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QOL was evaluated using the EQ-5D-5L with Japanese-specific utility values. Both EQ-5D utility values and mRS scores were assessed after completion of acute treatment. UW-mRS scores were estimated using ordinary least squares (OLS) and Tobit regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean (SD) EQ-5D utility value was 0.68 (0.27). Higher mRS scores were associated with greater severity and frequency of problems across EQ-5D domains, with a marked decline observed between mRS scores 3 and 4. UW-mRS scores estimated by OLS were: mRS 0: 0.90, mRS 1: 0.85, mRS 2: 0.74, mRS 3: 0.62, mRS 4: 0.41, and mRS 5: 0.28. The Tobit model yielded slightly higher values for mRS 1\u20133. UW-mRS estimates remained largely consistent across other regression models (fractional logit\/probit, beta regression, and two-part models). However, UW-mRS values differed between early (\u2264\u200914\u00a0days from onset) and late (&gt;\u200914\u00a0days) assessments and varied considerably when utility values were calculated using tariffs from other countries or with the EQ-5D-3L crosswalk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this real-world, consecutive cohort of hospitalized Japanese patients with ischemic stroke, utility values were estimated using the EQ-5D-5L, and the UW-mRS was characterized as a practical tool for deriving utility values from mRS scores.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11136-025-04114-7","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T08:45:19Z","timestamp":1767948319000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Utility-weighted modified rankin scale scores in patients with ischemic stroke: a multicenter observational study"],"prefix":"10.1007","volume":"35","author":[{"given":"Fumi","family":"Irie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koutarou","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryu","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Wakisaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Ago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanari","family":"Kitazono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5348-8762","authenticated-orcid":false,"given":"Masahiro","family":"Kamouchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"onbehalf of the Fukuoka Stroke Registry Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"issue":"3","key":"4114_CR1","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1111\/j.1747-4949.2009.00271.x","volume":"4","author":"TJ Quinn","year":"2009","unstructured":"Quinn, T. 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