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Treatment of this condition remains a challenge, due to the scarce evidence for the effectiveness of the therapeutic approaches available. Current attention is focused on transcranial direct current stimulation (tDCS), which has yielded promising results for pain treatment. Rather than focusing only on pain relief, in this study, we aimed to determine how active or sham tDCS (over three cortical targets -the primary motor cortex, the dorsolateral prefrontal cortex and the operculo-insular cortex-) affect\u00a0QoL in patients with FM.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Using a double-blind, placebo-controlled design, we applied fifteen tDCS sessions of 20\u2019 to initial 130 participants (randomized to any of the four treatment groups). We evaluated the QoL (assessed by SF-36) and the symptoms\u2019 impact (assessed by FIQ-R) in baseline, after treatment and at 6 months follow-up.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>All groups were comparable as regards age, medication pattern and severity of symptoms before the treatment. We found that QoL and symptoms\u2019 impact improved in all treatment groups (including the sham) and this improvement lasted for up to 6 months. However, we did not observe any group effect nor group*treatment interaction.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>After the intervention, we observed a non-specific effect that may be due to placebo, favoured by the expectations of tDCS efficacy and psychosocial variables inherent to the intervention (daily relationship with therapists and other patients in the clinic). Therefore, active\u00a0tDCS is not superior to sham stimulation in improving QoL in FM.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11136-022-03106-1","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T03:02:32Z","timestamp":1646103752000},"page":"2519-2534","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Active and sham transcranial direct current stimulation (tDCS) improved quality of life in female patients with fibromyalgia"],"prefix":"10.1007","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9674-6744","authenticated-orcid":false,"given":"N.","family":"Samartin-Veiga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0009-920X","authenticated-orcid":false,"given":"A. 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