{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:17:22Z","timestamp":1791281842487,"version":"4.1.0"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rev Endocr Metab Disord"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1007\/s11154-006-9005-1","type":"journal-article","created":{"date-parts":[[2006,9,13]],"date-time":"2006-09-13T16:23:47Z","timestamp":1158164627000},"page":"91-99","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Anorexia nervosa and osteoporosis"],"prefix":"10.1007","volume":"7","author":[{"given":"Madhusmita","family":"Misra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Klibanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,9,14]]},"reference":[{"key":"9005_CR1","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1176\/ajp.148.7.917","volume":"148","author":"AR Lucas","year":"1991","unstructured":"Lucas AR, Beard CM, O\u2019Fallon WM, Kurland LT. 50-year trends in the incidence of anorexia nervosa in Rochester, MN: a population-based study. Am J Psychiatry 1991;148:917\u201322","journal-title":"Am J Psychiatry"},{"key":"9005_CR2","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1002\/eat.10050","volume":"31","author":"K Von Ranson","year":"2002","unstructured":"Von Ranson K, Iacono W, McGue M. Disordered eating and substance abuse in an epidemiological sample. 1. Associations within individuals. Int J Eat Disord 2002;31:389\u2013403","journal-title":"Int J Eat Disord"},{"key":"9005_CR3","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1002\/1098-108X(199512)18:4<335::AID-EAT2260180406>3.0.CO;2-T","volume":"18","author":"A Andersen","year":"1995","unstructured":"Andersen A, Woodward P, LaFrance N. Bone mineral density of eating disorder subgroups. Int J Eat Disord 1995;18:335\u201342","journal-title":"Int J Eat Disord"},{"key":"9005_CR4","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1007\/BF00582161","volume":"50","author":"P Hay","year":"1992","unstructured":"Hay P, Delahunt J, Hall A, Mitchell A, Harper G, Salmond C. Predictors of osteopenia in premenopausal women with anorexia nervosa. Calcif Tissue Int 1992;50:498\u2013501","journal-title":"Calcif Tissue Int"},{"key":"9005_CR5","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1001\/jama.265.9.1133","volume":"265","author":"N Rigotti","year":"1991","unstructured":"Rigotti N, Neer R, Skates S, Herzog D, Nussbaum S. The clinical course of osteoporosis in anorexia nervosa. A longitudinal study of cortical bone mass. JAMA 1991;265:1133\u20138","journal-title":"JAMA"},{"key":"9005_CR6","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1007\/s00198-005-1972-7","volume":"16","author":"J Bolton","year":"2005","unstructured":"Bolton J, Patel S, Lacey J, White S. A prospective study of changes in bone turnover and bone density associated with regaining weight in women with anorexia nervosa. Osteoporos Int 2005;16:1955\u201362","journal-title":"Osteoporos Int"},{"key":"9005_CR7","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/S0022-3956(99)00002-3","volume":"33","author":"C Lennkh","year":"1999","unstructured":"Lennkh C, de Zwaan M, Bailer U, Strnad A, Nagy C, El-Giamal N, et al. Osteopenia in anorexia nervosa: specific mechanisms of bone loss. J Psychiatr Res 1999;33:349\u201356","journal-title":"J Psychiatr Res"},{"key":"9005_CR8","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1210\/jc.84.6.2049","volume":"84","author":"S Grinspoon","year":"1999","unstructured":"Grinspoon S, Miller K, Coyle C, Krempin J, Armstrong C, Pitts S, et al. Severity of osteopenia in estrogen-deficient women with anorexia nervosa and hypothalamic amenorrhea. J Clin Endocrinol Metab 1999;84:2049\u201355","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR9","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1542\/peds.86.3.440","volume":"86","author":"L Bachrach","year":"1990","unstructured":"Bachrach L, Guido D, Katzman D, Litt I, Marcus R. Decreased bone density in adolescent girls with anorexia nervosa. Pediatrics 1990;86:440\u20137","journal-title":"Pediatrics"},{"key":"9005_CR10","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s007870200011","volume":"11","author":"G Jagielska","year":"2002","unstructured":"Jagielska G, Wolanczyk T, Komender J, Tomaszewicz-Libudzic C, Przedlacki J, Ostrowski K. Bone mineral density in adolescent girls with anorexia nervosa\u2014a cross-sectional study. Eur Child Adolesc Psychiatry 2002;11:57\u201362","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"9005_CR11","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1542\/peds.2004-0540","volume":"114","author":"M Misra","year":"2004","unstructured":"Misra M, Aggarwal A, Miller KK, Almazan C, Worley M, Soyka LA, et al. Effects of anorexia nervosa on clinical, hematologic, biochemical, and bone density parameters in community-dwelling adolescent girls. Pediatrics 2004;114:1574\u201383","journal-title":"Pediatrics"},{"key":"9005_CR12","doi-asserted-by":"publisher","first-page":"4489","DOI":"10.1210\/jc.84.12.4489","volume":"84","author":"L Soyka","year":"1999","unstructured":"Soyka L, Grinspoon S, Levitsky L, Herzog D, Klibanski A. The effects of anorexia nervosa on bone metabolism in female adolescents. J Clin Endocrinol Metab 1999;84:4489\u201396","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR13","doi-asserted-by":"publisher","first-page":"4177","DOI":"10.1210\/jc.2001-011889","volume":"87","author":"L Soyka","year":"2002","unstructured":"Soyka L, Misra M, Frenchman A, Miller K, Grinspoon S, Schoenfeld D, et al. Abnormal bone mineral accrual in adolescent girls with anroexia nervosa. J Clin Endocrinol Metab 2002;87:4177\u201385","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR14","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1515\/IJAMH.2002.14.4.297","volume":"14","author":"M Schneider","year":"2002","unstructured":"Schneider M, Fisher M, Weinerman S, Lesser M. Correlates of low bone density in females with anorexia nervosa. Int J Adolesc Med Health 2002;14:297\u2013306","journal-title":"Int J Adolesc Med Health"},{"key":"9005_CR15","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1002\/eat.1081","volume":"30","author":"J Turner","year":"2001","unstructured":"Turner J, Bulsara M, McDermott B, Byrne G, Prince R, Forbes D. Predictors of low bone density in young adolescent females with anorexia nervosa and other dieting disorders. Int J Eat Disord 2001;30:245\u201351","journal-title":"Int J Eat Disord"},{"key":"9005_CR16","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1097\/00004583-200205000-00019","volume":"41","author":"J Castro","year":"2002","unstructured":"Castro J, Toro J, Lazaro L, Pons F, Halperin I. Bone mineral density in male adolescents with anorexia nervosa. J Am Acad Child Adolesc Psychiatry 2002;41:613\u20138","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"9005_CR17","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1210\/jc.75.4.1060","volume":"75","author":"G Theintz","year":"1992","unstructured":"Theintz G, Buchs B, Rizzoli R, Slosman D, Clavien H, Sizonenko P, et al. Longitudinal monitoring of bone mass accumulation in healthy adolescents: evidence for a marked reduction after 16 years of age at the levels of lumbar spine and femoral neck in female subjects. J Clin Endocrinol Metab 1992;75:1060\u20135","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR18","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/S1043-2760(00)00336-2","volume":"12","author":"L. Bachrach","year":"2001","unstructured":"Bachrach L. Acquisition of optimal bone mass in childhood and adolescence. Trends Endocrinol Metab 2001;12:22\u20138","journal-title":"Trends Endocrinol Metab"},{"key":"9005_CR19","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1210\/jcem-68-3-548","volume":"68","author":"B Biller","year":"1989","unstructured":"Biller B, Saxe V, Herzog D, Rosenthal D, Holzman S, Klibanski A. Mechanisms of osteoporosis in adult and adolescent women with anorexia nervosa. J Clin Endocrinol Metab 1989;68:548\u201354","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR20","doi-asserted-by":"crossref","first-page":"790","DOI":"10.7326\/0003-4819-133-10-200011210-00011","volume":"133","author":"S Grinspoon","year":"2000","unstructured":"Grinspoon S, Thomas E, Pitts S, Gross E, Mickley D, Miller K, et al. Prevalence and predictive factors for regional osteopenia in women with anorexia nervosa. Ann Intern Med 2000;133:790\u20134","journal-title":"Ann Intern Med"},{"key":"9005_CR21","doi-asserted-by":"publisher","first-page":"3864","DOI":"10.1210\/jc.81.11.3864","volume":"81","author":"S Grinspoon","year":"1996","unstructured":"Grinspoon S, Baum H, Lee K, Anderson E, Herzog D, Klibanski A. Effects of short-term recombinant human insulin-like growth factor I administration on bone turnover in osteopenic women with anorexia nervosa. J Clin Endocrinol Metab 1996;81:3864\u201370","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR22","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1056\/NEJM197410242911701","volume":"291","author":"R Boyar","year":"1974","unstructured":"Boyar R, Katz J, Finkelstein J, Kapen S, Weiner H, Weitzman E, et al. Anorexia nervosa. Immaturity of the 24-hour luteinizing hormone secretory pattern. N Engl J Med 1974;291:861\u20135","journal-title":"N Engl J Med"},{"key":"9005_CR23","first-page":"562","volume":"141","author":"J Cara","year":"1987","unstructured":"Cara J, Rosenfield R, Furlanetto R. A longitudinal study of the relationship of plasma somatomedin-C concentration to the pubertal growth spurt. Am J Dis Child 1987 May;141:562\u20134","journal-title":"Am J Dis Child"},{"key":"9005_CR24","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1210\/er.23.3.279","volume":"23","author":"BL Riggs","year":"2002","unstructured":"Riggs BL, Khosla S, Melton LJ, III. Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 2002;23:279\u2013302","journal-title":"Endocr Rev"},{"key":"9005_CR25","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s10495-005-1893-0","volume":"10","author":"G Gu","year":"2005","unstructured":"Gu G, Hentunen T, Nars M, Harkonen P, Vaananen H. Estrogen protects primary osteocytes against glucocorticoid-induced apoptosis. Apoptosis 2005;10:583\u201395","journal-title":"Apoptosis"},{"key":"9005_CR26","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1007\/s00774-005-0627-2","volume":"23","author":"M Iu","year":"2005","unstructured":"Iu M, Kaji H, Naito J, Sowa H, Sugimoto T, Chihara K. Low-dose parathyroid hormone and estrogen reverse alkaline phosphatase activity suppressed by dexamethasone in mouse osteoblastic cells. J Bone Miner Metab 2005;23:450\u20135","journal-title":"J Bone Miner Metab"},{"key":"9005_CR27","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1359\/JBMR.050803","volume":"20","author":"HHP Michael","year":"2005","unstructured":"Michael HHP, Vaananen HK, Hentunen TA. Estrogen and testosterone use different cellular pathways to inhibit osteoclastogenesis and bone resorption. J Bone Miner Res 2005;20:2224\u201332","journal-title":"J Bone Miner Res"},{"key":"9005_CR28","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1210\/jc.80.3.898","volume":"80","author":"A Klibanski","year":"1995","unstructured":"Klibanski A, Biller B, Schoenfeld D, Herzog D, Saxe V. The effects of estrogen administration on trabecular bone loss in young women with anorexia nervosa. J Clin Endocrinol Metab 1995;80:898\u2013904","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR29","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1210\/jc.2004-1181","volume":"90","author":"KK Miller","year":"2005","unstructured":"Miller KK, Grieco KA, Klibanski A. Testosterone administration in women with anorexia nervosa. J Clin Endocrinol Metab 2005;90:1428\u201333","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR30","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1359\/jbmr.1999.14.1.136","volume":"14","author":"C Gordon","year":"1999","unstructured":"Gordon C, Grace E, Emans S, Goodman E, Crawford M, Leboff M. Changes in bone turnover markers and menstrual function after short-term oral DHEA in young women with anorexia nervosa. J Bone Miner Res 1999;14:136\u201345","journal-title":"J Bone Miner Res"},{"key":"9005_CR31","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1097\/00004583-200011000-00010","volume":"39","author":"J Castro","year":"2000","unstructured":"Castro J, Lazaro L, Pons F, Halperin I, Toro J. Predictors of bone mineral density reduction in adolescents with anorexia nervosa. J Am Acad Child Adolesc Psychiatry 2000;39:365\u201370","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"9005_CR32","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/0006-3223(94)00182-3","volume":"37","author":"T Iketani","year":"1995","unstructured":"Iketani T, Kiriike N, Nakanishi S, Nakasuji T. Effects of weight gain and resumption of menses on reduced bone density in patients with anorexia nervosa. Biol Psychiatry 1995;37:521\u20137","journal-title":"Biol Psychiatry"},{"key":"9005_CR33","doi-asserted-by":"publisher","first-page":"4434","DOI":"10.1210\/jc.2004-0720","volume":"89","author":"KK Miller","year":"2004","unstructured":"Miller KK, Grinspoon S, Gleysteen S, Grieco KA, Ciampa J, Breu J, et al. Preservation of neuroendocrine control of reproductive function despite severe undernutrition. J Clin Endocrinol Metab 2004;89:4434\u20138","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR34","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/0006-3223(94)90594-0","volume":"36","author":"C Pomeroy","year":"1994","unstructured":"Pomeroy C, Eckert E, Hu S, Eiken B, Mentink M, Crosby R, et al. Role of interleukin-6 and transforming growth factor-beta in anorexia nervosa. Biol Psychiatr 1994;36:836\u20139","journal-title":"Biol Psychiatr"},{"key":"9005_CR35","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0306-4530(02)00131-2","volume":"29","author":"KG Kahl","year":"2004","unstructured":"Kahl KG, Kruse N, Rieckmann P, Schmidt MH. Cytokine mRNA expression patterns in the disease course of female adolescents with anorexia nervosa. Psychoneuroendocrinology 2004;29:13\u201320","journal-title":"Psychoneuroendocrinology"},{"key":"9005_CR36","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1159\/000026606","volume":"40","author":"P Monteleone","year":"1999","unstructured":"Monteleone P, Maes M, Fabrazzo M, Tortorella A, Lin A, Bosmans E, et al. Immunoendocrine findings in patients with eating disorders. Neuropsychobiol 1999;40:115\u201320","journal-title":"Neuropsychobiol"},{"key":"9005_CR37","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1002\/1098-108X(200011)28:3<293::AID-EAT6>3.0.CO;2-F","volume":"28","author":"N Raymond","year":"2000","unstructured":"Raymond N, Dysken M, Bettin K, Eckert E, Crow S, Markus K, et al. Cytokine production in patients with anorexia nervosa, bulimia nervosa, and obesity. Int J Eating Disord 2000;28:293\u2013302","journal-title":"Int J Eating Disord"},{"key":"9005_CR38","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.cyto.2004.03.006","volume":"26","author":"N Vaisman","year":"2004","unstructured":"Vaisman N, Hahn T, Karov Y, Sigler E, Barak Y, Barak V. Changes in cytokine production and impaired hematopoiesis in patients with anorexia nervosa: the effect of refeeding. Cytokine 2004;26:255\u201361","journal-title":"Cytokine"},{"key":"9005_CR39","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1097\/00006842-200105000-00021","volume":"63","author":"M Corcos","year":"2001","unstructured":"Corcos M, Guilbaud O, Chaouat G, Cayol V, Speranza M, Chambry J, et al. Cytokines and anorexia nervosa. Psychosom Med 2001;63:502\u20134","journal-title":"Psychosom Med"},{"key":"9005_CR40","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0165-1781(01)00283-9","volume":"103","author":"F Brambilla","year":"2001","unstructured":"Brambilla F, Monti D, Franceschi C. Plasma concentrations of interleukin-1-beta, interleukin-6 and tumor necrosis factor-alpha, and of their soluble receptors and receptor antagonist in anorexia nervosa. Psychiatry Res 2001;103:107\u201314","journal-title":"Psychiatry Res"},{"key":"9005_CR41","doi-asserted-by":"publisher","first-page":"3816","DOI":"10.1210\/jc.2003-030088","volume":"88","author":"M Misra","year":"2003","unstructured":"Misra M, Soyka LA, Miller KK, Herzog DB, Grinspoon S, de Chen D, et al. Serum osteoprotegerin in adolescent girls with anorexia nervosa. J Clin Endocrinol Metab 2003;88:3816\u201322","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR42","doi-asserted-by":"publisher","first-page":"2883","DOI":"10.1210\/jc.87.6.2883","volume":"87","author":"S Grinspoon","year":"2002","unstructured":"Grinspoon S, Thomas L, Miller K, Herzog D, Klibanski A. Effects of recombinant human IGF-I and oral contraceptive administration on bone density in anorexia nervosa. J Clin Endocrinol Metab 2002;87:2883\u201391","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR43","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S1083-3188(02)00145-6","volume":"15","author":"NH Golden","year":"2002","unstructured":"Golden NH, Lanzkowsky L, Schebendach J, Palestro CJ, Jacobson MS, Shenker IR. The effect of estrogen\u2013progestin treatment on bone mineral density in anorexia nervosa. J Pediatr Adolesc Gynecol 2002;15:135\u201343","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"9005_CR44","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1530\/eje.0.1460045","volume":"146","author":"M Munoz","year":"2002","unstructured":"Munoz M, Morande G, Garcia-Centenera J, Hervas F, Pozo J, Argente J. The effects of estrogen administration on bone mineral density in adolescents with anorexia nervosa. Eur J Endocrinol 2002;146:45\u201350","journal-title":"Eur J Endocrinol"},{"key":"9005_CR45","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1067\/mpd.2002.125003","volume":"141","author":"CM Gordon","year":"2002","unstructured":"Gordon CM, Goodman E, Emans SJ, Grace E, Becker KA, Rosen CJ, et al. Physiologic regulators of bone turnover in young women with anorexia nervosa. J Pediatr 2002;141:64\u201370","journal-title":"J Pediatr"},{"key":"9005_CR46","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1530\/eje.0.1390276","volume":"139","author":"M Hotta","year":"1998","unstructured":"Hotta M, Shibasaki T, Sato K, Demura H. The importance of body weight history in the occurrence and recovery of osteoporosis in patients with anorexia nervosa: evaluation by dual X-ray absorptiometry and bone metabolic markers. Eur J Endocrinol 1998;139:276\u201383","journal-title":"Eur J Endocrinol"},{"key":"9005_CR47","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/8756-3282(96)00162-7","volume":"19","author":"S Kooh","year":"1996","unstructured":"Kooh S, Noriega E, Leslie K, Muller C, Harrison J. Bone mass and soft tissue composition in adolescents with anorexia nervosa. Bone 1996;19:181\u20138","journal-title":"Bone"},{"key":"9005_CR48","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1172\/JCI118137","volume":"96","author":"S Grinspoon","year":"1995","unstructured":"Grinspoon S, Baum H, Peterson S, Klibanski A. Effects of rhIGF-I administration on bone turnover during short-term fasting. J Clin Invest 1995;96:900\u20136","journal-title":"J Clin Invest"},{"key":"9005_CR49","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1210\/jcem-72-3-602","volume":"72","author":"L Bachrach","year":"1991","unstructured":"Bachrach L, Katzman D, Litt I, Guido D, Marcus R. Recovery from osteopenia in adolescent girls with anorexia nervosa. J Clin Endocrinol Metab 1991;72:602\u20136","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR50","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1002\/(SICI)1098-108X(200007)28:1<107::AID-EAT13>3.0.CO;2-M","volume":"28","author":"D Hartman","year":"2000","unstructured":"Hartman D, Crisp A, Rooney B, Rackow C, Atkinson R, Patel S. Bone density of women who have recovered from anorexia nervosa. Int J Eat Disord 2000;28:107\u201312","journal-title":"Int J Eat Disord"},{"key":"9005_CR51","doi-asserted-by":"publisher","first-page":"5227","DOI":"10.1210\/jc.86.11.5227","volume":"86","author":"S Zipfel","year":"2001","unstructured":"Zipfel S, Seibel MJ, Lowe B, Beumont PJ, Kasperk C, Herzog W. Osteoporosis in eating disorders: a follow-up study of patients with anorexia and bulimia nervosa. J Clin Endocrinol Metab 2001;86:5227\u201333","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR52","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/S0022-3476(94)70030-3","volume":"125","author":"N Golden","year":"1994","unstructured":"Golden N, Kreitzer P, Jacobson M, Chasalow F, Schebendach J, Freedman S, et al. Disturbances in growth hormone secretion and action in adolescents with anorexia nervosa. J Pediatr 1994;125:655\u201360","journal-title":"J Pediatr"},{"key":"9005_CR53","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1210\/jc.75.3.762","volume":"75","author":"D Counts","year":"1992","unstructured":"Counts D, Gwirtsman H, Carlsson L, Lesem M, Cutler G. The effect of anorexia nervosa and refeeding on growth hormone-binding protein, the insulin-like growth factors (IGFs), and the IGF-binding proteins. J Clin Endocrinol Metab 1992;75:762\u20137","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR54","doi-asserted-by":"publisher","first-page":"5615","DOI":"10.1210\/jc.2003-030532","volume":"88","author":"M Misra","year":"2003","unstructured":"Misra M, Miller K, Bjornson J, Hackman A, Aggarwal A, Chung J, et al. Alterations in growth hormone secretory dynamics in adolescent girls with anorexia nervosa and effects on bone metabolism. J Clin Endocrinol Metab 2003;88:5615\u201323","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR55","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1210\/jc.82.7.2084","volume":"82","author":"J Argente","year":"1997","unstructured":"Argente J, Caballo N, Barrios V, Munoz M, Pozo J, Chowen J, et al. Multiple endocrine abnormalities of the growth hormone and insulin like growth factor-I axis in patients with anorexia nervosa: effect of long- and short-term weight recuperation. J Clin Endocrinol Metab 1997;82:2084\u201392","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR56","doi-asserted-by":"publisher","first-page":"3225","DOI":"10.1210\/jc.82.10.3225","volume":"82","author":"M Scacchi","year":"1997","unstructured":"Scacchi M, Pincelli AI, Caumo A, Tomasi P, Delitala G, Baldi G, et al. Spontaneous nocturnal growth hormone secretion in anorexia nervosa. J Clin Endocrinol Metab 1997;82:3225\u20139","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR57","doi-asserted-by":"publisher","first-page":"2056","DOI":"10.1210\/jc.84.6.2056","volume":"84","author":"RK Stoving","year":"1999","unstructured":"Stoving RK, Veldhuis JD, Flyvbjerg A, Vinten J, Hangaard J, Koldkjar OG, et al. Jointly amplified basal and pulsatile growth hormone (GH) secretion and increased process irregularity in women with anorexia nervosa: indirect evidence for disruption of feedback regulation within the GH-insulin-like growth factor I axis. J Clin Endocrinol Metab 1999;84:2056\u201363","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR58","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1210\/er.19.1.55","volume":"19","author":"C Ohlsson","year":"1998","unstructured":"Ohlsson C, Bengtsson B, Isaksson O, Andreassen T, Slootweg M. Growth hormone and bone. Endocr Rev 1998;19:55\u201379","journal-title":"Endocr Rev"},{"key":"9005_CR59","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/S0022-3476(05)81714-7","volume":"123","author":"S Abrams","year":"1993","unstructured":"Abrams S, Silber T, Esteban N, Vieira N, Stuff J, Meyers R, et al. Mineral balance and bone turnover in adolescents with anorexia nervosa. J Pediatr 1993;123:326\u201331","journal-title":"J Pediatr"},{"key":"9005_CR60","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1359\/jbmr.2001.16.10.1879","volume":"16","author":"V Abad","year":"2001","unstructured":"Abad V, Chrousos G, Reynolds J, Nieman L, Hill S, Weinstein R, et al. Glucocorticoid excess during adolescence leads to a major persistent deficit in bone mass and an increase in central body fat. J Bone Miner Res 2001;16:1879\u201385","journal-title":"J Bone Miner Res"},{"key":"9005_CR61","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1111\/j.1572-0241.2002.05609.x","volume":"97","author":"M Cino","year":"2002","unstructured":"Cino M, Greenberg G. Bone mineral density in Crohn\u2019s disease: a longitudinal study of budesonide, prednisone, and nonsteroid therapy. Am J Gastroenterol 2002;97:915\u201321","journal-title":"Am J Gastroenterol"},{"key":"9005_CR62","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1046\/j.0300-0664.2001.01454.doc.x","volume":"56","author":"C Di Somma","year":"2002","unstructured":"Di Somma C, Pivonello R, Loche S, Faggiano A, Marzullo P, Di Sarno A, et al. Severe impairment of bone mass and turnover in Cushing\u2019s disease: comparison between childhood-onset and adulthood-onset disease. Clin Endocrinol (Oxf) 2002;56:153\u20138","journal-title":"Clin Endocrinol (Oxf)"},{"key":"9005_CR63","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/BF00869084","volume":"8","author":"B Lettgen","year":"1994","unstructured":"Lettgen B, Jeken C, Reiners C. Influence of steroid medication on bone mineral density in children with nephrotic syndrome. Pediatr Nephrol 1994;8:667\u201370","journal-title":"Pediatr Nephrol"},{"key":"9005_CR64","doi-asserted-by":"publisher","first-page":"2859","DOI":"10.1210\/jc.80.10.2859","volume":"80","author":"A Hermus","year":"1995","unstructured":"Hermus A, Smals A, Swinkels L, Huysmans D, Pieters G, Sweep C, et al. Bone mineral density and bone turnover before and after surgical cure of Cushing\u2019s syndrome. J Clin Endocrinol Metab 1995;80:2859\u201365","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR65","doi-asserted-by":"crossref","unstructured":"Misra M, Miller K, Almazan C, Ramaswamy K, Lapcharoensap W, Worley M, Neubauer G, Herzog D, Klibanski A. Alterations in cortisol secretory dynamics in adolescent girls with anorexia nervosa and effects on bone metabolism. J Clin Endocrinol Metab 2004:Submitted.","DOI":"10.1210\/jc.2004-0723"},{"key":"9005_CR66","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1056\/NEJM197701272960403","volume":"296","author":"R Boyar","year":"1977","unstructured":"Boyar R, Hellman L, Roffwarg H, Katz J, Zumoff B, O\u2019Connor J, et al. Cortisol secretion and metabolism in anorexia nervosa. N Engl J Med 1977;296:190\u20133","journal-title":"N Engl J Med"},{"key":"9005_CR67","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1097\/00006842-197810000-00005","volume":"40","author":"B Walsh","year":"1978","unstructured":"Walsh B, Katz J, Levin J, Kream J, Fukushima D, Hellman L, et al. Adrenal activity in anorexia nervosa. Psychosom Med 1978;40:499\u2013506","journal-title":"Psychosom Med"},{"key":"9005_CR68","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1126\/science.7624778","volume":"269","author":"L Campfield","year":"1995","unstructured":"Campfield L, Smith F, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995;269:546\u20139","journal-title":"Science"},{"key":"9005_CR69","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1126\/science.7624776","volume":"269","author":"M Pelleymounter","year":"1995","unstructured":"Pelleymounter M, Cullen M, Baker M, Hecht R, Winters D, Boone T, et al. Effects of the obese gene product on body weight regulation in ob\/ob mice. Science 1995;269:540\u20133","journal-title":"Science"},{"key":"9005_CR70","doi-asserted-by":"publisher","first-page":"3861","DOI":"10.1210\/jc.81.11.3861","volume":"81","author":"S Grinspoon","year":"1996","unstructured":"Grinspoon S, Gulick T, Askari H, Landt M, Lee K, Anderson E, et al. Serum leptin levels in women with anorexia nervosa. J Clin Endocrinol Metab 1996;81:3861\u20133","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR71","doi-asserted-by":"publisher","first-page":"3486","DOI":"10.1210\/jc.2003-032251","volume":"89","author":"M Misra","year":"2004","unstructured":"Misra M, Miller KK, Almazan C, Ramaswamy K, Aggarwal A, Herzog DB, et al. Hormonal and body composition predictors of soluble leptin receptor, leptin, and free leptin index in adolescent girls with anorexia nervosa and controls and relation to insulin sensitivity. J Clin Endocrinol Metab 2004;89:3486\u201395","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR72","doi-asserted-by":"crossref","unstructured":"Misra M, Miller KK, Kuo K, Griffin K, Stewart V, Hunter E, et al. Secretory dynamics of leptin in adolescent girls with anorexia nervosa and healthy adolescents. Am J Physiol Endocrinol Metab:00041.2005","DOI":"10.1152\/ajpendo.00041.2005"},{"key":"9005_CR73","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1210\/jc.2002-020645","volume":"88","author":"V Tolle","year":"2003","unstructured":"Tolle V, Kadem M, Bluet-Pajot M-T, Frere D, Foulon C, Bossu C, et al. Balance in ghrelin and leptin plasma levels in anorexia nervosa patients and constitutionally thin women. J Clin Endocrinol Metab 2003;88:109\u201316","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR74","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1093\/ajcn\/80.3.774","volume":"80","author":"M Heer","year":"2004","unstructured":"Heer M, Mika C, Grzella I, Heussen N, Herpertz-Dahlmann B. Bone turnover during inpatient nutritional therapy and outpatient follow-up in patients with anorexia nervosa compared with that in healthy control subjects. Am J Clin Nutr 2004;80:774\u201381","journal-title":"Am J Clin Nutr"},{"key":"9005_CR75","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1530\/eje.0.1420373","volume":"142","author":"S Herpertz","year":"2000","unstructured":"Herpertz S, Albers N, Wagner R, Pelz B, Kopp W, Mann K, et al. Longitudinal changes of circadian leptin, insulin and cortisol plasma levels and their correlation during refeeding in patients with anorexia nervosa. Eur J Endocrinol 2000;142:373\u20139","journal-title":"Eur J Endocrinol"},{"key":"9005_CR76","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1038\/sj.mp.4000418","volume":"3","author":"L Audi","year":"1998","unstructured":"Audi L, Mantzoros C, Vidal-Puig A, Vargas D, Gussinye M, Carrascosa A. Leptin in relation to resumption of menses in women with anorexia nervosa. Mol Psychiatr 1998;3:544\u20137","journal-title":"Mol Psychiatr"},{"key":"9005_CR77","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0092-8674(00)81558-5","volume":"100","author":"P Ducy","year":"2000","unstructured":"Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT, et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 2000;100:197\u2013207","journal-title":"Cell"},{"key":"9005_CR78","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1038\/35038090","volume":"407","author":"M Tschop","year":"2000","unstructured":"Tschop M, Smiley D, Heiman M. Ghrelin induces adiposity in rodents. Nature 2000;407:908\u201313","journal-title":"Nature"},{"key":"9005_CR79","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/35051587","volume":"409","author":"M Nakazato","year":"2001","unstructured":"Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, et al. A role for ghrelin in the central regulation of feeding. Nature 2001;409:194\u20138","journal-title":"Nature"},{"key":"9005_CR80","doi-asserted-by":"publisher","first-page":"5478","DOI":"10.1210\/jc.2003-030564","volume":"88","author":"F Tassone","year":"2003","unstructured":"Tassone F, Broglio F, Destefanis S, Rovere S, Benso A, Gottero C, et al. Neuroendocrine and metabolic effects of acute ghrelin administration in human obesity. J Clin Endocrinol Metab 2003;88:5478\u201383","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR81","doi-asserted-by":"publisher","first-page":"4908","DOI":"10.1210\/jc.85.12.4908","volume":"85","author":"K Takaya","year":"2000","unstructured":"Takaya K, Ariyasu H, Kanamoto N, Iwakura H, Yoshimoto A, Harada M, et al. Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab 2000;85:4908\u201311","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR82","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1210\/jc.86.3.1169","volume":"86","author":"E Arvat","year":"2001","unstructured":"Arvat E, Maccario M, Di Vito L, Broglio F, Benso A, Gottero C, et al. Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone. J Clin Endocrinol Metab 2001;86:1169\u201374","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR83","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1210\/en.2002-220852","volume":"144","author":"GS Tannenbaum","year":"2003","unstructured":"Tannenbaum GS, Epelbaum J, Bowers CY. Interrelationship between the novel peptide ghrelin and somatostatin\/growth hormone-releasing hormone in regulation of pulsatile growth hormone secretion. Endocrinology 2003;144:967\u201374","journal-title":"Endocrinology"},{"key":"9005_CR84","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1111\/j.1365-2265.2004.02176.x","volume":"62","author":"S Kojima","year":"2005","unstructured":"Kojima S, Nakahara T, Nagai N, Muranaga T, Tanaka M, Yasuhara D, et al. Altered ghrelin and peptide YY responses to meals in bulimia nervosa. Clin Endocrinol (Oxf) 2005;62:74\u20138","journal-title":"Clin Endocrinol (Oxf)"},{"key":"9005_CR85","doi-asserted-by":"publisher","first-page":"5718","DOI":"10.1210\/jc.2004-1244","volume":"89","author":"NR Vulliemoz","year":"2004","unstructured":"Vulliemoz NR, Xiao E, Xia-Zhang L, Germond M, Rivier J, Ferin M. Decrease in luteinizing hormone pulse frequency during a five-hour peripheral ghrelin infusion in the ovariectomized rhesus monkey. J Clin Endocrinol Metab 2004;89:5718\u201323","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR86","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1677\/joe.1.05837","volume":"184","author":"G Maccarinelli","year":"2005","unstructured":"Maccarinelli G, Sibilia V, Torsello A, Raimondo F, Pitto M, Giustina A, et al. Ghrelin regulates proliferation and differentiation of osteoblastic cells. J Endocrinol 2005;184:249\u201356","journal-title":"J Endocrinol"},{"key":"9005_CR87","doi-asserted-by":"publisher","first-page":"5707","DOI":"10.1210\/jc.2004-0353","volume":"89","author":"M Hotta","year":"2004","unstructured":"Hotta M, Ohwada R, Katakami H, Shibasaki T, Hizuka N, Takano K. Plasma levels of intact and degraded ghrelin and their responses to glucose infusion in anorexia nervosa. J Clin Endocrinol Metab 2004;89:5707\u201312","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR88","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1210\/jc.2003-031861","volume":"89","author":"M Misra","year":"2004","unstructured":"Misra M, Miller KK, Herzog DB, Ramaswamy K, Aggarwal A, Almazan C, et al. Growth hormone and ghrelin responses to an oral glucose load in adolescent girls with anorexia nervosa and controls. J Clin Endocrinol Metab 2004;89:1605\u201312","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR89","unstructured":"Misra M, Miller KK, Kuo K, Griffin K, Stewart V, Hunter E, Herzog DB, Klibanski A. Secretory dynamics of ghrelin in adolescent girls with anorexia nervosa and healthy adolescents. Am J Physiol Endocrinol Metab:00615.2004"},{"key":"9005_CR90","doi-asserted-by":"crossref","first-page":"5082","DOI":"10.1210\/jc.2005-0512","volume":"90","author":"M Misra","year":"2005","unstructured":"Misra M, Miller K, Stewart V, Hunter E, Kuo K, Herzog D, Klibanski A. Ghrelin and bone metabolism in adolescent girls with anorexia nervosa and healthy adolescents. J Clin Endocrinol Metab:Jul 5 2005; 90:5082\u20137","journal-title":"J Clin Endocrinol Metab:Jul"},{"key":"9005_CR91","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1038\/nature00887","volume":"418","author":"R Batterham","year":"2002","unstructured":"Batterham R, Cowley M, Small C, Herzog H, Cohen M, Dakin C, et al. Gut hormone PYY(3\u201336) physiologically inhibits food intake. Nature 2002;418:650\u20134","journal-title":"Nature"},{"key":"9005_CR92","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1210\/jc.2004-1251","volume":"90","author":"S Stock","year":"2005","unstructured":"Stock S, Leichner P, Wong ACK, Ghatei MA, Kieffer TJ, Bloom SR, et al. Ghrelin, Peptide YY, glucose-dependent insulinotropic polypeptide, and hunger responses to a mixed meal in anorexic, obese, and control female adolescents. J Clin Endocrinol Metab 2005;90:2161\u20138","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR93","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1210\/jc.2005-1878","volume":"91","author":"M Misra","year":"2006","unstructured":"Misra M, Miller K, Tsai P, Gallagher K, Lin A, Lee N, et al. Elevated Peptide YY levels in adolescent girls with anorexia nervosa. J Clin Endocrinol Metab 2006;91:1027\u201333","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR94","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1172\/JCI200214588","volume":"109","author":"PA Baldock","year":"2002","unstructured":"Baldock PA, Sainsbury A, Couzens M, Enriquez RF, Thomas GP, Gardiner EM, et al. Hypothalamic Y2 receptors regulate bone formation. J Clin Invest 2002;109:915\u201321","journal-title":"J Clin Invest"},{"key":"9005_CR95","doi-asserted-by":"publisher","first-page":"3179","DOI":"10.1210\/jc.2004-1659","volume":"90","author":"NH Golden","year":"2005","unstructured":"Golden NH, Iglesias EA, Jacobson MS, Carey D, Meyer W, Schebendach J, et al. Alendronate for the treatment of osteopenia in anorexia nervosa: a randomized, double-blind, placebo-controlled trial 10.1210\/jc.2004-1659. J Clin Endocrinol Metab 2005;90:3179\u201385","journal-title":"J Clin Endocrinol Metab"},{"key":"9005_CR96","doi-asserted-by":"publisher","first-page":"3903","DOI":"10.1210\/jc.2003-031885","volume":"89","author":"KK Miller","year":"2004","unstructured":"Miller KK, Grieco KA, Mulder J, Grinspoon S, Mickley D, Yehezkel R, et al. Effects of risedronate on bone density in anorexia nervosa. J Clin Endocrinol Metab 2004;89:3903\u20136","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Reviews in Endocrine and Metabolic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11154-006-9005-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11154-006-9005-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11154-006-9005-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11154-006-9005-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T00:25:07Z","timestamp":1652574307000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11154-006-9005-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":96,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["9005"],"URL":"https:\/\/doi.org\/10.1007\/s11154-006-9005-1","relation":{},"ISSN":["1389-9155","1573-2606"],"issn-type":[{"value":"1389-9155","type":"print"},{"value":"1573-2606","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6]]},"assertion":[{"value":"14 September 2006","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}