{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:09:23Z","timestamp":1792076963966,"version":"4.4.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2007,12,11]],"date-time":"2007-12-11T00:00:00Z","timestamp":1197331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Qual Life Res"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1007\/s11136-007-9284-3","type":"journal-article","created":{"date-parts":[[2007,12,10]],"date-time":"2007-12-10T07:56:14Z","timestamp":1197273374000},"page":"61-73","source":"Crossref","is-referenced-by-count":19,"title":["Handling missing quality of life data in HIV clinical trials: what is practical?"],"prefix":"10.1007","volume":"17","author":[{"given":"Diane L.","family":"Fairclough","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Thijs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Chan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik W.","family":"Finnern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert W.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,12,11]]},"reference":[{"issue":"1","key":"9284_CR1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1086\/505147","volume":"194","author":"R. P. Walensky","year":"2006","unstructured":"Walensky, R. P., Paltiel, A. D., Losina, E., Mercincavage, L. M., Schackman, B. R., Sax, P. E., Weinstein, M. C., & Freedberg, K. A. (2006) The survival benefits of AIDS treatment in the United States. The Journal of Infectious Diseases, 194(1), 11\u201319.","journal-title":"The Journal of Infectious Diseases"},{"issue":"9","key":"9284_CR2","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1089\/apc.2005.19.563","volume":"19","author":"P. E. Sax","year":"2005","unstructured":"Sax, P. E., Gathe, J. C. Jr. (2005). Beyond efficacy: The impact of combination antiretroviral therapy on quality of life. AIDS Patient Care STDS, 19(9), 563\u2013576.","journal-title":"AIDS Patient Care STDS"},{"issue":"12","key":"9284_CR3","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1097\/00002030-199812000-00012","volume":"12","author":"C. Cohen","year":"1998","unstructured":"Cohen, C., Revicki, D. A., Nabulsi, A., Sarocco, P. W., & Jiang, P. (1998). A randomized trial of the effect of ritonavir in maintaining quality of life in advanced HIV disease. Advanced HIV Disease Ritonavir Study Group. AIDS, 12(12), 1495\u20131502.","journal-title":"AIDS"},{"key":"9284_CR4","volume-title":"Statistical analysis with missing data","author":"R. J. A. Little","year":"1987","unstructured":"Little, R. J. A., & Rubin, D. B. (1987). Statistical analysis with missing data. New York: John Wiley & Sons."},{"issue":"1","key":"9284_CR5","first-page":"1","volume":"22","author":"G. W. Donaldson","year":"2005","unstructured":"Donaldson, G. W., & Moinpour, C. M. (2005). Learning to live with missing quality-of-life data in advanced-stage disease trials. Journal of Clinical Oncology, 22(1), 1\u20135.","journal-title":"Journal of Clinical Oncology"},{"key":"9284_CR6","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/(SICI)1097-0258(19980315\/15)17:5\/7<781::AID-SIM821>3.0.CO;2-O","volume":"17","author":"D. L. Fairclough","year":"1998","unstructured":"Fairclough, D. L. et\u00a0al. (1998). Comparison of several model-based methods for analysing incomplete quality of life data in cancer clinical trials. Statistics in Medicine, 17, 781\u201396.","journal-title":"Statistics in Medicine"},{"key":"9284_CR7","doi-asserted-by":"crossref","DOI":"10.1201\/9781420035438","volume-title":"Design and analysis of quality of life studies in clinical trials","author":"D. L. Fairclough","year":"2002","unstructured":"Fairclough, D. L. (2002). Design and analysis of quality of life studies in clinical trials. Boca Raton, Florida: Chapman & Hall\/CRC."},{"key":"9284_CR8","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1191\/0962280204sm357ra","volume":"13","author":"D. L. Fairclough","year":"2004","unstructured":"Fairclough, D. L. (2004). Patient reported outcomes as endpoints in medical research. Statistical Methods in Medical Research, 13, 115\u2013138.","journal-title":"Statistical Methods in Medical Research"},{"key":"9284_CR9","first-page":"5862","volume":"71","author":"FDA","year":"2006","unstructured":"FDA. (2006). Draft guidance for industry on patient-reported outcome measures: use in medicinal product development to support labeling claims. Federal Register, 71, 5862\u20135863.","journal-title":"Federal Register"},{"key":"9284_CR10","doi-asserted-by":"crossref","unstructured":"Mallinckrodt, C. H., Christopher, J. Kaiser, C. J., Watkin, J. G., Detke, M. J., Molenberghs, G., & Carroll, R. J. (2004). Type I error rates from likelihood-based repeated measures analyses of incomplete longitudinal data. Pharmaceutical Statistics, 3, 171\u2013186.","DOI":"10.1002\/pst.131"},{"issue":"2","key":"9284_CR11","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1037\/1082-989X.7.2.147","volume":"7","author":"J. L. Schafer","year":"2002","unstructured":"Schafer, J. L., & Graham, J. W. (2002). Missing data: our view of the state of the art. Psychological Methods, 7(2), 147\u2013177.","journal-title":"Psychological Methods"},{"issue":"1","key":"9284_CR12","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1097\/01.qai.0000133054.43198.dc","volume":"37","author":"C. J. Cohen","year":"2004","unstructured":"Cohen, C. J., Clumeck, N., Molina, J. M., Thompson, M., Patel, K., Wintfeld, N., & Green, J. (2004). Health-related quality of life with enfuvirtide (ENF; T-20) in combination with an optimized background regimen. Journal of Acquired Immune Deficiency Syndromes, 37(1), 1140\u20131146.","journal-title":"Journal of Acquired Immune Deficiency Syndromes"},{"issue":"1","key":"9284_CR13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/135965359900400105","volume":"4","author":"D. A. Revicki","year":"1999","unstructured":"Revicki, D. A., Swartz, C., Wu, A. W., Haubrich, R., & Collier, A. C. (1999). Quality of life outcomes of saquinavir, zalcitabine and combination saquinavir plus zalcitabine therapy for adults with advanced HIV infection with CD4 counts between 50 and 300 cells\/mm3. Antiviral Therapy, 4(1), 35\u201344.","journal-title":"Antiviral Therapy"},{"key":"9284_CR14","doi-asserted-by":"crossref","unstructured":"van Leth, F., Conway, B., Laplume, H., Martin, D., Fisher, M., Jelaska, A., Wit, F. W., Lange, J. M. & 2NN study group. (2004). Quality of life in patients treated with first-line antiretroviral therapy containing nevirapine and\/or efavirenz. Antiviral Therapy, 9(5), 721\u2013728.","DOI":"10.1177\/135965350400900512"},{"key":"9284_CR15","doi-asserted-by":"crossref","unstructured":"Casado, A., Badia, X., Consiglio, E., Ferrer, E., Gonzalez, A., Pedrol, E., Gatell, J. M., Azuaje, C., Llibre, J. M., Aranda, M., Barrufet, P., Martinez-Lacasa, J., Podzamczer, D., & COMBINE Study Team. (2004). Health-related quality of life in HIV-infected naive patients treated with nelfinavir or nevirapine associated with ZDV\/3TC (the COMBINE-QoL substudy). HIV Clinical Trials, 5(3), 132\u2013139.","DOI":"10.1310\/EACX-1RFX-41R5-VH45"},{"key":"9284_CR16","doi-asserted-by":"crossref","unstructured":"Badia, X., Podzamczer, D., Moral, I., Roset, M., Arnaiz, J. A., Lonca, M., Casiro, A., Roson, B., Gatell, J. M., & BestQol Study Group. (2004). Health-related quality of life in HIV patients switching to twice-daily indinavir\/ritonavir regimen or continuing with three-times-daily indinavir-based therapy. Antiviral Therapy, 9(6), 979\u2013985.","DOI":"10.1177\/135965350400900615"},{"key":"9284_CR17","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0140-6736(06)69154-X","volume":"36","author":"C. B. Hicks","year":"2006","unstructured":"Hicks, C. B., Cahn, P., Cooper, D. A. et\u00a0al. (2006). Durable efficacy of tipranavir-ritonavir in combination with an optimised background regimen of antiretroviral drugs for treatment-experienced HIV-1-infected patients at 48\u00a0weeks in the randomized evaluation of strategic intervention in multi-drug reSistant patients with tipranavir (RESIST) studies: An analysis of combined data from two randomised open-label trials. Lancet, 36, 466\u2013475.","journal-title":"Lancet"},{"key":"9284_CR18","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/00005650-199802000-00003","volume":"38","author":"D. A. Revicki","year":"1998","unstructured":"Revicki, D. A., Sorensen, S., & Wu, A. W. (1998). Reliability and validity of physical and mental health summary scores from the Medical Outcomes Study HIV Health Survey. Medical Care, 38, 126\u2013137.","journal-title":"Medical Care"},{"key":"9284_CR19","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1023\/A:1018451930750","volume":"6","author":"A. W. Wu","year":"1997","unstructured":"Wu, A. W., Revicki, D. A., Jacobson, D., & Malitz, F. E. (1997). Evidence for reliability, validity and usefulness of the Medical Outcomes Study HIV Health Survey (MOS-HIV). Quality of Life Research, 6, 481\u2013493.","journal-title":"Quality of Life Research"},{"key":"9284_CR20","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1002\/sim.4780111603","volume":"11","author":"A. Heyting","year":"1992","unstructured":"Heyting, A., Tolboom, J., & Essers, J. (1992). Statistical handling of dropouts in longitudinal clinical trials. Statistics in Medicine, 11, 2043\u20132061.","journal-title":"Statistics in Medicine"},{"key":"9284_CR21","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1002\/sim.4780141707","volume":"14","author":"P. W. Lavori","year":"1995","unstructured":"Lavori, P. W., Dawson, R., & Shera, D. (1995). A multiple imputation strategy for clinical trials with truncation of patient data. Statistics in Medicine, 14, 1913\u20131925.","journal-title":"Statistics in Medicine"},{"key":"9284_CR22","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1081\/BIP-120019265","volume":"13","author":"C. H. Mallinckrodt","year":"2003","unstructured":"Mallinckrodt, C. H., Clairk, W. S., Carroll, R. J., & Molenberghs, G. (2003a). Assessing response profiles from incomplete longitudinal clinical trial data under regulatory considerations. Journal of Biopharmaceutical Statistics, 13, 179\u2013190.","journal-title":"Journal of Biopharmaceutical Statistics"},{"key":"9284_CR23","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/S0006-3223(02)01867-X","volume":"53","author":"C. H. Mallinckrodt","year":"2003","unstructured":"Mallinckrodt, C. H., Sanger, T. M., Dube, S., Debrota, D. J., Molenberghs, G., Carroll, R. J., Zeigler Potter, W. M., & Tollefson, G. D. (2003b). Assessing and interpreting treatment effects in longitudinal clinical trials with missing data. Biological Psychiatry, 53, 754\u2013760.","journal-title":"Biological Psychiatry"},{"key":"9284_CR24","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1080\/10543409808835259","volume":"8","author":"O. Siddiqui","year":"1998","unstructured":"Siddiqui, O., & Ali, M. W. (1998). A comparison of the random-effects pattern mixture model with last observation carried forward (LOCF) analysis in longitudinal clinical trials with dropouts, Journal of Biopharmaceutical Statistics, 8, 545\u2013563.","journal-title":"Journal of Biopharmaceutical Statistics"},{"key":"9284_CR25","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2307\/2529876","volume":"38","author":"N. M. Laird","year":"1982","unstructured":"Laird, N. M., & Ware, J. H. (1982). Random effects models for longitudinal data. Biometrics, 38, 963\u2013974.","journal-title":"Biometrics"},{"key":"9284_CR26","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1002\/sim.4780111408","volume":"11","author":"M. D. Schluchter","year":"1992","unstructured":"Schluchter, M. D. (1992). Methods for the analysis of informatively censored longitudinal data. Statistics in Medicine, 11, 1861\u20131870.","journal-title":"Statistics in Medicine"},{"issue":"4","key":"9284_CR27","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.2307\/2533439","volume":"50","author":"V. DeGruttola","year":"1994","unstructured":"DeGruttola, V., & Tu, X. M. (1994). Modeling progression of CD4-lymphocyte count and its relationship to survival time. Biometrics, 50(4), 1003\u20131014.","journal-title":"Biometrics"},{"key":"9284_CR28","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/biomet\/63.3.581","volume":"63","author":"D. B. Rubin","year":"1976","unstructured":"Rubin, D. B. (1976). Inference and missing data. Biometrika, 63, 581\u2013592.","journal-title":"Biometrika"},{"key":"9284_CR29","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1080\/01621459.1986.10478280","volume":"81","author":"D. B. Rubin","year":"1986","unstructured":"Rubin, D. B., & Schenker, N. (1986). Multiple imputation for interval estimation from simple random samples with ignorable nonresponse. Journal of the American Statistical Association, 81, 366\u2013374.","journal-title":"Journal of the American Statistical Association"},{"key":"9284_CR30","doi-asserted-by":"crossref","DOI":"10.1201\/9781439821862","volume-title":"Analysis of incomplete multivariate data","author":"J. L. Schafer","year":"1997","unstructured":"Schafer, J. L. (1997). Analysis of incomplete multivariate data. Chapman and Hall, London."},{"key":"9284_CR31","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1080\/01621459.1987.10478458","volume":"82","author":"M. A. Tanner","year":"1987","unstructured":"Tanner, M. A., & Wong, W. H. (1987). The calculation of posterior distributions by data augmentation (with discussion). Journal of the American Statistical Association, 82, 528\u2013550.","journal-title":"Journal of the American Statistical Association"},{"key":"9284_CR32","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/biostatistics\/3.2.245","volume":"3","author":"H. Thijs","year":"2002","unstructured":"Thijs, H., Molenberghs, G., Michiels, B., Verbeke, G., & Curran, D. (2002). Strategies to fit pattern-mixture models, Biostatistics, 3, 245\u2013265.","journal-title":"Biostatistics"},{"key":"9284_CR33","unstructured":"Dempster, A. P., & Rubin, D. B. (1983). Overview. In W. G. Madow, I. Olkin, & D. B. Rubin (Eds.), Incomplete data in sample surveys (Vol. II). Theory and annotated bibliography. New York: Academic Press (pp. 3\u201310)."},{"key":"9284_CR34","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/sim.2249","volume":"25","author":"E. F. Vonesh","year":"2006","unstructured":"Vonesh, E. F., Green, T., & Schluchter, M. D. (2006) Shared parameter models for the joint analysis of longitudinal data and event times. Statistics in Medicine, 25, 143\u2013163.","journal-title":"Statistics in Medicine"},{"key":"9284_CR35","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1198\/0003130042854","volume":"58","author":"X. Guo","year":"2004","unstructured":"Guo, X., Carlin, B. P. (2004). Separate and joint modeling of longitudinal and event time data using standard computer packages. The American Statistician, 58, 16\u201324.","journal-title":"The American Statistician"}],"container-title":["Quality of Life Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11136-007-9284-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11136-007-9284-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11136-007-9284-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T06:44:14Z","timestamp":1684133054000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11136-007-9284-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,11]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["9284"],"URL":"https:\/\/doi.org\/10.1007\/s11136-007-9284-3","relation":{},"ISSN":["0962-9343","1573-2649"],"issn-type":[{"value":"0962-9343","type":"print"},{"value":"1573-2649","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,11]]}}}