{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T18:46:10Z","timestamp":1794336370538,"version":"4.9.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rev Endocr Metab Disord"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1007\/s11154-019-09492-1","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T07:21:00Z","timestamp":1554103260000},"page":"207-217","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":302,"title":["Role of growth factors and cytokines in diabetic foot ulcer healing: A detailed review"],"prefix":"10.1007","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5787-7845","authenticated-orcid":false,"given":"Mohammad","family":"Zubair","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,4,1]]},"reference":[{"key":"9492_CR1","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.2337\/dc07-S004","volume":"30","author":"American Diabetes Association","year":"2007","unstructured":"American Diabetes Association. Standards of medical care in diabetes. Diabetes Care. 2007;30:S4\u2013S41.","journal-title":"Diabetes Care"},{"key":"9492_CR2","unstructured":"World Health Organization. Accessible at http:\/\/www.who.int\/diabetes\/en\/ , retrieved on 7 Nov 2018."},{"key":"9492_CR3","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.diabres.2018.02.023","volume":"138","author":"NH Cho","year":"2018","unstructured":"Cho NH, Shaw JE, Karuranga S, Huang Y, da Rocha Fernandes JD, Ohlrogge AW, et al. IDF Diabetes Atlas: global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018;138:271\u201381.","journal-title":"Diabetes Res Clin Pract"},{"key":"9492_CR4","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1056\/NEJM200105033441801","volume":"344","author":"J Tuomilehto","year":"2001","unstructured":"Tuomilehto J, Lindstr\u00f6m J, Eriksson JG. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001;344:1343\u201350.","journal-title":"N Engl J Med"},{"key":"9492_CR5","doi-asserted-by":"publisher","unstructured":"Pallela SR, Narahari P. A study to find the causes of diabetic foot infections in a selected community. International Surgery Journal. 2017;4(7):2153\u201356.\u00a0 https:\/\/doi.org\/10.18203\/2349-2902.isj20172576 .","DOI":"10.18203\/2349-2902.isj20172576"},{"key":"9492_CR6","unstructured":"American Diabetic Association. (2018). Accessible at: http:\/\/www.diabetes.org\/diabetes-basics\/statistics\/ . Retrieved on 11 Nov 2018."},{"issue":"8","key":"9492_CR7","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.3390\/molecules22081259","volume":"22","author":"JW Park","year":"2017","unstructured":"Park JW, Hwang SR, Yoon IS. Advanced growth factor delivery systems in wound management and skin regeneration. Molecules. 2017;22(8):1259.","journal-title":"Molecules."},{"key":"9492_CR8","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s11892-013-0453-1","volume":"14","author":"H Vlassara","year":"2014","unstructured":"Vlassara H, Uribarri J. Advanced glycation end products (AGE) and diabetes. Cause, effect, or both. Curr Diab Rep. 2014;14:453. https:\/\/doi.org\/10.1007\/s11892-013-0453-1 .","journal-title":"Curr Diab Rep"},{"key":"9492_CR9","doi-asserted-by":"publisher","unstructured":"Omanakuttan A, Nambiar J, Harris RM, Bose C, Pandurangan N, Varghese RK, et al. Anacardic acid inhibits the catalytic activity of matrix metalloproteinase-2 and matrix metalloproteinase-9. Molecular Pharmacology. 2012: Mol-112. https:\/\/doi.org\/10.1124\/mol.112.079020 .","DOI":"10.1124\/mol.112.079020"},{"key":"9492_CR10","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.12968\/jowc.2016.25.Sup4.S17","volume":"25","author":"P Rupert","year":"2016","unstructured":"Rupert P. Human acellular dermal wound matrix for complex diabetic wounds. J Wound Care. 2016;25:S17\u201321. https:\/\/doi.org\/10.12968\/jowc.2016.25.sup4.s17 .","journal-title":"J Wound Care"},{"key":"9492_CR11","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.cyto.2014.08.005","volume":"71","author":"TD Crafts","year":"2015","unstructured":"Crafts TD, Jensen AR, Blocher-Smith EC, Markel TA. Vascular endothelial growth factor: therapeutic possibilities and challenges for the treatment of ischemia. Cytokine. 2015;71:385\u201393. https:\/\/doi.org\/10.1016\/j.cyto.2014.08.005 .","journal-title":"Cytokine"},{"key":"9492_CR12","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1111\/wrr.12205","volume":"22","author":"S Barrientos","year":"2014","unstructured":"Barrientos S, Brem H, Stojadinovic O, Tomic-Canic M. Clinical application of growth factors and cytokines in wound healing. Wound Repair Regen. 2014;22:569\u201378. https:\/\/doi.org\/10.1111\/j.1524-475x.2008.00410.x .","journal-title":"Wound Repair Regen"},{"key":"9492_CR13","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1111\/iwj.12165","volume":"12","author":"S Gowda","year":"2015","unstructured":"Gowda S, Weinstein DA, Blalock TD. Topical application of recombinant platelet-derived growth factor increases the rate of healing and the level of proteins that regulate this response. Int Wound J. 2015;12:564\u201371. https:\/\/doi.org\/10.1111\/iwj.12165 .","journal-title":"Int Wound J"},{"key":"9492_CR14","doi-asserted-by":"crossref","unstructured":"Heldin C-H, R\u00f6nnstrand L. The platelet-derived growth factor receptor. In: Moudgil VK, editor. Receptor phosphorylation. Boca Raton: CRC Press; 1988. p. 149\u201362.","DOI":"10.1201\/9781351076241-6"},{"key":"9492_CR15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170639","volume":"12","author":"G Kolumam","year":"2017","unstructured":"Kolumam G, Wu X, Lee WP. IL-22R ligands IL-20, IL-22, and IL-24 promote wound healing in diabetic db\/db mice. PLoS One. 2017;12:e0170639. https:\/\/doi.org\/10.1371\/journal.pone.0170639 .","journal-title":"PLoS One"},{"key":"9492_CR16","doi-asserted-by":"publisher","first-page":"L868","DOI":"10.1152\/ajplung.00363.2015","volume":"310","author":"JC Gardner","year":"2016","unstructured":"Gardner JC, Wu H, Noel JG. Keratinocyte growth factor supports pulmonary innate immune defense through the maintenance of alveolar antimicrobial protein levels and macrophage function. Am J Phys Lung Cell Mol Phys. 2016;310:L868\u201379. https:\/\/doi.org\/10.1152\/ajplung.00363.2015 .","journal-title":"Am J Phys Lung Cell Mol Phys"},{"key":"9492_CR17","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.jss.2008.04.023","volume":"153","author":"P Bao","year":"2009","unstructured":"Bao P, Kodra A, Tomic-Canic M, Golinko MS, Ehrlich HP, Brem H. The role of vascular endothelial growth factor in wound healing. J Surg Res. 2009;153:347\u201358. https:\/\/doi.org\/10.1016\/j.jss.2008.04.023 .","journal-title":"J Surg Res"},{"key":"9492_CR18","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.femsim.2004.10.022","volume":"44","author":"LP Andersen","year":"2005","unstructured":"Andersen LP, Holck S, Janulaityte-G\u00fcnther D. Gastric inflammatory markers and interleukins in patients with functional dyspepsia, with and without helicobacter pylori infection. FEMS Immunol Med Microbiol. 2005;44:233\u20138. https:\/\/doi.org\/10.1016\/j.femsim.2004.10.022 .","journal-title":"FEMS Immunol Med Microbiol"},{"key":"9492_CR19","doi-asserted-by":"publisher","first-page":"2862","DOI":"10.1038\/jid.2015.278","volume":"135","author":"OT Avitabile","year":"2015","unstructured":"Avitabile OT, Madonna S. Interleukin-22 promotes wound repair in diabetes by improving keratinocyte pro-healing functions. J Invest Dermatol. 2015;135:2862\u201370. https:\/\/doi.org\/10.1038\/jid.2015.278 .","journal-title":"J Invest Dermatol"},{"issue":"1","key":"9492_CR20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170639","volume":"12","author":"G Kolumam","year":"2017","unstructured":"Kolumam G, Wu X, Lee WP, Hackney JA, Zavala-Solorio J, Gandham V, et al. IL-22R ligands IL-20, IL-22, and IL-24 promote wound healing in diabetic db\/db mice. PLoS One. 2017;12(1):e0170639.","journal-title":"PLoS One"},{"key":"9492_CR21","unstructured":"Braun AC. Bioresponsive delivery of anticatabolic and anabolic agents for muscle regeneration using bioinspired strategies. Available at https:\/\/opus.bibliothek.uni-wuerzburg.de\/opus4-wuerzburg\/frontdoor\/deliver\/index\/docId\/16904\/file\/Braun_Alexandra_Bioresponsive_delivery.pdf"},{"key":"9492_CR22","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.neubiorev.2016.01.001","volume":"63","author":"J Costales","year":"2016","unstructured":"Costales J, Kolevzon A. The therapeutic potential of insulin-like growth factor-1 in central nervous system disorders. Neurosci Biobehav Rev. 2016;63:207\u201322.","journal-title":"Neurosci Biobehav Rev"},{"key":"9492_CR23","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.tem.2016.03.019","volume":"27","author":"DR Clemmons","year":"2016","unstructured":"Clemmons DR. Role of IGF binding proteins in regulating metabolism. Trends Endocrinol Metab. 2016;27:375\u201391. https:\/\/doi.org\/10.1016\/j.tem.2016.03.019 .","journal-title":"Trends Endocrinol Metab"},{"issue":"1","key":"9492_CR24","doi-asserted-by":"publisher","first-page":"a009191","DOI":"10.1101\/cshperspect.a009191","volume":"6","author":"J Boucher","year":"2014","unstructured":"Boucher J, Kleinridders A, Kahn CR. Insulin receptor signaling in normal and insulin-resistant states. Cold Spring Harb Perspect Biol. 2014;6(1):a009191.","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"5","key":"9492_CR25","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1097\/01.ASN.0000065640.77499.D7","volume":"14","author":"RM Mason","year":"2003","unstructured":"Mason RM, Wahab NA. Extracellular matrix metabolism in diabetic nephropathy. J Am Soc Nephrol. 2003;14(5):1358\u201373.","journal-title":"J Am Soc Nephrol"},{"key":"9492_CR26","doi-asserted-by":"publisher","first-page":"421","DOI":"10.2337\/dc08-1161","volume":"32","author":"C Herder","year":"2009","unstructured":"Herder C, Brunner EJ, Rathmann W. Elevated levels of the anti-inflammatory interleukin-1 receptor antagonist precede the onset of type 2 diabetes. The Whitehall II study. Diabetes Care. 2009;32:421\u20133. https:\/\/doi.org\/10.2337\/dc08-1161 .","journal-title":"Diabetes Care"},{"issue":"2","key":"9492_CR27","doi-asserted-by":"publisher","first-page":"160","DOI":"10.12816\/0006040","volume":"7","author":"H Gazaerly El","year":"2013","unstructured":"El Gazaerly H, Elbardisey DM, Eltokhy HM, Teaama D. Effect of transforming growth factor Beta 1 on wound healing in induced diabetic rats. Int J Health Sci. 2013;7(2):160\u201372.","journal-title":"Int J Health Sci"},{"issue":"3","key":"9492_CR28","doi-asserted-by":"publisher","first-page":"e0173918","DOI":"10.1371\/journal.pone.0173918","volume":"12","author":"S Chen","year":"2017","unstructured":"Chen S, Feng B, Thomas AA, Chakrabarti S. miR-146a regulates glucose induced upregulation of inflammatory cytokines extracellular matrix proteins in the retina and kidney in diabetes. PLoS One. 2017;12(3):e0173918.","journal-title":"PLoS One"},{"issue":"11","key":"9492_CR29","doi-asserted-by":"publisher","first-page":"875","DOI":"10.7150\/ijms.12954","volume":"12","author":"Y Li","year":"2015","unstructured":"Li Y, Zhang Y, Li X, Shi L, Tao W, Shi L, et al. Association study of polymorphisms in miRNAs with T2DM in a Chinese population. Int J Med Sci. 2015;12(11):875\u201380.","journal-title":"Int J Med Sci"},{"key":"9492_CR30","doi-asserted-by":"publisher","first-page":"2906","DOI":"10.2337\/db12-0145","volume":"61","author":"J Xu","year":"2012","unstructured":"Xu J, Wu W, Zhang L. The role of microRNA-146a in the pathogenesis of the diabetic wound-healing impairment: correction with mesenchymal stem cell treatment. Diabetes. 2012;61:2906\u201312. https:\/\/doi.org\/10.2337\/db12-0145 .","journal-title":"Diabetes"},{"issue":"7","key":"9492_CR31","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.2337\/db12-1450","volume":"62","author":"RE Mirza","year":"2013","unstructured":"Mirza RE, Fang MM, Ennis WJ, Koh TJ. Blocking interleukin-1\u03b2 induces a healing-associated wound macrophage phenotype and improves healing in type 2 diabetes. Diabetes. 2013;62(7):2579\u201387. https:\/\/doi.org\/10.2337\/db12-1450 .","journal-title":"Diabetes"},{"key":"9492_CR32","unstructured":"Robson MC, Payne WG. Growth factor therapy to aid wound healing. Basic and Clinical Dermatology. 2005;33:491."},{"key":"9492_CR33","doi-asserted-by":"publisher","first-page":"S78","DOI":"10.1016\/S0168-8278(17)30420-8","volume":"66","author":"E Arfianti","year":"2017","unstructured":"Arfianti E, Barn V, Pok S, Larter CZ, Teoh NC, Farrell. Diabetes augments obesity in accelerating liver tumor development: role of oxidative stress-induced JNK signaling and DNA damage response. J Hepatol. 2017;66:S78\u20139. https:\/\/doi.org\/10.1016\/s0168-8278(17)30420-8 .","journal-title":"J Hepatol"},{"key":"9492_CR34","doi-asserted-by":"publisher","first-page":"19426","DOI":"10.1073\/pnas.0805230105","volume":"105","author":"IR Botusan","year":"2008","unstructured":"Botusan IR, Sunkari VG, Savu O. Stabilization of HIF-1\u03b1 is critical to improve wound healing in diabetic mice. Proc Natl Acad Sci. 2008;105:19426\u201331. https:\/\/doi.org\/10.1073\/pnas.0805230105 .","journal-title":"Proc Natl Acad Sci"},{"key":"9492_CR35","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3389\/fimmu.2012.00261","volume":"3","author":"CG Mueller","year":"2012","unstructured":"Mueller CG, Hess E. Emerging functions of RANKL in lymphoid tissues. Front Immunol. 2012;3:261. https:\/\/doi.org\/10.3389\/fimmu.2012.00261 .","journal-title":"Front Immunol"},{"key":"9492_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/394206","volume":"2014","author":"IT Lampropoulou","year":"2014","unstructured":"Lampropoulou IT, Stangou M, Papagianni A, Didangelos T, Iliadis F, Efstratiadis G. TNF-\u03b1 and microalbuminuria in patients with type 2 diabetes mellitus. J Diabetes Res. 2014;2014:1\u20137.","journal-title":"J Diabetes Res"},{"key":"9492_CR37","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/j.1440-1746.2006.04442.x","volume":"22","author":"M Sugimoto","year":"2007","unstructured":"Sugimoto M, Furuta T, Shirai N. Different effects of polymorphisms of tumor necrosis factor-alpha and interleukin-1 beta on development of peptic ulcer and gastric cancer. J Gastroenterol Hepatol. 2007;22:51\u20139. https:\/\/doi.org\/10.1111\/j.1440-1746.2006.04442.x .","journal-title":"J Gastroenterol Hepatol"},{"key":"9492_CR38","first-page":"1","volume":"2017","author":"L Liu","year":"2017","unstructured":"Liu L, Chen B, Zhang X, Tan L, Wang DW. Increased Cathepsin D correlates with clinical parameters in newly diagnosed type 2 diabetes. Dis Markers. 2017;2017:1\u20136.","journal-title":"Dis Markers"},{"key":"9492_CR39","doi-asserted-by":"crossref","first-page":"276","DOI":"10.2337\/db15-0881","volume":"65","author":"C Nowak","year":"2016","unstructured":"Nowak C, Sundstr\u00f6m J, Gustafsson S. Protein biomarkers for insulin resistance and type 2 diabetes risk in two large community cohorts. Diabetes. 2016;65:276\u201384.","journal-title":"Diabetes"},{"issue":"1","key":"9492_CR40","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15204-z","volume":"7","author":"V Necchi","year":"2017","unstructured":"Necchi V, Sommi P, Vanoli A, Fiocca R, Ricci V, Solcia E. Natural history of helicobacter pylori VacA toxin in human gastric epithelium in vivo. Vacuoles and beyond. Sci Rep. 2017;7(1):14526. https:\/\/doi.org\/10.1038\/s41598-017-15204-z .","journal-title":"Sci Rep"},{"key":"9492_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/2897656","volume":"2016","author":"SM Ayuk","year":"2016","unstructured":"Ayuk SM, Abrahamse H, Houreld NN. The role of matrix metalloproteinases in diabetic wound healing in relation to photobiomodulation. J Diabetes Res. 2016;2016:1\u20139.","journal-title":"J Diabetes Res"},{"key":"9492_CR42","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.surg.2015.07.003","volume":"159","author":"R Serra","year":"2016","unstructured":"Serra R, Gallelli L, Grande R. Hemorrhoids and matrix metalloproteinases: a multicenter study on the predictive role of biomarkers. Surgery. 2016;159:487\u201394. https:\/\/doi.org\/10.1016\/j.surg.2015.07.003 .","journal-title":"Surgery"},{"key":"9492_CR43","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/j.jdiacomp.2015.01.007","volume":"29","author":"K Singh","year":"2015","unstructured":"Singh K, Agrawal NK, Gupta SK, Mohan G, Chaturvedi S, Singh K. Decreased expression of heat shock proteins may lead to compromised wound healing in type 2 diabetes mellitus patients. J Diabetes Complicat. 2015;29:578\u201388. https:\/\/doi.org\/10.1016\/j.jdiacomp.2015.01.007 .","journal-title":"J Diabetes Complicat"},{"key":"9492_CR44","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.2337\/db08-0009","volume":"57","author":"G Gruden","year":"2008","unstructured":"Gruden G, Bruno G, Chaturvedi N. Prospective complications study group. Serum heat shock protein 27 and diabetes complications in the EURODIAB prospective complications study. A novel circulating marker for diabetic neuropathy. Diabetes. 2008;57:1966\u201370. https:\/\/doi.org\/10.2337\/db08-0009 .","journal-title":"Diabetes"},{"key":"9492_CR45","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1007\/s12192-010-0204-z","volume":"15","author":"M Nakhjavani","year":"2010","unstructured":"Nakhjavani M, Morteza A, Khajeali L. Increased serum HSP70 levels are associated with the duration of diabetes. Cell Stress Chaperones. 2010;15:959\u201364. https:\/\/doi.org\/10.1007\/s12192-010-0204-z .","journal-title":"Cell Stress Chaperones"},{"key":"9492_CR46","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.dsx.2015.02.015","volume":"9","author":"M Zubair","year":"2015","unstructured":"Zubair M, Ahmad J. Plasma heat shock proteins (HSPs) 70 and 47 levels in diabetic foot and its possible correlation with clinical variables in a north Indian tertiary care hospital. Diabetes & Metabolic Syndrome Clinical Research & Reviews. 2015;9:237\u201343. https:\/\/doi.org\/10.1016\/j.dsx.2015.02.015 .","journal-title":"Diabetes & Metabolic Syndrome Clinical Research & Reviews"},{"key":"9492_CR47","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-94-011-5390-4_28","volume":"52","author":"Y Tsukimi","year":"2001","unstructured":"Tsukimi Y, Nakai H, Itoh S, Amagase K, Okabe S. Involvement of heat shock proteins in the healing of acetic acid-induced gastric ulcers in rats. J Physiol Pharmacol. 2001;52:3. https:\/\/doi.org\/10.1007\/978-94-011-5390-4_28 .","journal-title":"J Physiol Pharmacol"},{"key":"9492_CR48","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.msec.2014.12.068","volume":"48","author":"MB Dreifke","year":"2015","unstructured":"Dreifke MB, Jayasuriya AA, Jayasuriya AC. Current wound healing procedures and potential care. Mater Sci Eng C. 2015;48:651\u201362. https:\/\/doi.org\/10.1016\/j.msec.2014.12.068 .","journal-title":"Mater Sci Eng C"},{"key":"9492_CR49","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1177\/147323000903700531","volume":"37","author":"T Velnar","year":"2009","unstructured":"Velnar T, Bailey T, Smrkolj V. The wound healing process: an overview of the cellular and molecular mechanisms. J Int Med Res. 2009;37:1528\u201342. https:\/\/doi.org\/10.1177\/147323000903700531 .","journal-title":"J Int Med Res"},{"key":"9492_CR50","doi-asserted-by":"publisher","first-page":"250","DOI":"10.4103\/2347-9264.158851","volume":"2","author":"FM Thiruvoth","year":"2015","unstructured":"Thiruvoth FM, Mohapatra DP, Sivakumar DK, Chittoria RK, Nandhagopal V. Current concepts in the physiology of adult wound healing. Plast Aesthet Res. 2015;2:250\u20136. https:\/\/doi.org\/10.4103\/2347-9264.158851 .","journal-title":"Plast Aesthet Res"},{"key":"9492_CR51","doi-asserted-by":"crossref","unstructured":"Foy Y, Li J, Kirsner R, Eaglstein W. Analysis of fibroblast defects in extracellular matrix. J Am Acad Dermatol. 2004;50(3):P168.","DOI":"10.1016\/j.jaad.2003.10.595"},{"issue":"4","key":"9492_CR52","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.jtv.2016.06.005","volume":"25","author":"S Jhamb","year":"2016","unstructured":"Jhamb S, Vangaveti VN, Malabu UH. Genetic and molecular basis of diabetic foot ulcers: a clinical review. J Tissue Viability. 2016;25(4):229\u201336.","journal-title":"J Tissue Viability"},{"key":"9492_CR53","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.bbrc.2004.02.065","volume":"316","author":"JY Lai","year":"2004","unstructured":"Lai JY, Borson ND, Strausbauch MA, Pittelkow MR. Mitosis increases levels of secretory leukocyte protease inhibitor in keratinocytes. Biochem Biophys Res Commun. 2004;316:407\u201310. https:\/\/doi.org\/10.1016\/j.bbrc.2004.02.065 .","journal-title":"Biochem Biophys Res Commun"},{"key":"9492_CR54","unstructured":"Ching YH, Sutton TL, Pierpont YN, Robson MC, Payne WG. The use of growth factors and other humoral agents to accelerate and enhance burn wound healing. Eplasty. 2011;11."},{"key":"9492_CR55","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1089\/wound.2017.0761","volume":"7","author":"J Larouche","year":"2018","unstructured":"Larouche J, Sheoran S, Maruyama K, Martino MM. Immune regulation of skin wound healing: mechanisms and novel therapeutic targets. Adv Wound Care. 2018;7:209\u201331. https:\/\/doi.org\/10.1089\/wound.2017.0761 .","journal-title":"Adv Wound Care"},{"key":"9492_CR56","doi-asserted-by":"publisher","unstructured":"Bakker AD, Schrooten J, Van Cleynenbreugel T, Vanlauwe J, Luyten J, Schepers E, Dubruel P, Schacht E, Lammens J, Luyten FP. Quantitative screening of engineered implants in a long bone defect model in rabbits. Tissue Eng Part C: Methods. 2008;14(3):251\u201360. https:\/\/doi.org\/10.1089\/ten.tec.2008.0022 .","DOI":"10.1089\/ten.tec.2008.0022"},{"key":"9492_CR57","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/bies.201400103","volume":"37","author":"A Pauli","year":"2015","unstructured":"Pauli A, Valen E, Schier AF. Identifying (non-) coding RNAs and small peptides. Challenges and opportunities. Bioessays. 2015;37:103\u201312. https:\/\/doi.org\/10.1002\/bies.201400103 .","journal-title":"Bioessays"},{"key":"9492_CR58","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1111\/wrr.12564","volume":"25","author":"DJ Margolis","year":"2017","unstructured":"Margolis DJ, Hampton M, Hoffstad O. NOS1AP genetic variation is associated with impaired healing of diabetic foot ulcers and diminished response to healing of circulating stem\/progenitor cells. Wound Repair Regen. 2017;25:733\u20136.","journal-title":"Wound Repair Regen"},{"key":"9492_CR59","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1016\/j.ijbiomac.2018.07.083","volume":"118","author":"V Viswanathan","year":"2018","unstructured":"Viswanathan V, Dhamodharan U, Srinivasan V, Rajaram R, Aravindhan V. Single nucleotide polymorphisms in cytokine\/chemokine genes are associated with severe infection, ulcer grade and amputation in diabetic foot ulcer. Int J Biol Macromol. 2018;118:1995\u20132000.","journal-title":"Int J Biol Macromol"},{"key":"9492_CR60","doi-asserted-by":"publisher","first-page":"18S","DOI":"10.1097\/PRS.0000000000002682","volume":"138","author":"LE Lindley","year":"2016","unstructured":"Lindley LE, Stojadinovic O, Pastar I, Tomic-Canic M. Biology and biomarkers for wound healing. Plast Reconstr Surg. 2016;138:18S\u201328S. https:\/\/doi.org\/10.1097\/prs.0000000000002682 .","journal-title":"Plast Reconstr Surg"},{"key":"9492_CR61","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0002-9440(10)62953-7","volume":"167","author":"O Stojadinovic","year":"2005","unstructured":"Stojadinovic O, Brem H, Vouthounis C. Molecular pathogenesis of chronic wounds: the role of \u03b2-catenin and c-myc in the inhibition of epithelialization and wound healing. Am J Pathol. 2005;167:59\u201369. https:\/\/doi.org\/10.1016\/s0002-9440(10)62953-7 .","journal-title":"Am J Pathol"},{"key":"9492_CR62","doi-asserted-by":"crossref","unstructured":"Brem H, Tomic-Canic M. Cellular and molecular basis of wound healing in diabetes. J Clin Investig. 2007;117(5):1219\u201322.","DOI":"10.1172\/JCI32169"},{"issue":"9","key":"9492_CR63","doi-asserted-by":"publisher","first-page":"2699","DOI":"10.3390\/ijms19092699","volume":"19","author":"T Johnson","year":"2018","unstructured":"Johnson T, G\u00f3mez B, McIntyre M, Dubick M, Christy R, Nicholson S, Burmeister D. The cutaneous microbiome and wounds: New molecular targets to promote wound healing. Int J Mol Sci. 2018;19(9):2699.","journal-title":"Int J Mol Sci"}],"container-title":["Reviews in Endocrine and Metabolic Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11154-019-09492-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11154-019-09492-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11154-019-09492-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T19:40:29Z","timestamp":1663184429000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11154-019-09492-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,1]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["9492"],"URL":"https:\/\/doi.org\/10.1007\/s11154-019-09492-1","relation":{},"ISSN":["1389-9155","1573-2606"],"issn-type":[{"value":"1389-9155","type":"print"},{"value":"1573-2606","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,1]]},"assertion":[{"value":"1 April 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}