{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T04:37:49Z","timestamp":1771043869724,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T00:00:00Z","timestamp":1482278400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100015661","name":"UCB Pharma","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015661","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Qual Life Res"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1007\/s11136-016-1483-3","type":"journal-article","created":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T07:26:39Z","timestamp":1482305199000},"page":"749-759","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Sensitivity and responsiveness of the EQ-5D-3L in patients with uncontrolled focal seizures: an analysis of Phase III trials of adjunctive brivaracetam"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4318-1481","authenticated-orcid":false,"given":"Clara","family":"Mukuria","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracey","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anju","family":"Keetharuth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Borghs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Brazier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,12,21]]},"reference":[{"issue":"4","key":"1483_CR1","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.0013-9580.2005.66104.x","volume":"46","author":"RS Fisher","year":"2005","unstructured":"Fisher, R. S., van Emde, B. W., Blume, W., Elger, C., Genton, P., Lee, P., et al. (2005). Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia, 46(4), 470\u2013472.","journal-title":"Epilepsia"},{"issue":"4","key":"1483_CR2","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.yebeh.2007.11.013","volume":"12","author":"A Jacoby","year":"2008","unstructured":"Jacoby, A., & Baker, G. A. (2008). Quality-of-life trajectories in epilepsy: A review of the literature. Epilepsy & Behavior, 12(4), 557\u2013571. doi: 10.1016\/j.yebeh.2007.11.013 .","journal-title":"Epilepsy & Behavior"},{"issue":"1","key":"1483_CR3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1528-1157.1997.tb01075.x","volume":"38","author":"OC Cockerell","year":"1997","unstructured":"Cockerell, O. C., Johnson, A. L., Sander, J. W., & Shorvon, S. D. (1997). Prognosis of epilepsy: A review and further analysis of the first nine years of the British National General Practice Study of Epilepsy, a prospective population-based study. Epilepsia, 38(1), 31\u201346.","journal-title":"Epilepsia"},{"issue":"5","key":"1483_CR4","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1056\/NEJM200002033420503","volume":"342","author":"P Kwan","year":"2000","unstructured":"Kwan, P., & Brodie, M. J. (2000). Early identification of refractory epilepsy. New England Journal of Medicine, 342(5), 314\u2013319.","journal-title":"New England Journal of Medicine"},{"key":"1483_CR5","volume-title":"Guide to the methods of technology appraisal 2013. Process and methods guides","author":"NICE","year":"2013","unstructured":"NICE. (2013). Guide to the methods of technology appraisal 2013. Process and methods guides (Vol. 2016). London: NICE."},{"issue":"3","key":"1483_CR6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0168-8510(90)90421-9","volume":"16","author":"Group TE","year":"1990","unstructured":"Group TE. (1990). EuroQol\u2014A new facility for the measurement of health-related quality of life. Health Policy, 16(3), 199\u2013208.","journal-title":"Health Policy"},{"issue":"2","key":"1483_CR7","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0167-6296(01)00130-8","volume":"21","author":"J Brazier","year":"2002","unstructured":"Brazier, J., Roberts, J., & Deverill, M. (2002). The estimation of a preference-based measure of health from the SF-36. Journal of Health Economics, 21(2), 271\u2013292.","journal-title":"Journal of Health Economics"},{"issue":"1","key":"1483_CR8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1528-1157.1998.tb01278.x","volume":"39","author":"JA Cramer","year":"1998","unstructured":"Cramer, J. A., Perrine, K., Devinsky, O., Bryant-Comstock, L., Meador, K., & Hermann, B. (1998). Development and cross-cultural translations of a 31-item quality of life in epilepsy inventory. Epilepsia, 39(1), 81\u201388.","journal-title":"Epilepsia"},{"issue":"1","key":"1483_CR9","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.jval.2012.10.010","volume":"16","author":"L Longworth","year":"2013","unstructured":"Longworth, L., & Rowen, D. (2013). Mapping to obtain EQ-5D utility values for use in NICE health technology assessments. Value in health: The Journal of the International Society for Pharmacoeconomics and Outcomes Research, 16(1), 202\u2013210. doi: 10.1016\/j.jval.2012.10.010 .","journal-title":"Value in health: The Journal of the International Society for Pharmacoeconomics and Outcomes Research"},{"issue":"5","key":"1483_CR10","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1007\/s11136-005-5231-3","volume":"15","author":"JT Langfitt","year":"2006","unstructured":"Langfitt, J. T., Vickrey, B. G., McDermott, M. P., Messing, S., Berg, A. T., Spencer, S. S., et al. (2006). Validity and responsiveness of generic preference-based HRQOL instruments in chronic epilepsy. Quality of Life Research, 15(5), 899\u2013914. doi: 10.1007\/s11136-005-5231-3 .","journal-title":"Quality of Life Research"},{"issue":"1","key":"1483_CR11","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/epi.12432","volume":"55","author":"P Ryvlin","year":"2014","unstructured":"Ryvlin, P., Werhahn, K. J., Blaszczyk, B., Johnson, M. E., & Lu, S. (2014). Adjunctive brivaracetam in adults with uncontrolled focal epilepsy: Results from a double-blind, randomized, placebo-controlled trial. Epilepsia, 55(1), 47\u201356. doi: 10.1111\/epi.12432 .","journal-title":"Epilepsia"},{"issue":"1","key":"1483_CR12","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/epi.12433","volume":"55","author":"V Biton","year":"2014","unstructured":"Biton, V., Berkovic, S. F., Abou-Khalil, B., Sperling, M. R., Johnson, M. E., & Lu, S. (2014). Brivaracetam as adjunctive treatment for uncontrolled partial epilepsy in adults: A phase III randomized, double-blind, placebo-controlled trial. Epilepsia, 55(1), 57\u201366. doi: 10.1111\/epi.12433 .","journal-title":"Epilepsia"},{"issue":"1","key":"1483_CR13","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/epi.12391","volume":"55","author":"P Kwan","year":"2014","unstructured":"Kwan, P., Trinka, E., van Paesschen, W., Rektor, I., Johnson, M. E., & Lu, S. (2014). Adjunctive brivaracetam for uncontrolled focal and generalized epilepsies: Results of a phase III, double-blind, randomized, placebo-controlled, flexible-dose trial. Epilepsia, 55(1), 38\u201346. doi: 10.1111\/epi.12391 .","journal-title":"Epilepsia"},{"issue":"11","key":"1483_CR14","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/00005650-199711000-00002","volume":"35","author":"P Dolan","year":"1997","unstructured":"Dolan, P. (1997). Modeling valuations for EuroQol health states. Medical Care, 35(11), 1095\u20131108.","journal-title":"Medical Care"},{"key":"1483_CR15","unstructured":"Vickrey, B. G., Perrine, K. R., Hays, R. D., Hermann, B. P., Cramer, J. A., Meador, K. J., Devinsky, O. (1993). Quality of Life in Epilepsy QOLIE-31 (version 1.0): Scoring manual. http:\/\/www.rand.org\/content\/dam\/rand\/www\/external\/health\/surveys_tools\/qolie\/qolie31_scoring.pdf . Accessed December 22, 2015."},{"key":"1483_CR16","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1528-1157.1981.tb06159.x","volume":"22","author":"International League Against Epilepsy","year":"1981","unstructured":"International League Against Epilepsy. (1981). Proposal for revised clinical and electroencephalographic classification of epileptic seizures. From the Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia, 22, 489\u2013501.","journal-title":"Epilepsia"},{"issue":"1","key":"1483_CR17","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","volume":"112","author":"J Cohen","year":"1992","unstructured":"Cohen, J. (1992). A power primer. Psychological Bulletin, 112(1), 155\u2013159.","journal-title":"Psychological Bulletin"},{"key":"1483_CR18","doi-asserted-by":"publisher","unstructured":"Fox-Rushby, J., Selai, C. (2003). What concepts does the EQ-5D measure? Intentions and interpretations. The measurement and valuation of health status using EQ-5D: A European perspective. Evidence from the EuroQol BIOMED Research Programme, 1 edn. Springer. doi: 10.1007\/978-94-017-0233-1","DOI":"10.1007\/978-94-017-0233-1"},{"issue":"5","key":"1483_CR19","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1046\/j.1528-1157.2002.32201.x","volume":"43","author":"GL Birbeck","year":"2002","unstructured":"Birbeck, G. L., Hays, R. D., Cui, X., & Vickrey, B. G. (2002). Seizure reduction and quality of life improvements in people with epilepsy. Epilepsia, 43(5), 535\u2013538.","journal-title":"Epilepsia"},{"issue":"12","key":"1483_CR20","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.1111\/j.1528-1167.2011.03213.x","volume":"52","author":"RS Taylor","year":"2011","unstructured":"Taylor, R. S., Sander, J. W., Taylor, R. J., & Baker, G. A. (2011). Predictors of health-related quality of life and costs in adults with epilepsy: a systematic review. Epilepsia, 52(12), 2168\u20132180. doi: 10.1111\/j.1528-1167.2011.03213.x .","journal-title":"Epilepsia"},{"key":"1483_CR21","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.seizure.2015.07.001","volume":"31","author":"WW Zadeh","year":"2015","unstructured":"Zadeh, W. W., Escartin, A., Byrnes, W., Tennigkeit, F., Borghs, S., Li, T., et al. (2015). Efficacy and safety of lacosamide as first add-on or later adjunctive treatment for uncontrolled partial-onset seizures: A multicentre open-label trial. Seizure, 31, 72\u201379. doi: 10.1016\/j.seizure.2015.07.001 .","journal-title":"Seizure"},{"issue":"1\u20132","key":"1483_CR22","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.yebeh.2010.04.001","volume":"18","author":"E Ben-Menachem","year":"2010","unstructured":"Ben-Menachem, E., Sander, J. W., Privitera, M., & Gilliam, F. (2010). Measuring outcomes of treatment with antiepileptic drugs in clinical trials. Epilepsy & Behavior, 18(1\u20132), 24\u201330. doi: 10.1016\/j.yebeh.2010.04.001 .","journal-title":"Epilepsy & Behavior"},{"issue":"1","key":"1483_CR23","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.yebeh.2012.02.025","volume":"24","author":"B Mulhern","year":"2012","unstructured":"Mulhern, B., Rowen, D., Jacoby, A., Marson, T., Snape, D., Hughes, D., et al. (2012). The development of a QALY measure for epilepsy: NEWQOL-6D. Epilepsy & Behavior, 24(1), 36\u201343. doi: 10.1016\/j.yebeh.2012.02.025 .","journal-title":"Epilepsy & Behavior"},{"key":"1483_CR24","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.yebeh.2014.04.011","volume":"36","author":"B Mulhern","year":"2014","unstructured":"Mulhern, B., Rowen, D., Snape, D., Jacoby, A., Marson, T., Hughes, D., et al. (2014). Valuations of epilepsy-specific health states: A comparison of patients with epilepsy and the general population. Epilepsy & Behavior, 36, 12\u201317. doi: 10.1016\/j.yebeh.2014.04.011 .","journal-title":"Epilepsy & Behavior"},{"issue":"5","key":"1483_CR25","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1185\/030079905X43695","volume":"21","author":"CE Selai","year":"2005","unstructured":"Selai, C. E., Trimble, M. R., Price, M. J., & Remak, E. (2005). Evaluation of health status in epilepsy using the EQ-5D questionnaire: A prospective, observational, 6-month study of adjunctive therapy with anti-epileptic drugs. Current Medical Research and Opinion, 21(5), 733\u2013739. doi: 10.1185\/030079905X43695 .","journal-title":"Current Medical Research and Opinion"},{"issue":"2\u20133","key":"1483_CR26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0920-1211(01)00201-7","volume":"44","author":"K Stavem","year":"2001","unstructured":"Stavem, K., Bjornaes, H., & Lossius, M. I. (2001). Properties of the 15D and EQ-5D utility measures in a community sample of people with epilepsy. Epilepsy Research, 44(2\u20133), 179\u2013189.","journal-title":"Epilepsy Research"},{"issue":"8","key":"1483_CR27","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1111\/epi.12672","volume":"55","author":"H Choi","year":"2014","unstructured":"Choi, H., Hamberger, M. J., Munger Clary, H., Loeb, R., Onchiri, F. M., Baker, G., et al. (2014). Seizure frequency and patient-centered outcome assessment in epilepsy. Epilepsia, 55(8), 1205\u20131212. doi: 10.1111\/epi.12672 .","journal-title":"Epilepsia"}],"container-title":["Quality of Life Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11136-016-1483-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11136-016-1483-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11136-016-1483-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T11:57:41Z","timestamp":1589716661000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11136-016-1483-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,21]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["1483"],"URL":"https:\/\/doi.org\/10.1007\/s11136-016-1483-3","relation":{},"ISSN":["0962-9343","1573-2649"],"issn-type":[{"value":"0962-9343","type":"print"},{"value":"1573-2649","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,21]]}}}