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Patients with atrial fibrillation (AF) report poor quality-of-life (QoL) and high distress. This cross-sectional study investigated patterns\/clusters of cognitive and behavioural responses to illness, and illness perceptions, and relationships with QoL, depression and anxiety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>AF patients (<jats:italic>N<\/jats:italic>\u2009=\u2009198) recruited at cardiology clinics completed the AF-Revised Illness Perception Questionnaire, Atrial-Fibrillation-Effect-on-Quality-of-Life Questionnaire, Patient Health Questionnaire-8 and Generalized Anxiety Disorder Questionnaire. Cluster analysis used Ward\u2019s and<jats:italic>K<\/jats:italic>-means methods. Hierarchical regressions examined relationships between clusters with QoL, depression and anxiety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two clusters of cognitive and behavioural responses to symptoms were outlined; (1) \u2018high avoidance\u2019; (2) \u2018low symptom-focussing\u2019. Patients in Cluster 1 had lower QoL (<jats:italic>M<\/jats:italic>\u2009=\u200940.36, SD\u2009=\u200918.40), greater symptoms of depression (<jats:italic>M<\/jats:italic>\u2009=\u20097.20, SD\u2009=\u20095.71) and greater symptoms of anxiety (<jats:italic>M<\/jats:italic>\u2009=\u20095.70, SD\u2009=\u20095.90) compared to patients in Cluster 2 who had higher QoL (<jats:italic>M<\/jats:italic>\u2009=\u200959.03, SD\u2009=\u200920.12), fewer symptoms of depression (<jats:italic>M<\/jats:italic>\u2009=\u20093.53, SD\u2009=\u20093.56) and fewer symptoms of anxiety (<jats:italic>M<\/jats:italic>\u2009=\u20092.56, SD\u2009=\u20093.56).<\/jats:p><jats:p>Two illness representation clusters were outlined; (1) \u2018high coherence and treatment control\u2019, (2) \u2018negative illness and emotional representations\u2019. Patients in Cluster 2 had significantly lower QoL (<jats:italic>M<\/jats:italic>\u2009=\u200946.57, SD\u2009=\u200919.94), greater symptoms of depression (<jats:italic>M<\/jats:italic>\u2009=\u20096.12, SD\u2009=\u20095.31) and greater symptoms of anxiety (<jats:italic>M<\/jats:italic>\u2009=\u20094.70, SD\u2009=\u20095.27), compared with patients in Cluster 1 who had higher QoL (<jats:italic>M<\/jats:italic>\u2009=\u200961.52, SD\u2009=\u200921.38), fewer symptoms of depression (<jats:italic>M<\/jats:italic>\u2009=\u20092.85, SD\u2009=\u20092.97) and fewer symptoms of anxiety (<jats:italic>M<\/jats:italic>\u2009=\u20092.16, SD\u2009=\u20093.63).<\/jats:p><jats:p>Overall, clusters of cognitive and behavioural responses to symptoms, and illness perceptions significantly explained between 14 and 29% of the variance in QoL, depression and anxiety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patterns of cognitive and behavioural responses to symptoms, and illness perceptions are important correlates of health-related outcomes in AF patients.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s11136-021-03006-w","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T09:46:42Z","timestamp":1633600002000},"page":"1415-1425","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Atrial fibrillation, quality of life and distress: a cluster analysis of cognitive and behavioural responses"],"prefix":"10.1007","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5736-7629","authenticated-orcid":false,"given":"Elaina C.","family":"Taylor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"O\u2019Neill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyndsay D.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rona","family":"Moss-Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,7]]},"reference":[{"key":"3006_CR1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/159850","author":"D Patel","year":"2013","unstructured":"Patel, D., Mc Conkey, N. 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