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Health-related quality of life (HRQoL) questionnaires were administered between diagnosis and beginning the therapy, and 2 years after. HRQoL differences according to age, comorbidity and stage were tested with ANOVA or Chi Square test and multivariate linear regression models.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>1276 patients were included, with a mean age of 58\u00a0years. Multivariate models of EORTC QLQ-C30 summary score and EQ-5D-5L index at diagnosis and at 2-year follow-up show the independent association of comorbidity and tumor stage with HRQoL. The standardized multivariate regression coefficient of EORTC QLQ-C30 summary score was lower (poorer HRQoL) for women with stage II and III than for those with stage 0 at diagnosis (\u2212\u00a00.11 and \u2212\u00a00.07, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and follow-up (\u2212\u00a00.15 and \u2212\u00a00.10, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The EQ-5D-5L index indicated poorer HRQoL for women with Charlson comorbidity index\u2009\u2265\u20092 than comorbidity 0 both at diagnosis (\u2212\u00a00.13, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and follow-up (\u2212\u00a00.18, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Therefore, we provided the reference norms at diagnosis and at the 2-year follow-up, stratified by age, comorbidity index, and tumor stage.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>These HRQoL reference norms can be useful to interpret the scores of women with non-metastatic breast cancer, comparing them with country-specific reference values for this population.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11136-022-03327-4","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T16:02:47Z","timestamp":1673452967000},"page":"989-1003","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Reference values of EORTC QLQ-C30, EORTC QLQ-BR23, and EQ-5D-5L for women with non-metastatic breast cancer at diagnosis and 2 years 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