{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:36:44Z","timestamp":1787161004170,"version":"build-2736575974"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Otsuka Phamaceutilcal Co., Ltd"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Qual Life Res"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>We explored the suitability of the Adult Social Care Outcomes Toolkit for Carers (ASCOT-Carer) against the widely used EQ-5D for evaluating the quality of life (QoL) of Japanese caregivers of patients with Alzheimer\u2019s disease. This research aimed to expand the available preference-based measures for assessing caregiver QoL in health economic evaluations in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a cross-sectional survey using a web-based questionnaire. The alignment between the ASCOT-Carer and established measures, as well as its construct alignment, were evaluated. These were respectively investigated through Pearson\u2019s correlation analysis with the EQ-5D-5L and factor analysis using the EQ-5D-5L and the eight-item short Japanese version of the Zarit Burden Interview (J_ZBI-8).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 705 live-in family caregivers of patients with Alzheimer\u2019s disease completed the main survey. The absolute correlation coefficients were between J_ZBI-8 and EQ-5D-5L scores, +\u20090.268; between J_ZBI-8 and ASCOT-Carer scores, +\u20090.472; and between EQ-5D-5L and ASCOT-Carer scores, +\u20090.463. Factor analysis revealed that the only factors showing moderate\/stronger correlations with factors constituted by J_ZBI-8 were those derived from ASCOT-Carer (inter-factor correlation: +0.31 and +\u20090.50). The ASCOT-Carer was a more important variable relative to the EQ-5D-5L for measuring caregivers\u2019 QoL related to caregiver burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The ASCOT-Carer may be a more suitable tool for evaluating the impact of caregiving burden on caregivers\u2019 QoL. When incorporating QoL based on caregiver burden in health economic evaluations, the ASCOT-Carer may be an appropriate option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11136-026-04252-6","type":"journal-article","created":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T21:03:04Z","timestamp":1777842184000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potential of ASCOT-Carer for evaluating the quality of life of family caregivers for patients with Alzheimer\u2019s disease in Japan"],"prefix":"10.1007","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6952-7770","authenticated-orcid":false,"given":"Shinichi","family":"Noto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5027-6289","authenticated-orcid":false,"given":"Kentaro","family":"Yamato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6395-5275","authenticated-orcid":false,"given":"Keisuke","family":"Onuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7275-359X","authenticated-orcid":false,"given":"Tomohiro","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,3]]},"reference":[{"issue":"2","key":"4252_CR1","doi-asserted-by":"publisher","first-page":"e105","DOI":"10.1016\/S2468-2667(21)00249-8","volume":"7","author":"GBD 2019 Dementia Forecasting Collaborators","year":"2022","unstructured":"GBD 2019 Dementia Forecasting Collaborators. 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