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WHO recommends differentiated service delivery (DSD) as an alternative, less resource-demanding way of expanding HIV services access. Monitoring client\u2019s health-related quality of life (HRQoL) is necessary to understand patients\u2019 perceptions of treatment and services but is understudied in sub-Saharan Africa. We assessed HRQoL among ART clients in Tanzania accessing two service models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cross-sectional survey from May\u2013August 2019 among stable ART clients randomly sampled from clinics and clubs in the Shinyanga region providing DSD and clinic-based care. HRQoL data were collected using a validated HIV-specific instrument\u2014Functional Assessment of HIV infection (FAHI), in addition to socio-demographic, HIV care, and service accessibility data. Descriptive analysis of HRQoL, logistic regression and a stepwise multiple linear regression were performed to examine HRQoL determinants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      629 participants were enrolled, of which 40% accessed DSD. Similar HRQoL scores\n                      <jats:italic>[mean (SD), p-value]<\/jats:italic>\n                      ; FAHI total [152.2 (22.2) vs 153.8 (20.6),\n                      <jats:italic>p<\/jats:italic>\n                      0.687] were observed among DSD and clinic-based care participants. Accessibility factors contributed more to emotional wellbeing among DSD participants compared to the clinic-based care participants (53.4% vs 18.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009\u2009&lt;\u20090.001). Satisfactory (&gt;\u200980% of maximum score) HRQoL scoring was associated with (OR [95% CI],\n                      <jats:italic>p<\/jats:italic>\n                      -value) being male (2.59 [1.36\u20134.92],\n                      <jats:italic>p<\/jats:italic>\n                      0.004) among clinic participants and with urban residence (4.72 [1.70\u201313.1],\n                      <jats:italic>p<\/jats:italic>\n                      0.001) among DSD participants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Similar HRQoL was observed in DSD and clinic-based care. Our research highlights focus areas to identify supporting interventions, ultimately optimizing HRQoL among PLHIV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11136-021-02889-z","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T05:03:10Z","timestamp":1625547790000},"page":"159-170","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Beyond viral suppression: Quality of life among stable ART clients in a differentiated service delivery intervention in Tanzania"],"prefix":"10.1007","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9182-6518","authenticated-orcid":false,"given":"Nwanneka Ebelechukwu","family":"Okere","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Censi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clementina","family":"Machibya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Costigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Katambi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Martelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josien","family":"de Klerk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Hermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela B.","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Pozniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias Rinke","family":"de Wit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Naniche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,30]]},"reference":[{"key":"2889_CR1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/1471-2458-7-244","volume":"7","author":"GM Louwagie","year":"2007","unstructured":"Louwagie GM, Bachmann MO, Meyer K, Booysen F le R, Fairall LR, Heunis C. 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