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Extraction of ascorbic acid from whole green acerola fruits was optimized using response surface methodology, with solvent composition and temperature as independent variables. Pure water at 35\u00a0\u00b0C provided the highest ascorbic acid recovery (340\u00a0mg g\u207b\u00b9 dry material) and reducing power, alongside strong antioxidant activity by ABTS and DPPH assays. The biological relevance of the optimized extract was evaluated using\n                    <jats:italic>Saccharomyces cerevisiae<\/jats:italic>\n                    wild-type and\n                    <jats:italic>erg6<\/jats:italic>\n                    \u0394 mutant strains as a cellular antioxidant model under menadione-induced oxidative stress. In the presence of the extract (500\u00a0mg L\u207b\u00b9), cell viability was maintained for up to 5\u00a0h in the wild-type strain and 3\u00a0h in the\n                    <jats:italic>erg6<\/jats:italic>\n                    \u0394 mutant, compared to approximately 1\u00a0h in untreated controls. The extract was subsequently stabilized by spray drying with arabic gum as carrier, yielding a powder with water activity of 0.213 and no significant loss of antioxidant composition or activity. These results establish mild aqueous extraction combined with spray drying as an effective strategy for producing a stable, vitamin C-rich green acerola powder with demonstrated cellular antioxidant activity, suitable for food ingredient applications.\n                  <\/jats:p>","DOI":"10.1007\/s11130-026-01536-7","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T06:17:02Z","timestamp":1783059422000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Green Acerola (Malpighia emarginata) Extraction Optimization, Cellular Antioxidant Activity, and Spray Drying: Toward a Stable Vitamin C-Rich Powder"],"prefix":"10.1007","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3994-3631","authenticated-orcid":false,"given":"Richtier G.","family":"Cruz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3737-3500","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Dupont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2757-2506","authenticated-orcid":false,"given":"Laurent","family":"Beney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0692-6237","authenticated-orcid":false,"given":"Simone P.","family":"Lira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2485-0240","authenticated-orcid":false,"given":"Thais Maria Ferreira de Souza","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"1536_CR1","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1042\/bj0260865","volume":"26","author":"J Svirbely","year":"1932","unstructured":"Svirbely J, Szent-Gy\u00f6rgyi A (1932) The chemical nature of vitamin C. 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No human participants, vertebrate animals, or clinical samples were involved. Therefore, ethical approval was not required.","order":1,"name":"Ethics","label":"Ethics Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"90"}}