{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:12:06Z","timestamp":1790266326079,"version":"4.1.0"},"reference-count":80,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100016991","name":"Universidad de Guadalajara","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016991","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Plant Foods Hum Nutr"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s11130-026-01482-4","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:55:04Z","timestamp":1778244904000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hass Avocado Bioactive Compounds Attenuating Oxidative Stress and Inflammation in Ischemia\u2013reperfusion Injury: An Integrative Review"],"prefix":"10.1007","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6615-4251","authenticated-orcid":false,"given":"Rebeca","family":"Escutia-Guti\u00e9rrez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3278-4447","authenticated-orcid":false,"given":"Walter \u00c1ngel","family":"Trujillo-Rangel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8087-3597","authenticated-orcid":false,"given":"Leonel","family":"Garc\u00eda-Benavides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6493-0408","authenticated-orcid":false,"given":"Marco","family":"P\u00e9rez-Cisneros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8684-193X","authenticated-orcid":false,"given":"Adalberto","family":"Zamudio-Ojeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1708-1495","authenticated-orcid":false,"given":"Ana","family":"Sandoval-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7101-9943","authenticated-orcid":false,"given":"Juan","family":"Armend\u00e1riz-Borunda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3899-4410","authenticated-orcid":false,"given":"Maykel","family":"Gonz\u00e1lez-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5629-2864","authenticated-orcid":false,"given":"Santiago Jos\u00e9","family":"Guevara-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"1482_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20205034","volume":"20","author":"ROS Soares","year":"2019","unstructured":"Soares ROS, Losada DM, Jordani MC et al (2019) Ischemia\/reperfusion injury revisited: an overview of the latest pharmacological strategies. Int J Mol Sci 20:5034. https:\/\/doi.org\/10.3390\/ijms20205034","journal-title":"Int J Mol Sci"},{"key":"1482_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/life14040477","author":"E Nakamura","year":"2024","unstructured":"Nakamura E, Aoki T, Endo Y et al (2024) Organ-specific mitochondrial alterations following ischemia-reperfusion injury in post-cardiac arrest syndrome: a comprehensive review. Life (Basel). https:\/\/doi.org\/10.3390\/life14040477","journal-title":"Life (Basel)"},{"key":"1482_CR3","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01688-x","author":"M Zhang","year":"2024","unstructured":"Zhang M, Liu Q, Meng H et al (2024) Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets. Signal Transduct Target Ther. https:\/\/doi.org\/10.1038\/s41392-023-01688-x","journal-title":"Signal Transduct Target Ther"},{"key":"1482_CR4","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1016\/j.jcmgh.2023.03.003","volume":"15","author":"J Liu","year":"2023","unstructured":"Liu J, Man K (2023) Mechanistic insight and clinical implications of ischemia\/reperfusion injury post liver transplantation. CMGH 15:1463\u20131474. https:\/\/doi.org\/10.1016\/j.jcmgh.2023.03.003","journal-title":"CMGH"},{"key":"1482_CR5","doi-asserted-by":"publisher","DOI":"10.1186\/S40001-022-00967-7","author":"M Bai","year":"2023","unstructured":"Bai M, Zhang J, Chen D et al (2023) Insights into research on myocardial ischemia\/reperfusion injury from 2012 to 2021: a bibliometric analysis. Eur J Med Res. https:\/\/doi.org\/10.1186\/S40001-022-00967-7","journal-title":"Eur J Med Res"},{"key":"1482_CR6","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1159\/000518879","volume":"146","author":"M Zhou","year":"2021","unstructured":"Zhou M, Yu Y, Luo X et al (2021) Myocardial ischemia-reperfusion injury: therapeutics from a mitochondria-centric perspective. Cardiology 146:781\u2013792. https:\/\/doi.org\/10.1159\/000518879","journal-title":"Cardiology"},{"key":"1482_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms21228549","volume":"21","author":"AR Fern\u00e1ndez","year":"2020","unstructured":"Fern\u00e1ndez AR, S\u00e1nchez-Tarjuelo R, Cravedi P et al (2020) Review: ischemia reperfusion injury-a translational perspective in organ transplantation. Int J Mol Sci 21:1\u201321. https:\/\/doi.org\/10.3390\/ijms21228549","journal-title":"Int J Mol Sci"},{"key":"1482_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20205034","author":"ROS Soares","year":"2019","unstructured":"Soares ROS, Losada DM, Jordani MC et al (2019) Ischemia\/reperfusion injury revisited: an overview of the latest pharmacological strategies. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms20205034","journal-title":"Int J Mol Sci"},{"key":"1482_CR9","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1159\/000489241","volume":"46","author":"MY Wu","year":"2018","unstructured":"Wu MY, Yiang GT, Liao WT et al (2018) Current mechanistic concepts in ischemia and reperfusion injury. Cell Physiol Biochem 46:1650\u20131667. https:\/\/doi.org\/10.1159\/000489241","journal-title":"Cell Physiol Biochem"},{"key":"1482_CR10","doi-asserted-by":"publisher","DOI":"10.1093\/toxres\/tfaf117","author":"M Akeel","year":"2025","unstructured":"Akeel M, Mohamed G, Hamad AG et al (2025) Avocado (Persea americana) pulp extract mitigates the testicular oxidative stress and inflammation induced by cadmium in male rats. Toxicol Res Camb. https:\/\/doi.org\/10.1093\/toxres\/tfaf117","journal-title":"Toxicol Res Camb"},{"key":"1482_CR11","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.freeradbiomed.2021.01.036","volume":"165","author":"M Dambrova","year":"2021","unstructured":"Dambrova M, Zuurbier CJ, Borutaite V et al (2021) Energy substrate metabolism and mitochondrial oxidative stress in cardiac ischemia\/reperfusion injury. Free Radic Biol Med 165:24\u201337. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2021.01.036","journal-title":"Free Radic Biol Med"},{"key":"1482_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/S41392-021-00507-5","author":"P Yu","year":"2021","unstructured":"Yu P, Zhang X, Liu N et al (2021) Pyroptosis: mechanisms and diseases. Signal Transduct Target Ther. https:\/\/doi.org\/10.1038\/S41392-021-00507-5","journal-title":"Signal Transduct Target Ther"},{"key":"1482_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101109","author":"HS Li","year":"2019","unstructured":"Li HS, Zhou YN, Li L et al (2019) HIF-1\u03b1 protects against oxidative stress by directly targeting mitochondria. Redox Biol. https:\/\/doi.org\/10.1016\/j.redox.2019.101109","journal-title":"Redox Biol"},{"key":"1482_CR14","doi-asserted-by":"publisher","first-page":"107","DOI":"10.2147\/hp.s49720","volume":"2","author":"NJ Howell","year":"2014","unstructured":"Howell NJ, Tennant DA (2014) The role of HIFs in ischemia-reperfusion injury. Hypoxia (Auckl) 2:107\u2013115. https:\/\/doi.org\/10.2147\/hp.s49720","journal-title":"Hypoxia (Auckl)"},{"key":"1482_CR15","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.12557","volume":"25","author":"P Dong","year":"2021","unstructured":"Dong P, Li Q, Han H (2021) HIF-1\u03b1 in cerebral ischemia. Mol Med Rep 25:41. https:\/\/doi.org\/10.3892\/mmr.2021.12557","journal-title":"Mol Med Rep"},{"key":"1482_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120561","author":"M Sadrkhanloo","year":"2022","unstructured":"Sadrkhanloo M, Entezari M, Orouei S et al (2022) Targeting Nrf2 in ischemia-reperfusion alleviation: from signaling networks to therapeutic targeting. Life Sci. https:\/\/doi.org\/10.1016\/j.lfs.2022.120561","journal-title":"Life Sci"},{"key":"1482_CR17","doi-asserted-by":"publisher","first-page":"160","DOI":"10.7324\/JAPS.2025.218012","volume":"15","author":"Y Rosa","year":"2025","unstructured":"Rosa Y, Riyanto R, Susanti G et al (2025) Persea americana leaf extract promotes wound healing by inhibiting NF-KB1. J Appl Pharm Sci 15,:160\u2013173. https:\/\/doi.org\/10.7324\/JAPS.2025.218012","journal-title":"J Appl Pharm Sci"},{"key":"1482_CR18","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9562.s1-004","volume":"01","author":"SM Palomares","year":"2011","unstructured":"Palomares SM, J. Cipolla M (2011) Vascular protection following cerebral ischemia and reperfusion. J Neurol Neurophysiol 01:S1-004. https:\/\/doi.org\/10.4172\/2155-9562.s1-004","journal-title":"J Neurol Neurophysiol"},{"key":"1482_CR19","doi-asserted-by":"publisher","first-page":"698","DOI":"10.2174\/1871527311312050015","volume":"12","author":"R Rodrigo","year":"2013","unstructured":"Rodrigo R, Fern\u00e1ndez-Gajardo R, Guti\u00e9rrez R et al (2013) Oxidative stress and pathophysiology of ischemic stroke: novel therapeutic opportunities. CNS Neurol Disord Drug Targets 12:698\u2013714. https:\/\/doi.org\/10.2174\/1871527311312050015","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"1482_CR20","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2910643","volume":"2018","author":"H Li","year":"2018","unstructured":"Li H, Xia Z, Chen Y et al (2018) Mechanism and therapies of oxidative stress-mediated cell death in ischemia reperfusion injury. Oxid Med Cell Longev 2018:2910643. https:\/\/doi.org\/10.1155\/2018\/2910643","journal-title":"Oxid Med Cell Longev"},{"key":"1482_CR21","doi-asserted-by":"publisher","first-page":"C12","DOI":"10.1152\/ajpcell.00131.2021","volume":"322","author":"CL Chen","year":"2022","unstructured":"Chen CL, Zhang L, Jin Z et al (2022) Mitochondrial redox regulation and myocardial ischemia-reperfusion injury. Am J Physiol Cell Physiol 322:C12-c23. https:\/\/doi.org\/10.1152\/ajpcell.00131.2021","journal-title":"Am J Physiol Cell Physiol"},{"key":"1482_CR22","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1007\/s10787-022-00946-8","volume":"30","author":"L Lucena P\u00e9rico","year":"2022","unstructured":"Lucena P\u00e9rico L, de C\u00e1ssia Dos Santos R, Peixoto Rodrigues V et al (2022) Role of the antioxidant pathway in the healing of peptic ulcers induced by ischemia-reperfusion in male and female rats treated with Eugenia punicifolia. Inflammopharmacology 30:1383\u20131394. https:\/\/doi.org\/10.1007\/s10787-022-00946-8","journal-title":"Inflammopharmacology"},{"key":"1482_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232415867","author":"T Hauet","year":"2022","unstructured":"Hauet T, Pisani DF (2022) New strategies protecting from ischemia\/reperfusion. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms232415867","journal-title":"Int J Mol Sci"},{"key":"1482_CR24","doi-asserted-by":"publisher","DOI":"10.7150\/IJBS.76223","volume":"19","author":"X Chang","year":"2023","unstructured":"Chang X, Liu R, Li R et al (2023) Molecular mechanisms of mitochondrial quality control in ischemic cardiomyopathy. Int J Biol Sci 19:426. https:\/\/doi.org\/10.7150\/IJBS.76223","journal-title":"Int J Biol Sci"},{"key":"1482_CR25","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.bbabio.2015.04.003","volume":"1847","author":"FH Hickmann","year":"2015","unstructured":"Hickmann FH, Cecatto C, Kleemann D et al (2015) Uncoupling, metabolic inhibition and induction of mitochondrial permeability transition in rat liver mitochondria caused by the major long-chain hydroxyl monocarboxylic fatty acids accumulating in LCHAD deficiency. Biochim Biophys Acta 1847:620\u2013628. https:\/\/doi.org\/10.1016\/j.bbabio.2015.04.003","journal-title":"Biochim Biophys Acta"},{"key":"1482_CR26","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1016\/j.kint.2022.07.034","volume":"102","author":"Y Ye","year":"2022","unstructured":"Ye Y, Chen A, Li L et al (2022) Repression of the antiporter SLC7A11\/glutathione\/glutathione peroxidase 4 axis drives ferroptosis of vascular smooth muscle cells to facilitate vascular calcification. Kidney Int 102:1259\u20131275. https:\/\/doi.org\/10.1016\/j.kint.2022.07.034","journal-title":"Kidney Int"},{"key":"1482_CR27","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10030574","author":"A Jurcau","year":"2022","unstructured":"Jurcau A, Ardelean AI (2022) Oxidative stress in ischemia\/reperfusion injuries following acute ischemic stroke. Biomedicines. https:\/\/doi.org\/10.3390\/biomedicines10030574","journal-title":"Biomedicines"},{"key":"1482_CR28","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1248\/yakushi.128.469","volume":"128","author":"G Khanna","year":"2008","unstructured":"Khanna G, Diwan V, Singh M et al (2008) Reduction of ischemic, pharmacological and remote preconditioning effects by an antioxidant N-acetyl cysteine pretreatment in isolated rat heart. Yakugaku Zasshi 128:469\u2013477. https:\/\/doi.org\/10.1248\/yakushi.128.469","journal-title":"Yakugaku Zasshi"},{"key":"1482_CR29","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1245049","volume":"2016","author":"S Di Meo","year":"2016","unstructured":"Di Meo S, Reed TT, Venditti P, Victor VM (2016) Role of ROS and RNS sources in physiological and pathological conditions. Oxid Med Cell Longev 2016:1245049. https:\/\/doi.org\/10.1155\/2016\/1245049","journal-title":"Oxid Med Cell Longev"},{"key":"1482_CR30","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1590\/s0102-865020180120000004","volume":"33","author":"L Zhang","year":"2018","unstructured":"Zhang L, Zhang Y, Yu X et al (2018) Alprostadil attenuates myocardial ischemia\/reperfusion injury by promoting antioxidant activity and eNOS activation in rats. Acta Cir Bras 33:1067\u20131077. https:\/\/doi.org\/10.1590\/s0102-865020180120000004","journal-title":"Acta Cir Bras"},{"issue":"7","key":"1482_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076723","volume":"24","author":"JA Roberts","year":"2023","unstructured":"Roberts JA, Rainbow RD, Sharma P (2023) Mitigation of cardiovascular disease and toxicity through NRF2 signalling. Int J Mol Sci 24(7):6723. https:\/\/doi.org\/10.3390\/ijms24076723","journal-title":"Int J Mol Sci"},{"key":"1482_CR32","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.bbi.2020.12.009","volume":"92","author":"M Franke","year":"2021","unstructured":"Franke M, Bieber M, Kraft P et al (2021) The NLRP3 inflammasome drives inflammation in ischemia\/reperfusion injury after transient middle cerebral artery occlusion in mice. Brain Behav Immun 92:223\u2013233. https:\/\/doi.org\/10.1016\/j.bbi.2020.12.009","journal-title":"Brain Behav Immun"},{"key":"1482_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12111944","volume":"12","author":"L Parte","year":"2023","unstructured":"Parte L, Garc\u00eda-Alonso I, Alonso-Varona A et al (2023) Inflammation in myocardial ischemia\/reperfusion injury: underlying mechanisms and therapeutic potential. Antioxidants 12:1944. https:\/\/doi.org\/10.3390\/antiox12111944","journal-title":"Antioxidants"},{"key":"1482_CR34","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.cell.2020.04.010","volume":"181","author":"B Honig","year":"2020","unstructured":"Honig B, Shapiro L (2020) Adhesion protein structure, molecular affinities, and principles of cell-cell recognition. Cell 181:520\u2013535. https:\/\/doi.org\/10.1016\/j.cell.2020.04.010","journal-title":"Cell"},{"key":"1482_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24112172","volume":"24","author":"M Flores","year":"2019","unstructured":"Flores M, Saravia C, Vergara CE et al (2019) Avocado oil: characteristics, properties, and applications. Molecules 24:2172. https:\/\/doi.org\/10.3390\/molecules24112172","journal-title":"Molecules"},{"key":"1482_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.fochx.2022.100507","volume":"16","author":"SP Bangar","year":"2022","unstructured":"Bangar SP, Dunno K, Dhull SB et al (2022) Avocado seed discoveries: chemical composition, biological properties, and industrial food applications. Food Chemistry: X 100507. https:\/\/doi.org\/10.1016\/j.fochx.2022.100507","journal-title":"Food Chemistry: X"},{"key":"1482_CR37","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1111\/BPH.13625","volume":"174","author":"A Milani","year":"2017","unstructured":"Milani A, Basirnejad M, Shahbazi S, Bolhassani A (2017) Carotenoids: biochemistry, pharmacology and treatment. Br J Pharmacol 174:1290\u20131324. https:\/\/doi.org\/10.1111\/BPH.13625","journal-title":"Br J Pharmacol"},{"key":"1482_CR38","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.41189","author":"OE Okobi","year":"2023","unstructured":"Okobi OE, Odoma VA, Okunromade O et al (2023) Effect of avocado consumption on risk factors of cardiovascular diseases: a systematic review and meta-analysis. Cureus. https:\/\/doi.org\/10.7759\/cureus.41189","journal-title":"Cureus"},{"key":"1482_CR39","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1056\/NEJM200001203420302","volume":"342","author":"S Yusuf","year":"2000","unstructured":"Yusuf S, Dagenais G, Pogue J et al (2000) Vitamin E supplementation and cardiovascular events in high-risk patients. N Engl J Med 342:154\u2013160. https:\/\/doi.org\/10.1056\/NEJM200001203420302","journal-title":"N Engl J Med"},{"key":"1482_CR40","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.3390\/nu10111618","volume":"10","author":"N Yahfoufi","year":"2018","unstructured":"Yahfoufi N, Alsadi N, Jambi M, Matar C (2018) The immunomodulatory and anti-inflammatory role of polyphenols. Nutrients 10:1618. https:\/\/doi.org\/10.3390\/nu10111618","journal-title":"Nutrients"},{"key":"1482_CR41","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7190943","volume":"2016","author":"SQ Rodr\u00edguez-Lara","year":"2016","unstructured":"Rodr\u00edguez-Lara SQ, Cardona-Mu\u00f1oz EG, Ram\u00edrez-Lizardo EJ et al (2016) Alternative interventions to prevent oxidative damage following ischemia\/reperfusion. Oxid Med Cell Longev 2016:7190943. https:\/\/doi.org\/10.1155\/2016\/7190943","journal-title":"Oxid Med Cell Longev"},{"key":"1482_CR42","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1111\/ijfs.14474","volume":"55","author":"D Campos","year":"2020","unstructured":"Campos D, Teran-Hilares F, Chirinos R et al (2020) Bioactive compounds and antioxidant activity from harvest to edible ripeness of avocado cv. Hass (Persea americana) throughout the harvest seasons. Int J Food Sci Technol 55:2208\u20132218. https:\/\/doi.org\/10.1111\/ijfs.14474","journal-title":"Int J Food Sci Technol"},{"key":"1482_CR43","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8100426","volume":"8","author":"DJ Bhuyan","year":"2019","unstructured":"Bhuyan DJ, Alsherbiny MA, Perera S et al (2019) The odyssey of bioactive compounds in avocado (Persea americana) and their health benefits. Antioxidants 8:426. https:\/\/doi.org\/10.3390\/antiox8100426","journal-title":"Antioxidants"},{"key":"1482_CR44","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14101225","author":"Z Xin","year":"2025","unstructured":"Xin Z, Gao Y, He L et al (2025) Bioactive antioxidants from avocado by-products: mechanistic study and laboratory-scale extraction optimization. Antioxidants. https:\/\/doi.org\/10.3390\/antiox14101225","journal-title":"Antioxidants"},{"issue":"2","key":"1482_CR45","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s11130-021-00887-7","volume":"76","author":"A Ochoa-Zarzosa","year":"2021","unstructured":"Ochoa-Zarzosa A, B\u00e1ez-Maga\u00f1a M, Guzm\u00e1n-Rodr\u00edguez JJ et al (2021) Bioactive molecules from native Mexican avocado fruit (Persea americana var. drymifolia): a review. Plant Foods Hum Nutr 76(2):133\u2013142. https:\/\/doi.org\/10.1007\/s11130-021-00887-7","journal-title":"Plant Foods Hum Nutr"},{"issue":"10","key":"1482_CR46","doi-asserted-by":"publisher","first-page":"5625","DOI":"10.1021\/jf1048832","volume":"59","author":"JG Rodr\u00edguez-Carpena","year":"2011","unstructured":"Rodr\u00edguez-Carpena JG, Morcuende D, Andrade MJ, Kylli P, Est\u00e9vez M (2011) Avocado (Persea americana Mill.) phenolics, in vitro antioxidant and antimicrobial activities, and inhibition of lipid and protein oxidation in porcine patties. J Agric Food Chem 59(10):5625\u20135635. https:\/\/doi.org\/10.1021\/jf1048832","journal-title":"J Agric Food Chem"},{"key":"1482_CR47","doi-asserted-by":"publisher","first-page":"225","DOI":"10.22038\/ijbms.2019.32806.7897","volume":"22","author":"N Kahkeshani","year":"2019","unstructured":"Kahkeshani N, Farzaei F, Fotouhi M et al (2019) Pharmacological effects of gallic acid in health and diseases: A mechanistic review. Iran J Basic Med Sci 22:225\u2013237. https:\/\/doi.org\/10.22038\/ijbms.2019.32806.7897","journal-title":"Iran J Basic Med Sci"},{"key":"1482_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jafr.2023.100573","volume":"12","author":"Y King-Loeza","year":"2023","unstructured":"King-Loeza Y, Cipri\u00e1n-Mac\u00edas DA, Cardador-Mart\u00ednez A et al (2023) Functional composition of avocado (Persea americana Mill. Var Hass) pulp, extra virgin oil, and residues is affected by fruit commercial classification. J Agric Food Res 12:100573. https:\/\/doi.org\/10.1016\/j.jafr.2023.100573","journal-title":"J Agric Food Res"},{"key":"1482_CR49","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S328096","author":"NZA Zuraini","year":"2021","unstructured":"Zuraini NZA, Sekar M, Wu YS et al (2021) Promising nutritional fruits against cardiovascular diseases: an overview of experimental evidence and understanding their mechanisms of action. Vasc Health Risk Manag. https:\/\/doi.org\/10.2147\/VHRM.S328096","journal-title":"Vasc Health Risk Manag"},{"key":"1482_CR50","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.16424","volume":"16","author":"M Badavi","year":"2014","unstructured":"Badavi M, Sadeghi N, Dianat M, Samarbafzadeh A (2014) Effects of gallic acid and cyclosporine A on antioxidant capacity and cardiac markers of rat isolated heart after ischemia\/reperfusion. Iran Red Crescent Med J 16:e16424. https:\/\/doi.org\/10.5812\/ircmj.16424","journal-title":"Iran Red Crescent Med J"},{"key":"1482_CR51","doi-asserted-by":"publisher","DOI":"10.22038\/ijbms.2023.68045.14874","volume":"26","author":"F Souri","year":"2023","unstructured":"Souri F, Badavi M, Dianat M et al (2023) Protective effects of gallic acid and SGK1 inhibitor on oxidative stress and cardiac damage in an isolated heart model of ischemia\/reperfusion injury in rats. Iran J Basic Med Sci 26:308. https:\/\/doi.org\/10.22038\/ijbms.2023.68045.14874","journal-title":"Iran J Basic Med Sci"},{"key":"1482_CR52","doi-asserted-by":"publisher","DOI":"10.1007\/S10616-014-9724-1","volume":"67","author":"G Bayramoglu","year":"2014","unstructured":"Bayramoglu G, Kurt H, Bayramoglu A et al (2014) Preventive role of gallic acid on hepatic ischemia and reperfusion injury in rats. Cytotechnology 67:845. https:\/\/doi.org\/10.1007\/S10616-014-9724-1","journal-title":"Cytotechnology"},{"key":"1482_CR53","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1111\/CNS.13814","volume":"28","author":"S Lv","year":"2022","unstructured":"Lv S, Yang H, Jing P, Song H (2022) \u0391-tocopherol pretreatment alleviates cerebral ischemia-reperfusion injury in rats. CNS Neurosci Ther 28:964\u2013970. https:\/\/doi.org\/10.1111\/CNS.13814","journal-title":"CNS Neurosci Ther"},{"key":"1482_CR54","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1254\/jjp.87.164","volume":"87","author":"EL Rhoden","year":"2001","unstructured":"Rhoden EL, Pereira-LIma L, Tel\u00f6ken C et al (2001) Beneficial effect of \u03b1-tocopherol in renal ischemia-reperfusion in rats. Jpn J Pharmacol 87:164\u2013166. https:\/\/doi.org\/10.1254\/jjp.87.164","journal-title":"Jpn J Pharmacol"},{"key":"1482_CR55","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.foodchem.2011.01.096","volume":"127","author":"Y Sato","year":"2011","unstructured":"Sato Y, Kobayashi M, Itagaki S et al (2011) Protective effect of lutein after ischemia-reperfusion in the small intestine. Food Chem 127:893\u2013898. https:\/\/doi.org\/10.1016\/j.foodchem.2011.01.096","journal-title":"Food Chem"},{"key":"1482_CR56","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.21873\/invivo.12407","volume":"35","author":"S Yuceli","year":"2021","unstructured":"Yuceli S, Yazici GN, Mammadov R et al (2021) The effect of lutein on ischemia-reperfusion-induced vasculitic neuropathic pain and neuropathy in rats. In Vivo 35:1537\u20131543. https:\/\/doi.org\/10.21873\/invivo.12407","journal-title":"In Vivo"},{"key":"1482_CR57","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2023.102741","author":"T Al-Otaibi","year":"2023","unstructured":"Al-Otaibi T, Hawsah MA, Alojayri G et al (2023) In vivo anticoccidial, antioxidant, and anti-inflammatory activities of avocado fruit, Persea americana (Lauraceae), against Eimeria papillata infection. Parasitol Int. https:\/\/doi.org\/10.1016\/j.parint.2023.102741","journal-title":"Parasitol Int"},{"issue":"14","key":"1482_CR58","doi-asserted-by":"publisher","DOI":"10.3390\/app14145978","volume":"14","author":"A Marra","year":"2024","unstructured":"Marra A, Manousakis V, Zervas GP et al (2024) Avocado and its by-products as natural sources of valuable anti-inflammatory and antioxidant bioactives for functional foods and cosmetics with health-promoting properties. Appl Sci 14(14):5978. https:\/\/doi.org\/10.3390\/app14145978","journal-title":"Appl Sci"},{"key":"1482_CR59","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1177\/1947603514554992","volume":"6","author":"BA Christiansen","year":"2015","unstructured":"Christiansen BA, Bhatti S, Goudarzi R, Emami S (2015) Management of osteoarthritis with avocado\/soybean unsaponifiables. Cartilage 6:30\u201344. https:\/\/doi.org\/10.1177\/1947603514554992","journal-title":"Cartilage"},{"key":"1482_CR60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.joca.2010.10.017","volume":"19","author":"Y Henrotin","year":"2011","unstructured":"Henrotin Y, Lambert C, Couchourel D et al (2011) Nutraceuticals: do they represent a new era in the management of osteoarthritis? - a narrative review from the lessons taken with five products. Osteoarthritis Cartilage 19:1\u201321. https:\/\/doi.org\/10.1016\/j.joca.2010.10.017","journal-title":"Osteoarthritis Cartilage"},{"key":"1482_CR61","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.arcmed.2007.01.008","volume":"38","author":"M Yaman","year":"2007","unstructured":"Yaman M, Eser O, Cosar M et al (2007) Oral administration of avocado soybean unsaponifiables (ASU) reduces ischemic damage in the rat hippocampus. Arch Med Res 38:489\u2013494. https:\/\/doi.org\/10.1016\/j.arcmed.2007.01.008","journal-title":"Arch Med Res"},{"key":"1482_CR62","doi-asserted-by":"publisher","first-page":"701","DOI":"10.3109\/02688697.2010.520767","volume":"25","author":"O Eser","year":"2010","unstructured":"Eser O, Songur A, Yaman M et al (2010) The protective effect of avocado soybean unsaponifilables on brain ischemia\/reperfusion injury in rat prefrontal cortex. Br J Neurosurg 25:701\u2013706. https:\/\/doi.org\/10.3109\/02688697.2010.520767","journal-title":"Br J Neurosurg"},{"key":"1482_CR63","doi-asserted-by":"publisher","DOI":"10.1186\/S12964-022-00860-0","author":"Y Zheng","year":"2022","unstructured":"Zheng Y, Li L, Chen B et al (2022) Chlorogenic acid exerts neuroprotective effect against hypoxia-ischemia brain injury in neonatal rats by activating Sirt1 to regulate the Nrf2-NF-\u03baB signaling pathway. Cell Commun Signal. https:\/\/doi.org\/10.1186\/S12964-022-00860-0","journal-title":"Cell Commun Signal"},{"key":"1482_CR64","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1007\/S00210-019-01670-X","volume":"392","author":"G Kumar","year":"2019","unstructured":"Kumar G, Mukherjee S, Paliwal P et al (2019) Neuroprotective effect of chlorogenic acid in global cerebral ischemia-reperfusion rat model. Naunyn-Schmiedeberg\u2019s Archives Pharmacol 2019 392:1293\u20131309. https:\/\/doi.org\/10.1007\/S00210-019-01670-X","journal-title":"Naunyn-Schmiedeberg\u2019s Archives Pharmacol 2019"},{"issue":"1","key":"1482_CR65","doi-asserted-by":"publisher","DOI":"10.1186\/S12964-022-00860-0","volume":"20","author":"Y Zheng","year":"2022","unstructured":"Zheng Y, Li L, Chen B et al (2022) Chlorogenic acid exerts neuroprotective effect against hypoxia-ischemia brain injury in neonatal rats by activating Sirt1 to regulate the Nrf2-NF-\u03baB signaling pathway. Cell Commun Signal (1):84. https:\/\/doi.org\/10.1186\/S12964-022-00860-0","journal-title":"Cell Commun Signal"},{"key":"1482_CR66","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1016\/j.jnutbio.2011.06.018","volume":"23","author":"N Yun","year":"2012","unstructured":"Yun N, Kang JW, Lee SM (2012) Protective effects of chlorogenic acid against ischemia\/reperfusion injury in rat liver: molecular evidence of its antioxidant and anti-inflammatory properties. J Nutr Biochem 23:1249\u20131255. https:\/\/doi.org\/10.1016\/j.jnutbio.2011.06.018","journal-title":"J Nutr Biochem"},{"key":"1482_CR67","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1007\/s12010-022-04123-z","volume":"195","author":"N Rong","year":"2023","unstructured":"Rong N, Yang R, Ibrahim IAA, Zhang W (2023) Cardioprotective role of scopoletin on isoproterenol-induced myocardial infarction in rats. Appl Biochem Biotechnol 195:919\u2013932. https:\/\/doi.org\/10.1007\/s12010-022-04123-z","journal-title":"Appl Biochem Biotechnol"},{"key":"1482_CR68","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1515\/ZNC-2021-0193","volume":"77","author":"LD Antika","year":"2022","unstructured":"Antika LD, Tasfiyati AN, Hikmat H, Septama AW (2022) Scopoletin: a review of its source, biosynthesis, methods of extraction, and pharmacological activities. Z Naturforsch C J Biosci 77:303\u2013316. https:\/\/doi.org\/10.1515\/ZNC-2021-0193","journal-title":"Z Naturforsch C J Biosci"},{"key":"1482_CR69","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfca.2023.105544","volume":"123","author":"C M\u00e9ndez Hern\u00e1ndez","year":"2023","unstructured":"M\u00e9ndez Hern\u00e1ndez C, R\u00edos Mesa D, Rodr\u00edguez-Gald\u00f3n B, Rodr\u00edguez-Rodr\u00edguez EM (2023) Study of environmental factors on the fat profile of Hass avocados. J Food Compos Anal 123:105544. https:\/\/doi.org\/10.1016\/j.jfca.2023.105544","journal-title":"J Food Compos Anal"},{"key":"1482_CR70","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3390\/NU15010224","volume":"15","author":"C Santa-Mar\u00eda","year":"2022","unstructured":"Santa-Mar\u00eda C, L\u00f3pez-Enr\u00edquez S, Montserrat-de la Paz S et al (2022) Update on Anti-Inflammatory Molecular Mechanisms Induced by Oleic Acid. Nutrients 2023 15:15. https:\/\/doi.org\/10.3390\/NU15010224","journal-title":"Nutrients 2023"},{"key":"1482_CR71","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.70547","volume":"13","author":"S Hamednia","year":"2025","unstructured":"Hamednia S, Shouhani Z, Tavakol S et al (2025) Effects of avocado products on cardiovascular risk factors in adults: a GRADE-assessed systematic review and meta-analysis. Food Sci Nutr 13:e70547. https:\/\/doi.org\/10.1002\/fsn3.70547","journal-title":"Food Sci Nutr"},{"issue":"1","key":"1482_CR72","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/S12933-015-0237-9","volume":"14","author":"L Perdomo","year":"2015","unstructured":"Perdomo L, Beneit N, Otero YF et al (2015) Protective role of oleic acid against cardiovascular insulin resistance and in the early and late cellular atherosclerotic process. Cardiovasc Diabetol 14(1):75. https:\/\/doi.org\/10.1186\/S12933-015-0237-9","journal-title":"Cardiovasc Diabetol"},{"key":"1482_CR73","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.chembiol.2019.03.001","volume":"26","author":"UN Das","year":"2019","unstructured":"Das UN (2019) Saturated fatty acids, MUFAs and PUFAs regulate ferroptosis. Cell Chem Biol 26:309\u2013311. https:\/\/doi.org\/10.1016\/j.chembiol.2019.03.001","journal-title":"Cell Chem Biol"},{"key":"1482_CR74","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1093\/JN\/135.3.431","volume":"135","author":"NZ Unlu","year":"2005","unstructured":"Unlu NZ, Bohn T, Clinton SK, Schwartz SJ (2005) Carotenoid absorption from salad and salsa by humans is enhanced by the addition of avocado or avocado oil. J Nutr 135:431\u2013436. https:\/\/doi.org\/10.1093\/JN\/135.3.431","journal-title":"J Nutr"},{"key":"1482_CR75","doi-asserted-by":"publisher","DOI":"10.3390\/APP14145978","author":"A Marra","year":"2024","unstructured":"Marra A, Manousakis V, Zervas GP et al (2024) Avocado and its by-products as natural sources of valuable anti-inflammatory and antioxidant bioactives for functional foods and cosmetics with health-promoting properties. Appl Sci. https:\/\/doi.org\/10.3390\/APP14145978","journal-title":"Appl Sci"},{"issue":"7","key":"1482_CR76","doi-asserted-by":"publisher","first-page":"977","DOI":"10.3390\/biom11070977","volume":"11","author":"GR Velderrain-Rodr\u0131\u0301guez","year":"2021","unstructured":"Velderrain-Rodr\u0131\u0301guez GR, Quero J, Osada J, Mart\u0131\u0301n-Belloso O, Rodr\u0131\u0301guez-Yoldi MJ (2021) Phenolic-Rich Extracts from Avocado Fruit Residues as Functional Food Ingredients with Antioxidant and Antiproliferative Properties. Biomolecules 11(7):977. https:\/\/doi.org\/10.3390\/biom11070977","journal-title":"Biomolecules"},{"issue":"12","key":"1482_CR77","doi-asserted-by":"publisher","first-page":"4376","DOI":"10.3390\/nu13124376","volume":"13","author":"ML Dreher","year":"2021","unstructured":"Dreher ML, Chen FW, Ford NA (2021) A Comprehensive Review of Hass Avocado Clinical Trials, Observational Studies, and Biological Mechanisms. Nutrients 13(12):4376. https:\/\/doi.org\/10.3390\/nu13124376","journal-title":"Nutrients"},{"issue":"1","key":"1482_CR78","doi-asserted-by":"publisher","DOI":"10.1186\/S12944-025-02454-4","volume":"24","author":"VV Olavarr\u00eda","year":"2025","unstructured":"Olavarr\u00eda VV, Campod\u00f3nico PR, Vollrath V et al (2025) Efficacy of an avocado-based Mediterranean diet on serum lipids for secondary prevention after ischemic stroke: a randomized phase 2 controlled pilot trial. Lipids Health Dis 24(1):37. https:\/\/doi.org\/10.1186\/S12944-025-02454-4","journal-title":"Lipids Health Dis"},{"key":"1482_CR79","doi-asserted-by":"publisher","DOI":"10.3390\/foods14152746","volume":"14","author":"APS Nascimento","year":"2025","unstructured":"Nascimento APS, Duarte MEM, Rocha APT, Barros AN (2025) Bioactive compounds, technological advances, and sustainable applications of avocado (Persea americana Mill.): a critical review. Foods 14:2746. https:\/\/doi.org\/10.3390\/foods14152746","journal-title":"Foods"},{"issue":"11","key":"1482_CR80","doi-asserted-by":"publisher","first-page":"808","DOI":"10.3390\/cells14110808","volume":"14","author":"YI Va\u0301zquez-Gala\u0301n","year":"2025","unstructured":"Va\u0301zquez-Gala\u0301n YI, Guzma\u0301n-Silahua S, Trujillo-Rangel WA, Rodr\u0131\u0301guez-Lara SQ (2025) Role of Ischemia\/Reperfusion and Oxidative Stress in Shock State. Cells 14(11):808. https:\/\/doi.org\/10.3390\/cells14110808","journal-title":"Cells"}],"container-title":["Plant Foods for Human Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11130-026-01482-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11130-026-01482-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11130-026-01482-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:09:08Z","timestamp":1783685348000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11130-026-01482-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,8]]},"references-count":80,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["1482"],"URL":"https:\/\/doi.org\/10.1007\/s11130-026-01482-4","relation":{},"ISSN":["0921-9668","1573-9104"],"issn-type":[{"value":"0921-9668","type":"print"},{"value":"1573-9104","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,8]]},"assertion":[{"value":"31 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"52"}}