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A total of 203 adults on DR-TB treatment were recruited to complete a questionnaire including the Redwood DR-TB stigma scale, the Functional Assessment of Chronic Illness Therapy-TB (FACCIT) scale, and the Multidimensional Scale of Perceived Social Support (MSPSS). Student \u2018t\u2019 test\/one-way ANOVA, Pearson\u2019s correlation, and hierarchical linear regression analysis were conducted to explore the factors associated with HRQoL and the relationships between stigma, social support, and HRQoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean overall HRQoL was 41.1\u2009\u00b1\u200912.9 among people with DR-TB. The HRQoL score of the physical domain was the lowest (25.8\u2009\u00b1\u200913.8). Participants who were young, male, single, with higher education, and HIV-negative had higher HRQoL than their counterparts (p\u2009&lt;\u20090.05). Stigma was negatively associated with HRQoL, while social support was positively related, collectively explaining 57.6% of the variance. In the final model, social support contributed more (B\u2009=\u20090.576) to predicting HRQoL than did stigma (B\u2009=\u2009\u2212\u00a00.414).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The overall HRQoL of people with DR-TB in Lagos, Nigeria, was poor. Strategies that improve social support systems and reduce stigma are needed to improve this. Further studies are also required to assess the changes in HRQoL over time and evaluate the impact of specific stigma-reduction interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11136-025-03902-5","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T11:17:36Z","timestamp":1739877456000},"page":"1305-1316","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The effects of stigma and social support on the health-related quality of life of people with drug resistance tuberculosis in Lagos, Nigeria"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8946-3244","authenticated-orcid":false,"given":"Olusola Adedeji","family":"Adejumo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Champaklal","family":"Jinabhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olusoji","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firoza","family":"Haffejee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,18]]},"reference":[{"key":"3902_CR1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159560","author":"N Ahmad","year":"2016","unstructured":"Ahmad, N., Javaid, A., Syed-Sulaiman, S. 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Approval was granted by the Health Research and Ethics Committee of the Lagos State University Teaching Hospital (LREC\/06\/10\/2179) and the Institutional Research Ethic Committee of Durban University of Technology, South Africa (IREC 066\/230). Gatekeepers\u2019 permission to interview participants was obtained from the Lagos State Ministry of Health and the medical directors of the DR-TB treatment centres where participants were recruited.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"A written informed consent was obtained from all participants included in the study. The objectives of the study were explained to the participants. They were also informed that participation or non-participation in the study would not affect the provision of healthcare services. In addition, they were informed that they were free to withdraw their consent at any time during the study. 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