{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:48:24Z","timestamp":1786981704432,"version":"build-2736575974"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Excellent Youth program of Shenyang Pharmaceutical University","award":["(Admission No. YQ202118)"],"award-info":[{"award-number":["(Admission No. YQ202118)"]}]},{"name":"Strategic Industrialization Project of Liaoning Provincial Department of Education","award":["(LJ212410163010)"],"award-info":[{"award-number":["(LJ212410163010)"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Plant Foods Hum Nutr"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s11130-025-01462-0","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T17:14:49Z","timestamp":1768238089000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Investigation into the Glucose-Regulating Activity and Mechanisms of Siraitia grosvenorii Extracts and their Application in the Innovation of Functional Biscuits"],"prefix":"10.1007","volume":"81","author":[{"given":"Qing","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"1462_CR1","doi-asserted-by":"publisher","unstructured":"Duan JJ, Zhu D, Zheng XX, Ju Y, Wang FZ, Sun YF, Fan B (2023) Siraitia grosvenorii (Swingle) C. Jeffrey: research progress of its active components, pharmacological effects, and extraction methods. Foods 12(7):1373. https:\/\/doi.org\/10.3390\/foods12071373","DOI":"10.3390\/foods12071373"},{"key":"1462_CR2","doi-asserted-by":"publisher","first-page":"114380","DOI":"10.1016\/j.indcrop.2021.114380","volume":"176","author":"ZB Liu","year":"2022","unstructured":"Liu ZB, Zhu XF, Mohsin A, Yin ZP, Zhuang YP, Zhou B, Du LX, Yin XJ, Liu N, Wang ZJ, Guo MJ (2022) Embryogenic callus induction, cell suspension culture, and spectrum-effect relationship between antioxidant activity and polyphenols composition of Siraitia grosvenorii cultured cells. Ind Crops Prod 176:114380. https:\/\/doi.org\/10.1016\/j.indcrop.2021.114380","journal-title":"Ind Crops Prod"},{"issue":"2","key":"1462_CR3","doi-asserted-by":"publisher","first-page":"107","DOI":"10.16375\/j.cnki.cn45-1395\/t.2022.02.016","volume":"33","author":"L Wang","year":"2022","unstructured":"Wang L, Li ZY, Zhong YY, An H, Ye Y (2022) The mechanism of the effective ingredients of Siraitia grosvenorii in the treatment of lung cancer based on network Pharmacology. J Guangxi Univ Sci Technol 33(2):107\u2013115. https:\/\/doi.org\/10.16375\/j.cnki.cn45-1395\/t.2022.02.016","journal-title":"J Guangxi Univ Sci Technol"},{"key":"1462_CR4","doi-asserted-by":"publisher","unstructured":"Suzuki YA, Tomoda M, Murata Y, Inui H, Sugiura M, Nakano Y (2007) Antidiabetic effect of long-term supplementation with Siraitia grosvenori on the spontaneously diabetic Goto-Kakizaki rat. Br J Nutr 97(4):770\u2013775. https:\/\/doi.org\/10.1017\/S0007114507381300","DOI":"10.1017\/S0007114507381300"},{"key":"1462_CR5","doi-asserted-by":"publisher","unstructured":"Suzuki YA, Murata Y, Inui H, Sugiura M, Nakano Y (2005) Triterpene glycosides of Siraitia grosvenori inhibit rat intestinal maltase and suppress the rise in blood glucose level after a single oral administration of maltose in rats. J Agric Food Chem 53(8):2941\u20132946. https:\/\/doi.org\/10.1021\/jf0478105","DOI":"10.1021\/jf0478105"},{"key":"1462_CR6","doi-asserted-by":"publisher","unstructured":"Bhusari S, Rodriguez C, Tarka SM Jr, Kwok D, Pugh G, Gujral J, Tonucci D (2021) Comparative in vitro metabolism of purified mogrosides derived from monk fruit extracts. Regul Toxicol Pharmacol 120:104856 https:\/\/doi.org\/10.1016\/j.yrtph.2020.104856","DOI":"10.1016\/j.yrtph.2020.104856"},{"key":"1462_CR7","doi-asserted-by":"publisher","unstructured":"Li H, Li RL, Jiang W, Zhou LM (2022) Research progress of pharmacological effects of Siraitia grosvenorii extract. J Pharm Pharmacol 74(7):953\u2013960. https:\/\/doi.org\/10.1093\/jpp\/rgab150","DOI":"10.1093\/jpp\/rgab150"},{"issue":"1","key":"1462_CR8","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1080\/07328303.2011.583511","volume":"30","author":"VSP Chaturvedula","year":"2011","unstructured":"Chaturvedula VSP, Prakash I (2011) Cucurbitane glycosides from Siraitia grosvenorii. J Carbohydr Chem 30(1):16\u201326. https:\/\/doi.org\/10.1080\/07328303.2011.583511","journal-title":"J Carbohydr Chem"},{"issue":"5","key":"1462_CR9","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1021\/acs.jnatprod.6b01086","volume":"80","author":"B Niu","year":"2017","unstructured":"Niu B, Ke CQ, Li BH, Li YY, Yi YJ, Luo YW, Shuai L, Yao S, Lin LG, Li J, Ye Y (2017) Cucurbitane glucosides from the crude extract of Siraitia grosvenorii with moderate effects on PGC-1\u03b1 promoter activity. J Nat Prod 80(5):1428\u20131435. https:\/\/doi.org\/10.1021\/acs.jnatprod.6b01086","journal-title":"J Nat Prod"},{"key":"1462_CR10","doi-asserted-by":"publisher","unstructured":"Li F, Yang FM, Liu X, Wang L, Chen B, Li LH, Wang MK (2017) Cucurbitane glycosides from the fruit of Siraitia grosvenori and their effects on glucose uptake in human HepG2 cells in vitro. Food Chem 228:567\u2013573. https:\/\/doi.org\/10.1016\/j.foodchem.2017.02.018","DOI":"10.1016\/j.foodchem.2017.02.018"},{"key":"1462_CR11","doi-asserted-by":"publisher","unstructured":"Xu YM, Li LM, Zheng PY, Zhao R, Cheng MQ, Su YF, Bao JJ, Li YX (2025) Purification of mogroside V from crude extract of Siraitia grosvenorii using boronic acid-functionalized silica gel and its hypoglycemic activity determination. Separations 12(6):135. https:\/\/doi.org\/10.3390\/separations12060135","DOI":"10.3390\/separations12060135"},{"key":"1462_CR12","doi-asserted-by":"publisher","first-page":"110212","DOI":"10.1016\/j.enzmictec.2023.110212","volume":"165","author":"YH Zhao","year":"2023","unstructured":"Zhao YH, Su YX, Li ZL, Luo C, Chen YJ, Wu XR (2023) Efficient snailase-based production of mogrol from Luo Han Guo extract in an aqueous-organic system. Enzyme Microb Technol 165:110212. https:\/\/doi.org\/10.1016\/j.enzmictec.2023.110212","journal-title":"Enzyme Microb Technol"},{"key":"1462_CR13","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.foodchem.2015.02.049","volume":"186","author":"M Miao","year":"2015","unstructured":"Miao M, Jiang B, Jiang H, Zhang T, Li XF (2015) Interaction mechanism between green tea extract and human \u03b1-amylase for reducing starch digestion. Food Chem 186:20\u201325. https:\/\/doi.org\/10.1016\/j.foodchem.2015.02.049","journal-title":"Food Chem"},{"issue":"18","key":"1462_CR14","doi-asserted-by":"publisher","first-page":"3167","DOI":"10.3390\/foods14183167","volume":"14","author":"JY Wei","year":"2025","unstructured":"Wei JY, Zhang LT, Mi J, Wei JJ, Luo Q, Lu L, Yan YM (2025) Chemical composition and inhibitory effect of Lycium barbarum L. bud tea and leaf tea on pancreatic lipase and \u03b1-amylase activity. Foods 14(18):3167. https:\/\/doi.org\/10.3390\/foods14183167","journal-title":"Foods"},{"key":"1462_CR15","doi-asserted-by":"publisher","unstructured":"Adisakwattana S, Ruengsamran T, Kampa P, Sompong W (2012) In vitro inhibitory effects of plant-based foods and their combinations on intestinal \u03b1-glucosidase and pancreatic \u03b1-amylase. BMC Complement Altern Med 12:110. https:\/\/doi.org\/10.1186\/1472-6882-12-110","DOI":"10.1186\/1472-6882-12-110"},{"key":"1462_CR16","doi-asserted-by":"publisher","unstructured":"Shen HY, Wang J, Ao JF, Hou YJ, Xi MH, Cai YY, Li M, Luo AW (2023) Structure-activity relationships and the underlying mechanism of \u03b1-amylase inhibition by hyperoside and quercetin: multi-spectroscopy and molecular docking analyses. Spectrochim Acta Part A Mol Biomol Spectrosc 285:121797. https:\/\/doi.org\/10.1016\/j.saa.2022.121797","DOI":"10.1016\/j.saa.2022.121797"},{"issue":"1","key":"1462_CR17","doi-asserted-by":"publisher","first-page":"22","DOI":"10.12691\/ajfst-7-1-4","volume":"7","author":"OA Peluola-Adeyemi","year":"2019","unstructured":"Peluola-Adeyemi OA, Bolaji OT, Abegunde TA, Ogungbesan VT (2019) Optimization of processing conditions on some selected mechanical properties of cookies from wheat-cocoyam flour using response surface methodology (RSM). Am J Food Sci Technol 7(1):22\u201326. https:\/\/doi.org\/10.12691\/ajfst-7-1-4","journal-title":"Am J Food Sci Technol"},{"key":"1462_CR18","doi-asserted-by":"publisher","unstructured":"Bana\u015b K, Piwowar A, Harasym J (2024) Agar-rapeseed oil hydroleogels as solid fat substitute in short-bread cookies. Food Hydrocoll 151:109889. https:\/\/doi.org\/10.1016\/j.foodhyd.2024.109889","DOI":"10.1016\/j.foodhyd.2024.109889"},{"issue":"15","key":"1462_CR19","doi-asserted-by":"publisher","first-page":"2356","DOI":"10.3390\/foods13152356","volume":"13","author":"K Felisiak","year":"2024","unstructured":"Felisiak K, Przybylska S, Tokarczyk G, Tabaszewska M, S\u0142upski J, Wydurska J (2024) Effect of Chickpea (Cicer arietinum L.) flour incorporation on quality, antioxidant properties, and bioactive compounds of shortbread cookies. Foods 13(15):2356. https:\/\/doi.org\/10.3390\/foods13152356","journal-title":"Foods"},{"key":"1462_CR20","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1007\/s11947-012-0785-x","volume":"6","author":"L Laguna","year":"2013","unstructured":"Laguna L, Hern\u00e1ndez MJ, Salvador A, Sanz T (2013) Study on resistant starch functionality in short dough biscuits by oscillatory and creep and recovery tests. Food Bioprocess Technol 6:1312\u20131320. https:\/\/doi.org\/10.1007\/s11947-012-0785-x","journal-title":"Food Bioprocess Technol"},{"issue":"5","key":"1462_CR21","doi-asserted-by":"publisher","first-page":"e15941","DOI":"10.1016\/j.heliyon.2023.e15941","volume":"9","author":"AE Ujong","year":"2023","unstructured":"Ujong AE, Emelike NJT, Woka FI, Otekeiwebia JNRF (2023) Formulation of fiber enriched crackers biscuit: effect on nutritional composition, physical and sensory properties. Heliyon 9(5):e15941. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e15941","journal-title":"Heliyon"},{"issue":"18","key":"1462_CR22","doi-asserted-by":"publisher","first-page":"2919","DOI":"10.3390\/foods11182919","volume":"11","author":"P Mart\u00ednez Noguera","year":"2022","unstructured":"Mart\u00ednez Noguera P, Lantoine J, Roux EL, Yang SY, Jakobi R, Krause S, Saint-Eve A, Bonazzi C, Rega B (2022) Saponins from pea ingredients to innovative sponge cakes and their association with perceived bitterness. Foods 11(18):2919. https:\/\/doi.org\/10.3390\/foods11182919","journal-title":"Foods"},{"issue":"5","key":"1462_CR23","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.3390\/molecules25051059","volume":"25","author":"K El Hazzam","year":"2020","unstructured":"El Hazzam K, Hafsa J, Sobeh M, Mhada M, Taourirte M, Kacimi EL, Yasri K A (2020) An insight into saponins from Quinoa (Chenopodium Quinoa Willd): a review. Molecules 25(5):1059. https:\/\/doi.org\/10.3390\/molecules25051059","journal-title":"Molecules"},{"key":"1462_CR24","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s43014-020-0020-5","volume":"2","author":"M Samtiya","year":"2020","unstructured":"Samtiya M, Aluko RE, Dhewa T (2020) Plant food anti-nutritional factors and their reduction strategies: an overview. Food Prod Process Nutr 2:6. https:\/\/doi.org\/10.1186\/s43014-020-0020-5","journal-title":"Food Prod Process Nutr"},{"issue":"12","key":"1462_CR25","doi-asserted-by":"publisher","first-page":"5921","DOI":"10.2903\/j.efsa.2019.5921","volume":"17","author":"M Younes","year":"2019","unstructured":"EFSA FAF Panel (EFSA Panel on Food Additives and Flavourings), Younes M, Aquilina G, Engel K-H, Fowler P, Frutos Fernandez MJ, F\u00fcrst P, G\u00fcrtler R, Gundert-Remy U, Hus\u00f8y T, Mennes W, Moldeus P, Oskarsson A, Shah R, Waalkens-Berendsen I, W\u00f6lfle D, Degen G, Herman L, Gott D, Leblanc J-C, Giarola A, Rincon AM, Tard A, Castle L (2019) Safety of use of monk fruit extract as a food additive in different food categories. EFSA J 17(12):5921. https:\/\/doi.org\/10.2903\/j.efsa.2019.5921","journal-title":"EFSA J"},{"key":"1462_CR26","doi-asserted-by":"publisher","first-page":"1177819","DOI":"10.3389\/fphar.2023.1177819","volume":"14","author":"XW Ye","year":"2023","unstructured":"Ye XW, Li CS, Zhang HX, Li Q, Cheng SQ, Wen J, Wang X, Ren HM, Xia LJ, Wang XX, Xu XF, Li XR (2023) Saponins of ginseng products: a review of their transformation in processing. Front Pharmacol 14:1177819. https:\/\/doi.org\/10.3389\/fphar.2023.1177819","journal-title":"Front Pharmacol"}],"container-title":["Plant Foods for Human Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11130-025-01462-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11130-025-01462-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11130-025-01462-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T08:09:31Z","timestamp":1776413371000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11130-025-01462-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,12]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["1462"],"URL":"https:\/\/doi.org\/10.1007\/s11130-025-01462-0","relation":{},"ISSN":["0921-9668","1573-9104"],"issn-type":[{"value":"0921-9668","type":"print"},{"value":"1573-9104","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,12]]},"assertion":[{"value":"17 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study involved sensory evaluations conducted by a trained panel, which was approved by the Ethics Review Committee of the Department of Functional Food and Wine at Shenyang Pharmaceutical University (approval date: September 5, 2024). Prior to the experiments, all participants were given written information about the study and provided written, voluntary consent to participate. They were assured that their personal information and responses would remain confidential and that they could withdraw from the study at any time.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publish"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14"}}