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All participants completed the EQ-5D-5L, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ-C30) and the Expanded Prostate Cancer Index Composite short form (EPIC-26) pre- and post-treatment. Paired t-tests were performed with latent change scores in a structural equation model framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>EQ-5D-5L showed minor changes from pre- to post-treatment for four dimensions and sum score (Cohen\u2019s d\u2009\u2264\u20090.20). EORTC-QLQ-C30 revealed a moderate decline in social function (-9.85, p\u2009&lt;\u20090.001, Cohen\u2019s d -0.52). EPIC-26 showed a large decline in sexual function (-38.1, p\u2009&lt;\u20090.001, Cohen\u2019s d -1.42), and urine incontinency (-24.3, p\u2009&lt;\u20090.001, Cohen\u2019s d -1.86). Correlations between change in EQ-5D-5L and change in domains found to be important for participants with PCa (sexual function, urine incontinence and social function) revealed small to medium correlations for the PCa group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The low responsiveness indicates that the EQ-5D-5L is not sensitive enough in detecting health status changes due to significant problem areas in PCa patients. Adding disease-specific measures is pivotal to measuring these changes in health status.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11136-026-04178-z","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T10:36:33Z","timestamp":1770201393000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Is EQ-5D-5L sensitive enough to detect treatment-related changes in health status of prostate cancer patients? 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