{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T22:59:13Z","timestamp":1776898753247,"version":"3.51.2"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973513"],"award-info":[{"award-number":["81973513"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Plant Foods Hum Nutr"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s11130-025-01379-8","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T08:07:30Z","timestamp":1750234050000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mechanism of Red Yeast Rice in the Improvement of Atherosclerosis in Apolipoprotein E-deficient Mice Explored Through Metabolomics Combined with Serum Pharmacochemistry and Network Pharmacology"],"prefix":"10.1007","volume":"80","author":[{"given":"Yanyan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongju","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shufang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongxia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"issue":"1","key":"1379_CR1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s00395-023-01023-z","volume":"119","author":"I Gianopoulos","year":"2024","unstructured":"Gianopoulos I, Daskalopoulou SS (2024) Macrophage profiling in atherosclerosis: understanding the unstable plaque. Basic Res Cardiol 119(1):35\u201356. https:\/\/doi.org\/10.1007\/s00395-023-01023-z","journal-title":"Basic Res Cardiol"},{"issue":"5","key":"1379_CR2","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1007\/s10495-023-01923-4","volume":"29","author":"LT Song","year":"2024","unstructured":"Song LT, Zhang BY, Li R, Duan YB, Chi YF, Xu YY, Hua XC, Xu Q (2024) Significance of neutrophil extracellular traps-related gene in the diagnosis and classification of atherosclerosis. Apoptosis 29(5):605\u2013619. https:\/\/doi.org\/10.1007\/s10495-023-01923-4","journal-title":"Apoptosis"},{"issue":"4","key":"1379_CR3","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.jacc.2019.05.042","volume":"74","author":"L Redondo-Bravo","year":"2019","unstructured":"Redondo-Bravo L, Fern\u00e1ndez-Alvira JM, G\u00f3rriz J, Mar\u00eda Mendiguren J, Sanz J, Fern\u00e1ndez-Friera L, Manuel Garc\u00eda-Ruiz J, Fern\u00e1ndez-Ortiz A, Ib\u00e1\u00f1ez B, Bueno H, Fuster V (2019) Does socioeconomic status influence the risk of subclinical atherosclerosis? A mediation model. J Am Coll Cardiol 74(4):526\u2013535. https:\/\/doi.org\/10.1016\/j.jacc.2019.05.042","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"1379_CR4","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.jacc.2021.12.016","volume":"79","author":"NJ Stone","year":"2022","unstructured":"Stone NJ, Smith SC, Orringer CE, Rigotti NA, Navar AM, Khan SS, Jones DW, Goldberg R, Mora S, Blaha M, Pencina MJ, Grundy SM (2022) Managing atherosclerotic cardiovascular risk in young adults: JACC state-of-the-art review. J Am Coll Cardiol 79(8):819\u2013836. https:\/\/doi.org\/10.1016\/j.jacc.2021.12.016","journal-title":"J Am Coll Cardiol"},{"issue":"7","key":"1379_CR5","doi-asserted-by":"publisher","first-page":"e34","DOI":"10.1161\/CIRCRESAHA.123.323156","volume":"134","author":"C Ma","year":"2024","unstructured":"Ma C, Li YH, Tian M, Deng Q, Qin X, Lu H, Gao J, Chen M, Weinstein LS, Zhang M, Bu P, Yang J, Zhang Y, Zhang C, Zhang W (2024) Gs\u03b1 regulates macrophage foam cell formation during atherosclerosis. Circ Res 134(7):e34\u2013e51. https:\/\/doi.org\/10.1161\/CIRCRESAHA.123.323156","journal-title":"Circ Res"},{"key":"1379_CR6","doi-asserted-by":"publisher","first-page":"133583","DOI":"10.1016\/j.jhazmat.2024.133583","volume":"466","author":"J Wen","year":"2024","unstructured":"Wen J, Sun H, Yang BW, Song EQ, Song Y (2024) Long-term polystyrene nanoplastic exposure disrupt hepatic lipid metabolism and cause atherosclerosis in ApoE-\/- mice. J Hazard Mater 466:133583. https:\/\/doi.org\/10.1016\/j.jhazmat.2024.133583","journal-title":"J Hazard Mater"},{"issue":"3","key":"1379_CR7","doi-asserted-by":"publisher","first-page":"258","DOI":"10.3390\/biomedicines9030258","volume":"9","author":"JM Su\u00e1rez-Rivero","year":"2021","unstructured":"Su\u00e1rez-Rivero JM, Pastor-Maldonado CJ, Povea-Cabello S, \u00c1lvarez-C\u00f3rdoba M, Villal\u00f3n-Garc\u00eda I, Talaver\u00f3n-Rey M, Su\u00e1rez-Carrillo A, Munuera-Cabeza M, S\u00e1nchez-Alc\u00e1zar JA (2021) From mitochondria to atherosclerosis: the inflammation path. Biomedicines 9(3):258. https:\/\/doi.org\/10.3390\/biomedicines9030258","journal-title":"Biomedicines"},{"issue":"1","key":"1379_CR8","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s12951-023-01899-y","volume":"21","author":"SY Chen","year":"2023","unstructured":"Chen SY, Su Y, Zhang MJ, Zhang Y, Xiu P, Luo W, Zhang Q, Zhang X, Liang H, Pui-Wai Lee A, Shao L, Xiu J (2023) Insights into the toxicological effects of nanomaterials on atherosclerosis: mechanisms involved and influence factors. J Nanobiotechnol 21(1):140. https:\/\/doi.org\/10.1186\/s12951-023-01899-y","journal-title":"J Nanobiotechnol"},{"key":"1379_CR9","doi-asserted-by":"publisher","first-page":"1301051","DOI":"10.3389\/fimmu.2023.1301051","volume":"14","author":"LM Zhao","year":"2023","unstructured":"Zhao LM, Ma D, Wang LJ, Su X, Feng L, Zhu L, Chen Y, Hao Y, Wang X, Feng J (2023) Metabolic changes with the occurrence of atherosclerotic plaques and the effects of Statins. Front Immunol 14:1301051. https:\/\/doi.org\/10.3389\/fimmu.2023.1301051","journal-title":"Front Immunol"},{"issue":"2","key":"1379_CR10","doi-asserted-by":"publisher","first-page":"e256956","DOI":"10.1136\/bcr-2023-256956","volume":"17","author":"B Ademi","year":"2024","unstructured":"Ademi B, Folker J, Rothwell WB (2024) Statin-induced debilitating weakness and myopathy. BMJ Case Rep 17(2):e256956. https:\/\/doi.org\/10.1136\/bcr-2023-256956","journal-title":"BMJ Case Rep"},{"issue":"2","key":"1379_CR11","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1007\/s11130-023-01055-9","volume":"78","author":"HY Xu","year":"2023","unstructured":"Xu HY, Li QC, Zhou WJ, Zhang HB, Chen ZX, Peng N, Gong SY, Liu B, Zeng F (2023) Anti-oxidative and anti-aging effects of probiotic fermented ginseng by modulating gut microbiota and metabolites in Caenorhabditis elegans. Plant Foods Hum Nutr 78(2):320\u2013328. https:\/\/doi.org\/10.1007\/s11130-023-01055-9","journal-title":"Plant Foods Hum Nutr"},{"key":"1379_CR12","doi-asserted-by":"publisher","first-page":"104715","DOI":"10.1016\/j.fbio.2024.104715","volume":"61","author":"X Yang","year":"2024","unstructured":"Yang X, Ren R, Lang XQ, Li XC, Qin LK, Zeng HY (2024) Effect of whole-grain tartary buckwheat fermentation with monascus purpureus on the metabolic syndrome and intestinal flora in mice. Food Biosci 61:104715. https:\/\/doi.org\/10.1016\/j.fbio.2024.104715","journal-title":"Food Biosci"},{"key":"1379_CR13","doi-asserted-by":"publisher","first-page":"103531","DOI":"10.1016\/j.fbio.2023.103531","volume":"57","author":"JC Zhang","year":"2024","unstructured":"Zhang JC, Shangguan YC, Ni J, He CB, Ma Y, Xiong HJ, Jian WJ, Li J (2024) Super-comminuted dietary fiber from pomelo peel regulates blood lipids and gut microbiota and prevents obesity in high-fat diet-fed mice. Food Biosci 57:103531. https:\/\/doi.org\/10.1016\/j.fbio.2023.103531","journal-title":"Food Biosci"},{"key":"1379_CR14","doi-asserted-by":"publisher","first-page":"112651","DOI":"10.1016\/j.foodres.2023.112651","volume":"167","author":"H Ree Yoon","year":"2023","unstructured":"Ree Yoon H, Han S, Chul Shin S, Cheong Yeom S, Jin Kim H (2023) Improved natural food colorant production in the filamentous fungus monascus ruber using CRISPR-based engineering. Food Res Int 167:112651. https:\/\/doi.org\/10.1016\/j.foodres.2023.112651","journal-title":"Food Res Int"},{"issue":"13","key":"1379_CR15","doi-asserted-by":"publisher","first-page":"7000","DOI":"10.1039\/d2fo00402j","volume":"13","author":"J Chen","year":"2022","unstructured":"Chen J, Zheng Q, Zheng ZX, Li YR, Liao HL, Zhao H, Guo DL, Ma YT (2022) Analysis of the differences in the chemical composition of monascus rice and highland barley monascus. Food Funct 13(13):7000\u20137019. https:\/\/doi.org\/10.1039\/d2fo00402j","journal-title":"Food Funct"},{"issue":"11","key":"1379_CR16","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1007\/s11883-023-01157-4","volume":"25","author":"M Banach","year":"2023","unstructured":"Banach M, Norata GD (2023) Rhabdomyolysis or severe acute hepatitis associated with the use of red yeast rice extracts: an update from the adverse event reporting systems. Curr Atheroscler Rep 25(11):879\u2013888. https:\/\/doi.org\/10.1007\/s11883-023-01157-4","journal-title":"Curr Atheroscler Rep"},{"key":"1379_CR17","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.3389\/fphar.2019.01449","volume":"10","author":"B Zhu","year":"2019","unstructured":"Zhu B, Qi FY, Wu JJ, Yin GQ, Hua JW, Zhang QY, Qin LP (2019) Red yeast rice: a systematic review of the traditional uses, chemistry, pharmacology, and quality control of an important Chinese folk medicine. Front Pharmacol 10:1449. https:\/\/doi.org\/10.3389\/fphar.2019.01449","journal-title":"Front Pharmacol"},{"key":"1379_CR18","doi-asserted-by":"publisher","first-page":"106370","DOI":"10.1016\/j.phrs.2022.106370","volume":"183","author":"M Banach","year":"2022","unstructured":"Banach M, Catapano AL, Cicero AFG, Escobar C, Foger B, Katsiki N, Latkovskis G, Rakowski M, Reiner Z, Sahebkar A, Sikand G, Penson PE, on behalf of the International Lipid Expert Panel (ILEP) (2022) Red yeast rice for dyslipidaemias and cardiovascular risk reduction: A position paper of the international lipid expert panel. Pharmacol Res 183:106370. https:\/\/doi.org\/10.1016\/j.phrs.2022.106370","journal-title":"Pharmacol Res"},{"issue":"2","key":"1379_CR19","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/s11130-024-01161-2","volume":"79","author":"RM Ibrahim","year":"2024","unstructured":"Ibrahim RM, El-Shiekh RA, Mohamed OG, Al-Karmalawy AA, Tripathi A, Abdel-Baki PM (2024) LC\/MS-based metabolomics reveals chemical variations of two broccoli varieties in relation to their anticholinesterase activity: in vitro and in Silico studies. Plant Foods Hum Nutr 79(2):359\u2013366. https:\/\/doi.org\/10.1007\/s11130-024-01161-2","journal-title":"Plant Foods Hum Nutr"},{"key":"1379_CR20","doi-asserted-by":"publisher","first-page":"118329","DOI":"10.1016\/j.jep.2024.118329","volume":"331","author":"H Yu","year":"2024","unstructured":"Yu H, Wang N, Zhao XR, Han L, Peng JY (2024) Integrated serum pharmacochemistry with network Pharmacology and Pharmacological validation to elucidate the mechanism of Yiqitongmai Decoction (YQTMD) against myocardial infarction. J Ethnopharmacol 331:118329. https:\/\/doi.org\/10.1016\/j.jep.2024.118329","journal-title":"J Ethnopharmacol"},{"key":"1379_CR21","doi-asserted-by":"publisher","first-page":"151119","DOI":"10.1016\/j.bbrc.2024.151119","volume":"742","author":"YJ Xing","year":"2025","unstructured":"Xing YJ, Wang WH, Cheng YM, Hu D, Du JH, He RF, Lv X, Yang YX (2025) Network Pharmacology and metabolomics elucidate the underlying effects and mechanisms of Maackiain against endometrial cancer. Biochem Biophys Res Commun 742:151119. https:\/\/doi.org\/10.1016\/j.bbrc.2024.151119","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"1379_CR22","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s11130-021-00926-3","volume":"76","author":"Z Aziz","year":"2021","unstructured":"Aziz Z, Yuliana ND, Simanjuntak P, Rafi M, Mulatsari E, Abdillah S (2021) Investigation of Yacon leaves (Smallanthus sonchifolius) for \u03b1-glucosidase inhibitors using metabolomics and in Silico approach. Plant Foods Hum Nutr 76(4):487\u2013493. https:\/\/doi.org\/10.1007\/s11130-021-00926-3","journal-title":"Plant Foods Hum Nutr"},{"issue":"2","key":"1379_CR23","doi-asserted-by":"publisher","first-page":"113700","DOI":"10.1016\/j.celrep.2024.113700","volume":"43","author":"M Pereira","year":"2024","unstructured":"Pereira M, Liang J, Edwards-Hicks J, Meadows AM, Hinz C, Liggi S, Hepprich M, Mudry JM, Han K, Griffin JL, Fraser I, Sack MN, (2024) Arachidonic acid Inhibition of the NLRP3 inflammasome is a mechanism to explain the anti-inflammatory effects of fasting. Cell Rep 43(2):113700. https:\/\/doi.org\/10.1016\/j.celrep.2024.113700","journal-title":"Cell Rep"},{"issue":"2","key":"1379_CR24","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1021\/acscatal.3c04954","volume":"14","author":"A Cruz","year":"2024","unstructured":"Cruz A, Gonz\u00e1lez-Lafont \u00c0, Lluch JM (2024) Theoretical study of the arachidonic acid conversion into leukotriene A4 catalyzed by human 5-lipoxygenase: hydroperoxidation and epoxidation mechanisms and arachidonic acid active site access. ACS Catal 14(2):637\u2013656. https:\/\/doi.org\/10.1021\/acscatal.3c04954","journal-title":"ACS Catal"},{"issue":"4","key":"1379_CR25","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1093\/infdis\/jiu158","volume":"210","author":"NM Tavares","year":"2014","unstructured":"Tavares NM, Ara\u00fajo-Santos T, Afonso L, Nogueira PM, Lopes UG, Soares RP, Bozza PT, Bandeira-Melo C, Borges VM, Brodskyn C (2014) Understanding the mechanisms controlling leishmania amazonensis infection in vitro: the role of LTB4 derived from human neutrophils. J Infect Dis 210(4):656\u2013666. https:\/\/doi.org\/10.1093\/infdis\/jiu158","journal-title":"J Infect Dis"},{"key":"1379_CR26","doi-asserted-by":"publisher","first-page":"106781","DOI":"10.1016\/j.prostaglandins.2023.106781","volume":"169","author":"M Molaie","year":"2023","unstructured":"Molaie M, Lotfi R, Heidari Moghadam R, Rezaiemanesh A, Karaji AG, Salari F (2023) Imbalanced serum levels of resolvin E1 (RvE1) and leukotriene B4 (LTB4) May contribute to the pathogenesis of atherosclerosis. Prostag Other Lipid Mediat 169:106781. https:\/\/doi.org\/10.1016\/j.prostaglandins.2023.106781","journal-title":"Prostag Other Lipid Mediat"},{"issue":"2","key":"1379_CR27","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1124\/mol.117.111047","volume":"94","author":"Z Gai","year":"2018","unstructured":"Gai Z, Visentin M, Gui T, Zhao L, Thasler WE, H\u00e4usler S, Hartling I, Cremonesi A, Hiller C, Kullak-Ublick GA (2018) Effects of farnesoid X receptor activation on arachidonic acid metabolism, NF-kB signaling, and hepatic inflammation. Mol Pharmacol 94(2):802\u2013811. https:\/\/doi.org\/10.1124\/mol.117.111047","journal-title":"Mol Pharmacol"},{"key":"1379_CR28","doi-asserted-by":"publisher","first-page":"154709","DOI":"10.1016\/j.phymed.2023.154709","volume":"112","author":"XB Wang","year":"2023","unstructured":"Wang XB, Wang ML, Chu YJ, Zhou PP, Zhang XY, Zou J, Zuo LH, Shi YY, Kang J, Li B, Cheng WB, Sun Z, Zhang XJ, Du SZ (2023) Integrated pharmacokinetics and pharmacometabolomics to reveal the synergistic mechanism of a multicomponent Chinese patent medicine, Mailuo Shutong pills against thromboangiitis obliterans. Phytomedicine 112:154709. https:\/\/doi.org\/10.1016\/j.phymed.2023.154709","journal-title":"Phytomedicine"},{"issue":"20","key":"1379_CR29","doi-asserted-by":"publisher","first-page":"2573","DOI":"10.1093\/eurheartj\/ehq501","volume":"32","author":"S Winnik","year":"2011","unstructured":"Winnik S, Lohmann C, Richter EK, Sch\u00e4fer N, Song WL, Leiber F, Mocharla P, Hofmann J, Klingenberg R, Bor\u00e9n J, Becher B, FitzGerald GA, L\u00fcscher TF, Matter CM, Beer JH (2011) Dietary \u03b1-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation. Eur Heart J 32(20):2573\u20132584. https:\/\/doi.org\/10.1093\/eurheartj\/ehq501","journal-title":"Eur Heart J"},{"key":"1379_CR30","doi-asserted-by":"publisher","first-page":"111879","DOI":"10.1016\/j.jep.2019.111879","volume":"238","author":"JX Liang","year":"2019","unstructured":"Liang JX, Zhang QQ, Huang YF, Pang HQ, Liu XG, Gao W, Li P, Yang H (2019) Comprehensive chemical profiling of monascus-fermented rice product and screening of lipid-lowering compounds other than Monacolins. J Ethnopharmacol 238:111879. https:\/\/doi.org\/10.1016\/j.jep.2019.111879","journal-title":"J Ethnopharmacol"},{"issue":"9","key":"1379_CR31","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1007\/s11655-017-2416-x","volume":"23","author":"M Wu","year":"2017","unstructured":"Wu M, Zhang WG, Liu LT (2017) Red yeast rice prevents atherosclerosis through regulating inflammatory signaling pathways. Chin J Integr Med 23(9):689\u2013695. https:\/\/doi.org\/10.1007\/s11655-017-2416-x","journal-title":"Chin J Integr Med"},{"issue":"1","key":"1379_CR32","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/S1875-5364(19)30009-3","volume":"17","author":"SJ Feng","year":"2019","unstructured":"Feng SJ, Tang ZH, Wang Y, Tang XY, Li TH, Tang W, Kuang ZM (2019) Potential protective effects of red yeast rice in endothelial function against atherosclerotic cardiovascular disease. Chin J Nat Med 17(1):50\u201358. https:\/\/doi.org\/10.1016\/S1875-5364(19)30009-3","journal-title":"Chin J Nat Med"},{"issue":"10","key":"1379_CR33","doi-asserted-by":"publisher","first-page":"e23154","DOI":"10.1002\/jbt.23154","volume":"36","author":"LW Zhang","year":"2022","unstructured":"Zhang LW, Shi Y, Yan MZ, Zhang GP (2022) Modulatory action of withaferin-A on oxidative damage through regulation of inflammatory mediators and apoptosis via PI3K\/AKT signaling pathway in high cholesterol-induced atherosclerosis in experimental rats. J Biochem Mol Toxicol 36(10):e23154. https:\/\/doi.org\/10.1002\/jbt.23154","journal-title":"J Biochem Mol Toxicol"},{"key":"1379_CR34","doi-asserted-by":"publisher","first-page":"114244","DOI":"10.1016\/j.biopha.2023.114244","volume":"159","author":"MS Savova","year":"2023","unstructured":"Savova MS, Mihaylova LV, Tews D, Wabitsch M, Georgiev MI (2023) Targeting PI3K\/AKT signaling pathway in obesity. Biomed Pharmacother 159:114244. https:\/\/doi.org\/10.1016\/j.biopha.2023.114244","journal-title":"Biomed Pharmacother"}],"container-title":["Plant Foods for Human Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11130-025-01379-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11130-025-01379-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11130-025-01379-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:25:15Z","timestamp":1760621115000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11130-025-01379-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,18]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["1379"],"URL":"https:\/\/doi.org\/10.1007\/s11130-025-01379-8","relation":{},"ISSN":["0921-9668","1573-9104"],"issn-type":[{"value":"0921-9668","type":"print"},{"value":"1573-9104","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,18]]},"assertion":[{"value":"28 May 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Animal experiments were accepted by the Ethics Committee of Yantai University (IACUC No. 2023-RX-03) and performed in compliance with the Institutional Animal Care and Use guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"140"}}