{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:10:13Z","timestamp":1793329813915,"version":"4.5.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82204745"],"award-info":[{"award-number":["82204745"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Key research and development Program of Shaanxi Province","award":["2024SF-YBXM-455"],"award-info":[{"award-number":["2024SF-YBXM-455"]}]},{"name":"Project of Traditional Chinese Medicine Administration of Shaanxi Province","award":["SZY-KJCYC-2025-JC-05"],"award-info":[{"award-number":["SZY-KJCYC-2025-JC-05"]}]},{"name":"Basic Science Research program of Shaanxi Institute of Basic Science","award":["Chemistry, Biology, 22JHQ090"],"award-info":[{"award-number":["Chemistry, Biology, 22JHQ090"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Plant Foods Hum Nutr"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s11130-025-01356-1","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T12:01:37Z","timestamp":1745928097000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Poricoic Acid A Protects Against High-Salt-Diet Induced Renal Fibrosis by Modulating Gut Microbiota and SCFA Metabolism"],"prefix":"10.1007","volume":"80","author":[{"given":"Xiaoyue","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanni","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"issue":"1","key":"1356_CR1","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1093\/cvr\/cvz029","volume":"116","author":"AG Woodman","year":"2020","unstructured":"Woodman AG, Mah R, Keddie DL, Noble RMN, Holody CD, Panahi S, Gragasin FS, Lemieux H, Bourque SL (2020) Perinatal iron deficiency and a high salt diet cause long-term kidney mitochondrial dysfunction and oxidative stress. Cardiovascular Res 116(1):183\u2013192. https:\/\/doi.org\/10.1093\/cvr\/cvz029","journal-title":"Cardiovascular Res"},{"issue":"3","key":"1356_CR2","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1161\/hypertensionaha.119.12761","volume":"74","author":"JP Van Beusecum","year":"2019","unstructured":"Van Beusecum JP, Barbaro NR, McDowell Z, Aden LA, Xiao L, Pandey AK, Itani HA, Himmel LE, Harrison DG, Kirabo A (2019) High salt activates CD11c+ antigen-presenting cells via SGK (serum glucocorticoid Kinase) 1 to promote renal inflammation and salt-sensitive hypertension. Hypertension 74(3):555\u2013563. https:\/\/doi.org\/10.1161\/hypertensionaha.119.12761","journal-title":"Hypertension"},{"key":"1356_CR3","doi-asserted-by":"publisher","first-page":"1142140","DOI":"10.3389\/fcimb.2023.1142140","volume":"13","author":"ML Luo","year":"2023","unstructured":"Luo ML, Cai JH, Luo SL, Hong XS, Xu LX, Lin HH, Chen X, Fu W (2023) Causal effects of gut microbiota on the risk of chronic kidney disease: a Mendelian randomization study. Front Cell Infect Mi 13:1142140. https:\/\/doi.org\/10.3389\/fcimb.2023.1142140","journal-title":"Front Cell Infect Mi"},{"issue":"3","key":"1356_CR4","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/s41581-020-00345-8","volume":"17","author":"D Mafra","year":"2021","unstructured":"Mafra D, Borges NA, Lindholm B, Shiels PG, Evenepoel P, Stenvinkel P (2021) Food as medicine: targeting the uraemic phenotype in chronic kidney disease. Nat Rev Nephrol 17(3):153\u2013171. https:\/\/doi.org\/10.1038\/s41581-020-00345-8","journal-title":"Nat Rev Nephrol"},{"issue":"1","key":"1356_CR5","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/s41392-024-01913-1","volume":"9","author":"H Miao","year":"2024","unstructured":"Miao H, Liu F, Wang YN, Yu XY, Zhuang SG, Guo Y, Vaziri ND, Ma SX, Su W, Shang YQ (2024) Targeting Lactobacillus johnsonii to reverse chronic kidney disease. Signal Transduct Tar 9(1):195. https:\/\/doi.org\/10.1038\/s41392-024-01913-1","journal-title":"Signal Transduct Tar"},{"key":"1356_CR6","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.bbrc.2022.03.105","volume":"608","author":"L Chen","year":"2022","unstructured":"Chen L, Fang W, Liu J, Qi XL, Zhao LH, Wang YY, Liu YP, Kong DJ, Sun XG, Li XM (2022) Poricoic acid A (PAA) inhibits T-cell acute lymphoblastic leukemia through inducing autophagic cell death and ferroptosis. Biochem Bioph Res Co 608:108\u2013115. https:\/\/doi.org\/10.1016\/j.bbrc.2022.03.105","journal-title":"Biochem Bioph Res Co"},{"issue":"4","key":"1356_CR7","doi-asserted-by":"publisher","first-page":"289","DOI":"10.3892\/etm.2021.9720","volume":"21","author":"Q Li","year":"2021","unstructured":"Li Q, Ming Y, Jia H, Wang G (2021) Poricoic acid A suppresses TGF-\u03b21-induced renal fibrosis and proliferation via the PDGF-C, Smad3 and MAPK pathways. Exp Thera Med 21(4):289. https:\/\/doi.org\/10.3892\/etm.2021.9720","journal-title":"Exp Thera Med"},{"key":"1356_CR8","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.freeradbiomed.2019.01.046","volume":"134","author":"DQ Chen","year":"2019","unstructured":"Chen DQ, Feng YL, Chen L, Liu JR, Wang M, Vaziri ND, Zhao YY (2019) Poricoic acid A enhances melatonin Inhibition of AKI-to-CKD transition by regulating Gas6\/Axl-NF-\u03baB\/Nrf2 axis. Free Radic Bio Med 134:494\u2013507. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2019.01.046","journal-title":"Free Radical Bio Med"},{"issue":"19","key":"1356_CR9","doi-asserted-by":"publisher","first-page":"9315","DOI":"10.1039\/d1fo01886h","volume":"12","author":"X Xie","year":"2021","unstructured":"Xie X, Chen C, Fu X, Liu RH (2021) Influence of Sargassum pallidum and the synergistic interaction mechanism of 6-gingerol and Poricoic acid A on inhibiting ovalbumin glycation. Food Funct 12(19):9315\u20139326. https:\/\/doi.org\/10.1039\/d1fo01886h","journal-title":"Food Funct"},{"issue":"12","key":"1356_CR10","doi-asserted-by":"publisher","first-page":"e23503","DOI":"10.1002\/jbt.23503","volume":"37","author":"YW Wu","year":"2023","unstructured":"Wu YW, Deng HH, Sun JZ, Tang J, Li X, Xu YC (2023) Poricoic acid A induces mitophagy to ameliorate podocyte injury in diabetic kidney disease via downregulating FUNDC1. J Biochem Mol Toxic 37(12):e23503. https:\/\/doi.org\/10.1002\/jbt.23503","journal-title":"J Biochem Mol Toxic"},{"key":"1356_CR11","doi-asserted-by":"publisher","first-page":"153232","DOI":"10.1016\/j.phymed.2020.153232","volume":"72","author":"DQ Chen","year":"2020","unstructured":"Chen DQ, Wang YN, Vaziri ND, Chen L, Hu HH, Zhao YY (2020) Poricoic acid A activates AMPK to attenuate fibroblast activation and abnormal extracellular matrix remodelling in renal fibrosis. Phytomedicine 72:153232. https:\/\/doi.org\/10.1016\/j.phymed.2020.153232","journal-title":"Phytomedicine"},{"key":"1356_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/2040622319869116","volume":"10","author":"DQ Chen","year":"2019","unstructured":"Chen DQ, Cao G, Zhao H, Chen L, Yang T, Wang M, Vaziri ND, Guo Y, Zhao YY (2019) Combined melatonin and Poricoic acid A inhibits renal fibrosis through modulating the interaction of Smad3 and \u03b2-catenin pathway in AKI-to-CKD continuum. Ther Adv Chronic Dis 10:1\u201319. https:\/\/doi.org\/10.1177\/2040622319869116","journal-title":"Ther Adv Chronic Dis"},{"key":"1356_CR13","doi-asserted-by":"publisher","first-page":"2080","DOI":"10.3390\/ijms18102080","volume":"18","author":"K Hosohata","year":"2017","unstructured":"Hosohata K (2017) Biomarkers for chronic kidney disease associated with high salt intake. Int J Mol Sci 18:2080. https:\/\/doi.org\/10.3390\/ijms18102080","journal-title":"Int J Mol Sci"},{"key":"1356_CR14","doi-asserted-by":"publisher","first-page":"569322","DOI":"10.3389\/fphys.2020.569322","volume":"11","author":"LL Sheng","year":"2020","unstructured":"Sheng LL, Zhuang SG (2020) New insights into the role and mechanism of partial epithelial-mesenchymal transition in kidney fibrosis. Front Physiol 11:569322. https:\/\/doi.org\/10.3389\/fphys.2020.569322","journal-title":"Front Physiol"},{"key":"1356_CR15","doi-asserted-by":"publisher","first-page":"872474","DOI":"10.3389\/fphar.2022.872474","volume":"13","author":"YH Ni","year":"2022","unstructured":"Ni YH, Deng HF, Zhou L, Huang CS, Wang NN, Yue LX, Li GF, Yu HJ, Zhou W, Gao Y (2022) Ginsenoside Rb1 ameliorated bavachin-induced renal fibrosis via suppressing Bip\/eIF2\u03b1\/CHOP signaling-mediated EMT. Front Physiol 13:872474. https:\/\/doi.org\/10.3389\/fphar.2022.872474","journal-title":"Front Physiol"},{"issue":"4","key":"1356_CR16","doi-asserted-by":"publisher","first-page":"252","DOI":"10.3390\/toxins13040252","volume":"13","author":"J Rysz","year":"2021","unstructured":"Rysz J, Franczyk B, Lawinski J, Olszewski R, Cialkowska-Rysz A, Gluba-Brz\u00f3zka A (2021) The impact of CKD on uremic toxins and gut microbiota. Toxins 13(4):252. https:\/\/doi.org\/10.3390\/toxins13040252","journal-title":"Toxins"},{"key":"1356_CR17","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s40168-018-0433-4","volume":"6","author":"PM Miranda","year":"2018","unstructured":"Miranda PM, De Palma G, Serkis V, Lu J, Louis-Auguste MP, McCarville JL, Verdu EF, Collins SM, Bercik P (2018) High salt diet exacerbates colitis in mice by decreasing Lactobacillus levels and butyrate production. Microbiome 6:57. https:\/\/doi.org\/10.1186\/s40168-018-0433-4","journal-title":"Microbiome"},{"issue":"4","key":"1356_CR18","doi-asserted-by":"publisher","first-page":"764","DOI":"10.3390\/nu14040764","volume":"14","author":"MX Shi","year":"2022","unstructured":"Shi MX, Yue YS, Ma C, Dong L, Chen F (2022) Pasteurized Akkermansia muciniphila ameliorate the LPS-induced intestinal barrier dysfunction via modulating AMPK and NF-\u03baB through TLR2 in Caco-2 cells. Nutrients 14(4):764. https:\/\/doi.org\/10.3390\/nu14040764","journal-title":"Nutrients"},{"key":"1356_CR19","doi-asserted-by":"publisher","first-page":"3531","DOI":"10.2147\/DDDT.S150825","volume":"11","author":"L Li","year":"2017","unstructured":"Li L, Ma L, Fu P (2017) Gut microbiota-derived short-chain fatty acids and kidney diseases. Drug Des Dev Ther 11:3531\u20133542. https:\/\/doi.org\/10.2147\/DDDT.S150825","journal-title":"Drug Des Dev Ther"}],"container-title":["Plant Foods for Human Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11130-025-01356-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11130-025-01356-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11130-025-01356-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T10:41:36Z","timestamp":1748688096000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11130-025-01356-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,29]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["1356"],"URL":"https:\/\/doi.org\/10.1007\/s11130-025-01356-1","relation":{},"ISSN":["0921-9668","1573-9104"],"issn-type":[{"value":"0921-9668","type":"print"},{"value":"1573-9104","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,29]]},"assertion":[{"value":"9 April 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The animal experiments were approved by the Northwest University Animal Care Committee. The animal ethical approval communication number is SCXK 2020-0030.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent To Participate"}},{"value":"All authors approved for Publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent To Publish"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"115"}}