{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:23:54Z","timestamp":1783686234885,"version":"3.55.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Key Research and Development Project of Liaoning Province","award":["No.2023JH2\/101300165"],"award-info":[{"award-number":["No.2023JH2\/101300165"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Plant Foods Hum Nutr"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s11130-026-01513-0","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T18:56:58Z","timestamp":1778871418000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cyanidin-3-O-galactoside Attenuates Metabolic Dysfunction-associated Steatotic Liver Disease by Modulating the CCL3-FABP4 Axis"],"prefix":"10.1007","volume":"81","author":[{"given":"Yujing","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochao","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"1513_CR1","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1053\/j.gastro.2025.02.044","volume":"169","author":"ZM Younossi","year":"2025","unstructured":"Younossi ZM, Zelber-Sagi S, Lazarus JV, Wong VW, Yilmaz Y, Duseja A et al (2025) Global consensus recommendations for metabolic dysfunction-associated steatotic liver disease and steatohepatitis. Gastroenterology 169:1017\u201332e. https:\/\/doi.org\/10.1053\/j.gastro.2025.02.044","journal-title":"Gastroenterology"},{"key":"1513_CR2","doi-asserted-by":"publisher","unstructured":"Lim GEH, Tang A, Ng CH, Chin YH, Lim WH, Tan DJH et al \u00b7(2023)\u00b7An observational data meta-analysis on the differences in prevalence and risk factors between MAFLD vs NAFLD.\u00b7Clin Gastroenterol Hepatol\u00b721:619\u2009\u2013\u200929e7. https:\/\/doi.org\/10.1016\/j.cgh.2021.11.038","DOI":"10.1016\/j.cgh.2021.11.038"},{"key":"1513_CR3","doi-asserted-by":"publisher","unstructured":"Zhu LR, Li SS, Zheng WQ, Ni WJ, Cai M, Liu HP\u00b7(2023)\u00b7Targeted modulation of gut microbiota by traditional Chinese medicine and natural products for liver disease therapy.\u00b7Front Immunol\u00b714:1086078. https:\/\/doi.org\/10.3389\/fimmu.2023.1086078","DOI":"10.3389\/fimmu.2023.1086078"},{"key":"1513_CR4","doi-asserted-by":"publisher","unstructured":"Guo X, Yin X, Liu Z, Wang J\u00b7(2022)\u00b7Non-alcoholic fatty liver disease (NAFLD) pathogenesis and natural products for prevention and treatment.\u00b7Int. J Mol Sci\u00b723 https:\/\/doi.org\/10.3390\/ijms232415489","DOI":"10.3390\/ijms232415489"},{"key":"1513_CR5","doi-asserted-by":"publisher","unstructured":"Hughes CE, Nibbs RJB\u00b7(2018)\u00b7A guide to chemokines and their receptors.\u00b7FEBS J\u00b7285:2944-71. https:\/\/doi.org\/10.1111\/febs.14466","DOI":"10.1111\/febs.14466"},{"key":"1513_CR6","doi-asserted-by":"publisher","unstructured":"Mollica Poeta V, Massara M, Capucetti A, Bonecchi R (2019) Chemokines and chemokine receptors: new targets for cancer immunotherapy. Front Immunol 10(379). https:\/\/doi.org\/10.3389\/fimmu.2019.00379","DOI":"10.3389\/fimmu.2019.00379"},{"key":"1513_CR7","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1097\/MCO.0000000000000031","volume":"17","author":"AE Thumser","year":"2014","unstructured":"Thumser AE, Moore JB, Plant NJ\u00b7(2014)\u00b7Fatty acid binding proteins: tissue-specific functions in health and disease.\u00b7Curr Opin Clin Nutr Metab Care\u00b717:124\u2013129. https:\/\/doi.org\/10.1097\/MCO.0000000000000031","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"1513_CR8","doi-asserted-by":"publisher","first-page":"22173","DOI":"10.3390\/ijms151222173","volume":"15","author":"T Auguet","year":"2014","unstructured":"Auguet T, Berlanga A, Guiu-Jurado E, Martinez S, Porras JA, Aragones G et al (2014) Altered fatty acid metabolism-related gene expression in liver from morbidly obese women with non-alcoholic fatty liver disease. Int J Mol Sci 15:22173\u201322187. https:\/\/doi.org\/10.3390\/ijms151222173","journal-title":"Int J Mol Sci"},{"key":"1513_CR9","doi-asserted-by":"publisher","unstructured":"Field CS, Baixauli F, Kyle RL, Puleston DJ, Cameron AM, Sanin DE et al \u00b7(2020)\u00b7Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function.\u00b7Cell Metab\u00b731:422\u2009\u2013\u200937 e5.https:\/\/doi.org\/10.1016\/j.cmet.2019.11.021","DOI":"10.1016\/j.cmet.2019.11.021"},{"key":"1513_CR10","doi-asserted-by":"publisher","unstructured":"Coilly A, Desterke C, Guettier C, Samuel D, Chiappini F\u00b7(2019)\u00b7FABP4 and MMP9 levels identified as predictive factors for poor prognosis in patients with nonalcoholic fatty liver using data mining approaches and gene expression analysis.\u00b7Sci Rep\u00b79:19785.https:\/\/doi.org\/10.1038\/s41598-019-56235-y","DOI":"10.1038\/s41598-019-56235-y"},{"key":"1513_CR11","doi-asserted-by":"publisher","unstructured":"Yu W, Gao J, Hao R, Yang J, Wei J\u00b7(2021)\u00b7Effects of simulated digestion on black chokeberry (Aronia melanocarpa (Michx.) Elliot) anthocyanins and intestinal flora.\u00b7J. Food Sci Technol\u00b758 :1511\u20131523.https:\/\/doi.org\/10.1007\/s13197-020-04664-3","DOI":"10.1007\/s13197-020-04664-3"},{"key":"1513_CR12","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s11130-017-0644-z","volume":"72","author":"J Wei","year":"2017","unstructured":"Wei J, Zhang G, Zhang X, Xu D, Gao J, Fan J (2017) Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver. Plant Foods Hum Nutr 72:425\u2013431. https:\/\/doi.org\/10.1007\/s11130-017-0644-z","journal-title":"Plant Foods Hum Nutr"},{"key":"1513_CR13","doi-asserted-by":"publisher","first-page":"5973","DOI":"10.1021\/acs.jafc.7b02136","volume":"65","author":"J Wei","year":"2017","unstructured":"Wei J, Zhang G, Zhang X, Xu D, Gao J, Fan J et al (2017) Anthocyanins from black chokeberry (Aroniamelanocarpa Elliot) Delayed aging-related degenerative changes of brain. J Agric Food Chem 65:5973\u20135984. https:\/\/doi.org\/10.1021\/acs.jafc.7b02136","journal-title":"J Agric Food Chem"},{"key":"1513_CR14","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1007\/s11130-024-01213-7","volume":"79","author":"J Wei","year":"2024","unstructured":"Wei J, Tang X, He Y, Peng Z, Liu H, He Y et al (2024) Aronia melanocarpa elliot anthocyanins inhibits alcoholic liver disease by activation of alpha7nAChR. Plant Foods Hum Nutr 79:779\u2013794. https:\/\/doi.org\/10.1007\/s11130-024-01213-7","journal-title":"Plant Foods Hum Nutr"},{"key":"1513_CR15","doi-asserted-by":"publisher","first-page":"108785","DOI":"10.1016\/j.fbio.2026.108785","volume":"79","author":"Y He","year":"2026","unstructured":"He Y, Bao X, Li F, Zhao M, Tang X, Wei J (2026) Cyanidin-3-O-galactoside regulates macrophage immunometabolic dysregulation via the C-C motif chemokine Ligand 3 and fatty acid binding protein 4 axis: A multi-omics study. Food Biosci 79:108785. https:\/\/doi.org\/10.1016\/j.fbio.2026.108785","journal-title":"Food Biosci"},{"key":"1513_CR16","doi-asserted-by":"publisher","unstructured":"Liu B, Zhang J, Sun P, Yi R, Han X, Zhao X\u00b7(2019) Raw bowl tea (Tuocha) polyphenol prevention of nonalcoholic fatty liver disease by regulating intestinal function in mice. Biomolecules 9. https:\/\/doi.org\/10.3390\/biom9090435","DOI":"10.3390\/biom9090435"},{"key":"1513_CR17","doi-asserted-by":"publisher","first-page":"e70118","DOI":"10.1002\/dmrr.70118","volume":"42","author":"J Ren","year":"2026","unstructured":"Ren J, Jiang T, Wei X, Bian T, Xu M, Zhao Y et al (2026) Unravelling the mechanisms of tea against NAFLD: an integration of bibliometrics, network pharmacology, and the gut-liver axis. Diabetes Metab Res Rev 42:e70118. https:\/\/doi.org\/10.1002\/dmrr.70118","journal-title":"Diabetes Metab Res Rev"},{"key":"1513_CR18","doi-asserted-by":"publisher","unstructured":"Zuo G, Chen M, Zuo Y, Liu F, Yang Y, Li J et al (2024) Tea Polyphenol Epigallocatechin Gallate protects against nonalcoholic fatty liver disease and associated Endotoxemia in rats via modulating gut microbiota dysbiosis and alleviating intestinal barrier dysfunction and related inflammation. J Agric Food Chem. https:\/\/doi.org\/10.1021\/acs.jafc.3c04832","DOI":"10.1021\/acs.jafc.3c04832"},{"key":"1513_CR19","doi-asserted-by":"publisher","first-page":"3591","DOI":"10.1111\/bph.15083","volume":"177","author":"X Li","year":"2020","unstructured":"Li X, Shi Z, Zhu Y, Shen T, Wang H, Shui G et al (2020) Cyanidin-3-O-glucoside improves non-alcoholic fatty liver disease by promoting PINK1-mediated mitophagy in mice. Br J Pharmacol 177:3591\u20133607. https:\/\/doi.org\/10.1111\/bph.15083","journal-title":"Br J Pharmacol"},{"key":"1513_CR20","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s12967-022-03343-5","volume":"20","author":"J Zhu","year":"2022","unstructured":"Zhu J, Wen Y, Zhang Q, Nie F, Cheng M, Zhao X (2022) The monomer TEC of blueberry improves NASH by augmenting tRF-47-mediated autophagy\/pyroptosis signaling pathway. J Transl Med 20:128. https:\/\/doi.org\/10.1186\/s12967-022-03343-5","journal-title":"J Transl Med"},{"key":"1513_CR21","doi-asserted-by":"publisher","first-page":"4663","DOI":"10.1021\/acs.jafc.0c06695","volume":"69","author":"Y Xu","year":"2021","unstructured":"Xu Y, Ke H, Li Y, Xie L, Su H, Xie J et al \u00b7(2021)\u00b7Malvidin-3-O-Glucoside from blueberry ameliorates nonalcoholic fatty liver disease by regulating transcription factor EB-mediated lysosomal function and activating the Nrf2\/ARE signaling pathway. J Agric Food Chem 69:4663\u20134673. https:\/\/doi.org\/10.1021\/acs.jafc.0c06695","journal-title":"J Agric Food Chem"},{"key":"1513_CR22","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/s11130-026-01467-3","volume":"81","author":"T Hernandez-Perez","year":"2026","unstructured":"Hernandez-Perez T, Paredes-Lopez O (2026) Antiobesity potential of selected latin american edible plants: a review. Plant Foods Hum Nutr 81:18. https:\/\/doi.org\/10.1007\/s11130-026-01467-3","journal-title":"Plant Foods Hum Nutr"},{"key":"1513_CR23","doi-asserted-by":"publisher","unstructured":"de Bessa ME, Andrade VT, Guimaraes GM, Cerqueira A, Viana CCR, Furtado MM et al (2026) Carbohydrate-rich extract from Pereskia aculeata leaves: in vitro prebiotic-related properties and metabolic effects in an experimental model of obesity. Plant Foods Hum Nutr 81. https:\/\/doi.org\/10.1007\/s11130-026-01486-0","DOI":"10.1007\/s11130-026-01486-0"},{"key":"1513_CR24","doi-asserted-by":"publisher","unstructured":"Nagata N, Chen G, Xu L, Ando H (2022) An update on the chemokine system in the development of NAFLD. Med (Kaunas) 58. https:\/\/doi.org\/10.3390\/medicina58060761","DOI":"10.3390\/medicina58060761"},{"key":"1513_CR25","doi-asserted-by":"publisher","first-page":"154914","DOI":"10.1016\/j.metabol.2021.154914","volume":"125","author":"L Xu","year":"2021","unstructured":"Xu L, Chen Y, Nagashimada M, Ni Y, Zhuge F, Chen G et al (2021) CC chemokine ligand 3 deficiency ameliorates diet-induced steatohepatitis by regulating liver macrophage recruitment and M1\/M2 status in mice. Metabolism 125:154914. https:\/\/doi.org\/10.1016\/j.metabol.2021.154914","journal-title":"Metabolism"},{"key":"1513_CR26","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.3389\/fimmu.2020.01802","volume":"11","author":"X Pan","year":"2020","unstructured":"Pan X, Chiwanda Kaminga A, Liu A, Wen SW, Chen J, Luo J (2020) Chemokines in Non-alcoholic fatty liver disease: a systematic review and network meta-analysis. Front Immunol 11:1802. https:\/\/doi.org\/10.3389\/fimmu.2020.01802","journal-title":"Front Immunol"},{"key":"1513_CR27","doi-asserted-by":"publisher","first-page":"979","DOI":"10.3109\/00365521.2013.836754","volume":"49","author":"JB Suh","year":"2014","unstructured":"Suh JB, Kim SM, Cho GJ, Choi KM (2014) Serum AFBP levels are elevated in patients with nonalcoholic fatty liver disease. Scand J Gastroenterol 49:979\u2013985. https:\/\/doi.org\/10.3109\/00365521.2013.836754","journal-title":"Scand J Gastroenterol"},{"key":"1513_CR28","doi-asserted-by":"publisher","unstructured":"Shen J, Chan HL, Wong GL, Choi PC, Chan AW, Chan HY et al (2012) Non-invasive diagnosis of non-alcoholic steatohepatitis by combined serum biomarkers. J Hepatol\u00b756 1363\u20131370. https:\/\/doi.org\/10.1016\/j.jhep.2011.12.025","DOI":"10.1016\/j.jhep.2011.12.025"},{"key":"1513_CR29","first-page":"675","volume":"3","author":"G Kirovski","year":"2010","unstructured":"Kirovski G, Gabele E, Dorn C, Moleda L, Niessen C, Weiss TS et al (2010) Hepatic steatosis causes induction of the chemokine RANTES in the absence of significant hepatic inflammation. Int J Clin Exp Pathol 3:675\u2013680","journal-title":"Int J Clin Exp Pathol"}],"container-title":["Plant Foods for Human Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11130-026-01513-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11130-026-01513-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11130-026-01513-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:09:01Z","timestamp":1783685341000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11130-026-01513-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,15]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["1513"],"URL":"https:\/\/doi.org\/10.1007\/s11130-026-01513-0","relation":{},"ISSN":["0921-9668","1573-9104"],"issn-type":[{"value":"0921-9668","type":"print"},{"value":"1573-9104","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,15]]},"assertion":[{"value":"8 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments adhere to the ARRIVE guidelines. This article does not contain any studies with human participants performed by any of the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"62"}}