY Lee","year":"2021","unstructured":"Lee DY, Chun YS, Kim JK et al (2021) Curcumin attenuates sarcopenia in chronic forced exercise executed aged mice by regulating muscle degradation and protein synthesis with antioxidant and anti-inflammatory effects. J Agric Food Chem 69(22):6214\u20136228. https:\/\/doi.org\/10.1021\/acs.jafc.1c00699","journal-title":"J Agric Food Chem"},{"key":"1199_CR21","doi-asserted-by":"publisher","first-page":"788","DOI":"10.3389\/fphys.2017.00788","volume":"8","author":"MS Yoon","year":"2017","unstructured":"Yoon MS (2017) mTOR as a key regulator in maintaining skeletal muscle mass. Front Physiol 8:788. https:\/\/doi.org\/10.3389\/fphys.2017.00788","journal-title":"Front Physiol"},{"issue":"1","key":"1199_CR22","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1152\/japplphysiol.00704.2009","volume":"108","author":"JE Cho","year":"1985","unstructured":"Cho JE, Fournier M, Da X et al (1985) (2010) Time course expression of Foxo transcription factors in skeletal muscle following corticosteroid administration. J Appl Physiol 108(1):137\u2013145. https:\/\/doi.org\/10.1152\/japplphysiol.00704.2009","journal-title":"J Appl Physiol"},{"issue":"1","key":"1199_CR23","doi-asserted-by":"publisher","first-page":"C38","DOI":"10.1152\/ajpcell.00315.2009","volume":"298","author":"SM Senf","year":"2010","unstructured":"Senf SM, Dodd SL, Judge AR (2010) FOXO signaling is required for disuse muscle atrophy and is directly regulated by Hsp70. Am J Physiol Cell Physiol 298(1):C38-45. https:\/\/doi.org\/10.1152\/ajpcell.00315.2009","journal-title":"Am J Physiol Cell Physiol"},{"key":"1199_CR24","doi-asserted-by":"publisher","first-page":"146","DOI":"10.3389\/fnut.2019.00146","volume":"6","author":"RD Barclay","year":"2019","unstructured":"Barclay RD, Burd NA, Tyler C et al (2019) The Role of the IGF-1 signaling cascade in muscle protein synthesis and anabolic resistance in aging skeletal muscle. Front Nutr 6:146. https:\/\/doi.org\/10.3389\/fnut.2019.00146","journal-title":"Front Nutr"},{"issue":"1","key":"1199_CR25","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/2044-5040-1-4","volume":"1","author":"S Schiaffino","year":"2011","unstructured":"Schiaffino S, Mammucari C (2011) Regulation of skeletal muscle growth by the IGF1-Akt\/PKB pathway: insights from genetic models. Skelet Muscle 1(1):4. https:\/\/doi.org\/10.1186\/2044-5040-1-4","journal-title":"Skelet Muscle"},{"issue":"4","key":"1199_CR26","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1113\/EP086649","volume":"103","author":"JM Kuczmarski","year":"2018","unstructured":"Kuczmarski JM, Hord JM, Lee Y et al (2018) Effect of Eukarion-134 on Akt-mTOR signalling in the rat soleus during 7 days of mechanical unloading. Exp Physiol 103(4):545\u2013558. https:\/\/doi.org\/10.1113\/EP086649","journal-title":"Exp Physiol"},{"key":"1199_CR27","doi-asserted-by":"publisher","first-page":"153664","DOI":"10.1016\/j.phymed.2021.153664","volume":"91","author":"S Fakhri","year":"2021","unstructured":"Fakhri S, Iranpanah A, Gravandi MM et al (2021) Natural products attenuate PI3K\/Akt\/mTOR signaling pathway: A promising strategy in regulating neurodegeneration. Phytomedicine 91:153664. https:\/\/doi.org\/10.1016\/j.phymed.2021.153664","journal-title":"Phytomedicine"}],"container-title":["Plant Foods for Human Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11130-024-01199-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11130-024-01199-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11130-024-01199-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T22:53:14Z","timestamp":1726786394000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11130-024-01199-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,15]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["1199"],"URL":"https:\/\/doi.org\/10.1007\/s11130-024-01199-2","relation":{},"ISSN":["0921-9668","1573-9104"],"issn-type":[{"value":"0921-9668","type":"print"},{"value":"1573-9104","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,15]]},"assertion":[{"value":"2 June 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The protocol of the experiment was approved by the Institutional Animal Care and Use Committee of Xiangya School of Public Health, Central South University (Approval No. XYGW-2021\u201375).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable. All authors have agreed.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}