{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T02:12:03Z","timestamp":1794622323163,"version":"4.9.1"},"reference-count":163,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rev Endocr Metab Disord"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1007\/s11154-016-9390-z","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T02:25:06Z","timestamp":1476930306000},"page":"247-258","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Skin steroidogenesis in health and disease"],"prefix":"10.1007","volume":"17","author":[{"given":"Georgios","family":"Nikolakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantine A.","family":"Stratakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodora","family":"Kanaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Slominski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos C.","family":"Zouboulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,10,20]]},"reference":[{"key":"9390_CR1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/978-3-540-35989-0_20","volume-title":"Neuroimmunology of the skin","author":"CC Zouboulis","year":"2009","unstructured":"Zouboulis CC. Acne Vulgaris and Rosacea. In: Granstein R, Luger T, editors. Neuroimmunology of the skin. Berlin Heidelberg: Springer; 2009. p. 219\u201332."},{"issue":"2","key":"9390_CR2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4161\/derm.1.2.8354","volume":"1","author":"WC Chen","year":"2009","unstructured":"Chen WC, Zouboulis CC. Hormones and the pilosebaceous unit. Dermato-Endocrinol. 2009;1(2):81\u20136.","journal-title":"Dermato-Endocrinol"},{"issue":"5\u20136","key":"9390_CR3","first-page":"230","volume":"54","author":"CC Zouboulis","year":"2000","unstructured":"Zouboulis CC. Human skin: an independent peripheral endocrine organ. Horm Res. 2000;54(5\u20136):230\u201342.","journal-title":"Horm Res"},{"issue":"8","key":"9390_CR4","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.bbi.2010.06.013","volume":"24","author":"A Buske-Kirschbaum","year":"2010","unstructured":"Buske-Kirschbaum A, Ebrecht M, Hellhammer DH. Blunted HPA axis responsiveness to stress in atopic patients is associated with the acuity and severeness of allergic inflammation. Brain Behav Immun. 2010;24(8):1347\u201353.","journal-title":"Brain Behav Immun"},{"key":"9390_CR5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00217.2011","author":"C Skobowiat","year":"2011","unstructured":"Skobowiat C, Dowdy JC, Sayre RM, Tuckey RC, Slominski AT. Cutaneous hypothalamic pituitary adrenal (HPA) axis homologue - regulation by ultraviolet radiation. Am J Physiol Endocrinol Metab. 2011. doi: 10.1152\/ajpendo.00217.2011 .","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"3","key":"9390_CR6","doi-asserted-by":"publisher","first-page":"E484","DOI":"10.1152\/ajpendo.00217.2011.10.1152\/ajpendo.00217.2011","volume":"301","author":"C Skobowiat","year":"2011","unstructured":"Skobowiat C, Dowdy JC, Sayre RM, Tuckey RC, Slominski A. Cutaneous hypothalamic-pituitary-adrenal axis homolog: regulation by ultraviolet radiation. Am J Physiol Endocrinol Metab. 2011;301(3):E484\u201393. doi: 10.1152\/ajpendo.00217.2011.10.1152\/ajpendo.00217.2011 .","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"9390_CR7","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.mce.2006.12.012","volume":"265\u2013266","author":"A Slominski","year":"2007","unstructured":"Slominski A, Wortsman J, Tuckey RC, Paus R. Differential expression of HPA axis homolog in the skin. Mol Cell Endocrinol. 2007;265\u2013266:143\u20139.","journal-title":"Mol Cell Endocrinol"},{"issue":"6","key":"9390_CR8","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/S1734-1140(11)70703-4","volume":"63","author":"A Gadek-Michalska","year":"2011","unstructured":"Gadek-Michalska A, Tadeusz J, Rachwalska P, Spyrka J, Bugajski J. Effect of prior stress on interleukin-1beta and HPA axis responses to acute stress. Pharmacol Rep : PR. 2011;63(6):1393\u2013403.","journal-title":"Pharmacol Rep : PR"},{"issue":"10","key":"9390_CR9","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1096\/fj.04-1968fje","volume":"19","author":"N Ito","year":"2005","unstructured":"Ito N, Ito T, Kromminga A, Bettermann A, Takigawa M, Kees F, et al. Human hair follicles display a functional equivalent of the hypothalamic-pituitary-adrenal axis and synthesize cortisol. FASEB J. 2005;19(10):1332\u20134. doi: 10.1096\/fj.04-1968fje .","journal-title":"FASEB J"},{"key":"9390_CR10","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.jsbmb.2013.02.006","volume":"137","author":"A Slominski","year":"2013","unstructured":"Slominski A, Zbytek B, Nikolakis G, Manna PR, Skobowiat C, Zmijewski M, et al. Steroidogenesis in the skin: Implications for local immune functions. J Steroid Biochem Mol Biol. 2013;137:107\u201323. doi: 10.1016\/j.jsbmb.2013.02.006 .","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"3","key":"9390_CR11","first-page":"221","volume":"17","author":"DM Stocco","year":"1996","unstructured":"Stocco DM, Clark BJ. Regulation of the acute production of steroids in steroidogenic cells. Endocr Rev. 1996;17(3):221\u201344.","journal-title":"Endocr Rev"},{"issue":"1","key":"9390_CR12","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2174\/1568008053174714","volume":"5","author":"PR Manna","year":"2005","unstructured":"Manna PR, Stocco DM. Regulation of the steroidogenic acute regulatory protein expression: functional and physiological consequences. Curr Drug Targets Immune Endocr - Metabol Disord. 2005;5(1):93\u2013108.","journal-title":"Curr Drug Targets Immune Endocr - Metabol Disord"},{"issue":"12","key":"9390_CR13","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1194\/jlr.R016675","volume":"52","author":"WL Miller","year":"2011","unstructured":"Miller WL, Bose HS. Early steps in steroidogenesis: intracellular cholesterol trafficking. J Lipid Res. 2011;52(12):2111\u201335. doi: 10.1194\/jlr.R016675 .","journal-title":"J Lipid Res"},{"issue":"21","key":"9390_CR14","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1111\/j.1432-1033.2004.04356.x","volume":"271","author":"A Slominski","year":"2004","unstructured":"Slominski A, Zjawiony J, Wortsman J, Semak I, Stewart J, Pisarchik A, et al. A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin. Europ J Biochem \/ FEBS. 2004;271(21):4178\u201388.","journal-title":"Europ J Biochem \/ FEBS"},{"issue":"6","key":"9390_CR15","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1046\/j.1523-1747.2003.12244.x","volume":"120","author":"D Thiboutot","year":"2003","unstructured":"Thiboutot D, Jabara S, McAllister JM, Sivarajah A, Gilliland K, Cong Z, et al. Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1). J Invest Dermatol. 2003;120(6):905\u201314.","journal-title":"J Invest Dermatol"},{"issue":"10","key":"9390_CR16","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1038\/sj.jid.5700442","volume":"126","author":"W Chen","year":"2006","unstructured":"Chen W, Tsai SJ, Liao CY, Tsai RY, Chen YJ, Pan BJ, et al. Higher levels of steroidogenic acute regulatory protein and type I 3beta-hydroxysteroid dehydrogenase in the scalp of men with androgenetic alopecia. J Invest Dermatol. 2006;126(10):2332\u20135. doi: 10.1038\/sj.jid.5700442 .","journal-title":"J Invest Dermatol"},{"issue":"6","key":"9390_CR17","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00109-006-0155-0","volume":"85","author":"I Tiala","year":"2007","unstructured":"Tiala I, Suomela S, Huuhtanen J, Wakkinen J, Holtta-Vuori M, Kainu K, et al. The CCHCR1 (HCR) gene is relevant for skin steroidogenesis and downregulated in cultured psoriatic keratinocytes. J Mol Med (Berl). 2007;85(6):589\u2013601.","journal-title":"J Mol Med (Berl)"},{"issue":"1","key":"9390_CR18","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.bbrc.2010.11.059","volume":"404","author":"RF Hannen","year":"2011","unstructured":"Hannen RF, Michael AE, Jaulim A, Bhogal R, Burrin JM, Philpott MP. Steroid synthesis by primary human keratinocytes; implications for skin disease. Biochem Biophys Res Commun. 2011;404(1):62\u20137. doi: 10.1016\/j.bbrc.2010.11.059 .","journal-title":"Biochem Biophys Res Commun"},{"issue":"1\u20132","key":"9390_CR19","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.mce.2012.05.005","volume":"362","author":"T Inoue","year":"2012","unstructured":"Inoue T, Miki Y, Abe K, Hatori M, Hosaka M, Kariya Y, et al. Sex steroid synthesis in human skin in situ: the roles of aromatase and steroidogenic acute regulatory protein in the homeostasis of human skin. Mol Cell Endocrinol. 2012;362(1\u20132):19\u201328. doi: 10.1016\/j.mce.2012.05.005 .","journal-title":"Mol Cell Endocrinol"},{"issue":"6","key":"9390_CR20","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1046\/j.0022-202x.2001.01587.x","volume":"117","author":"MV Patel","year":"2001","unstructured":"Patel MV, McKay IA, Burrin JM. Transcriptional regulators of steroidogenesis, DAX-1 and SF-1, are expressed in human skin. J Invest Dermatol. 2001;117(6):1559\u201365. doi: 10.1046\/j.0022-202x.2001.01587.x .","journal-title":"J Invest Dermatol"},{"issue":"3","key":"9390_CR21","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1677\/jme.0.0300381","volume":"30","author":"PR Manna","year":"2003","unstructured":"Manna PR, Eubank DW, Lalli E, Sassone-Corsi P, Stocco DM. Transcriptional regulation of the mouse steroidogenic acute regulatory protein gene by the cAMP response-element binding protein and steroidogenic factor 1. J Mol Endocrinol. 2003;30(3):381\u201397.","journal-title":"J Mol Endocrinol"},{"issue":"1","key":"9390_CR22","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1210\/en.2008-0368","volume":"150","author":"PR Manna","year":"2009","unstructured":"Manna PR, Dyson MT, Jo Y, Stocco DM. Role of dosage-sensitive sex reversal, adrenal hypoplasia congenita, critical region on the X chromosome, gene 1 in protein kinase A- and protein kinase C-mediated regulation of the steroidogenic acute regulatory protein expression in mouse Leydig tumor cells: mechanism of action. Endocrinology. 2009;150(1):187\u201399. doi: 10.1210\/en.2008-0368 .","journal-title":"Endocrinology"},{"issue":"1","key":"9390_CR23","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000067823","volume":"206","author":"D Thiboutot","year":"2003","unstructured":"Thiboutot D, Chen W. Update and future of hormonal therapy in acne. Dermatology. 2003;206(1):57\u201367.","journal-title":"Dermatology"},{"issue":"7","key":"9390_CR24","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1111\/j.1468-3083.2006.01663.x","volume":"20","author":"W Chen","year":"2006","unstructured":"Chen W, Yang CC, Liao CY, Hung CL, Tsai SJ, Chen KF, et al. Expression of sex-determining genes in human sebaceous glands and their possible role in the pathogenesis of acne. J Eur Acad Dermatol Venereol. 2006;20(7):846\u201352. doi: 10.1111\/j.1468-3083.2006.01663.x .","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"9390_CR25","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.mad.2015.08.007","volume":"150","author":"PR Manna","year":"2015","unstructured":"Manna PR, Stetson CL, Daugherty C, Shimizu I, Syapin PJ, Garrel G, et al. Up-regulation of steroid biosynthesis by retinoid signaling: implications for aging. Mech Ageing Dev. 2015;150:74\u201382. doi: 10.1016\/j.mad.2015.08.007 .","journal-title":"Mech Ageing Dev"},{"issue":"7","key":"9390_CR26","first-page":"2746","volume":"81","author":"A Slominski","year":"1996","unstructured":"Slominski A, Ermak G, Mihm M. ACTH receptor, CYP11A1, CYP17 and CYP21A2 genes are expressed in skin. J Clin Endocrinol Metab. 1996;81(7):2746\u20139.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"9390_CR27","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0014-5793(99)00889-3","volume":"455","author":"A Slominski","year":"1999","unstructured":"Slominski A, Gomez-Sanchez CE, Foecking MF, Wortsman J. Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells. FEBS Lett. 1999;455(3):364\u20136.","journal-title":"FEBS Lett"},{"key":"9390_CR28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-4165(99)00215-9","volume":"1474","author":"A Slominski","year":"2000","unstructured":"Slominski A, Gomez-Sanchez C, Foecking MF, Wortsman J. Active steroidogenesis in the normal rat skin. Biochim Biophys Acta. 2000;1474:1\u20134.","journal-title":"Biochim Biophys Acta"},{"issue":"1\u20132","key":"9390_CR29","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jneuroim.2005.01.014","volume":"162","author":"A Slominski","year":"2005","unstructured":"Slominski A, Zbytek B, Semak I, Sweatman T, Wortsman J. CRH stimulates POMC activity and corticosterone production in dermal fibroblasts. J Neuroimmunol. 2005;162(1\u20132):97\u2013102.","journal-title":"J Neuroimmunol"},{"issue":"4","key":"9390_CR30","doi-asserted-by":"crossref","first-page":"E701","DOI":"10.1152\/ajpendo.00519.2004","volume":"288","author":"A Slominski","year":"2005","unstructured":"Slominski A, Zbytek B, Szczesniewski A, Semak I, Kaminski J, Sweatman T, et al. CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH. Am J Physiol Endocrinol Metab. 2005;288(4):E701\u20136.","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"5","key":"9390_CR31","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/sj.jid.5700204","volume":"126","author":"A Slominski","year":"2006","unstructured":"Slominski A, Zbytek B, Szczesniewski A, Wortsman J. Cultured human dermal fibroblasts do produce cortisol. J Invest Dermatol. 2006;126(5):1177\u20138.","journal-title":"J Invest Dermatol"},{"issue":"1","key":"9390_CR32","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0960-0760(01)00076-0","volume":"78","author":"D Rogoff","year":"2001","unstructured":"Rogoff D, Gomez-Sanchez CE, Foecking MF, Wortsman J, Slominski A. Steroidogenesis in the human skin: 21-hydroxylation in cultured keratinocytes. J Steroid Biochem Mol Biol. 2001;78(1):77\u201381.","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"2","key":"9390_CR33","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1046\/j.0022-202x.2001.01648.x","volume":"118","author":"A Slominski","year":"2002","unstructured":"Slominski A, Wortsman J, Foecking MF, Shackleton C, Gomez-Sanchez C, Szczesniewski A. Gas chromatography\/mass spectrometry characterization of corticosteroid metabolism in human immortalized keratinocytes. J Invest Dermatol. 2002;118(2):310\u20135. doi: 10.1046\/j.0022-202x.2001.01648.x .","journal-title":"J Invest Dermatol"},{"issue":"5","key":"9390_CR34","doi-asserted-by":"crossref","first-page":"757","DOI":"10.33549\/physiolres.931544","volume":"58","author":"CF Sharpley","year":"2009","unstructured":"Sharpley CF, Kauter KG, McFarlane JR. An initial exploration of in vivo hair cortisol responses to a brief pain stressor: latency, localization and independence effects. Physiol Res. 2009;58(5):757\u201361.","journal-title":"Physiol Res"},{"issue":"12","key":"9390_CR35","doi-asserted-by":"publisher","first-page":"10265","DOI":"10.1074\/jbc.M110.188268","volume":"286","author":"S Vukelic","year":"2011","unstructured":"Vukelic S, Stojadinovic O, Pastar I, Rabach M, Krzyzanowska A, Lebrun E, et al. Cortisol synthesis in epidermis is induced by IL-1 and tissue injury. J Biol Chem. 2011;286(12):10265\u201375. doi: 10.1074\/jbc.M110.188268 .","journal-title":"J Biol Chem"},{"issue":"6","key":"9390_CR36","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1002\/jcb.23081","volume":"112","author":"N Cirillo","year":"2011","unstructured":"Cirillo N, Prime SS. Keratinocytes synthesize and activate cortisol. J Cell Biochem. 2011;112(6):1499\u2013505. doi: 10.1002\/jcb.23081 .","journal-title":"J Cell Biochem"},{"issue":"1","key":"9390_CR37","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1210\/er.2010-0013","volume":"32","author":"WL Miller","year":"2011","unstructured":"Miller WL, Auchus RJ. The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders. Endocr Res. 2011;32(1):81\u2013151. doi: 10.1210\/er.2010-0013 .","journal-title":"Endocr Res"},{"issue":"1","key":"9390_CR38","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/jid.2010.257","volume":"131","author":"A Tiganescu","year":"2011","unstructured":"Tiganescu A, Walker EA, Hardy RS, Mayes AE, Stewart PM. Localization, age- and site-dependent expression, and regulation of 11beta-hydroxysteroid dehydrogenase type 1 in skin. J Invest Dermatol. 2011;131(1):30\u20136. doi: 10.1038\/jid.2010.257 .","journal-title":"J Invest Dermatol"},{"key":"9390_CR39","doi-asserted-by":"crossref","unstructured":"Skobowiat C, Sayre RM, Dowdy JC, Slominski AT. Ultraviolet radiation regulates cortisol activity in a waveband dependent manner in human skin ex-vivo. Br J Dermatol. 2013;in press.","DOI":"10.1111\/bjd.12096"},{"issue":"2","key":"9390_CR40","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/1523-1747.ep12650440","volume":"99","author":"E Proksch","year":"1992","unstructured":"Proksch E, Feingold KR, Elias PM. Epidermal HMG CoA reductase activity in essential fatty acid deficiency: barrier requirements rather than eicosanoid generation regulate cholesterol synthesis. J Invest Dermatol. 1992;99(2):216\u201320.","journal-title":"J Invest Dermatol"},{"issue":"1","key":"9390_CR41","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0014-5793(86)80533-6","volume":"200","author":"DM Cassidy","year":"1986","unstructured":"Cassidy DM, Lee CM, Laker MF, Kealey T. Lipogenesis in isolated human sebaceous glands. FEBS Lett. 1986;200(1):173\u20136.","journal-title":"FEBS Lett"},{"issue":"2","key":"9390_CR42","first-page":"95","volume":"35","author":"S Alesci","year":"2001","unstructured":"Alesci S, Koch CA, Bornstein SR, Pacak K. Adrenal androgens regulation and adrenopause. Endocr Regul. 2001;35(2):95\u2013100.","journal-title":"Endocr Regul"},{"issue":"2","key":"9390_CR43","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1055\/s-2007-961807","volume":"39","author":"CC Zouboulis","year":"2007","unstructured":"Zouboulis CC, Chen WC, Thornton MJ, Qin K, Rosenfield R. Sexual hormones in human skin. Hormone Meta Res = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2007;39(2):85\u201395. doi: 10.1055\/s-2007-961807 .","journal-title":"Hormone Meta Res = Hormon- und Stoffwechselforschung = Hormones et metabolisme"},{"issue":"11","key":"9390_CR44","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1210\/me.2004-0532","volume":"19","author":"DM Stocco","year":"2005","unstructured":"Stocco DM, Wang X, Jo Y, Manna PR. Multiple signaling pathways regulating steroidogenesis and steroidogenic acute regulatory protein expression: more complicated than we thought. Mol Endocrinol. 2005;19(11):2647\u201359.","journal-title":"Mol Endocrinol"},{"issue":"1","key":"9390_CR45","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1210\/mend.16.1.0759","volume":"16","author":"PR Manna","year":"2002","unstructured":"Manna PR, Dyson MT, Eubank DW, Clark BJ, Lalli E, Sassone-Corsi P, et al. Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response-element binding protein family. Mol Endocrinol. 2002;16(1):184\u201399.","journal-title":"Mol Endocrinol"},{"issue":"6","key":"9390_CR46","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1093\/molehr\/gap025","volume":"15","author":"PR Manna","year":"2009","unstructured":"Manna PR, Dyson MT, Stocco DM. Regulation of the steroidogenic acute regulatory protein gene expression: present and future perspectives. Mol Hum Reprod. 2009;15(6):321\u201333. doi: 10.1093\/molehr\/gap025 .","journal-title":"Mol Hum Reprod"},{"issue":"5","key":"9390_CR47","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1111\/j.1600-0625.2009.00996.x","volume":"19","author":"W Chen","year":"2010","unstructured":"Chen W, Tsai SJ, Sheu HM, Tsai JC, Zouboulis CC. Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone. Exp Dermatol. 2010;19(5):470\u20132. doi: 10.1111\/j.1600-0625.2009.00996.x .","journal-title":"Exp Dermatol"},{"issue":"10","key":"9390_CR48","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1001\/archderm.1990.01670340064009","volume":"126","author":"L Milewich","year":"1990","unstructured":"Milewich L, Sontheimer RD, Herndon Jr JH. Steroid sulfatase activity in epidermis of acne-prone and non-acne-prone skin of patients with acne vulgaris. Arch Dermatol. 1990;126(10):1312\u20134.","journal-title":"Arch Dermatol"},{"issue":"6","key":"9390_CR49","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1046\/j.0022-202x.2001.01547.x","volume":"117","author":"R Hoffmann","year":"2001","unstructured":"Hoffmann R, Rot A, Niiyama S, Billich A. Steroid sulfatase in the human hair follicle concentrates in the dermal papilla. J Invest Dermatol. 2001;117(6):1342\u20138. doi: 10.1046\/j.0022-202x.2001.01547.x .","journal-title":"J Invest Dermatol"},{"key":"9390_CR50","first-page":"99","volume":"53","author":"A Billich","year":"2000","unstructured":"Billich A, Rot A, Lam C, Schmidt JB, Schuster I. Immunohistochemical localization of steroid sulfatase in acne lesions: implications for the contribution of dehydroepiandrosterone sulfate to the pathogenesis of acne. Hormone Metab Res = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2000;53:99.","journal-title":"Hormone Metab Res = Hormon- und Stoffwechselforschung = Hormones et metabolisme"},{"issue":"5","key":"9390_CR51","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1046\/j.0022-202x.2001.doc.x","volume":"116","author":"M Fritsch","year":"2001","unstructured":"Fritsch M, Orfanos CE, Zouboulis CC. Sebocytes are the key regulators of androgen homeostasis in human skin. J Invest Dermatol. 2001;116(5):793\u2013800. doi: 10.1046\/j.0022-202x.2001.doc.x .","journal-title":"J Invest Dermatol"},{"issue":"5","key":"9390_CR52","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.clindermatol.2004.03.010","volume":"22","author":"D Thiboutot","year":"2004","unstructured":"Thiboutot D. Acne: hormonal concepts and therapy. Clin Dermatol. 2004;22(5):419\u201328. doi: 10.1016\/j.clindermatol.2004.03.010 .","journal-title":"Clin Dermatol"},{"issue":"5\u20136","key":"9390_CR53","first-page":"218","volume":"54","author":"F Labrie","year":"2000","unstructured":"Labrie F, Luu-The V, Labrie C, Pelletier G, El-Alfy M. Intracrinology and the skin. Horm Res. 2000;54(5\u20136):218\u201329.","journal-title":"Horm Res"},{"issue":"5","key":"9390_CR54","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1046\/j.1523-1747.2002.00613.x","volume":"119","author":"W Chen","year":"2002","unstructured":"Chen W, Thiboutot D, Zouboulis CC. Cutaneous androgen metabolism: basic research and clinical perspectives. J Invest Dermatol. 2002;119(5):992\u20131007. doi: 10.1046\/j.1523-1747.2002.00613.x .","journal-title":"J Invest Dermatol"},{"issue":"3","key":"9390_CR55","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1046\/j.1523-1747.1998.00322.x","volume":"111","author":"D Thiboutot","year":"1998","unstructured":"Thiboutot D, Martin P, Volikos L, Gilliland K. Oxidative activity of the type 2 isozyme of 17beta-hydroxysteroid dehydrogenase (17beta-HSD) predominates in human sebaceous glands. J Invest Dermatol. 1998;111(3):390\u20135. doi: 10.1046\/j.1523-1747.1998.00322.x .","journal-title":"J Invest Dermatol"},{"issue":"4\u20135","key":"9390_CR56","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.jsbmb.2006.01.010","volume":"99","author":"N Sakurai","year":"2006","unstructured":"Sakurai N, Miki Y, Suzuki T, Watanabe K, Narita T, Ando K, et al. Systemic distribution and tissue localizations of human 17beta-hydroxysteroid dehydrogenase type 12. J Steroid Biochem Mol Biol. 2006;99(4\u20135):174\u201381. doi: 10.1016\/j.jsbmb.2006.01.010 .","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"2","key":"9390_CR57","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1210\/endo.140.2.6531","volume":"140","author":"I Dufort","year":"1999","unstructured":"Dufort I, Rheault P, Huang XF, Soucy P, Luu-The V. Characteristics of a highly labile human type 5 17beta-hydroxysteroid dehydrogenase. Endocrinology. 1999;140(2):568\u201374.","journal-title":"Endocrinology"},{"issue":"3","key":"9390_CR58","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1159\/000211412","volume":"9","author":"G Courchay","year":"1996","unstructured":"Courchay G, Boyera N, Bernard BA, Mahe Y. Messenger RNA expression of steroidogenesis enzyme subtypes in the human pilosebaceous unit. Skin Pharmacol. 1996;9(3):169\u201376.","journal-title":"Skin Pharmacol"},{"issue":"6","key":"9390_CR59","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0960-0760(93)90308-J","volume":"46","author":"KN Qin","year":"1993","unstructured":"Qin KN, New MI, Cheng KC. Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase. J Steroid Biochem Mol Biol. 1993;46(6):673\u20139.","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"1\u20132","key":"9390_CR60","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0303-7207(01)00444-0","volume":"178","author":"A Brodie","year":"2001","unstructured":"Brodie A, Inkster S, Yue W. Aromatase expression in the human male. Mol Cell Endocrinol. 2001;178(1\u20132):23\u20138.","journal-title":"Mol Cell Endocrinol"},{"issue":"10","key":"9390_CR61","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1073\/pnas.87.10.3640","volume":"87","author":"S Andersson","year":"1990","unstructured":"Andersson S, Russell DW. Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases. Proc Natl Acad Sci U S A. 1990;87(10):3640\u20134.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"9390_CR62","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1210\/endo-126-2-1165","volume":"126","author":"PB Grino","year":"1990","unstructured":"Grino PB, Griffin JE, Wilson JD. Testosterone at high concentrations interacts with the human androgen receptor similarly to dihydrotestosterone. Endocrinology. 1990;126(2):1165\u201372.","journal-title":"Endocrinology"},{"issue":"1","key":"9390_CR63","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1046\/j.1523-1747.1998.00080.x","volume":"110","author":"W Chen","year":"1998","unstructured":"Chen W, Zouboulis CC, Fritsch M, Blume-Peytavi U, Kodelja V, Goerdt S, et al. Evidence of heterogeneity and quantitative differences of the type 1 5alpha-reductase expression in cultured human skin cells--evidence of its presence in melanocytes. J Invest Dermatol. 1998;110(1):84\u20139. doi: 10.1046\/j.1523-1747.1998.00080.x .","journal-title":"J Invest Dermatol"},{"issue":"4","key":"9390_CR64","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1210\/edrv.21.4.0404","volume":"21","author":"D Deplewski","year":"2000","unstructured":"Deplewski D, Rosenfield RL. Role of hormones in pilosebaceous unit development. Endocr Rev. 2000;21(4):363\u201392.","journal-title":"Endocr Rev"},{"issue":"7","key":"9390_CR65","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s00403-012-1265-x","volume":"304","author":"JJ Lai","year":"2012","unstructured":"Lai JJ, Chang P, Lai KP, Chen L, Chang C. The role of androgen and androgen receptor in skin-related disorders. Arch Dermatol Res. 2012;304(7):499\u2013510. doi: 10.1007\/s00403-012-1265-x .","journal-title":"Arch Dermatol Res"},{"issue":"2","key":"9390_CR66","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1055\/s-2007-961814","volume":"39","author":"K Seiffert","year":"2007","unstructured":"Seiffert K, Seltmann H, Fritsch M, Zouboulis CC. Inhibition of 5alpha-reductase activity in SZ95 sebocytes and HaCaT keratinocytes in vitro. Hormone Metab Res = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2007;39(2):141\u20138. doi: 10.1055\/s-2007-961814 .","journal-title":"Hormone Metab Res = Hormon- und Stoffwechselforschung = Hormones et metabolisme"},{"issue":"1","key":"9390_CR67","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/j.1349-7006.2007.00656.x","volume":"99","author":"M Uemura","year":"2008","unstructured":"Uemura M, Tamura K, Chung S, Honma S, Okuyama A, Nakamura Y, et al. Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer. Cancer Sci. 2008;99(1):81\u20136. doi: 10.1111\/j.1349-7006.2007.00656.x .","journal-title":"Cancer Sci"},{"issue":"2","key":"9390_CR68","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1038\/jid.2009.225","volume":"130","author":"M Samson","year":"2010","unstructured":"Samson M, Labrie F, Zouboulis CC, Luu-The V. Biosynthesis of dihydrotestosterone by a pathway that does not require testosterone as an intermediate in the SZ95 sebaceous gland cell line. J Invest Dermatol. 2010;130(2):602\u20134. doi: 10.1038\/jid.2009.225 .","journal-title":"J Invest Dermatol"},{"issue":"2","key":"9390_CR69","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/j.0022-202X.2004.12645.x","volume":"123","author":"N Kanda","year":"2004","unstructured":"Kanda N, Watanabe S. 17beta-estradiol stimulates the growth of human keratinocytes by inducing cyclin D2 expression. J Invest Dermatol. 2004;123(2):319\u201328. doi: 10.1111\/j.0022-202X.2004.12645.x .","journal-title":"J Invest Dermatol"},{"issue":"6","key":"9390_CR70","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2165\/00128071-200304060-00001","volume":"4","author":"NJ Raine-Fenning","year":"2003","unstructured":"Raine-Fenning NJ, Brincat MP, Muscat-Baron Y. Skin aging and menopause : implications for treatment. Am J Clin Dermatol. 2003;4(6):371\u20138.","journal-title":"Am J Clin Dermatol"},{"issue":"5","key":"9390_CR71","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/1523-1747.ep12456427","volume":"87","author":"JP Bentley","year":"1986","unstructured":"Bentley JP, Brenner RM, Linstedt AD, West NB, Carlisle KS, Rokosova BC, et al. Increased hyaluronate and collagen biosynthesis and fibroblast estrogen receptors in macaque sex skin. J Invest Dermatol. 1986;87(5):668\u201373.","journal-title":"J Invest Dermatol"},{"issue":"2","key":"9390_CR72","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1111\/j.0022-202X.2004.23231.x","volume":"123","author":"N Kanda","year":"2004","unstructured":"Kanda N, Watanabe S. 17beta-estradiol enhances the production of granulocyte-macrophage colony-stimulating factor in human keratinocytes. J Invest Dermatol. 2004;123(2):329\u201337. doi: 10.1111\/j.0022-202X.2004.23231.x .","journal-title":"J Invest Dermatol"},{"issue":"3","key":"9390_CR73","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1517\/14728222.9.3.617","volume":"9","author":"MJ Thornton","year":"2005","unstructured":"Thornton MJ. Oestrogen functions in skin and skin appendages. Expert Opin Ther Targets. 2005;9(3):617\u201329. doi: 10.1517\/14728222.9.3.617 .","journal-title":"Expert Opin Ther Targets"},{"issue":"1","key":"9390_CR74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jdermsci.2004.10.011","volume":"38","author":"N Kanda","year":"2005","unstructured":"Kanda N, Watanabe S. Regulatory roles of sex hormones in cutaneous biology and immunology. J Dermatol Sci. 2005;38(1):1\u20137. doi: 10.1016\/j.jdermsci.2004.10.011 .","journal-title":"J Dermatol Sci"},{"issue":"3","key":"9390_CR75","first-page":"342","volume":"15","author":"ER Simpson","year":"1994","unstructured":"Simpson ER, Mahendroo MS, Means GD, Kilgore MW, Hinshelwood MM, Graham-Lorence S, et al. Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. Endocr Rev. 1994;15(3):342\u201355.","journal-title":"Endocr Rev"},{"issue":"4","key":"9390_CR76","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1210\/er.2008-0016","volume":"30","author":"RJ Santen","year":"2009","unstructured":"Santen RJ, Brodie H, Simpson ER, Siiteri PK, Brodie A. History of aromatase: saga of an important biological mediator and therapeutic target. Endocr Rev. 2009;30(4):343\u201375. doi: 10.1210\/er.2008-0016 .","journal-title":"Endocr Rev"},{"issue":"2","key":"9390_CR77","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1096\/fj.14-251363fj.14-251363","volume":"29","author":"E Pomari","year":"2015","unstructured":"Pomari E, Dalla Valle L, Pertile P, Colombo L, Thornton MJ. Intracrine sex steroid synthesis and signaling in human epidermal keratinocytes and dermal fibroblasts. FASEB J. 2015;29(2):508\u201324. doi: 10.1096\/fj.14-251363fj.14-251363 .","journal-title":"FASEB J"},{"issue":"24","key":"9390_CR78","doi-asserted-by":"crossref","first-page":"11673","DOI":"10.1073\/pnas.90.24.11673","volume":"90","author":"Y Ito","year":"1993","unstructured":"Ito Y, Fisher CR, Conte FA, Grumbach MM, Simpson ER. Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries. Proc Natl Acad Sci U S A. 1993;90(24):11673\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"9390_CR79","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1210\/jc.2006-1181","volume":"92","author":"L Lin","year":"2007","unstructured":"Lin L, Ercan O, Raza J, Burren CP, Creighton SM, Auchus RJ, et al. Variable phenotypes associated with aromatase (CYP19) insufficiency in humans. J Clin Endocrinol Metab. 2007;92(3):982\u201390. doi: 10.1210\/jc.2006-1181 .","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"9390_CR80","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1210\/jcem.83.4.4697","volume":"83","author":"CA Stratakis","year":"1998","unstructured":"Stratakis CA, Vottero A, Brodie A, Kirschner LS, DeAtkine D, Lu Q, et al. The aromatase excess syndrome is associated with feminization of both sexes and autosomal dominant transmission of aberrant P450 aromatase gene transcription. J Clin Endocrinol Metab. 1998;83(4):1348\u201357. doi: 10.1210\/jcem.83.4.4697 .","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"9390_CR81","doi-asserted-by":"publisher","first-page":"4676","DOI":"10.1210\/jc.2013-3990","volume":"98","author":"CA Stratakis","year":"2013","unstructured":"Stratakis CA. An aroma of complexity: how the unique genetics of aromatase (CYP19A1) explain diverse phenotypes from hens and hyenas to human gynecomastia, and testicular and other tumors. J Clin Endocrinol Metab. 2013;98(12):4676\u201381. doi: 10.1210\/jc.2013-3990 .","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"9390_CR82","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1046\/j.1439-0353.2004.04037.x","volume":"2","author":"F Conrad","year":"2004","unstructured":"Conrad F, Paus R. Estrogens and the hair follicle. J Dtsch Dermatol Ges. 2004;2(6):412\u201323.","journal-title":"J Dtsch Dermatol Ges"},{"issue":"2","key":"9390_CR83","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/0006-291X(92)92303-F","volume":"189","author":"N Harada","year":"1992","unstructured":"Harada N. A unique aromatase (P-450AROM) mRNA formed by alternative use of tissue-specific exons 1 in human skin fibroblasts. Biochem Biophys Res Commun. 1992;189(2):1001\u20137.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"9390_CR84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1096\/fasebj.11.1.9034159","volume":"11","author":"CN Falany","year":"1997","unstructured":"Falany CN. Sulfation and sulfotransferases. introduction: changing view of sulfation and the cytosolic sulfotransferases. FASEB J. 1997;11(1):1\u20132.","journal-title":"FASEB J"},{"issue":"7","key":"9390_CR85","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1248\/bpb.34.1147","volume":"34","author":"A Kushida","year":"2011","unstructured":"Kushida A, Hattori K, Yamaguchi N, Kobayashi T, Date A, Tamura H. Sulfation of estradiol in human epidermal keratinocyte. Biol Pharm Bull. 2011;34(7):1147\u201351.","journal-title":"Biol Pharm Bull"},{"issue":"6","key":"9390_CR86","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1210\/er.2006-0020","volume":"27","author":"U Ohnemus","year":"2006","unstructured":"Ohnemus U, Uenalan M, Inzunza J, Gustafsson JA, Paus R. The hair follicle as an estrogen target and source. Endocr Rev. 2006;27(6):677\u2013706. doi: 10.1210\/er.2006-0020 .","journal-title":"Endocr Rev"},{"issue":"4","key":"9390_CR87","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1097\/MOP.0b013e328305e415","volume":"20","author":"NS Ma","year":"2008","unstructured":"Ma NS, Geffner ME. Gynecomastia in prepubertal and pubertal men. Curr Opin Pediatr. 2008;20(4):465\u201370. doi: 10.1097\/MOP.0b013e328305e415 .","journal-title":"Curr Opin Pediatr"},{"key":"9390_CR88","doi-asserted-by":"crossref","unstructured":"Balunas MJ, Su B, Brueggemeier RW, Kinghorn AD. Natural products as aromatase inhibitors. Anticancer Agents Med Chem. 2008;8.","DOI":"10.2174\/187152008785133092"},{"key":"9390_CR89","doi-asserted-by":"crossref","unstructured":"Brueggemeier RW, Hackett JC, Diaz-Cruz ES. Aromatase inhibitors in the treatment of breast cancer. Endocr Rev. 2005;26.","DOI":"10.1210\/er.2004-0015"},{"key":"9390_CR90","doi-asserted-by":"crossref","unstructured":"Bulun SE, Lin Z, Imir G, Amin S, Demura M, Yilmaz B et al. Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment. Pharmacol Rev. 2005;57.","DOI":"10.1124\/pr.57.3.6"},{"key":"9390_CR91","doi-asserted-by":"publisher","first-page":"351","DOI":"10.2147\/CIA.S34034","volume":"7","author":"P Bernard","year":"2012","unstructured":"Bernard P, Scior T, Do QT. Modulating testosterone pathway: a new strategy to tackle male skin aging? Clin Interv Aging. 2012;7:351\u201361. doi: 10.2147\/CIA.S34034 .","journal-title":"Clin Interv Aging"},{"issue":"2","key":"9390_CR92","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.fertnstert.2011.05.040","volume":"96","author":"AO Caglayan","year":"2011","unstructured":"Caglayan AO, Dundar M, Tanriverdi F, Baysal NA, Unluhizarci K, Ozkul Y, et al. Idiopathic hirsutism: local and peripheral expression of aromatase (CYP19A) and 5alpha-reductase genes (SRD5A1 and SRD5A2). Fertil Steril. 2011;96(2):479\u201382. doi: 10.1016\/j.fertnstert.2011.05.040 .","journal-title":"Fertil Steril"},{"issue":"2","key":"9390_CR93","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1034\/j.1600-0625.2003.120209.x","volume":"12","author":"MJ Thornton","year":"2003","unstructured":"Thornton MJ, Taylor AH, Mulligan K, Al-Azzawi F, Lyon CC, O\u2019Driscoll J, et al. Oestrogen receptor beta is the predominant oestrogen receptor in human scalp skin. Exp Dermatol. 2003;12(2):181\u201390. doi: 10.1034\/j.1600-0625.2003.120209.x .","journal-title":"Exp Dermatol"},{"issue":"8","key":"9390_CR94","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1073\/pnas.83.8.2496","volume":"83","author":"Y Berthois","year":"1986","unstructured":"Berthois Y, Katzenellenbogen JA, Katzenellenbogen BS. Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture. Proc Natl Acad Sci U S A. 1986;83(8):2496\u2013500.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"9390_CR95","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1096\/fj.03-1088fje","volume":"18","author":"S Verdier-Sevrain","year":"2004","unstructured":"Verdier-Sevrain S, Yaar M, Cantatore J, Traish A, Gilchrest BA. Estradiol induces proliferation of keratinocytes via a receptor mediated mechanism. FASEB J. 2004;18(11):1252\u20134. doi: 10.1096\/fj.03-1088fje .","journal-title":"FASEB J"},{"issue":"2","key":"9390_CR96","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1210\/endo.142.2.7958","volume":"142","author":"D Turgeon","year":"2001","unstructured":"Turgeon D, Carrier JS, Levesque E, Hum DW, Belanger A. Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members. Endocrinology. 2001;142(2):778\u201387.","journal-title":"Endocrinology"},{"issue":"1\u20133","key":"9390_CR97","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jsbmb.2006.02.005","volume":"100","author":"W Tang","year":"2006","unstructured":"Tang W, Eggertsen G, Chiang JY, Norlin M. Estrogen-mediated regulation of CYP7B1: a possible role for controlling DHEA levels in human tissues. J Steroid Biochem Mol Biol. 2006;100(1\u20133):42\u201351. doi: 10.1016\/j.jsbmb.2006.02.005 .","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"4","key":"9390_CR98","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.steroids.2005.01.002","volume":"70","author":"BT Zhu","year":"2005","unstructured":"Zhu BT, Lee AJ. NADPH-dependent metabolism of 17beta-estradiol and estrone to polar and nonpolar metabolites by human tissues and cytochrome P450 isoforms. Steroids. 2005;70(4):225\u201344. doi: 10.1016\/j.steroids.2005.01.002 .","journal-title":"Steroids"},{"issue":"3\u20135","key":"9390_CR99","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.jsbmb.2008.03.016","volume":"109","author":"S Chouinard","year":"2008","unstructured":"Chouinard S, Yueh M-F, Tukey RH, Giton F, Fiet J, Pelletier G, et al. Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling. J Steroid Biochem Mol Biol. 2008;109(3\u20135):247\u201353. doi: 10.1016\/j.jsbmb.2008.03.016 .","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"1\u20136","key":"9390_CR100","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0960-0760(97)00183-0","volume":"65","author":"A Belanger","year":"1998","unstructured":"Belanger A, Hum DW, Beaulieu M, Levesque E, Guillemette C, Tchernof A, et al. Characterization and regulation of UDP-glucuronosyltransferases in steroid target tissues. J Steroid Biochem Mol Biol. 1998;65(1\u20136):301\u201310.","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"5","key":"9390_CR101","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1111\/j.0022-202X.2004.22416.x","volume":"122","author":"Y Higashi","year":"2004","unstructured":"Higashi Y, Fuda H, Yanai H, Lee Y, Fukushige T, Kanzaki T, et al. Expression of cholesterol sulfotransferase (SULT2B1b) in human skin and primary cultures of human epidermal keratinocytes. J Invest Dermatol. 2004;122(5):1207\u201313. doi: 10.1111\/j.0022-202X.2004.22416.x .","journal-title":"J Invest Dermatol"},{"issue":"1\u20135","key":"9390_CR102","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.jsbmb.2006.09.011","volume":"102","author":"CN Falany","year":"2006","unstructured":"Falany CN, He D, Dumas N, Frost AR, Falany JL. Human cytosolic sulfotransferase 2B1: isoform expression, tissue specificity and subcellular localization. J Steroid Biochem Mol Biol. 2006;102(1\u20135):214\u201321. doi: 10.1016\/j.jsbmb.2006.09.011 .","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"1","key":"9390_CR103","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/1523-1747.ep12515856","volume":"96","author":"TP Dooley","year":"1991","unstructured":"Dooley TP, Walker CJ, Hirshey SJ, Falany CN, Diani AR. Localization of minoxidil sulfotransferase in rat liver and the outer root sheath of anagen pelage and vibrissa follicles. J Invest Dermatol. 1991;96(1):65\u201370.","journal-title":"J Invest Dermatol"},{"issue":"7","key":"9390_CR104","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1111\/j.1600-0625.2008.00839.x","volume":"18","author":"YE Marin","year":"2009","unstructured":"Marin YE, Seiberg M, Lin CB. Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival. Exp Dermatol. 2009;18(7):611\u20138. doi: 10.1111\/j.1600-0625.2008.00839.x .","journal-title":"Exp Dermatol"},{"issue":"3\u20135","key":"9390_CR105","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.jsbmb.2007.03.026","volume":"104","author":"O Hennebert","year":"2007","unstructured":"Hennebert O, Chalbot S, Alran S, Morfin R. Dehydroepiandrosterone 7alpha-hydroxylation in human tissues: possible interference with type 1 11beta-hydroxysteroid dehydrogenase-mediated processes. J Steroid Biochem Mol Biol. 2007;104(3\u20135):326\u201333. doi: 10.1016\/j.jsbmb.2007.03.026 .","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"5","key":"9390_CR106","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2165\/00128071-200809050-00001","volume":"9","author":"HP Gollnick","year":"2008","unstructured":"Gollnick HP, Finlay AY, Shear N. Can we define acne as a chronic disease? if so, how and when? Am J Clin Dermatol. 2008;9(5):279\u201384.","journal-title":"Am J Clin Dermatol"},{"issue":"2","key":"9390_CR107","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.0906-6705.2005.0285a.x","volume":"14","author":"CC Zouboulis","year":"2005","unstructured":"Zouboulis CC, Eady A, Philpott M, Goldsmith LA, Orfanos C, Cunliffe WC, et al. What is the pathogenesis of acne? Exp Dermatol. 2005;14(2):143\u201352.","journal-title":"Exp Dermatol"},{"issue":"10","key":"9390_CR108","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.2174\/138920112802273173","volume":"13","author":"VA Zampeli","year":"2012","unstructured":"Zampeli VA, Makrantonaki E, Tzellos T, Zouboulis CC. New pharmaceutical concepts for sebaceous gland diseases: implementing today\u2019s pre-clinical data into tomorrow\u2019s daily clinical practice. Curr Pharm Biotechnol. 2012;13(10):1898\u2013913.","journal-title":"Curr Pharm Biotechnol"},{"issue":"4","key":"9390_CR109","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1159\/000051771","volume":"203","author":"CC Zouboulis","year":"2001","unstructured":"Zouboulis CC. Is acne vulgaris a genuine inflammatory disease? Dermatology. 2001;203(4):277\u20139.","journal-title":"Dermatology"},{"issue":"5","key":"9390_CR110","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.clindermatol.2004.03.004","volume":"22","author":"CC Zouboulis","year":"2004","unstructured":"Zouboulis CC. Acne and sebaceous gland function. Clin Dermatol. 2004;22(5):360\u20136. doi: 10.1016\/j.clindermatol.2004.03.004 .","journal-title":"Clin Dermatol"},{"issue":"10","key":"9390_CR111","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1111\/j.600-0625.2009.00890.x","volume":"18","author":"I Kurokawa","year":"2009","unstructured":"Kurokawa I, Danby FW, Ju Q, Wang X, Xiang LF, Xia L, et al. New developments in our understanding of acne pathogenesis and treatment. Exp Dermatol. 2009;18(10):821\u201332. doi: 10.1111\/j.600-0625.2009.00890.x .","journal-title":"Exp Dermatol"},{"issue":"3","key":"9390_CR112","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4161\/derm.1.3.8496","volume":"1","author":"R Ganceviciene","year":"2009","unstructured":"Ganceviciene R, Bohm M, Fimmel S, Zouboulis CC. The role of neuropeptides in the multifactorial pathogenesis of acne vulgaris. Dermatoendocrinology. 2009;1(3):170\u20136.","journal-title":"Dermatoendocrinology"},{"issue":"3","key":"9390_CR113","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1159\/000095056","volume":"213","author":"MK Oeff","year":"2006","unstructured":"Oeff MK, Seltmann H, Hiroi N, Nastos A, Makrantonaki E, Bornstein SR, et al. Differential regulation of Toll-like receptor and CD14 pathways by retinoids and corticosteroids in human sebocytes. Dermatology. 2006;213(3):266. doi: 10.1159\/000095056 .","journal-title":"Dermatology"},{"issue":"12","key":"9390_CR114","doi-asserted-by":"publisher","first-page":"3739","DOI":"10.1172\/JCI3933539335","volume":"119","author":"JJ Lai","year":"2009","unstructured":"Lai JJ, Lai KP, Chuang KH, Chang P, Yu IC, Lin WJ, et al. Monocyte\/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-alpha expression. J Clin Invest. 2009;119(12):3739\u201351. doi: 10.1172\/JCI3933539335 .","journal-title":"J Clin Invest"},{"issue":"6","key":"9390_CR115","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s00403-009-1019-6","volume":"302","author":"WJ Lee","year":"2010","unstructured":"Lee WJ, Jung HD, Chi SG, Kim BS, Lee SJ, do Kim W. Effect of dihydrotestosterone on the upregulation of inflammatory cytokines in cultured sebocytes. Arch Dermatol Res. 2010;302(6):429\u201333. doi: 10.1007\/s00403-009-1019-6 .","journal-title":"Arch Dermatol Res"},{"issue":"10","key":"9390_CR116","doi-asserted-by":"publisher","first-page":"7148","DOI":"10.1073\/pnas.10218099999\/10\/7148","volume":"99","author":"CC Zouboulis","year":"2002","unstructured":"Zouboulis CC, Seltmann H, Hiroi N, Chen W, Young M, Oeff M, et al. Corticotropin-releasing hormone: an autocrine hormone that promotes lipogenesis in human sebocytes. Proc Natl Acad Sci U S A. 2002;99(10):7148\u201353. doi: 10.1073\/pnas.10218099999\/10\/7148 .","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"9390_CR117","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1159\/000017838","volume":"196","author":"AW Lucky","year":"1998","unstructured":"Lucky AW. A review of infantile and pediatric acne. Dermatology. 1998;196(1):95\u20137.","journal-title":"Dermatology"},{"issue":"3","key":"9390_CR118","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.clindermatol.2013.11.005","volume":"32","author":"CC Zouboulis","year":"2014","unstructured":"Zouboulis CC. Acne as a chronic systemic disease. Clin Dermatol. 2014;32(3):389\u201396. doi: 10.1016\/j.clindermatol.2013.11.005 .","journal-title":"Clin Dermatol"},{"key":"9390_CR119","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/978-1-4615-0621-8_8","volume":"511","author":"J Imperato-McGinley","year":"2002","unstructured":"Imperato-McGinley J. 5alpha-reductase-2 deficiency and complete androgen insensitivity: lessons from nature. Adv Exp Med Biol. 2002;511:121\u201331. discussion 31\u20134.","journal-title":"Adv Exp Med Biol"},{"issue":"8\u20139","key":"9390_CR120","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s00228-003-0633-z","volume":"59","author":"AC Eklof","year":"2003","unstructured":"Eklof AC, Thurelius AM, Garle M, Rane A, Sjoqvist F. The anti-doping hot-line, a means to capture the abuse of doping agents in the Swedish society and a new service function in clinical pharmacology. Eur J Clin Pharmacol. 2003;59(8\u20139):571\u20137. doi: 10.1007\/s00228-003-0633-z .","journal-title":"Eur J Clin Pharmacol"},{"issue":"6","key":"9390_CR121","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1046\/j.1523-1747.1999.00771.x","volume":"113","author":"CC Zouboulis","year":"1999","unstructured":"Zouboulis CC, Seltmann H, Neitzel H, Orfanos CE. Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95). J Invest Dermatol. 1999;113(6):1011\u201320. doi: 10.1046\/j.1523-1747.1999.00771.x .","journal-title":"J Invest Dermatol"},{"issue":"3","key":"9390_CR122","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1111\/j.1365-2133.2006.07671.x","volume":"156","author":"E Makrantonaki","year":"2007","unstructured":"Makrantonaki E, Zouboulis CC. Testosterone metabolism to 5alpha-dihydrotestosterone and synthesis of sebaceous lipids is regulated by the peroxisome proliferator-activated receptor ligand linoleic acid in human sebocytes. Br J Dermatol. 2007;156(3):428\u201332. doi: 10.1111\/j.1365-2133.2006.07671.x .","journal-title":"Br J Dermatol"},{"issue":"9","key":"9390_CR123","first-page":"635","volume":"59","author":"Z Zaidi","year":"2009","unstructured":"Zaidi Z. Acne vulgaris--an update on pathophysiology and treatment. J Pak Med Assoc. 2009;59(9):635\u20137.","journal-title":"J Pak Med Assoc"},{"issue":"9","key":"9390_CR124","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1001\/archderm.136.9.1125","volume":"136","author":"D Thiboutot","year":"2000","unstructured":"Thiboutot D, Bayne E, Thorne J, Gilliland K, Flanagan J, Shao Q, et al. Immunolocalization of 5alpha-reductase isozymes in acne lesions and normal skin. Arch Dermatol. 2000;136(9):1125\u20139.","journal-title":"Arch Dermatol"},{"issue":"3","key":"9390_CR125","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.jaad.2003.07.021","volume":"50","author":"J Leyden","year":"2004","unstructured":"Leyden J, Bergfeld W, Drake L, Dunlap F, Goldman MP, Gottlieb AB, et al. A systemic type I 5 alpha-reductase inhibitor is ineffective in the treatment of acne vulgaris. J Am Acad Dermatol. 2004;50(3):443\u20137. doi: 10.1016\/j.jaad.2003.07.021 .","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"9390_CR126","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1159\/000086464","volume":"137","author":"H Saito","year":"2005","unstructured":"Saito H. Much atopy about the skin: genome-wide molecular analysis of atopic eczema. Int Arch Allergy Immunol. 2005;137(4):319\u201325.","journal-title":"Int Arch Allergy Immunol"},{"key":"9390_CR127","unstructured":"Bolognia JL, Schaffer JV, Duncan KO, Ko CJ. Dermatology Essentials E- Book. Elsevier Health Sciences; 2014."},{"issue":"4","key":"9390_CR128","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1111\/all.12369","volume":"69","author":"M Kono","year":"2014","unstructured":"Kono M, Nomura T, Ohguchi Y, Mizuno O, Suzuki S, Tsujiuchi H, et al. Comprehensive screening for a complete set of Japanese-population-specific filaggrin gene mutations. Allergy. 2014;69(4):537\u201340. doi: 10.1111\/all.12369 .","journal-title":"Allergy"},{"key":"9390_CR129","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1159\/000323299","volume":"41","author":"K Yamanaka","year":"2011","unstructured":"Yamanaka K, Mizutani H. The role of cytokines\/chemokines in the pathogenesis of atopic dermatitis. Curr Probl Dermatol. 2011;41:80\u201392.","journal-title":"Curr Probl Dermatol"},{"key":"9390_CR130","doi-asserted-by":"crossref","unstructured":"Sevilla LM, Latorre V, Sanchis A, Perez P. Epidermal Inactivation of the Glucocorticoid Receptor Triggers Skin Barrier Defects and Cutaneous Inflammation. J Invest Dermatol. 2012.","DOI":"10.1038\/jid.2012.281"},{"issue":"8","key":"9390_CR131","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1056\/NEJMcp042829","volume":"352","author":"FC Powell","year":"2005","unstructured":"Powell FC. Clinical practice. Rosacea N Engl J Med. 2005;352(8):793\u2013803. doi: 10.1056\/NEJMcp042829 .","journal-title":"Rosacea N Engl J Med"},{"issue":"4","key":"9390_CR132","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0190-9622(08)80678-0","volume":"25","author":"N Kurkcuoglu","year":"1991","unstructured":"Kurkcuoglu N, Alaybeyi F. Substance P immunoreactivity in rosacea. J Am Acad Dermatol. 1991;25(4):725\u20136.","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"9390_CR133","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0190-9622(08)80863-8","volume":"28","author":"FC Powell","year":"1993","unstructured":"Powell FC, Corbally N, Powell D. Substance P and rosacea. J Am Acad Dermatol. 1993;28(1):132\u20133.","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"9390_CR134","first-page":"111","volume":"11","author":"U Wollina","year":"1996","unstructured":"Wollina U. Rhinophyma--unusual expression of simple-type keratins and S100A in sebocytes and abundance of VIP receptor-positive dermal cells. Histol Histopathol. 1996;11(1):111\u20135.","journal-title":"Histol Histopathol"},{"issue":"2","key":"9390_CR135","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1111\/j.1365-2133.2008.08958.x","volume":"160","author":"A Slominski","year":"2009","unstructured":"Slominski A. On the role of the corticotropin-releasing hormone signalling system in the aetiology of inflammatory skin disorders. Br J Dermatol. 2009;160(2):229\u201332. doi: 10.1111\/j.1365-2133.2008.08958.x .","journal-title":"Br J Dermatol"},{"issue":"3 Suppl","key":"9390_CR136","first-page":"13","volume":"74","author":"G Murphy","year":"2004","unstructured":"Murphy G. Ultraviolet light and rosacea. Cutis. 2004;74(3 Suppl):13\u20136. 32\u20134.","journal-title":"Cutis"},{"issue":"1","key":"9390_CR137","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/j.1365-2133.2005.06368.x","volume":"152","author":"K Yano","year":"2005","unstructured":"Yano K, Kadoya K, Kajiya K, Hong YK, Detmar M. Ultraviolet B irradiation of human skin induces an angiogenic switch that is mediated by upregulation of vascular endothelial growth factor and by downregulation of thrombospondin-1. Br J Dermatol. 2005;152(1):115\u201321. doi: 10.1111\/j.1365-2133.2005.06368.x .","journal-title":"Br J Dermatol"},{"issue":"11","key":"9390_CR138","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1111\/exd.12519","volume":"23","author":"G Nikolakis","year":"2014","unstructured":"Nikolakis G, Zouboulis CC. Skin and glucocorticoids: effects of local skin glucocorticoid impairment on skin homeostasis. Exp Dermatol. 2014;23(11):807\u20138.","journal-title":"Exp Dermatol"},{"issue":"10","key":"9390_CR139","doi-asserted-by":"publisher","first-page":"2539","DOI":"10.1210\/me.2006-0116","volume":"20","author":"B Zbytek","year":"2006","unstructured":"Zbytek B, Wortsman J, Slominski A. Characterization of a ultraviolet B-induced corticotropin-releasing hormone-proopiomelanocortin system in human melanocytes. Mol Endocrinol. 2006;20(10):2539\u201347. doi: 10.1210\/me.2006-0116 .","journal-title":"Mol Endocrinol"},{"issue":"6","key":"9390_CR140","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1111\/exd.12376","volume":"23","author":"AT Slominski","year":"2014","unstructured":"Slominski AT, Manna PR, Tuckey RC. Cutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity. Exp Dermatol. 2014;23(6):369\u201374. doi: 10.1111\/exd.12376 .","journal-title":"Exp Dermatol"},{"issue":"3","key":"9390_CR141","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1111\/bjd.12096","volume":"168","author":"C Skobowiat","year":"2013","unstructured":"Skobowiat C, Sayre RM, Dowdy JC, Slominski AT. Ultraviolet radiation regulates cortisol activity in a waveband-dependent manner in human skin ex vivo. Br J Dermatol. 2013;168(3):595\u2013601. doi: 10.1111\/bjd.12096 .","journal-title":"Br J Dermatol"},{"issue":"5","key":"9390_CR142","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1054\/bjoc.2001.1931","volume":"85","author":"MR Karagas","year":"2001","unstructured":"Karagas MR, Cushing Jr GL, Greenberg ER, Mott LA, Spencer SK, Nierenberg DW. Non-melanoma skin cancers and glucocorticoid therapy. Br J Cancer. 2001;85(5):683\u20136. doi: 10.1054\/bjoc.2001.1931 .","journal-title":"Br J Cancer"},{"key":"9390_CR143","doi-asserted-by":"crossref","unstructured":"Karimi K, Lindgren TH, Koch CA, Brodell RT. Obesity as risk factor for malignant melanoma and non-melanoma skin cancer. Rev Endocr Metab Disord. 2016.","DOI":"10.1007\/s11154-016-9393-9"},{"issue":"1","key":"9390_CR144","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1097\/DAD.0b013e3182914c64","volume":"36","author":"JH Zhou","year":"2014","unstructured":"Zhou JH, Kim KB, Myers JN, Fox PS, Ning J, Bassett RL, et al. Immunohistochemical expression of hormone receptors in melanoma of pregnant women, nonpregnant women, and men. Am J Dermatopathol. 2014;36(1):74\u20139. doi: 10.1097\/DAD.0b013e3182914c64 .","journal-title":"Am J Dermatopathol"},{"issue":"1","key":"9390_CR145","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2174\/18715206113139990308","volume":"14","author":"AT Slominski","year":"2014","unstructured":"Slominski AT, Zmijewski MA, Semak I, Zbytek B, Pisarchik A, Li W, et al. Cytochromes p450 and skin cancer: role of local endocrine pathways. Anticancer Agents Med Chem. 2014;14(1):77\u201396.","journal-title":"Anticancer Agents Med Chem"},{"issue":"7","key":"9390_CR146","first-page":"2174","volume":"40","author":"EF Hawkins","year":"1980","unstructured":"Hawkins EF, Horn D, Markland Jr FS. Receptor for glucocorticoids in RPMI 3460 melanoma cells. Cancer Res. 1980;40(7):2174\u20138.","journal-title":"Cancer Res"},{"issue":"3","key":"9390_CR147","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/BF00510057","volume":"275","author":"FH Rampen","year":"1983","unstructured":"Rampen FH. Comments on the contribution by H. J. Grill et al. Steroid hormone receptors in melanoma. Arch Dermatol Res. 1983;275(3):208\u20139.","journal-title":"Arch Dermatol Res"},{"issue":"1\u20132","key":"9390_CR148","first-page":"97","volume":"272","author":"HJ Grill","year":"1982","unstructured":"Grill HJ, Benes P, Manz B, Schramm P, Morsches B, Korting GW, et al. Steroid hormone receptors in human melanoma. Arch Dermatol Res. 1982;272(1\u20132):97\u2013101.","journal-title":"Arch Dermatol Res"},{"issue":"6","key":"9390_CR149","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/1523-1747.ep12544454","volume":"74","author":"JP Neifeld","year":"1980","unstructured":"Neifeld JP, Lippman ME. Steroid hormone receptors and melanoma. J Invest Dermatol. 1980;74(6):379\u201381.","journal-title":"J Invest Dermatol"},{"issue":"11","key":"9390_CR150","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1111\/j.1600-0560.2010.01607.x","volume":"37","author":"TJ Nasabzadeh","year":"2010","unstructured":"Nasabzadeh TJ, Stefanato CM, Doole JE, Radfar A, Bhawan J, Venna S. Recurrent erythema multiforme triggered by progesterone sensitivity. J Cutan Pathol. 2010;37(11):1164\u20137. doi: 10.1111\/j.1600-0560.2010.01607.x .","journal-title":"J Cutan Pathol"},{"issue":"2","key":"9390_CR151","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.autrev.2015.11.003","volume":"15","author":"T Nguyen","year":"2016","unstructured":"Nguyen T, Razzaque Ahmed A. Autoimmune progesterone dermatitis: update and insights. Autoimmun Rev. 2016;15(2):191\u20137. doi: 10.1016\/j.autrev.2015.11.003 .","journal-title":"Autoimmun Rev"},{"issue":"5","key":"9390_CR152","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.jaip.2013.06.005","volume":"1","author":"JL Hill","year":"2013","unstructured":"Hill JL, Carr TF. Iatrogenic autoimmune progesterone dermatitis treated with a novel intramuscular progesterone desensitization protocol. J Allergy Clin Immunol Pract. 2013;1(5):537\u20138. doi: 10.1016\/j.jaip.2013.06.005 .","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"3","key":"9390_CR153","doi-asserted-by":"publisher","first-page":"1121 e9","DOI":"10.1016\/j.fertnstert.2010.10.038","volume":"95","author":"A Prieto-Garcia","year":"2011","unstructured":"Prieto-Garcia A, Sloane DE, Gargiulo AR, Feldweg AM, Castells M. Autoimmune progesterone dermatitis: clinical presentation and management with progesterone desensitization for successful in vitro fertilization. Fertil Steril. 2011;95(3):1121 e9\u201313. doi: 10.1016\/j.fertnstert.2010.10.038 .","journal-title":"Fertil Steril"},{"issue":"11","key":"9390_CR154","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1111\/j.1600-0560.2010.01616.x","volume":"37","author":"TH McCalmont","year":"2010","unstructured":"McCalmont TH. Fact or fiction? J Cutan Pathol. 2010;37(11):1130\u20131. doi: 10.1111\/j.1600-0560.2010.01616.x .","journal-title":"J Cutan Pathol"},{"issue":"4","key":"9390_CR155","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1007\/s13671-013-0059-5","volume":"2","author":"M Solomon","year":"2013","unstructured":"Solomon M, Itsekson AM, Lev-Sagie A. Autoimmune progesterone dermatitis. Curr Dermatol Rep. 2013;2(4):258\u201363. doi: 10.1007\/s13671-013-0059-5 .","journal-title":"Curr Dermatol Rep"},{"issue":"2","key":"9390_CR156","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF03401334","volume":"13","author":"ML Batrinos","year":"2014","unstructured":"Batrinos ML. The endocrinology of baldness. Hormones (Athens). 2014;13(2):197\u2013212.","journal-title":"Hormones (Athens)"},{"issue":"5","key":"9390_CR157","doi-asserted-by":"crossref","first-page":"250","DOI":"10.4161\/derm.1.5.9499","volume":"1","author":"CC Zouboulis","year":"2009","unstructured":"Zouboulis CC. The skin as an endocrine organ. Dermatoendocrinology. 2009;1(5):250\u20132.","journal-title":"Dermatoendocrinology"},{"issue":"1","key":"9390_CR158","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1677\/joe.0.1560059","volume":"156","author":"NA Hibberts","year":"1998","unstructured":"Hibberts NA, Howell AE, Randall VA. Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp. J Endocrinol. 1998;156(1):59\u201365.","journal-title":"J Endocrinol"},{"issue":"3","key":"9390_CR159","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000099583","volume":"214","author":"W Chen","year":"2007","unstructured":"Chen W, Yang CC, Tsai RY, Liao CY, Yen YT, Hung CL, et al. Expression of sex-determining genes in the scalp of men with androgenetic alopecia. Dermatology. 2007;214(3):199\u2013204.","journal-title":"Dermatology"},{"issue":"3","key":"9390_CR160","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/1523-1747.ep12335779","volume":"109","author":"ME Sawaya","year":"1997","unstructured":"Sawaya ME, Price VH. Different levels of 5alpha-reductase type I and II, aromatase, and androgen receptor in hair follicles of women and men with androgenetic alopecia. J Invest Dermatol. 1997;109(3):296\u2013300.","journal-title":"J Invest Dermatol"},{"issue":"1","key":"9390_CR161","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.3892\/mmr.2015.3478","volume":"12","author":"MJ Lee","year":"2015","unstructured":"Lee MJ, Cha HJ, Lim KM, Lee OK, Bae S, Kim CH, et al. Analysis of the microRNA expression profile of normal human dermal papilla cells treated with 5alpha-dihydrotestosterone. Mol Med Rep. 2015;12(1):1205\u201312. doi: 10.3892\/mmr.2015.3478 .","journal-title":"Mol Med Rep"},{"issue":"3","key":"9390_CR162","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1111\/j.0022-202X.2004.22344.x","volume":"122","author":"F Conrad","year":"2004","unstructured":"Conrad F, Ohnemus U, Bodo E, Bettermann A, Paus R. Estrogens and human scalp hair growth-still more questions than answers. J Invest Dermatol. 2004;122(3):840\u20132. doi: 10.1111\/j.0022-202X.2004.22344.x .","journal-title":"J Invest Dermatol"},{"issue":"4","key":"9390_CR163","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1034\/j.1600-0625.2002.110413.x","volume":"11","author":"R Hoffmann","year":"2002","unstructured":"Hoffmann R, Niiyama S, Huth A, Kissling S, Happle R. 17alpha-estradiol induces aromatase activity in intact human anagen hair follicles ex vivo. Exp Dermatol. 2002;11(4):376\u201380.","journal-title":"Exp Dermatol"}],"container-title":["Reviews in Endocrine and Metabolic Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11154-016-9390-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11154-016-9390-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11154-016-9390-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T19:56:46Z","timestamp":1657483006000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11154-016-9390-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":163,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["9390"],"URL":"https:\/\/doi.org\/10.1007\/s11154-016-9390-z","relation":{},"ISSN":["1389-9155","1573-2606"],"issn-type":[{"value":"1389-9155","type":"print"},{"value":"1573-2606","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9]]}}}