{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:50:39Z","timestamp":1790142639185,"version":"4.0.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Special Fund for Basic scientific research in universities under the auspices of Liaoning Province","award":["LJ212410152058"],"award-info":[{"award-number":["LJ212410152058"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Plant Foods Hum Nutr"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11130-025-01431-7","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T14:30:39Z","timestamp":1763389839000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Combined Use of Aqueous Extracts and Polysaccharides from Angelica sinensis and Platycladus orientalis Treats Androgenetic Alopecia"],"prefix":"10.1007","volume":"80","author":[{"given":"Donglin","family":"Sui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shugang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouhao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunqing","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"1431_CR1","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1007\/s13555-024-01208-x","volume":"14","author":"B Craiglow","year":"2024","unstructured":"Craiglow B, Lee YW, Va\u00f1\u00f3-Galv\u00e1n S, Egeberg A, Dutronc Y, Durand F, Pierce E, Yu G, Chen Y-F, Mostaghimi A (2024) Improvement in measures of quality of life and Symp-toms of anxiety and depression in patients with severe alopecia areata achieving Susta-ined scalp hair regrowth with baricitinib. Dermatol Ther 14:1959\u20131968. https:\/\/doi.org\/10.1007\/s13555-024-01208-x","journal-title":"Dermatol Ther"},{"key":"1431_CR2","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1007\/s12016-025-09034-5","volume":"68","author":"Y Xiao","year":"2025","unstructured":"Xiao Y, Zhang Y, Deng S, Yang X, Yao X (2025) Immune and non-immune interactions in the pathogenesis of androgenetic alopecia. Clin Rev Allergy Immunol 68:22. https:\/\/doi.org\/10.1007\/s12016-025-09034-5","journal-title":"Clin Rev Allergy Immunol"},{"key":"1431_CR3","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13799","volume":"33","author":"LT Elsaie","year":"2020","unstructured":"Elsaie LT, Elshahid AR, Hasan HM, Soultan FAZM, Jafferany M, Elsaie ML (2020) Cros-s sectional quality of life assessment in patients with androgenetic alopecia. Dermatol Ther 33:e13799. https:\/\/doi.org\/10.1111\/dth.13799","journal-title":"Dermatol Ther"},{"key":"1431_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-023-03398-1","volume":"14","author":"Y Cai","year":"2023","unstructured":"Cai Y, Jia Z, Zhang Y, Kang B, Chen C, Liu W, Li W, Zhang W (2023) Cell-free fat extract restores hair loss: a novel therapeutic strategy for androgenetic alopecia. Stem Cell Res Ther 14:219. https:\/\/doi.org\/10.1186\/s13287-023-03398-1","journal-title":"Stem Cell Res Ther"},{"key":"1431_CR5","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5611","author":"L Chen","year":"2016","unstructured":"Chen L, Wang J, Mouser G, Li YC, Marcovici G (2016) Blockade of androgen markers using a novel betasitosterol, thioctic acid and carnitine-containing compound in Prostat-e and hair follicle cell-based assays. Phytother Res. https:\/\/doi.org\/10.1002\/ptr.5611","journal-title":"Phytother Res"},{"key":"1431_CR6","doi-asserted-by":"publisher","first-page":"e00548","DOI":"10.1128\/msystems.00548-25","volume":"10","author":"X Wang","year":"2025","unstructured":"Wang X, Li F, Sun Y, Meng F, Song Y, Su X (2025) Microbial dysbiosis and its diagno-stic potential in androgenetic alopecia: insights from multi-kingdom sequencing and machi-ne learning. mSystems 10:e00548\u2013e00525. https:\/\/doi.org\/10.1128\/msystems.00548-25","journal-title":"mSystems"},{"key":"1431_CR7","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.bioactmat.2024.02.023","volume":"36","author":"J Xiong","year":"2024","unstructured":"Xiong J, Liu Z, Jia L, Sun Y, Guo R, Xi T, Li Z, Wu M, Jiang H, Li Y (2024) Bioins-pired engineering ADSC nanovesicles thermosensitive hydrogel enhance autophagy of derm-al papilla cells for androgenetic alopecia treatment. Bioact Mater 36:112\u2013125. https:\/\/doi.org\/10.1016\/j.bioactmat.2024.02.023","journal-title":"Bioact Mater"},{"key":"1431_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169116","author":"P Gentile","year":"2022","unstructured":"Gentile P (2022) Hair loss and telogen effluvium related to COVID-19: the potential implication of adipose-derived mesenchymal stem cells and platelet-rich plasma as reg-enerative strategies. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms23169116","journal-title":"Int J Mol Sci"},{"key":"1431_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15020340","author":"S Pulat","year":"2023","unstructured":"Pulat S, Subedi L, Pandey P, Bhosle SR, Hur J-S, Shim J-H, Cho S-S, Kim K-T, Ha H-H, Kim H, Park JW (2023) Topical delivery of Atraric acid derived from Stereocaulon japonicum with enhanced skin permeation and hair regrowth activity for androgenic Al-opecia. Pharmaceutics. https:\/\/doi.org\/10.3390\/pharmaceutics15020340","journal-title":"Pharmaceutics"},{"key":"1431_CR10","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1111\/bph.16046","volume":"180","author":"S Sayed","year":"2023","unstructured":"Sayed S, Song J, Wang L, Muluh TA, Liu B, Lin Z, Tang Y, Su Z, Li H, Xue VW, LiuS, Chen X, Zhou G, Sun Q, Lu D (2023) Isoxazole 9 (ISX9), a small molecule targetin-g Axin, activates Wnt\/\u03b2-catenin signalling and promotes hair regrowth. Br J Pharmacol 180:1748\u20131765. https:\/\/doi.org\/10.1111\/bph.16046","journal-title":"Br J Pharmacol"},{"key":"1431_CR11","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202101334R","volume":"35","author":"X Ma","year":"2021","unstructured":"Ma X, Takahashi Y, Wu W, Chen J, Dehdarani M, Liang W, Shin Y-H, Benyajati S, Ma J-x (2021) Soluble very low-density lipoprotein receptor (sVLDLR) inhibits fibrosis in neo-vascular age-related macular degeneration. FASEB J 35:e22058. https:\/\/doi.org\/10.1096\/fj.202101334R","journal-title":"FASEB J"},{"key":"1431_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.102617","author":"L Jiang","year":"2020","unstructured":"Jiang L, Jia M, Wei X, Guo J, Hao S, Mei A, Zhi X, Wang X, Li Q, Jin J, Zhang J, Li S, Meng D (2020) Bach1-induced suppression of angiogenesis is dependent on the BTB domain. EBioMedicine. https:\/\/doi.org\/10.1016\/j.ebiom.2019.102617","journal-title":"EBioMedicine"},{"key":"1431_CR13","doi-asserted-by":"publisher","first-page":"5354","DOI":"10.1021\/acsmaterialslett.4c01891","volume":"6","author":"H Xing","year":"2024","unstructured":"Xing H, Jiang X, Zhao Z, Yang Y, Wang Z, Yi Y, Sun G, Liu S, Ma D (2024) Multista-ge transdermal nitric oxide delivery system for the efficient treatment of androgenic alopecia. ACS Mater Lett 6:5354\u20135362. https:\/\/doi.org\/10.1021\/acsmaterialslett.4c01891","journal-title":"ACS Mater Lett"},{"key":"1431_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.666860","author":"J Zhao","year":"2021","unstructured":"Zhao J, Lin H, Wang L, Guo K, Jing R, Li X, Chen Y, Hu Z, Gao S, Xu N (2021) Suppression of FGF5 and FGF18 Expression by Cholesterol-Modified siRNAs Promotes Hair Growth in Mice. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2021.666860","journal-title":"Front Pharmacol"},{"key":"1431_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.146316","volume":"321","author":"Y Lv","year":"2025","unstructured":"Lv Y, Zhang Y, Zhou X, Yang W, Zhang T, Zhang H, Li Y, Zhao R, Kong X (2025) Bi-functional sodium hyaluronate microneedle patches integrating 5\u03b1-reductase and ROS regu-lation for boosted hair regeneration. Int J Biol Macromol 321:146316. https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.146316","journal-title":"Int J Biol Macromol"},{"key":"1431_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114693","volume":"283","author":"X Zhou","year":"2022","unstructured":"Zhou X, Shao T, Xie X, Ding M, Jiang X, Su P, Jin Z (2022) Tongqiao huoxue decocti-on for the treatment of acute ischemic stroke: a systematic review and meta-analysis. J Ethnopharmacol 283:114693. https:\/\/doi.org\/10.1016\/j.jep.2021.114693","journal-title":"J Ethnopharmacol"},{"key":"1431_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1405342","author":"Y Tian","year":"2024","unstructured":"Tian Y, Shen X, Hu T, Liang Z, Ding Y, Dai H, Liu X, Lu T, Yin F, Shu Y, Guo Z, Su L, Li L (2024) Structural analysis and blood-enriching effects comparison based on biol-ogical potency of Angelica sinensis polysaccharides. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2024.1405342","journal-title":"Front Pharmacol"},{"key":"1431_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.964559","author":"G Feng","year":"2022","unstructured":"Feng G, Li D, Liu J, Sun S, Zhang P, Liu W, Zhang Y, Meng B, Li J, Chai L (2022) The herbal combination of radix astragali, radix Angelicae sinensis, and caulis loniceraeregulates the functions of type 2 innate lymphocytes and macrophages contributing to the resolution of Collagen-Induced arthritis. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2022.964559","journal-title":"Front Pharmacol"},{"key":"1431_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.984858","author":"L Song","year":"2022","unstructured":"Song L, Wang J, Gong M, Zhang Y, Li Y, Wu X, Qin L, Duan Y (2022) Detoxification technology and mechanism of processing with Angelicae sinensis radix in reducing the he-patotoxicity induced by rhizoma dioscoreae bulbiferae in vivo. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2022.984858","journal-title":"Front Pharmacol"},{"key":"1431_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.121745","volume":"328","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Wang H, Zheng Y, Wu Z, Liu J, Cheng F, Wang K (2024) Degradation of Angelica sinensis polysaccharide: structures and protective activities against ethanol-induced acute liver injury. Carbohydr Polym 328:121745. https:\/\/doi.org\/10.1016\/j.carbpol.2023.121745","journal-title":"Carbohydr Polym"},{"key":"1431_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1515976","author":"M Hu","year":"2025","unstructured":"Hu M, Wang L, Zhang F, Xie Y, Zhang T, Liu H, Li Z, Zhang J (2025) Network pharm-acology combined with molecular docking and experimental validation of the mechanism of action of Columbianetin acetate in the treatment of ovarian cancer. Front Oncol. https:\/\/doi.org\/10.3389\/fonc.2025.1515976","journal-title":"Front Oncol"},{"key":"1431_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29122876","author":"C Xu","year":"2024","unstructured":"Xu C, Dai J, Du W, Ji H (2024) Antioxidant properties of Platycladus orientalis Flavonoi-ds for treating UV-induced damage in androgenetic alopecia hair. Molecules. https:\/\/doi.org\/10.3390\/molecules29122876","journal-title":"Molecules"},{"key":"1431_CR23","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.carbpol.2019.03.003","volume":"213","author":"J Ren","year":"2019","unstructured":"Ren J, Hou C, Shi C, Lin Z, Liao W, Yuan E (2019) A polysaccharide isolated and purif-ied from Platycladus orientalis (L.) Franco leaves, characterization, bioactivity and its regu-lation on macrophage polarization. Carbohydr Polym 213:276\u2013285. https:\/\/doi.org\/10.1016\/j.carbpol.2019.03.003","journal-title":"Carbohydr Polym"},{"key":"1431_CR24","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.biopha.2016.07.022","volume":"83","author":"Y Zhang","year":"2016","unstructured":"Zhang Y, Han L, Chen S-S, Guan J, Qu F-Z, Zhao Y-Q (2016) Hair growth promoting activity of cedrol isolated from the leaves of Platycladus orientalis. Biomed Pharmacother 83:641\u2013647. https:\/\/doi.org\/10.1016\/j.biopha.2016.07.022","journal-title":"Biomed Pharmacother"},{"key":"1431_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26146568","author":"S An","year":"2025","unstructured":"An S, Zheng M, Park IG, Song L, Kim J, Noh M, Sung J-H (2025) CXCL12 drives re-versible fibroimmune remodeling in androgenetic alopecia revealed by single-cell RNA sequencing. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms26146568","journal-title":"Int J Mol Sci"},{"key":"1431_CR26","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1007\/s40265-023-01880-x","volume":"83","author":"S Devjani","year":"2023","unstructured":"Devjani S, Ezemma O, Kelley KJ, Stratton E, Senna M (2023) Androgenetic alopecia: T-herapy update. Drugs 83:701\u2013715. https:\/\/doi.org\/10.1007\/s40265-023-01880-x","journal-title":"Drugs"},{"key":"1431_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.144896","volume":"318","author":"W Luo","year":"2025","unstructured":"Luo W, Huang B, Lei M, Wu Z, Yu Q, Zhang D, Yan C (2025) Structural characterizati-on and anti-inflammatory effects of Angelica pubescens polysaccharide APRP50-2-1 in rhe-umatoid arthritis. Int J Biol Macromol 318:144896. https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.144896","journal-title":"Int J Biol Macromol"},{"key":"1431_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2024.110795","volume":"36","author":"Q Zhang","year":"2025","unstructured":"Zhang Q, Sun L, Wu L, Wang X, Chen L, Chen Y, Liu Y, Gu W, Shi D, Liu W, Li J, Huang Y-Y, Li B, Luo H-B (2025) Platycladus orientalis (L.) Franco demonstrates effectiv-e anti-psoriasis effects by inhibiting PDE4 with favorable safety profiles. Chin Chem Lett 36:110795. https:\/\/doi.org\/10.1016\/j.cclet.2024.110795","journal-title":"Chin Chem Lett"},{"key":"1431_CR29","doi-asserted-by":"publisher","first-page":"335","DOI":"10.7150\/ijbs.10874","volume":"11","author":"Z Cao","year":"2015","unstructured":"Cao Z, Liu R, Zhang H, Liao H, Zhang Y, Hinton RJ, Feng JQ (2015) Osterix controls cementoblast differentiation through downregulation of Wnt-signaling via enhancing DKK1 expression. Int J Biol Sci 11:335\u2013344. https:\/\/doi.org\/10.7150\/ijbs.10874","journal-title":"Int J Biol Sci"},{"key":"1431_CR30","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1111\/bph.15438","volume":"178","author":"YC Ryu","year":"2021","unstructured":"Ryu YC, Lee D-H, Shim J, Park J, Kim Y-R, Choi S, Bak SS, Sung YK, Lee S-H, Choi K-Y (2021) KY19382, a novel activator of Wnt\/\u03b2-catenin signalling, promotes hair regro-wth and hair follicle neogenesis. Br J Pharmacol 178:2533\u20132546. https:\/\/doi.org\/10.1111\/bph.15438","journal-title":"Br J Pharmacol"},{"key":"1431_CR31","doi-asserted-by":"publisher","first-page":"118585","DOI":"10.1016\/j.jep.2024.118585","volume":"334","author":"GK-W Yuen","year":"2024","unstructured":"Yuen GK-W, Lin S, Dong TT-X, Tsim KW-K (2024) Sophoricoside, a genistein glycoside from fructus Sophorae, promotes hair growth via activation of M4 muscarinic achr in dermal papilla cells. J Ethnopharmacol 334:118585. https:\/\/doi.org\/10.1016\/j.jep.2024.118585","journal-title":"J Ethnopharmacol"},{"key":"1431_CR32","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkaf032","volume":"13","author":"J Cui","year":"2025","unstructured":"Cui J, Wang M, Lin C, Xu X, Zhang Z (2025) Exploring machine learning strategies for single-cell transcriptomic analysis in wound healing. Burns Trauma 13:tkaf032. https:\/\/doi.org\/10.1093\/burnst\/tkaf032","journal-title":"Burns Trauma"},{"key":"1431_CR33","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-03085-7","volume":"13","author":"Y Ren","year":"2022","unstructured":"Ren Y, Liu J, Xu H, Wang S, Li S, Xiang M, Chen S (2022) Knockout of integrin \u03b21 in induced pluripotent stem cells accelerates skin-wound healing by promoting cell migrati-on in extracellular matrix. Stem Cell Res Ther 13:389. https:\/\/doi.org\/10.1186\/s13287-022-03085-7","journal-title":"Stem Cell Res Ther"},{"key":"1431_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1482898","author":"S Park","year":"2024","unstructured":"Park S, Park HW, Seo DB, Yoo DS, Bae S (2024) In vitro hair growth-promoting effectsof Araliadiol via the p38\/PPAR-\u03b3 signaling pathway in human hair follicle stem cells and dermal papilla cells. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2024.1482898","journal-title":"Front Pharmacol"}],"container-title":["Plant Foods for Human Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11130-025-01431-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11130-025-01431-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11130-025-01431-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T07:34:50Z","timestamp":1768462490000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11130-025-01431-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,17]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1431"],"URL":"https:\/\/doi.org\/10.1007\/s11130-025-01431-7","relation":{},"ISSN":["0921-9668","1573-9104"],"issn-type":[{"value":"0921-9668","type":"print"},{"value":"1573-9104","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,17]]},"assertion":[{"value":"12 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"194"}}