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While multimorbidity is known to worsen clinical outcomes, the role of distinct comorbidity patterns in shaping patients\u2019 experience remains unclear. This cross-sectional study assessed whether the number and patterns of comorbidities differentially affect HRQoL, care needs, and priorities of AF patients and caregivers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An online survey on living with AF and multimorbidity was disseminated between May 2022 and January 2023 in the UK, Italy, Spain, Romania, and Denmark. The analysis included 633 AF patients (46.9% females, median age 73 years) and 198 caregivers (26.8% females, median age 57 years). Exposure variables were the number and patterns (derived through latent class analysis) of comorbidities. Outcomes included HRQoL (measured with the EQ-5D-3L), perceived management problems and health priorities assessed through a structured questionnaire developed ad hoc for the survey.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Three patterns emerged: unspecific (65.5%), diabetes-kidney-liver (18.2%), and complex (16.4%). More comorbidities and belonging to the complex pattern were associated with worse HRQoL, mainly due to limited mobility, dependency, and pain. Main issues were managing multiple diseases, medi ions, and appointments. The diabetes-kidney-liver group prioritized improving quality of life (OR=3.08, 95%CI:1.68\u20136.00) and living longer (OR=1.67, 95%CI:1.05\u20132.64), while pain relief was a distinct priority in the complex pattern (OR=2.32, 95%CI:1.38\u20133.86).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both number and combinations of AF comorbidities shape patients\u2019 and caregivers\u2019 experiences. Considering comorbidity profiles can help define targeted care plans and caregiver support initiatives.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11136-025-04117-4","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T12:26:19Z","timestamp":1775046379000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quality of life, care needs and priorities in atrial fibrillation: the impact of number and patterns of comorbidities"],"prefix":"10.1007","volume":"35","author":[{"given":"Caterina","family":"Trevisan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6345-6836","authenticated-orcid":false,"given":"Adele","family":"Ravelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 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Also, second and third affiliation information are swapped","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"DL has received investigator\u2010initiated quality improvement grants from Bristol\u2010Myers Squibb and Pfizer (paid to the Institution). She is a co-applicant on the AFFIRMO project on multimorbidity in AF (Grant Agreement No. 899871), ARISTOTELES project on artificial intelligence for management of chronic long-term conditions (Grant Agreement No. 101080189), and the TARGET project on digital twins for personalised management of atrial fibrillation and stroke (Grant Agreement No. 101136244), all of which are funded by the Horizon Europe Research & Innovation programme.All other authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed were in accordance with the ethical standards of the institutional and\/or national research committees and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study protocol was approved by the Ethics Committees from the United Kingdom (REC 21\/YH\/0307), Italy (015534, ref. 5308\/AO\/22), Spain (2021-12-15-HCUVA), and Romania (2SNI\/13.01.2022). According to the guidelines of the Danish Research Ethics Committee, ethical approval was not required for Denmark.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}],"article-number":"109"}}