{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:59:20Z","timestamp":1790600360983,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2023B03J1316"],"award-info":[{"award-number":["2023B03J1316"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Plant Foods Hum Nutr"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s11130-026-01547-4","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:49:38Z","timestamp":1785214178000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of In Vitro Static Digestion and Fermentation on Phenolic Profiles and Antioxidant Activity of Pitaya (Selenicereus undatus) Flower Tea"],"prefix":"10.1007","volume":"81","author":[{"given":"Jingsen","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caifeng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5688-6766","authenticated-orcid":false,"given":"Xinbo","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"1547_CR1","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s11130-013-0391-8","volume":"68","author":"L Garc\u00eda-Cruz","year":"2013","unstructured":"Garc\u00eda-Cruz L, Valle-Guadarrama S, Salinas-Moreno Y et al (2013) Physical, chemical, and antioxidant activity characterization of pitaya (Stenocereus pruinosus) fruits. Plant Foods Hum Nutr 68:403\u2013410. https:\/\/doi.org\/10.1007\/s11130-013-0391-8","journal-title":"Plant Foods Hum Nutr"},{"key":"1547_CR2","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/s11130-026-01507-y","volume":"81","author":"KZ Lodi","year":"2026","unstructured":"Lodi KZ, Rotini ACFL, Richetti B et al (2026) Valorization of pitaya (Selenicereus monacanthus) peels: proof of concept for food formulation. Plant Foods Hum Nutr 81:58. https:\/\/doi.org\/10.1007\/s11130-026-01507-y","journal-title":"Plant Foods Hum Nutr"},{"key":"1547_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13080956","volume":"13","author":"CF Shi","year":"2024","unstructured":"Shi CF, Long HQ, Hu J et al (2024) Comparative study of flavonoid profiles, antioxidant, and antiproliferative activities in hot-air and vacuum drying of different parts of pitaya (Hylocereus undatus Britt) flowers. Antioxidants (Basel) 13:956. https:\/\/doi.org\/10.3390\/antiox13080956","journal-title":"Antioxidants (Basel)"},{"key":"1547_CR4","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1007\/s11101-023-09891-y","volume":"24","author":"APG da Silva","year":"2025","unstructured":"da Silva APG, Sganzerla WG, John OD et al (2025) A comprehensive review of the classification, sources, biosynthesis, and biological properties of hydroxybenzoic and hydroxycinnamic acids. Phytochem Rev 24:1061\u20131090. https:\/\/doi.org\/10.1007\/s11101-023-09891-y","journal-title":"Phytochem Rev"},{"key":"1547_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043813","volume":"24","author":"T Lippolis","year":"2023","unstructured":"Lippolis T, Cofano M, Caponio GR et al (2023) Bioaccessibility and bioavailability of diet polyphenols and their modulation of gut microbiota. Int J Mol Sci 24:3813. https:\/\/doi.org\/10.3390\/ijms24043813","journal-title":"Int J Mol Sci"},{"key":"1547_CR6","doi-asserted-by":"publisher","first-page":"28805","DOI":"10.1038\/s41598-025-13104-1","volume":"15","author":"S Lachowicz-Wisniewska","year":"2025","unstructured":"Lachowicz-Wisniewska S, Swieca M, Kapusta I et al (2025) Comparative assessment of polyphenol stability, bioactivity, and digestive availability in purified compounds and fruit extracts from four black chokeberry cultivars. Sci Rep 15:28805. https:\/\/doi.org\/10.1038\/s41598-025-13104-1","journal-title":"Sci Rep"},{"key":"1547_CR7","doi-asserted-by":"publisher","first-page":"5752","DOI":"10.1039\/d2fo00469k","volume":"13","author":"S Zhang","year":"2022","unstructured":"Zhang S, Deng N, Zheng BS et al (2022) The effect of in vitro gastrointestinal digestion on the phenolic profiles, bioactivities and bioaccessibility of Rhodiola. Food Funct 13:5752\u20135765. https:\/\/doi.org\/10.1039\/d2fo00469k","journal-title":"Food Funct"},{"key":"1547_CR8","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1039\/c3fo60702j","volume":"5","author":"M Minekus","year":"2014","unstructured":"Minekus M, Alminger M, Alvito P et al (2014) A standardised static in vitro digestion method suitable for food: an international consensus. Food Funct 5:1113\u20131124. https:\/\/doi.org\/10.1039\/c3fo60702j","journal-title":"Food Funct"},{"key":"1547_CR9","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1038\/s41596-018-0119-1","volume":"14","author":"A Brodkorb","year":"2019","unstructured":"Brodkorb A, Egger L, Alminger M et al (2019) INFOGEST static in vitro simulation of gastrointestinal food digestion. Nat Protoc 14:991\u20131014. https:\/\/doi.org\/10.1038\/s41596-018-0119-1","journal-title":"Nat Protoc"},{"key":"1547_CR10","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/BF00756522","volume":"11","author":"V Meunier","year":"1995","unstructured":"Meunier V, Bourrie M, Berger Y et al (1995) The human intestinal epithelial cell line Caco-2; pharmacological and pharmacokinetic applications. Cell Biol Toxicol 11:187\u2013194. https:\/\/doi.org\/10.1007\/BF00756522","journal-title":"Cell Biol Toxicol"},{"key":"1547_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/foods14132253","volume":"14","author":"E Elejalde","year":"2025","unstructured":"Elejalde E, Alonso RM, Villar\u00e1n MC et al (2025) Exploring the bioavailability of red grape skin extract polyphenols: a Caco-2 cell model study. Foods 14:2253. https:\/\/doi.org\/10.3390\/foods14132253","journal-title":"Foods"},{"key":"1547_CR12","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1038\/nprot.2007.303","volume":"2","author":"I Hubatsch","year":"2007","unstructured":"Hubatsch I, Ragnarsson EGE, Artursson P (2007) Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers. Nat Protoc 2:2111\u20132119. https:\/\/doi.org\/10.1038\/nprot.2007.303","journal-title":"Nat Protoc"},{"key":"1547_CR13","doi-asserted-by":"publisher","first-page":"144","DOI":"10.5344\/ajev.1965.16.3.144","volume":"16","author":"VL Singleton","year":"1965","unstructured":"Singleton VL, Rossi JA (1965) Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enol Vitic 16:144\u2013158. https:\/\/doi.org\/10.5344\/ajev.1965.16.3.144","journal-title":"Am J Enol Vitic"},{"key":"1547_CR14","doi-asserted-by":"publisher","first-page":"4619","DOI":"10.1021\/jf010586o","volume":"49","author":"B Ou","year":"2001","unstructured":"Ou B, Hampsch-Woodill M, Prior RL (2001) Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe. J Agric Food Chem 49:4619\u20134626. https:\/\/doi.org\/10.1021\/jf010586o","journal-title":"J Agric Food Chem"},{"key":"1547_CR15","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.foodchem.2013.09.071","volume":"146","author":"HZ Huang","year":"2014","unstructured":"Huang HZ, Sun YJ, Lou ST et al (2014) In vitro digestion combined with cellular assay to determine the antioxidant activity in Chinese bayberry (Myrica rubra Sieb. et Zucc.) fruits: a comparison with traditional methods. Food Chem 146:363\u2013370. https:\/\/doi.org\/10.1016\/j.foodchem.2013.09.071","journal-title":"Food Chem"},{"key":"1547_CR16","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1111\/j.1365-2621.2010.02254.x","volume":"45","author":"L Ryan","year":"2010","unstructured":"Ryan L, Prescott SL (2010) Stability of the antioxidant capacity of twenty-five commercially available fruit juices subjected to an in vitro digestion. Int J Food Sci Technol 45:1191\u20131197. https:\/\/doi.org\/10.1111\/j.1365-2621.2010.02254.x","journal-title":"Int J Food Sci Technol"},{"key":"1547_CR17","doi-asserted-by":"publisher","first-page":"8317","DOI":"10.1021\/acs.jafc.3c01087","volume":"71","author":"MY Wang","year":"2023","unstructured":"Wang MY, Lu YL, Wu QF et al (2023) Biotransformation and gut microbiota-mediated bioactivity of flavonols. J Agric Food Chem 71:8317\u20138331. https:\/\/doi.org\/10.1021\/acs.jafc.3c01087","journal-title":"J Agric Food Chem"},{"key":"1547_CR18","doi-asserted-by":"publisher","first-page":"956378","DOI":"10.3389\/fmicb.2022.956378","volume":"13","author":"Y Zhao","year":"2022","unstructured":"Zhao Y, Cheng J, Wang C et al (2022) Potential roles of gut microbes in biotransformation of natural products: an overview. Front Microbiol 13:956378. https:\/\/doi.org\/10.3389\/fmicb.2022.956378","journal-title":"Front Microbiol"},{"key":"1547_CR19","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1021\/jf405261a","volume":"62","author":"LY Du","year":"2014","unstructured":"Du LY, Zhao M, Xu J et al (2014) Analysis of the metabolites of isorhamnetin 3-O-glucoside produced by human intestinal flora in vitro by applying ultraperformance liquid chromatography\/quadrupole time-of-flight mass spectrometry. J Agric Food Chem 62:2489\u20132495. https:\/\/doi.org\/10.1021\/jf405261a","journal-title":"J Agric Food Chem"},{"key":"1547_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/foods11193108","volume":"11","author":"CM Xu","year":"2022","unstructured":"Xu CM, Kong LQ, Tian Y (2022) Investigation of the phenolic component bioavailability using the in vitro digestion\/Caco-2 cell model, as well as the antioxidant activity in Chinese red wine. Foods 11:3108. https:\/\/doi.org\/10.3390\/foods11193108","journal-title":"Foods"},{"key":"1547_CR21","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1002\/cem.695","volume":"16","author":"J Trygg","year":"2002","unstructured":"Trygg J, Wold S (2002) Orthogonal projections to latent structures (O-PLS). J Chemom 16:119\u2013128. https:\/\/doi.org\/10.1002\/cem.695","journal-title":"J Chemom"},{"key":"1547_CR22","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S (2000) KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28:27\u201330. https:\/\/doi.org\/10.1093\/nar\/28.1.27","journal-title":"Nucleic Acids Res"},{"key":"1547_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9050451","volume":"9","author":"N Tena","year":"2020","unstructured":"Tena N, Mart\u00edn J, Asuero AG (2020) State of the art of anthocyanins: antioxidant activity, sources, bioavailability, and therapeutic effect in human health. Antioxidants (Basel) 9:451. https:\/\/doi.org\/10.3390\/antiox9050451","journal-title":"Antioxidants (Basel)"},{"key":"1547_CR24","doi-asserted-by":"publisher","first-page":"7364","DOI":"10.1021\/jf061889r","volume":"54","author":"JP Suomela","year":"2006","unstructured":"Suomela JP, Ahotupa M, Yang B et al (2006) Absorption of flavonols derived from sea buckthorn (Hippophae rhamnoides L.) and their effect on emerging risk factors for cardiovascular disease in humans. J Agric Food Chem 54:7364\u20137369. https:\/\/doi.org\/10.1021\/jf061889r","journal-title":"J Agric Food Chem"},{"key":"1547_CR25","doi-asserted-by":"publisher","first-page":"4313","DOI":"10.1021\/jf980117v","volume":"46","author":"MK Piskula","year":"1998","unstructured":"Piskula MK, Terao J (1998) Quercetin\u2019s solubility affects its accumulation in rat plasma after oral administration. J Agric Food Chem 46:4313\u20134317. https:\/\/doi.org\/10.1021\/jf980117v","journal-title":"J Agric Food Chem"},{"key":"1547_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29215102","volume":"29","author":"Y Kiriyama","year":"2024","unstructured":"Kiriyama Y, Tokumaru H, Sadamoto H et al (2024) Effects of phenolic acids produced from food-derived flavonoids and amino acids by the gut microbiota on health and disease. Molecules 29:5102. https:\/\/doi.org\/10.3390\/molecules29215102","journal-title":"Molecules"},{"key":"1547_CR27","doi-asserted-by":"publisher","first-page":"18129","DOI":"10.3390\/molecules191118129","volume":"19","author":"XW Wu","year":"2014","unstructured":"Wu XW, Wang RF, Liu LJ et al (2014) Absorbability, mechanism and structure-property relationship of three phenolic acids from the flowers of Trollius chinensis. Molecules 19:18129\u201318138. https:\/\/doi.org\/10.3390\/molecules191118129","journal-title":"Molecules"}],"container-title":["Plant Foods for Human Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11130-026-01547-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11130-026-01547-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11130-026-01547-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:13:23Z","timestamp":1790597603000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11130-026-01547-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["1547"],"URL":"https:\/\/doi.org\/10.1007\/s11130-026-01547-4","relation":{},"ISSN":["0921-9668","1573-9104"],"issn-type":[{"value":"0921-9668","type":"print"},{"value":"1573-9104","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]},"assertion":[{"value":"30 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"101"}}