{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T04:33:08Z","timestamp":1780893188950,"version":"3.54.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T00:00:00Z","timestamp":1540166400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004351","name":"Sultan Qaboos University","doi-asserted-by":"publisher","award":["IG\/MED\/HAEM\/14\/01"],"award-info":[{"award-number":["IG\/MED\/HAEM\/14\/01"]}],"id":[{"id":"10.13039\/501100004351","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Oman Research Council","award":["ORG\/HSS\/ 13\/002"],"award-info":[{"award-number":["ORG\/HSS\/ 13\/002"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Qual Life Res"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s11136-018-2031-0","type":"journal-article","created":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T06:54:02Z","timestamp":1540191242000},"page":"473-479","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hemoglobin F as a predictor of health-related quality of life in children with sickle cell anemia"],"prefix":"10.1007","volume":"28","author":[{"given":"Mohamed-Rachid","family":"Boulassel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Al-Badi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Elshinawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhaina","family":"Al-Hinai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muna","family":"Al-Saadoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Al-Qarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hammad","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rizwan Nabi","family":"Qureshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser","family":"Wali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,22]]},"reference":[{"issue":"10091","key":"2031_CR1","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/S0140-6736(17)30193-9","volume":"390","author":"RE Ware","year":"2017","unstructured":"Ware, R. E., de Montalembert, M., Tshilolo, L., & Abboud, M. R. (2017). Sickle cell disease. The Lancet, 390(10091), 311\u2013323.","journal-title":"The Lancet"},{"issue":"10","key":"2031_CR2","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1001\/jama.2014.10517","volume":"312","author":"BP Yawn","year":"2014","unstructured":"Yawn, B. P., Buchanan, G. R., Afenyi-Annan, A. N., Ballas, S. K., Hassell, K. L., James, A. H., et al. (2014). Management of sickle cell disease: Summary of the 2014 evidence-based report by expert panel members. Journal of the American Medical Association, 312(10), 1033\u20131048.","journal-title":"Journal of the American Medical Association"},{"issue":"6","key":"2031_CR3","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1111\/ejh.12103","volume":"90","author":"SW Sharef","year":"2013","unstructured":"Sharef, S. W., Al-Hajri, M., Beshlawi, I., Al-Shahrabally, A., Elshinawy, M., Zachariah, M., et al. (2013). Optimizing hydroxyurea use in children with sickle cell disease: Low dose regimen is effective. European Journal of Haematology, 90(6), 519\u2013524.","journal-title":"European Journal of Haematology"},{"key":"2031_CR4","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1182\/asheducation.V2012.1.284.3798319","volume":"2012","author":"JA Panepinto","year":"2012","unstructured":"Panepinto, J. A. (2012). Health-related quality of life in patients with hemoglobinopathies. Hematology. American Society of Hematology Education Program, 2012, 284\u2013289.","journal-title":"Hematology. American Society of Hematology Education Program"},{"issue":"2","key":"2031_CR5","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1097\/MPH.0000000000000177","volume":"37","author":"LM Beverung","year":"2015","unstructured":"Beverung, L. M., Varni, J. W., & Panepinto, J. A. (2015). Clinically meaningful interpretation of pediatric health-related quality of life in sickle cell disease. Journal of Pediatric Hematology\/Oncology, 37(2), 128\u2013133.","journal-title":"Journal of Pediatric Hematology\/Oncology"},{"issue":"1","key":"2031_CR6","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1590\/S0103-05822013000100005","volume":"31","author":"AS Menezes","year":"2013","unstructured":"Menezes, A. S., Len, C. A., Hil\u00e1rio, M. O., Terreri, M. T., & Braga, J. A. (2013). Quality of life in patients with sickle cell disease. Revista Paulista de Pediatria, 31(1), 24\u201329.","journal-title":"Revista Paulista de Pediatria"},{"issue":"2","key":"2031_CR7","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1002\/pbc.24176","volume":"59","author":"JA Panepinto","year":"2012","unstructured":"Panepinto, J. A., & Bonner, M. (2012). Health-related quality of life in sickle cell disease: Past, present, and future. Pediatric Blood & Cancer, 59(2), 377\u2013385.","journal-title":"Pediatric Blood & Cancer"},{"issue":"6","key":"2031_CR8","doi-asserted-by":"publisher","first-page":"e26369","DOI":"10.1002\/pbc.26369","volume":"64","author":"SM Badawy","year":"2017","unstructured":"Badawy, S. M., Thompson, A. A., Lai, J. S., Penedo, F. J., Rychlik, K., & Liem, R. I. (2017). Health-related quality of life and adherence to hydroxyurea in adolescents and young adults with sickle cell disease. Pediatric Blood & Cancer, 64(6), e26369.","journal-title":"Pediatric Blood & Cancer"},{"issue":"4","key":"2031_CR9","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1097\/MPH.0b013e3182114c54","volume":"33","author":"CD Thornburg","year":"2011","unstructured":"Thornburg, C. D., Calatroni, A., & Panepinto, J. A. (2011). Differences in health-related quality of life in children with sickle cell disease receiving hydroxyurea. Journal of Pediatric Hematology\/Oncology, 33(4), 251\u2013254.","journal-title":"Journal of Pediatric Hematology\/Oncology"},{"issue":"2","key":"2031_CR10","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1002\/ajh.23877","volume":"90","author":"LM Beverung","year":"2015","unstructured":"Beverung, L. M., Strouse, J. J., Hulbert, M. L., Neville, K., Liem, R. I., Inusa, B., et al. (2015). Health-related quality of life in children with sickle cell anemia: Impact of blood transfusion therapy. American Journal of Hematology, 90(2), 139\u2013143.","journal-title":"American Journal of Hematology"},{"issue":"4","key":"2031_CR11","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.bbmt.2014.12.007","volume":"21","author":"M Bhatia","year":"2015","unstructured":"Bhatia, M., Kolva, E., Cimini, L., Jin, Z., Satwani, P., Savone, M., et al. (2015). Health-related quality of life after allogeneic hematopoietic stem cell transplantation for sickle cell disease. Biology of Blood and Marrow Transplantation, 21(4), 666\u2013672.","journal-title":"Biology of Blood and Marrow Transplantation"},{"issue":"4","key":"2031_CR12","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1093\/jpepsy\/jsx120","volume":"43","author":"AM Psihogios","year":"2018","unstructured":"Psihogios, A. M., Daniel, L. C., Tarazi, R., Smith-Whitley, K., Patterson, C. A., & Barakat, L. P. (2018). Family functioning, medical self-management, and health outcomes among school-aged children with sickle cell disease: A mediation model. Journal of Pediatric Psychology, 43(4), 423\u2013433.","journal-title":"Journal of Pediatric Psychology"},{"issue":"1","key":"2031_CR13","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s11136-008-9412-8","volume":"18","author":"JA Panepinto","year":"2009","unstructured":"Panepinto, J. A., Pajewski, N. M., Foerster, L. M., Sabnis, S., & Hoffmann, R. G. (2009). Impact of family income and sickle cell disease on the health-related quality of life of children. Quality of Life Research, 18(1), 5\u201313.","journal-title":"Quality of Life Research"},{"key":"2031_CR14","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s12888-015-0461-6","volume":"15","author":"MG Sehlo","year":"2015","unstructured":"Sehlo, M. G., & Kamfar, H. Z. (2015). Depression and quality of life in children with sickle cell disease: The effect of social support. BMC Psychiatry, 15, 78.","journal-title":"BMC Psychiatry"},{"issue":"1","key":"2031_CR15","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s10880-013-9379-7","volume":"21","author":"LP Barakat","year":"2014","unstructured":"Barakat, L. P., Daniel, L. C., Smith, K., Ren\u00e9e Robinson, M., & Patterson, C. A. (2014). Parental problem-solving abilities and the association of sickle cell disease complications with health-related quality of life for school-age children. Journal of Clinical Psychology in Medical Settings, 21(1), 56\u201365.","journal-title":"Journal of Clinical Psychology in Medical Settings"},{"key":"2031_CR16","doi-asserted-by":"publisher","first-page":"4070547","DOI":"10.1155\/2017\/4070547","volume":"2017","author":"DK McClish.","year":"2017","unstructured":"McClish., D. K., Smith, W. R., Levenson, J. L., Aisiku, I. P., Roberts, J. D., Roseff, S. D., et al. (2017). Comorbidity, pain, utilization, and psychosocial outcomes in older versus younger sickle cell adults: The PiSCES project. BioMed Research International, 2017, 4070547.","journal-title":"BioMed Research International"},{"issue":"10","key":"2031_CR17","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1097\/01.mph.0000139456.12036.8d","volume":"26","author":"AM Trzepacz","year":"2004","unstructured":"Trzepacz, A. M., Vannatta, K., Gerhardt, C. A., Ramey, C., & Noll, R. B. (2004). Emotional, social, and behavioral functioning of children with sickle cell disease and comparison peers. Journal of Pediatric Hematology\/Oncology., 26(10), 642\u2013648.","journal-title":"Journal of Pediatric Hematology\/Oncology."},{"issue":"5","key":"2031_CR18","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1007\/s10943-016-0332-6","volume":"56","author":"MAK Rizvi","year":"2017","unstructured":"Rizvi, M. A. K., & Hossain, M. Z. (2017). Relationship between religious belief and happiness: A systematic literature review. Journal of Religion and Health, 56(5), 1561\u20131582.","journal-title":"Journal of Religion and Health"},{"issue":"2","key":"2031_CR19","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1111\/j.1365-2214.2011.01224.x","volume":"38","author":"HF Gharaibeh","year":"2012","unstructured":"Gharaibeh, H. F., & Gharaibeh, M. K. (2012). Factors influencing health-related quality of life of thalassaemic Jordanian children. Child Care Health and Development, 38(2), 211\u2013218.","journal-title":"Child Care Health and Development"},{"issue":"5","key":"2031_CR20","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1097\/MPH.0000000000000565","volume":"38","author":"ST Mevada","year":"2016","unstructured":"Mevada, S. T., Al Saadoon, M., Zachariah, M., Rawas, A., Wali, A. H., Y (2016). Impact of burden of thalassemia major on health-related quality of life in Omani children. Journal of Pediatric Hematology\/Oncology, 38(5), 384\u2013388.","journal-title":"Journal of Pediatric Hematology\/Oncology"},{"issue":"4","key":"2031_CR21","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.pedhc.2009.12.006","volume":"25","author":"JC Dale","year":"2011","unstructured":"Dale, J. C., Cochran, C. J., Roy, L., Jernigan, E., & Buchanan, G. R. (2011). Health-related quality of life in children and adolescents with sickle cell disease. Journal of Pediatric Health Care, 25(4), 208\u2013215.","journal-title":"Journal of Pediatric Health Care"},{"issue":"2","key":"2031_CR22","doi-asserted-by":"publisher","first-page":"107","DOI":"10.4103\/0973-1075.132622","volume":"20","author":"VM Bhagat","year":"2014","unstructured":"Bhagat, V. M., Baviskar, S. R., Mudey, A. B., & Goyal, R. C. (2014). Poor health related quality of life among patients of sickle cell disease. Indian Journal of Palliative Care, 20(2), 107\u2013111.","journal-title":"Indian Journal of Palliative Care"},{"issue":"1","key":"2031_CR23","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1002\/pbc.22222","volume":"54","author":"AM Brandow","year":"2010","unstructured":"Brandow, A. M., Brousseau, D. C., Pajewski, N. M., & Panepinto, J. A. (2010). Vaso-occlusive painful events in sickle cell disease: Impact on child well-being. Pediatric Blood & Cancer, 54(1), 92\u201397.","journal-title":"Pediatric Blood & Cancer"},{"issue":"4","key":"2031_CR24","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.jpeds.2009.11.008","volume":"156","author":"LM Ingerski","year":"2010","unstructured":"Ingerski, L. M., Modi, A. C., Hood, K. K., Pai, A. L., Zeller, M., Piazza-Waggoner, C., et al. (2010). Health-related quality of life across pediatric chronic conditions. Journal of Pediatrics, 156(4), 639\u2013644.","journal-title":"Journal of Pediatrics"},{"issue":"2","key":"2031_CR25","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3109\/03630261003677213","volume":"34","author":"S Alkindi","year":"2010","unstructured":"Alkindi, S., Al Zadjali, S., Al Madhani, A., Daar, S., Al Haddabi, A., Al Abri, H., et al (2010). Forecasting hemoglobinopathy burden through neonatal screening in Omani neonates. Hemoglobin, 34(2), 135\u2013144.","journal-title":"Hemoglobin"},{"issue":"1","key":"2031_CR26","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1186\/s12955-017-0700-2","volume":"15","author":"JA Panepinto","year":"2017","unstructured":"Panepinto, J. A., Paul Scott, J., Badaki-Makun, O., Darbari, D. S., Chumpitazi, C. E., Airewele, G. E., et al (2017). Determining the longitudinal validity and meaningful differences in HRQL of the PedsQL\u2122 sickle cell disease module. Health and Quality of Life Outcomes, 15(1), 124.","journal-title":"Health and Quality of Life Outcomes"},{"issue":"5","key":"2031_CR27","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1002\/pbc.21738","volume":"52","author":"CD Thornburg","year":"2009","unstructured":"Thornburg, C. D., Dixon, N., Burgett, S., Mortier, N. A., Schultz, W. H., Zimmerman, S. A., et al. (2009). A pilot study of hydroxyurea to prevent chronic organ damage in young children with sickle cell anemia. Pediatric Blood & Cancer, 52(5), 609\u2013615.","journal-title":"Pediatric Blood & Cancer"},{"issue":"4","key":"2031_CR28","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1182\/blood-2013-09-528067","volume":"123","author":"MH Steinberg","year":"2014","unstructured":"Steinberg, M. H., Chui, D. H., Dover, G. J., Sebastiani, P., & Alsultan, A. (2014). Fetal hemoglobin in sickle cell anemia: A glass half full? Blood, 123(4), 481\u2013485.","journal-title":"Blood"},{"issue":"3 Suppl 3","key":"2031_CR29","first-page":"15","volume":"34","author":"S Charache","year":"1997","unstructured":"Charache, S. (1997). Mechanism of action of hydroxyurea in the management of sickle cell anemia in adults. Seminars in Hematology, 34(3 Suppl 3), 15\u201321.","journal-title":"Seminars in Hematology"},{"issue":"1","key":"2031_CR30","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/j.1365-2141.1988.tb07607.x","volume":"69","author":"N Murray","year":"1988","unstructured":"Murray, N., Serjeant, B. E., & Serjeant, G. R. (1988). Sickle cell-hereditary persistence of fetal haemoglobin and its differentiation from other sickle cell syndromes. British Journal of Haematology, 69(1), 89\u201392.","journal-title":"British Journal of Haematology"},{"issue":"23","key":"2031_CR31","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1056\/NEJM199406093302303","volume":"330","author":"OS Platt","year":"1994","unstructured":"Platt, O. S., Brambilla, D. J., Rosse, W. F., Milner, P. F., Castro, O., Steinberg, M. H., et al. (1994). Mortality in sickle cell disease. Life expectancy and risk factors for early death. New England Journal of Medicine, 330(23), 1639\u20131644.","journal-title":"New England Journal of Medicine"},{"issue":"1","key":"2031_CR32","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0268-960X(03)00037-7","volume":"18","author":"I Okpala","year":"2004","unstructured":"Okpala, I. (2004). The intriguing contribution of white blood cells to sickle cell disease\u2014a red cell disorder. Blood Reviews, 18(1), 65\u201373.","journal-title":"Blood Reviews"},{"issue":"2","key":"2031_CR33","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.ejogrb.2006.08.009","volume":"133","author":"M Litos","year":"2007","unstructured":"Litos, M., Sarris, I., Bewley, S., Seed, P., Okpala, I., & Oteng-Ntim, E. (2007). White blood cell count as a predictor of the severity of sickle cell disease during pregnancy. European Journal of Obstetrics & Gynecology and Reproductive Biology, 133(2), 169\u2013172.","journal-title":"European Journal of Obstetrics & Gynecology and Reproductive Biology"},{"key":"2031_CR34","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.physbeh.2015.02.018","volume":"142","author":"R Calia","year":"2015","unstructured":"Calia, R., Lai, C., Aceto, P., Luciani, M., Camardese, G., Lai, S., et al. (2015). Emotional self-efficacy and alexithymia may affect compliance, renal function and quality of life in kidney transplant recipients: Results from a preliminary cross-sectional study. Physiology & Behavior, 142, 152\u2013154.","journal-title":"Physiology & Behavior"},{"issue":"4","key":"2031_CR35","doi-asserted-by":"publisher","first-page":"678","DOI":"10.3109\/0886022X.2015.1010989","volume":"37","author":"R Calia","year":"2015","unstructured":"Calia, R., Lai, C., Aceto, P., Luciani, M., Camardese, G., Lai, S., et al. (2015). Attachment style predict compliance, quality of life and renal function in adult patients after kidney transplant: Preliminary results. Renal Failure, 37(4), 678\u2013680.","journal-title":"Renal Failure"}],"container-title":["Quality of Life Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11136-018-2031-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11136-018-2031-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11136-018-2031-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T20:21:40Z","timestamp":1571689300000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11136-018-2031-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,22]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["2031"],"URL":"https:\/\/doi.org\/10.1007\/s11136-018-2031-0","relation":{},"ISSN":["0962-9343","1573-2649"],"issn-type":[{"value":"0962-9343","type":"print"},{"value":"1573-2649","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,22]]},"assertion":[{"value":"16 October 2018","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2018","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors stated that they had no interests which might be perceived as posing a conflict or bias.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}