{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:45:49Z","timestamp":1791891949562,"version":"4.3.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Plant Foods Hum Nutr"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1007\/s11130-024-01276-6","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T12:00:48Z","timestamp":1735560048000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Anti-hyperglycemic and Anti-hyperlipidemic Effects of Trigonella foenum-graecum L. Seeds on Fructose-induced Diabetic Wistar Rats"],"prefix":"10.1007","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3047-594X","authenticated-orcid":false,"given":"Ibrahim","family":"Hinad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssef","family":"S\u2019hih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelhalem","family":"Mesfioui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aboubaker","family":"Elhessni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moulay Laarbi","family":"Ouahidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,30]]},"reference":[{"key":"1276_CR1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1018-9078","author":"A Petersmann","year":"2019","unstructured":"Petersmann A, M\u00fcller-Wieland D, M\u00fclle UA, Landgraf R, Nauck M, Heinemann L, Schleicher E (2019) Definition, classification and diagnosis of diabetes Mellitus. Exp Clin Endocrinol Diabetes. https:\/\/doi.org\/10.1055\/a-1018-9078","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"1276_CR2","doi-asserted-by":"publisher","DOI":"10.1055\/a-1624-2897","author":"E Schleicher","year":"2022","unstructured":"Schleicher E, Gerdes C, Petersmann A, M\u00fcller-Wieland D, Ulrich AM, Freckmann G, Heinemann L, Nauck M, R\u00fcdiger L (2022) Definition, classification and diagnosis of diabetes mellitus. Exp Clin Endocrinol Diabetes. https:\/\/doi.org\/10.1055\/a-1624-2897","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"1276_CR3","volume-title":"IDF Diabetes atlas 10th edition","author":"IDF","year":"2021","unstructured":"IDF (2021) IDF Diabetes atlas 10th edn. International Diabetes Federation, Brussels"},{"key":"1276_CR4","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1152\/physrev.00045.2011","volume":"93","author":"JM Forbes","year":"2013","unstructured":"Forbes JM, Cooper ME (2013) Mechanisms of diabetic complications. Physiol Rev 93:137\u2013188. https:\/\/doi.org\/10.1152\/physrev.00045.2011","journal-title":"Physiol Rev"},{"key":"1276_CR5","doi-asserted-by":"publisher","unstructured":"Mariadoss AVA, Sivakumar AS, Lee CH, Kim HS (2022) Diabetes mellitus and diabetic foot ulcer: etiology, biochemical and molecular based treatment strategies via gene and nanotherapy. Biomed Pharm 151. https:\/\/doi.org\/10.1016\/j.biopha.2022.113134","DOI":"10.1016\/j.biopha.2022.113134"},{"key":"1276_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.12.01","author":"M Eddouks","year":"2016","unstructured":"Eddouks M, Ajebli M, Hebi M (2016) Ethnopharmacological survey of medicinal plants used in daraa-tafilalet region (Province of Errachidia) Morocco. J Ethnopharmacol. https:\/\/doi.org\/10.1016\/j.jep.2016.12.01","journal-title":"J Ethnopharmacol"},{"key":"1276_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15171\/jhp.2018.01","volume":"7","author":"F Jamshidi-Kia","year":"2018","unstructured":"Jamshidi-Kia F, Zahra L, Hossein A (2018) Medicinal plants: past history and future perspective. J Herbmed Pharmacol 7:1\u20137. https:\/\/doi.org\/10.15171\/jhp.2018.01","journal-title":"J Herbmed Pharmacol"},{"key":"1276_CR8","doi-asserted-by":"publisher","unstructured":"Askarpour M, Farkhondeh A, Marilyn S, Venkatakrishnan KC, Amir H, Ehsan G (2020) Effect of fenugreek supplementation on blood lipids and body weight: a systematic review and meta-analysis of randomized controlled trials. J Ethnopharmacol 253. https:\/\/doi.org\/10.1016\/j.jep.2019.112538","DOI":"10.1016\/j.jep.2019.112538"},{"key":"1276_CR9","doi-asserted-by":"publisher","first-page":"841","DOI":"10.2135\/cropsci2007.09.0519","volume":"48","author":"SN Acharya","year":"2008","unstructured":"Acharya SN, Thomas JE, Basu SK (2008) Fenugreek, an alternative crop for semiarid regions of North America. Crop Sci 48:841. https:\/\/doi.org\/10.2135\/cropsci2007.09.0519","journal-title":"Crop Sci"},{"key":"1276_CR10","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jfoodeng.2004.10.015","volume":"7","author":"E Altunta\u015f","year":"2016","unstructured":"Altunta\u015f E, Engin \u00d6, Faruk T\u00d6 (2016) Some physical properties of fenugreek (Trigonella Foenum-Graceum L.) seeds. J F Eng 7:43. https:\/\/doi.org\/10.1016\/j.jfoodeng.2004.10.015","journal-title":"J F Eng"},{"key":"1276_CR11","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.jff.2019.04.039","volume":"57","author":"K Venkatakrishnan","year":"2019","unstructured":"Venkatakrishnan K, Hui-Fang C, Chin-Kun W (2019) Popular functional foods and herbs for the management of type-2-diabetes mellitus: a comprehensive review with special reference to clinical trials and its proposed mechanism. J Funct Foods 57:425\u2013438. https:\/\/doi.org\/10.1016\/j.jff.2019.04.039","journal-title":"J Funct Foods"},{"key":"1276_CR12","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.biopha.2016.12.078","volume":"88","author":"S Mbarki","year":"2017","unstructured":"Mbarki S, Hichem A, Hafsia B, Abdelfettah E, Najla H (2017) Phytochemical study and protective effect of Trigonella foenum graecum (fenugreek seeds) against carbon tetrachloride-induced toxicity in liver and kidney of male rat. Biomed Pharmacother 88:19\u201326. https:\/\/doi.org\/10.1016\/j.biopha.2016.12.078","journal-title":"Biomed Pharmacother"},{"key":"1276_CR13","doi-asserted-by":"publisher","first-page":"2552","DOI":"10.3390\/nu12092552","volume":"12","author":"D Tewari","year":"2020","unstructured":"Tewari D, Artur J, Ma\u0142gorzata \u0141-G, Weronika G, Wioletta A-B, Jacek B, Nina S, Agnieszka K, Olaf KH, Atanas GA (2020) Fenugreek (Trigonella foenum-graecum L.) seeds dietary supplementation regulates liver antioxidant defense systems in aging mice. Nutrients 12:2552. https:\/\/doi.org\/10.3390\/nu12092552","journal-title":"Nutrients"},{"key":"1276_CR14","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s11010-016-2662-9","volume":"414","author":"S Gautam","year":"2016","unstructured":"Gautam S, Nayab I, Pragya Y, Rohit S, Tadigoppula N, Arvind KS (2016) 4-Hydroxyisoleucine attenuates the inflammation-mediated insulin resistance by the activation of AMPK and suppression of SOCS-3 coimmunoprecipitation with both the IR-\u03b2 subunit as well as IRS-1. Mol Cell Biochem 414:95\u2013104. https:\/\/doi.org\/10.1007\/s11010-016-2662-9","journal-title":"Mol Cell Biochem"},{"key":"1276_CR15","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.jff.2013.10.016","volume":"6","author":"S Khole","year":"2014","unstructured":"Khole S, Suchandra C, Prasad V, Arun D, Saroj G (2014) Bioactive constituents of germinated fenugreek seeds with strong antioxidant potential. J Funct Foods 6:270\u2013279. https:\/\/doi.org\/10.1016\/j.jff.2013.10.016","journal-title":"J Funct Foods"},{"key":"1276_CR16","doi-asserted-by":"publisher","first-page":"5727","DOI":"10.2147\/DDDT.S92355","volume":"9","author":"F Gao","year":"2015","unstructured":"Gao F, Wen D, Mohammad IZ, Raja AS, Liumeng J, Qin C, Furong L (2015) 4-Hydroxyisoleucine ameliorates an insulin resistant-like state in 3T3-L1 adipocytes by regulating TACE\/TIMP3 expression. Drug Des Devel Ther 9:5727\u20135736. https:\/\/doi.org\/10.2147\/DDDT.S92355","journal-title":"Drug Des Devel Ther"},{"key":"1276_CR17","doi-asserted-by":"publisher","first-page":"272","DOI":"10.4161\/cbt.8.3.7443","volume":"8","author":"S Shabbeer","year":"2009","unstructured":"Shabbeer S, Michelle S, Ravi KA, Sushant K, Manuel H, Antonio J, Nancy ED, Michael C, Saeed RK (2009) Fenugreek: a naturally occurring edible spice as an anticancer agent. Cancer Biol Ther 8:272\u2013278. https:\/\/doi.org\/10.4161\/cbt.8.3.7443","journal-title":"Cancer Biol Ther"},{"key":"1276_CR18","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1002\/ptr.3129","volume":"24","author":"U Aswar","year":"2010","unstructured":"Aswar U, Subhash LB, Mohan V, Prasad AT (2010) Effect of furostanol glycosides from \u2018Trigonella foenum-graecum\u2019\u2019on the reproductive system of male albino rats: furostanol glycosides of fenugreek on male rats. Phytother Res 24:1482\u20131488. https:\/\/doi.org\/10.1002\/ptr.3129","journal-title":"Phytother Res"},{"key":"1276_CR19","doi-asserted-by":"publisher","unstructured":"Alsieni MA, Haddad AE, Abdulbasit IA, Madeha NA (2021) Comparison between the antioxidant and antidiabetic activity of fenugreek and buckthorn in streptozotocin-induced diabetic male rats. Biomed Res Int 1\u201312. https:\/\/doi.org\/10.1155\/2021\/7202447","DOI":"10.1155\/2021\/7202447"},{"key":"1276_CR20","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0378-8741(01)00374-9","volume":"79","author":"V Vats","year":"2002","unstructured":"Vats V, Grover JK, Rathi SS (2002) Evaluation of anti-hyperglycemic and hypoglycemic effect of Trigonella foenum-graecum Linn, ocimum sanctum Linn and pterocarpus marsupium linn in normal and alloxanized diabetic rats. J Ethnopharmacol 79:95\u2013100. https:\/\/doi.org\/10.1016\/S0378-8741(01)00374-9","journal-title":"J Ethnopharmacol"},{"key":"1276_CR21","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1111\/jdi.12235","volume":"5","author":"S Skovso","year":"2014","unstructured":"Skovso S (2014) Modeling type 2 diabetes in rats using high fat diet and streptozotocin. J Diabetes Investig 5:349\u2013358. https:\/\/doi.org\/10.1111\/jdi.12235","journal-title":"J Diabetes Investig"},{"key":"1276_CR22","doi-asserted-by":"publisher","first-page":"09","DOI":"10.26480\/gws.01.2020.09.12","volume":"4","author":"HS Mahyuddin","year":"2020","unstructured":"Mahyuddin HS, Roshidi MAH, Ferdosh S, Noh AL (2020) Antibacterial activity of compounds from azolla pinnata extracted using soxhlet and supercritical fluid (sfe) methods, Sci. Herit j 4:09\u201312. https:\/\/doi.org\/10.26480\/gws.01.2020.09.12","journal-title":"Herit j"},{"key":"1276_CR23","doi-asserted-by":"publisher","first-page":"e0146821","DOI":"10.1371\/journal.pone.0146821","volume":"11","author":"J Dupas","year":"2016","unstructured":"Dupas J, Christelle G, Annie F, Anthony G, Charl\u00e8ne A, Fran\u00e7ois G, Jacques M (2016) Progressive induction of type 2 diabetes: effects of a reality\u2013like fructose enriched diet in young wistar rats. PLoS ONE 11:e0146821. https:\/\/doi.org\/10.1371\/journal.pone.0146821","journal-title":"PLoS ONE"},{"key":"1276_CR24","doi-asserted-by":"publisher","unstructured":"S\u2019hih Y, Hinad I, Elgui R, Elhessni A, Mesfioui A, Loukili A, Ouahidi ML (2023) Contribution to the study of the acute and subacute toxicity of aqueous extract of Lawsonia Inermis L. leaves in Wistar rats. Sciendo 97\u2013105. https:\/\/doi.org\/10.2478\/9788367405256-014","DOI":"10.2478\/9788367405256-014"},{"key":"1276_CR25","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jnutbio.2019.05.016","volume":"71","author":"AK Rai","year":"2019","unstructured":"Rai AK, Natasha J, Chandan K, Aditya S, Ishbal A, Shadab A, Anand PG, Jiaur RG, Akhilesh KT (2019) Fructose-induced AGEs-RAGE signaling in skeletal muscle contributes to impairment of glucose homeostasis. J Nutr Biochem 71:35\u201344. https:\/\/doi.org\/10.1016\/j.jnutbio.2019.05.016","journal-title":"J Nutr Biochem"},{"key":"1276_CR26","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3945\/an.116.013912","volume":"8","author":"A Gugliucci","year":"2017","unstructured":"Gugliucci A (2017) Formation of fructose-mediated Advanced Glycation End products and their roles in metabolic and inflammatory diseases. Advan Nutr 8:54\u201362. https:\/\/doi.org\/10.3945\/an.116.013912","journal-title":"Advan Nutr"},{"key":"1276_CR27","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s11010-016-2828-5","volume":"423","author":"M Balakumar","year":"2016","unstructured":"Balakumar M, Raji D, Prabhu C, Sathishkumar C, Prabu P, Mohan V, Balasubramanyam M (2016) High-fructose diet is as detrimental as high-fat diet in the induction of insulin resistance and diabetes mediated by hepatic\/pancreatic endoplasmic reticulum (ER) stress. Mol Cell Biochem 423:93\u2013104. https:\/\/doi.org\/10.1007\/s11010-016-2828-5","journal-title":"Mol Cell Biochem"},{"key":"1276_CR28","doi-asserted-by":"publisher","first-page":"113187","DOI":"10.1016\/j.physbeh.2020.113187","volume":"228","author":"L De Souza","year":"2021","unstructured":"De Souza L, Wellinghton D, Barros M, Raul MD, Eslen D, Adriano E, Sara PB, Giovana KR, Geisson MN, Alex R, Guilherme FFS, Eduardo LGM (2021) Impact of different fructose concentrations on metabolic and behavioral parameters of male and female mice. Phys Behav 228:113187. https:\/\/doi.org\/10.1016\/j.physbeh.2020.113187","journal-title":"Phys Behav"},{"key":"1276_CR29","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.nutres.2007.09.006","volume":"27","author":"A Eidi","year":"2007","unstructured":"Eidi A, Eidi M, Sokhteh M (2007) Effect of fenugreek (Trigonella foenum-graecum L) seeds on serum parameters in normal and streptozotocin-induced diabetic rats. Nutr Resear 27:728\u2013733. https:\/\/doi.org\/10.1016\/j.nutres.2007.09.006","journal-title":"Nutr Resear"},{"key":"1276_CR30","doi-asserted-by":"publisher","first-page":"29717","DOI":"10.3402\/fnr.v59.29717","volume":"59","author":"S Arshadi","year":"2015","unstructured":"Arshadi S, Azarbayjani MA, Hajiaghaalipour F, Ashril Y, Maghsoud P, Salar B, Robert SS, Noor Azuan A, Firouzeh D (2015) Evaluation of Trigonella foenum-graecum extract in combination with swimming exercise compared to glibenclamide consumption on type 2 Diabetic rodents. Food Nutr Resear 59:29717. https:\/\/doi.org\/10.3402\/fnr.v59.29717","journal-title":"Food Nutr Resear"},{"key":"1276_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.31893\/jabb.21007","volume":"9","author":"F Rouag","year":"2021","unstructured":"Rouag F, Samir D, Mabrouk B, Rouya M, Ines R, Habiba F, Abdelkrim T (2021) The effect of oral gavage (force-feeding) administration of fenugreek seeds (Trigonella foenum-graecum L.) on biochemical and neurobehavioural parameters in male wistar rats. J Anim Behav Biometeorol 9:1\u20137. https:\/\/doi.org\/10.31893\/jabb.21007","journal-title":"J Anim Behav Biometeorol"},{"key":"1276_CR32","doi-asserted-by":"publisher","first-page":"559","DOI":"10.3892\/ijfn.2020.2","volume":"7","author":"M Marzouk","year":"2013","unstructured":"Marzouk M, Soliman AM, Omar TY (2013) Hypoglycemic and antioxidative effects of fenugreek and termis seeds powder in streptozotocin-diabetic rats. Euro Rev Med Pharmacol Sci 7:559\u2013565. https:\/\/doi.org\/10.3892\/ijfn.2020.2","journal-title":"Euro Rev Med Pharmacol Sci"},{"key":"1276_CR33","doi-asserted-by":"publisher","unstructured":"Hinad I, S\u2019hih Y, Elhessni A, Mesfioui A, Ouahidi ML (2022) Medicinal plants used in the traditional treatment of diabetes in Ksar Elkebir Region (North-Western Morocco). Pan Afr Med J 42. https:\/\/doi.org\/10.11604\/pamj.2022.42.319.32572","DOI":"10.11604\/pamj.2022.42.319.32572"},{"key":"1276_CR34","doi-asserted-by":"publisher","first-page":"10","DOI":"10.26538\/tjnpr\/v7i10.29","volume":"7","author":"I Hinad","year":"2023","unstructured":"Hinad I, S\u2019hih Y, Elgui R, Mesfioui A, Elhessni A, Ouahidi ML (2023) Acute and subacute toxicity study of Trigonella foenum-graecum.L seed extract in Wistar Rat. TJNPR 7:10. https:\/\/doi.org\/10.26538\/tjnpr\/v7i10.29","journal-title":"TJNPR"}],"container-title":["Plant Foods for Human Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11130-024-01276-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11130-024-01276-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11130-024-01276-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T23:30:46Z","timestamp":1743377446000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11130-024-01276-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,30]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["1276"],"URL":"https:\/\/doi.org\/10.1007\/s11130-024-01276-6","relation":{},"ISSN":["0921-9668","1573-9104"],"issn-type":[{"value":"0921-9668","type":"print"},{"value":"1573-9104","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,30]]},"assertion":[{"value":"30 November 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"23"}}