{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:20:36Z","timestamp":1792783236067,"version":"4.5.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Odense University Hospital","id":[{"id":"https:\/\/ror.org\/00ey0ed83","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Qual Life Res"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Electronic patient-reported outcomes (ePROs) have shown clinical benefits in oncology. Although widely used for symptom monitoring during and after cancer treatment, their potential to replace existing workflows, such as treatment readiness assessment without a direct clinical encounter, remains underexplored. Real-world evidence on the feasibility, acceptability, and resource implications of such approaches is limited. This study evaluated the implementation and use of an ePRO-based system to support treatment readiness assessments in lung cancer care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A mixed-methods study guided by the RE-AIM framework was conducted in routine lung cancer care at a Danish oncology department. Quantitative data from the ePRO platform and electronic health records were used to assess uptake and questionnaire completion. Qualitative data from field observations and semi-structured patient interviews were used to examine workflow integration, user experiences, and perceived value. Changes in staff time use before and after implementation were estimated by combining registry data, field observations, and staff input.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 704 patients completed at least one ePRO questionnaire between December 2020 and March 2024, corresponding to 6,134 completed questionnaires. Treatment-level completion increased from 17.7% to 76.3%. In practice, ePRO data were used alongside blood test results, prior medical history, and clinical judgement to assess treatment readiness. The ePRO-based workflow was estimated to reduce nurses\u2019 time use by approximately 6\u00a0min per treatment. Patients and staff generally found the system meaningful and acceptable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The ePRO-based system appeared feasible to integrate into routine lung cancer care and supported more targeted treatment readiness assessments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11136-026-04363-0","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:33:13Z","timestamp":1786545193000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Implementation of an ePRO-based system supporting treatment readiness assessments in lung cancer care: a mixed-methods study"],"prefix":"10.1007","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4672-8959","authenticated-orcid":false,"given":"Lasse Lybecker","family":"Scheel-Hincke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2566-663X","authenticated-orcid":false,"given":"Johanne Dam","family":"Lyhne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne","family":"Skovbjerg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Skov","family":"Villadsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0564-146X","authenticated-orcid":false,"given":"Rasmus Blechingberg","family":"Friis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette B\u00f8g","family":"Horup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8197-7302","authenticated-orcid":false,"given":"Anne Mette","family":"\u00d8lholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"4363_CR1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.4137\/HSI.S11093","volume":"6","author":"T Weldring","year":"2013","unstructured":"Weldring, T., & Smith, S. 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R.B.F. received speaking and lecture fees from Bristol-Myers Squibb Denmark and travel reimbursement from Roche, AstraZeneca, and MSD Denmark. S.S. and A.S.V. were involved in the development and implementation of the ePRO system evaluated in this study. The remaining authors have no conflicts of interest to declare.","order":1,"name":"Ethics","label":"Conflict of interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted as part of a quality improvement initiative initiated by the Region of Southern Denmark and is registered in the region\u2019s internal project registry (project no. 24\/15914). The project involved no intervention beyond routine clinical practice. According to regional procedures for quality improvement initiatives, no further approval was required.","order":2,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Interview participants received verbal and written information about the project and provided informed consent prior to participation. Observational fieldwork involved only clinical staff, who were informed in advance.","order":3,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No identifiable individual-level data are included in this manuscript. Results are reported only in anonymised form. According to regional procedures, no separate consent to publish was required.","order":4,"name":"Ethics","label":"Consent to publish","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"262"}}