{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:55:11Z","timestamp":1761519311680,"version":"3.37.3"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Qual Life Res"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s11136-020-02582-7","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T16:02:59Z","timestamp":1596211379000},"page":"3325-3331","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Health-related quality of life in patients with non-functioning pituitary adenoma: a special focus on hydrocortisone replacement dose"],"prefix":"10.1007","volume":"29","author":[{"given":"Carl Mathis","family":"Wild","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mareike","family":"Stieg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnter K.","family":"Stalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias K.","family":"Auer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9490-3566","authenticated-orcid":false,"given":"Anastasia P.","family":"Athanasoulia-Kaspar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"key":"2582_CR1","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1007\/s11102-015-0636-7","volume":"18","author":"CD Andela","year":"2015","unstructured":"Andela, C. D., Scharloo, M., Pereira, A. M., Kaptein, A. A., & Biermasz, N. R. (2015). Quality of life (QoL) impairments in patients with a pituitary adenoma: A systematic review of QoL studies. Pituitary, 18, 752\u2013776.","journal-title":"Pituitary"},{"key":"2582_CR2","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1530\/EJE-14-0941","volume":"172","author":"SM Leistner","year":"2015","unstructured":"Leistner, S. M., Klotsche, J., Dimopoulou, C., et al. (2015). Reduced sleep quality and depression associate with decreased quality of life in patients with pituitary adenomas. European Journal of Endocrinology, 172, 733\u2013743.","journal-title":"European Journal of Endocrinology"},{"key":"2582_CR3","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1111\/j.1365-2265.2008.03288.x","volume":"69","author":"AA van der Klaauw","year":"2008","unstructured":"van der Klaauw, A. A., Kars, M., Biermasz, N. R., et al. (2008). Disease-specific impairments in quality of life during long-term follow-up of patients with different pituitary adenomas. Clinical Endocrinology Oxford, 69, 775\u2013784.","journal-title":"Clinical Endocrinology Oxford"},{"key":"2582_CR4","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1530\/EJE-14-0397","volume":"171","author":"O Ragnarsson","year":"2014","unstructured":"Ragnarsson, O., Mattsson, A. F., Monson, J. P., et al. (2014). The relationship between glucocorticoid replacement and quality of life in 2737 hypopituitary patients. European Journal of Endocrinology, 171, 571\u2013579.","journal-title":"European Journal of Endocrinology"},{"key":"2582_CR5","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1007\/s00701-013-1809-7","volume":"155","author":"M Milian","year":"2013","unstructured":"Milian, M., Honegger, J., Gerlach, C., & Psaras, T. (2013). Health-related quality of life and psychiatric symptoms improve effectively within a short time in patients surgically treated for pituitary tumors\u2014A longitudinal study of 106 patients. Acta Neurochirurgica, 155, 1637\u20131645.","journal-title":"Acta Neurochirurgica"},{"key":"2582_CR6","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1530\/EJE-14-0023","volume":"171","author":"J Tiemensma","year":"2014","unstructured":"Tiemensma, J., Andela, C. D., Kaptein, A. A., et al. (2014). Psychological morbidity and impaired quality of life in patients with stable treatment for primary adrenal insufficiency: CROSS-sectional study and review of the literature. European Journal of Endocrinology, 171, 171\u2013182.","journal-title":"European Journal of Endocrinology"},{"key":"2582_CR7","doi-asserted-by":"publisher","first-page":"3912","DOI":"10.1210\/jc.2007-0685","volume":"92","author":"S Hahner","year":"2007","unstructured":"Hahner, S., Loeffler, M., Fassnacht, M., et al. (2007). Impaired subjective health status in 256 patients with adrenal insufficiency on standard therapy based on cross-sectional analysis. The Journal of Clinical Endocrinology and Metabolism, 92, 3912\u20133922.","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"2582_CR8","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s11102-008-0126-2","volume":"11","author":"K Danilowicz","year":"2008","unstructured":"Danilowicz, K., Bruno, O. D., Manavela, M., Gomez, R. M., & Barkan, A. (2008). Correction of cortisol overreplacement ameliorates morbidities in patients with hypopituitarism: A pilot study. Pituitary, 11, 279\u2013285.","journal-title":"Pituitary"},{"key":"2582_CR9","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1046\/j.1365-2265.1999.00723.x","volume":"50","author":"M Wichers","year":"1999","unstructured":"Wichers, M., Springer, W., Bidlingmaier, F., & Klingmuller, D. (1999). The influence of hydrocortisone substitution on the quality of life and parameters of bone metabolism in patients with secondary hypocortisolism. Clinical Endocrinology Oxford, 50, 759\u2013765.","journal-title":"Clinical Endocrinology Oxford"},{"issue":"4","key":"2582_CR10","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1111\/cen.12967","volume":"84","author":"A Karppinen","year":"2016","unstructured":"Karppinen, A., Ritvonen, E., Roine, R., et al. (2016). Health-related quality of life in patients treated for non-functioning pituitary adenomas during the years 2000\u20132010. Clinical Endocrinology Oxford, 84(4), 532\u2013539.","journal-title":"Clinical Endocrinology Oxford"},{"key":"2582_CR11","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1530\/eje.0.1490091","volume":"149","author":"J Romijn","year":"2003","unstructured":"Romijn, J., Smit, J., & Lamberts, S. (2003). Intrinsic imperfections of endocrine replacement therapy. European Journal of Endocrinology, 149, 91\u201397.","journal-title":"European Journal of Endocrinology"},{"key":"2582_CR12","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1530\/EJE-09-0884","volume":"162","author":"S Hahner","year":"2010","unstructured":"Hahner, S., Loeffler, M., Bleicken, B., et al. (2010). Epidemiology of adrenal crisis in chronic adrenal insufficiency: The need for new prevention strategies. European Journal of Endocrinology, 162, 597\u2013602.","journal-title":"European Journal of Endocrinology"},{"key":"2582_CR13","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1046\/j.1365-2265.1997.780907.x","volume":"46","author":"SR Peacey","year":"1997","unstructured":"Peacey, S. R., Guo, C. Y., Robinson, A. M., et al. (1997). Glucocorticoid replacement therapy: Are patients over treated and does it matter? Clinical Endocrinology Oxford, 46, 255\u2013261.","journal-title":"Clinical Endocrinology Oxford"},{"key":"2582_CR14","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1530\/EJE-08-0880","volume":"160","author":"K L\u00f8v\u00e5s","year":"2009","unstructured":"L\u00f8v\u00e5s, K., Gjesdal, C. G., Christensen, M., et al. (2009). Glucocorticoid replacement therapy and pharmacogenetics in Addison's disease: Effects on bone. European Journal of Endocrinology, 160, 993\u20131002.","journal-title":"European Journal of Endocrinology"},{"key":"2582_CR15","doi-asserted-by":"publisher","first-page":"3954","DOI":"10.1210\/jc.2006-0524","volume":"91","author":"H Filipsson","year":"2006","unstructured":"Filipsson, H., Monson, J. P., Koltowska-Haggstrom, M., Mattsson, A., & Johannsson, G. (2006). The impact of glucocorticoid replacement regimens on metabolic outcome and comorbidity in hypopituitary patients. The Journal of Clinical Endocrinology and Metabolism, 91, 3954\u20133961.","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"2582_CR16","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/0039-128X(90)90103-I","volume":"55","author":"NV Esteban","year":"1990","unstructured":"Esteban, N. V., & Yergey, A. L. (1990). Cortisol production rates measured by liquid chromatography\/mass spectrometry. Steroids, 55, 152\u2013158.","journal-title":"Steroids"},{"key":"2582_CR17","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/S0022-3476(05)80128-3","volume":"117","author":"BL Linder","year":"1990","unstructured":"Linder, B. L., Esteban, N. V., Yergey, A. L., Winterer, J. C., Loriaux, D. L., & Cassorla, F. (1990). Cortisol production rate in childhood and adolescence. The Journal of Pediatrics, 117, 892\u2013896.","journal-title":"The Journal of Pediatrics"},{"key":"2582_CR18","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","volume":"30","author":"JE Ware Jr","year":"1992","unstructured":"Ware, J. E., Jr., & Sherbourne, C. D. (1992). The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Medical Care, 30, 473\u2013483.","journal-title":"Medical Care"},{"key":"2582_CR19","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s00115-006-2098-7","volume":"78","author":"C K\u00fchner","year":"2007","unstructured":"K\u00fchner, C., B\u00fcrger, C., Keller, F., & Hautzinger, M. (2007). Reliability and validity of the revised beck depression inventory (BDI-II). Der Nervenarzt, 78, 651\u2013656.","journal-title":"Der Nervenarzt"},{"key":"2582_CR20","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1590\/1516-4446-2012-1048","volume":"35","author":"Y-P Wang","year":"2013","unstructured":"Wang, Y.-P., & Gorenstein, C. (2013). Psychometric properties of the beck depression inventory-II: A comprehensive review. Revista Brasileira de Psiquiatria, 35, 416\u2013431.","journal-title":"Revista Brasileira de Psiquiatria"},{"key":"2582_CR21","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/S0005-7967(98)00023-0","volume":"36","author":"PJ Bieling","year":"1998","unstructured":"Bieling, P. J., Antony, M. M., & Swinson, R. P. (1998). The state-trait anxiety inventory, trait version: Structure and content re-examined. Behaviour Research and Therapy, 36, 777\u2013788.","journal-title":"Behaviour Research and Therapy"},{"key":"2582_CR22","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.eurpsy.2003.05.003","volume":"18","author":"H Caci","year":"2003","unstructured":"Caci, H., Bayl\u00e9, F. J., Dossios, C., Robert, P., & Boyer, P. (2003). The Spielberger trait anxiety inventory measures more than anxiety. European Psychiatry, 18, 394\u2013400.","journal-title":"European Psychiatry"},{"key":"2582_CR23","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","volume":"28","author":"DJ Buysse","year":"1989","unstructured":"Buysse, D. J., Reynolds, C. F., 3rd, Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989). The pittsburgh sleep quality index: A new instrument for psychiatric practice and research. Psychiatry Research, 28, 193\u2013213.","journal-title":"Psychiatry Research"},{"key":"2582_CR24","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","volume":"14","author":"MW Johns","year":"1991","unstructured":"Johns, M. W. (1991). A new method for measuring daytime sleepiness: The Epworth sleepiness scale. Sleep, 14, 540\u2013545.","journal-title":"Sleep"},{"key":"2582_CR25","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S1087-0792(98)90050-8","volume":"2","author":"M Johns","year":"1998","unstructured":"Johns, M. (1998). Rethinking the assessment of sleepiness. Sleep Medicine Reviews, 2, 3\u201315.","journal-title":"Sleep Medicine Reviews"},{"key":"2582_CR26","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1111\/cen.12550","volume":"82","author":"E Ritvonen","year":"2015","unstructured":"Ritvonen, E., Karppinen, A., Sintonen, H., et al. (2015). Normal long-term health-related quality of life can be achieved in patients with functional pituitary adenomas having surgery as primary treatment. Clinical Endocrinology Oxford, 82, 412\u2013421.","journal-title":"Clinical Endocrinology Oxford"},{"key":"2582_CR27","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1111\/cen.12484","volume":"81","author":"N Kluger","year":"2014","unstructured":"Kluger, N., Matikainen, N., Sintonen, H., Ranki, A., Roine, R. P., & Schalin-Jantti, C. (2014). Impaired health-related quality of life in Addison's disease\u2014impact of replacement therapy, comorbidities and socio-economic factors. Clinical Endocrinology Oxford, 81, 511\u2013518.","journal-title":"Clinical Endocrinology Oxford"},{"key":"2582_CR28","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/j.1365-2265.2009.03596.x","volume":"72","author":"B Bleicken","year":"2010","unstructured":"Bleicken, B., Hahner, S., Loeffler, M., et al. (2010). Influence of hydrocortisone dosage scheme on health-related quality of life in patients with adrenal insufficiency. Clinical Endocrinology, 72, 297\u2013304.","journal-title":"Clinical Endocrinology"},{"issue":"2","key":"2582_CR29","doi-asserted-by":"publisher","first-page":"R83","DOI":"10.1530\/EJE-15-1237","volume":"175","author":"SA Morgan","year":"2016","unstructured":"Morgan, S. A., Hassan-Smith, Z. K., & Lavery, G. G. (2016). Mechanisms in endocrinology: Tissue-specific activation of cortisol in Cushing's syndrome. European Journal of Endocrinology, 175(2), R83\u2013R89.","journal-title":"European Journal of Endocrinology"},{"issue":"3","key":"2582_CR30","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/S2213-8587(17)30398-4","volume":"6","author":"AM Isidori","year":"2018","unstructured":"Isidori, A. M., Venneri, M. A., Graziadio, C., et al. (2018). Effect of once-daily, modified-release hydrocortisone versus standard glucocorticoid therapy on metabolism and innate immunity in patients with adrenal insufficiency (DREAM): A single-blind, randomised controlled trial. Lancet Diabetes Endocrinology, 6(3), 173\u2013185.","journal-title":"Lancet Diabetes Endocrinology"}],"container-title":["Quality of Life Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11136-020-02582-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11136-020-02582-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11136-020-02582-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T00:50:38Z","timestamp":1627692638000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11136-020-02582-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,31]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["2582"],"URL":"https:\/\/doi.org\/10.1007\/s11136-020-02582-7","relation":{},"ISSN":["0962-9343","1573-2649"],"issn-type":[{"type":"print","value":"0962-9343"},{"type":"electronic","value":"1573-2649"}],"subject":[],"published":{"date-parts":[[2020,7,31]]},"assertion":[{"value":"4 July 2020","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2020","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"CMW and MKA declare no conflict of interest. MS received speakers\u2019 fees by Novartis, Ipsen, Pfizer, consultancy fees by Novartis and research funding by Novartis, Pfizer. APAK and GKS received consultancy fees and\/or reimbursements of delegate fees for conferences\/educational events and\/or travel expenses and\/or funding for research projects from Pfizer, Ipsen, Lilly, Shire, Novartis, Sandoz, NovoNordisk, and HRA.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The study was an observational, non-interventional study involving human participants.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}},{"value":"The study was approved by the medical ethics committee of the Ludwig-Maximilians-University of Munich. Informed consent was obtained from all individual participants included in the study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}