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The aim of this study is to estimate the impacts of testing positive for COVID-19 using the EQ-5D-5\u00a0L instrument.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Our study is a secondary analysis of data collected in the Alberta POST-COVID-19 Follow-up Study, linking survey responses to administrative health data. The data included 11,705 individuals tested for COVID-19 in Alberta from October 2021 to September 2023. Survey data included test results, age, sex, and EQ-5D-5\u00a0L response. Linked administrative data included socioeconomic status, comorbidities, hospital, and intensive care unit admissions. We used linear regression to estimate differences in HRQoL pre- and post-COVID-19 testing and ordinal logistic regression to estimate the odds of worsening HRQoL in each of the EQ-5D domains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>COVID-19-positive individuals were younger (mean 48.5 vs. 53.4 years), more often female (64.4% vs. 62.6%), and tested more recently (mean 274 vs. 519 days since test) compared to COVID-19-negative respondents. We estimated reductions in EQ-5D-5\u00a0L index score ranging from 0.0464 (CI 0.0393-0.0536) to 0.0702 (CI 0.0626-0.0777) points for respondents testing positive, and up to 0.0276 (CI 0.0190-0.0362) points for respondents testing negative. Positive respondents were also more likely to report problems within each of the EQ-5D-5\u00a0L domains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Previous COVID-19 infection has an important impact on HRQoL. These results can support health economic models and provide insight into optimal COVID-19 mitigation strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11136-026-04174-3","type":"journal-article","created":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T13:09:01Z","timestamp":1772370541000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The impact of testing positive versus negative for COVID-19 on health-related quality of life: cross-sectional evidence from the Alberta post-COVID-19 follow-up survey"],"prefix":"10.1007","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6957-7236","authenticated-orcid":false,"given":"Erin","family":"Kirwin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Adibnia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Wiggins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Sander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arto","family":"Ohinmaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Norris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Rafferty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon E.","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Round","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Canadian Immunization Research Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,1]]},"reference":[{"issue":"10453","key":"4174_CR1","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/S0140-6736(24)01136-X","volume":"404","author":"T Greenhalgh","year":"2024","unstructured":"Greenhalgh, T., Sivan, M., Perlowski, A., & Nikolich, J. 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AO, FX and JAJ are members of the EuroQol Group, who holds the copyright for EQ-5D instruments. JR has received funding from Canada\u2019s Drug Agency (CDA) and the Canadian Clinical Research Network to undertake model-based economic evaluations of COVID-19 therapies.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"85"}}