{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:13:50Z","timestamp":1791980030004,"version":"4.4.0"},"reference-count":99,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rev Endocr Metab Disord"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1007\/s11154-019-09509-9","type":"journal-article","created":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T03:04:21Z","timestamp":1572231861000},"page":"283-294","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["Vasopressin and Copeptin in health and disease"],"prefix":"10.1007","volume":"20","author":[{"given":"Mirjam","family":"Christ-Crain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,10,28]]},"reference":[{"key":"9509_CR1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1093\/clinchem\/45.1.98","volume":"45","author":"M Kluge","year":"1999","unstructured":"Kluge M, Riedl S, Erhart-Hofmann B, Hartmann J, Waldhauser F. Improved extraction procedure and RIA for determination of arginine8-vasopressin in plasma: role of premeasurement sample treatment and reference values in children. Clin Chem. 1999;45:98\u2013103.","journal-title":"Clin Chem"},{"key":"9509_CR2","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1210\/jc.2010-2499","volume":"96","author":"S Balanescu","year":"2011","unstructured":"Balanescu S, et al. Correlation of plasma copeptin and vasopressin concentrations in hypo-, iso-, and hyperosmolar States. J Clin Endocrinol Metab. 2011;96:1046\u201352.","journal-title":"J Clin Endocrinol Metab"},{"key":"9509_CR3","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1373\/clinchem.2005.060038","volume":"52","author":"NG Morgenthaler","year":"2006","unstructured":"Morgenthaler NG, Struck J, Alonso C, Bergmann A. Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin. Clin Chem. 2006;52:112\u20139.","journal-title":"Clin Chem"},{"key":"9509_CR4","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0079-6123(08)64390-3","volume":"60","author":"D Richter","year":"1983","unstructured":"Richter D, Schmale H. The structure of the precursor to arginine-vasopressin: a model preprohormone. Prog Brain Res. 1983;60:227\u201333.","journal-title":"Prog Brain Res"},{"key":"9509_CR5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/295299a0","volume":"295","author":"H Land","year":"1982","unstructured":"Land H, Schutz G, Schmale H, Richter D. Nucleotide sequence of cloned cDNA encoding bovine arginine vasopressin-neurophysin II precursor. Nature. 1982;295:299\u2013303.","journal-title":"Nature"},{"key":"9509_CR6","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1399-3011.1986.tb01827.x","volume":"27","author":"B Levy","year":"1986","unstructured":"Levy B, Chauvet MT. Chauvet, J. & Acher, R. Ontogeny of bovine neurohypophysial hormone precursors. II. Foetal copeptin, the third domain of the vasopressin precursor. Int J Pept Protein Res. 1986;27:320\u20134.","journal-title":"Int J Pept Protein Res"},{"key":"9509_CR7","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/302342a0","volume":"302","author":"H Land","year":"1983","unstructured":"Land H, et al. Deduced amino acid sequence from the bovine oxytocin-neurophysin I precursor cDNA. Nature. 1983;302:342\u20134.","journal-title":"Nature"},{"key":"9509_CR8","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1385\/JMN:18:3:223","volume":"18","author":"R Acher","year":"2002","unstructured":"Acher R, Chauvet J, Rouille Y. Dynamic processing of neuropeptides: sequential conformation shaping of neurohypophysial preprohormones during intraneuronal secretory transport. J Mol Neurosci. 2002;18:223\u20138.","journal-title":"J Mol Neurosci"},{"key":"9509_CR9","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1023\/A:1022564803093","volume":"18","author":"FM de Bree","year":"1998","unstructured":"de Bree FM, Burbach JP. Structure-function relationships of the vasopressin prohormone domains. Cell Mol Neurobiol. 1998;18:173\u201391.","journal-title":"Cell Mol Neurobiol"},{"key":"9509_CR10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF00218970","volume":"164","author":"F Vandesande","year":"1975","unstructured":"Vandesande F, Dierickx K. Identification of the vasopressin producing and of the oxytocin producing neurons in the hypothalamic magnocellular neurosecretroy system of the rat. Cell Tissue Res. 1975;164:153\u201362.","journal-title":"Cell Tissue Res"},{"key":"9509_CR11","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/299355a0","volume":"299","author":"GE Gillies","year":"1982","unstructured":"Gillies GE, Linton EA, Lowry PJ. Corticotropin releasing activity of the new CRF is potentiated several times by vasopressin. Nature. 1982;299:355\u20137.","journal-title":"Nature"},{"key":"9509_CR12","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/305325a0","volume":"305","author":"C Rivier","year":"1983","unstructured":"Rivier C, Vale W. Modulation of stress-induced ACTH release by corticotropin-releasing factor, catecholamines and vasopressin. Nature. 1983;305:325\u20137.","journal-title":"Nature"},{"key":"9509_CR13","doi-asserted-by":"crossref","first-page":"23282","DOI":"10.1016\/S0021-9258(18)50088-0","volume":"267","author":"MH Nathanson","year":"1992","unstructured":"Nathanson MH, et al. Mechanisms of subcellular cytosolic Ca2+ signaling evoked by stimulation of the vasopressin V1a receptor. J Biol Chem. 1992;267:23282\u20139.","journal-title":"J Biol Chem"},{"key":"9509_CR14","unstructured":"Jard, S. Vasopressin and oxytocin receptors: an overview. In: Imura H, Shizume K, eds. Progress in Endocrinology. Amsterdam: Elsevier Science Publishers, 1183 (1988)."},{"key":"9509_CR15","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/0006-291X(88)90625-0","volume":"151","author":"G Nagy","year":"1988","unstructured":"Nagy G, Mulchahey JJ, Smyth DG, Neill JD. The glycopeptide moiety of vasopressin-neurophysin precursor is neurohypophysial prolactin releasing factor. Biochem Biophys Res Commun. 1988;151:524\u20139.","journal-title":"Biochem Biophys Res Commun"},{"key":"9509_CR16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1210\/endo-125-1-35","volume":"125","author":"JF Hyde","year":"1989","unstructured":"Hyde JF, North WG, Ben-Jonathan N. The vasopressin-associated glycopeptide is not a prolactin-releasing factor: studies with lactating Brattleboro rats. Endocrinology. 1989;125:35\u201340.","journal-title":"Endocrinology"},{"key":"9509_CR17","doi-asserted-by":"crossref","first-page":"8191","DOI":"10.1021\/bi0400094","volume":"43","author":"C Barat","year":"2004","unstructured":"Barat C, Simpson L, Breslow E. Properties of human vasopressin precursor constructs: inefficient monomer folding in the absence of copeptin as a potential contributor to diabetes insipidus. Biochemistry. 2004;43:8191\u2013203.","journal-title":"Biochemistry"},{"key":"9509_CR18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev.biochem.69.1.69","volume":"69","author":"AJ Parodi","year":"2000","unstructured":"Parodi AJ. Protein glucosylation and its role in protein folding. Annu Rev Biochem. 2000;69:69\u201393.","journal-title":"Annu Rev Biochem"},{"key":"9509_CR19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0968-0004(02)00004-X","volume":"28","author":"JD Schrag","year":"2003","unstructured":"Schrag JD, Procopio DO, Cygler M, Thomas DY, Bergeron JJ. Lectin control of protein folding and sorting in the secretory pathway. Trends Biochem Sci. 2003;28:49\u201357.","journal-title":"Trends Biochem Sci"},{"key":"9509_CR20","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1042\/CS20080140","volume":"116","author":"SS Bhandari","year":"2009","unstructured":"Bhandari SS, et al. Gender and renal function influence plasma levels of copeptin in healthy individuals. Clin Sci (Lond). 2009;116:257\u201363.","journal-title":"Clin Sci (Lond)"},{"key":"9509_CR21","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1373\/clinchem.2009.141689","volume":"56","author":"KH Darzy","year":"2010","unstructured":"Darzy KH, Dixit KC, Shalet SM, Morgenthaler NG, Brabant G. Circadian secretion pattern of copeptin, the C-terminal vasopressin precursor fragment. Clin Chem. 2010;56:1190\u20131.","journal-title":"Clin Chem"},{"key":"9509_CR22","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3109\/1354750X.2014.940504","volume":"19","author":"C Walti","year":"2014","unstructured":"Walti C, Siegenthaler J, Christ-Crain M. Copeptin levels are independent of ingested nutrient type after standardised meal administration--the CoMEAL study. Biomarkers. 2014;19:557\u201362.","journal-title":"Biomarkers"},{"key":"9509_CR23","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1365-2362.2006.01591.x","volume":"36","author":"JJ Puder","year":"2006","unstructured":"Puder JJ, et al. Menstrual cycle symptoms are associated with changes in low-grade inflammation. Eur J Clin Investig. 2006;36:58\u201364.","journal-title":"Eur J Clin Investig"},{"key":"9509_CR24","doi-asserted-by":"crossref","first-page":"3973","DOI":"10.1210\/jc.2007-0232","volume":"92","author":"G Szinnai","year":"2007","unstructured":"Szinnai G, et al. Changes in plasma copeptin, the c-terminal portion of arginine vasopressin during water deprivation and excess in healthy subjects. J Clin Endocrinol Metab. 2007;92:3973\u20138.","journal-title":"J Clin Endocrinol Metab"},{"key":"9509_CR25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/09537109777492","volume":"8","author":"T Wun","year":"1997","unstructured":"Wun T. Vasopressin and platelets: a concise review. Platelets. 1997;8:15\u201322.","journal-title":"Platelets"},{"key":"9509_CR26","doi-asserted-by":"crossref","first-page":"I129","DOI":"10.1161\/01.HYP.5.2_Pt_2.I129","volume":"5","author":"JJ Preibisz","year":"1983","unstructured":"Preibisz JJ, Sealey JE, Laragh JH, Cody RJ, Weksler BB. Plasma and platelet vasopressin in essential hypertension and congestive heart failure. Hypertension. 1983;5:I129\u201338.","journal-title":"Hypertension"},{"key":"9509_CR27","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1172\/JCI108377","volume":"57","author":"G Baumann","year":"1976","unstructured":"Baumann G, Dingman JF. Distribution, blood transport, and degradation of antidiuretic hormone in man. J Clin Invest. 1976;57:1109\u201316.","journal-title":"J Clin Invest"},{"key":"9509_CR28","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1172\/JCI107423","volume":"52","author":"GL Robertson","year":"1973","unstructured":"Robertson GL, Mahr EA, Athar S, Sinha T. Development and clinical application of a new method for the radioimmunoassay of arginine vasopressin in human plasma. J Clin Invest. 1973;52:2340\u201352.","journal-title":"J Clin Invest"},{"key":"9509_CR29","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1210\/jc.2012-1981","volume":"97","author":"W Fenske","year":"2012","unstructured":"Fenske W, Allolio B. Clinical review: Current state and future perspectives in the diagnosis of diabetes insipidus: a clinical review. J Clin Endocrinol Metab. 2012;97:3426\u201337.","journal-title":"J Clin Endocrinol Metab"},{"key":"9509_CR30","unstructured":"Robertson GL. Posterior pituitary. In: Felig P, Baxter J, Frohman L, editors. Endocrinology and metabolism. New York: McGraw-Hill; 385. p. 432\u20131995."},{"key":"9509_CR31","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S1521-690X(03)00049-6","volume":"17","author":"JG Verbalis","year":"2003","unstructured":"Verbalis JG. Disorders of body water homeostasis. Best Pract Res Clin Endocrinol Metab. 2003;17:471\u2013503.","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"9509_CR32","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1210\/jc.2010-2345","volume":"96","author":"W Fenske","year":"2011","unstructured":"Fenske W, et al. Copeptin in the differential diagnosis of the polydipsia-polyuria syndrome--revisiting the direct and indirect water deprivation tests. J Clin Endocrinol Metab. 2011;96:1506\u201315.","journal-title":"J Clin Endocrinol Metab"},{"key":"9509_CR33","doi-asserted-by":"crossref","first-page":"F965","DOI":"10.1152\/ajprenal.00085.2003","volume":"285","author":"MA Cadnapaphornchai","year":"2003","unstructured":"Cadnapaphornchai MA, et al. Effect of primary polydipsia on aquaporin and sodium transporter abundance. Am J Physiol Ren Physiol. 2003;285:F965\u201371.","journal-title":"Am J Physiol Ren Physiol"},{"key":"9509_CR34","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0140-6736(97)12169-9","volume":"352","author":"S Kumar","year":"1998","unstructured":"Kumar S, Berl T. Sodium. Lancet. 1998;352:220\u20138.","journal-title":"Lancet"},{"key":"9509_CR35","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1210\/jc.2008-0330","volume":"93","author":"W Fenske","year":"2008","unstructured":"Fenske W, et al. Value of fractional uric acid excretion in differential diagnosis of hyponatremic patients on diuretics. J Clin Endocrinol Metab. 2008;93:2991\u20137.","journal-title":"J Clin Endocrinol Metab"},{"key":"9509_CR36","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1210\/jc.2008-1426","volume":"94","author":"W Fenske","year":"2009","unstructured":"Fenske W, et al. Copeptin in the differential diagnosis of hyponatremia. J Clin Endocrinol Metab. 2009;94:123\u20139.","journal-title":"J Clin Endocrinol Metab"},{"key":"9509_CR37","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1172\/JCI103541","volume":"36","author":"RW Berliner","year":"1957","unstructured":"Berliner RW, Davidson DG. Production of hypertonic urine in the absence of pituitary antidiuretic hormone. J Clin Invest. 1957;36:1416\u201327.","journal-title":"J Clin Invest"},{"key":"9509_CR38","doi-asserted-by":"crossref","first-page":"721","DOI":"10.7326\/0003-4819-73-5-721","volume":"73","author":"M Miller","year":"1970","unstructured":"Miller M, Dalakos T, Moses AM, Fellerman H, Streeten DH. Recognition of partial defects in antidiuretic hormone secretion. Ann Intern Med. 1970;73:721\u20139.","journal-title":"Ann Intern Med"},{"key":"9509_CR39","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1056\/NEJM198112243052601","volume":"305","author":"RL Zerbe","year":"1981","unstructured":"Zerbe RL, Robertson GL. A comparison of plasma vasopressin measurements with a standard indirect test in the differential diagnosis of polyuria. N Engl J Med. 1981;305:1539\u201346.","journal-title":"N Engl J Med"},{"key":"9509_CR40","first-page":"108","volume":"32","author":"PH Baylis","year":"1998","unstructured":"Baylis PH. Diabetes insipidus. J R Coll Physicians Lond. 1998;32:108\u201311.","journal-title":"J R Coll Physicians Lond"},{"key":"9509_CR41","first-page":"345","volume":"50","author":"PH Baylis","year":"1981","unstructured":"Baylis PH, Gaskill MB, Robertson GL. Vasopressin secretion in primary polydipsia and cranial diabetes insipidus. Q J Med. 1981;50:345\u201358.","journal-title":"Q J Med"},{"key":"9509_CR42","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1172\/JCI105040","volume":"43","author":"JW Czaczkes","year":"1964","unstructured":"Czaczkes JW, Kleeman CR. The effect of various states of hydration and the plasma concentration on the turnover of antidiuretic hormone in mammals. J Clin Invest. 1964;43:1649\u201358.","journal-title":"J Clin Invest"},{"key":"9509_CR43","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1210\/jc.2006-2046","volume":"92","author":"M Katan","year":"2007","unstructured":"Katan M, et al. Anterior and posterior pituitary function testing with simultaneous insulin tolerance test and a novel copeptin assay. J Clin Endocrinol Metab. 2007;92:2640\u20133.","journal-title":"J Clin Endocrinol Metab"},{"key":"9509_CR44","unstructured":"Winzeler, B. et al. Postoperative copeptin concentration predicts diabetes insipidus after pituitary surgery. J Clin Endocrinol Metab, jc20144527 (2015)."},{"key":"9509_CR45","doi-asserted-by":"crossref","unstructured":"Timper, K. et al. Diagnostic accuracy of copeptin in the differential diagnosis of the polyuria-polydipsia syndrome: A prospective multicenter study. J Clin Endocrinol Metab, jc20144507 (2015).","DOI":"10.1210\/jc.2014-4507"},{"key":"9509_CR46","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1056\/NEJMoa1803760","volume":"379","author":"W Fenske","year":"2018","unstructured":"Fenske W, et al. A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus. N Engl J Med. 2018;379:428\u201339.","journal-title":"N Engl J Med"},{"key":"9509_CR47","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0278-5846(85)90031-4","volume":"9","author":"NP Nair","year":"1985","unstructured":"Nair NP, et al. Effect of normal aging on the prolactin response to graded doses of sulpiride and to arginine. Prog Neuro-Psychopharmacol Biol Psychiatry. 1985;9:633\u20137.","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"9509_CR48","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1056\/NEJM196906262802603","volume":"280","author":"TJ Merimee","year":"1969","unstructured":"Merimee TJ, Rabinowtitz D, Fineberg SE. Arginine-initiated release of human growth hormone. Factors modifying the response in normal man. N Engl J Med. 1969;280:1434\u20138.","journal-title":"N Engl J Med"},{"key":"9509_CR49","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1210\/jcem-67-6-1186","volume":"67","author":"J Alba-Roth","year":"1988","unstructured":"Alba-Roth J, Muller OA, Schopohl J, von Werder K. Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion. J Clin Endocrinol Metab. 1988;67:1186\u20139.","journal-title":"J Clin Endocrinol Metab"},{"key":"9509_CR50","doi-asserted-by":"crossref","unstructured":"Winzeler B, et al. Arginine-stimulated copeptin measurements in the differential diagnosis of diabetes insipidus: a prospective diagnostic study. Lancet. 2019.","DOI":"10.1016\/S0140-6736(19)31255-3"},{"key":"9509_CR51","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1016\/j.amjmed.2006.05.005","volume":"119","author":"A Upadhyay","year":"2006","unstructured":"Upadhyay A, Jaber BL, Madias NE. Incidence and prevalence of hyponatremia. Am J Med. 2006;119:S30\u20135.","journal-title":"Am J Med"},{"key":"9509_CR52","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0002-9343(93)90179-S","volume":"94","author":"WW Tang","year":"1993","unstructured":"Tang WW, Kaptein EM, Feinstein EI, Massry SG. Hyponatremia in hospitalized patients with the acquired immunodeficiency syndrome (AIDS) and the AIDS-related complex. Am J Med. 1993;94:169\u201374.","journal-title":"Am J Med"},{"key":"9509_CR53","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.amjmed.2007.09.001","volume":"120","author":"JG Verbalis","year":"2007","unstructured":"Verbalis JG, Goldsmith SR, Greenberg A, Schrier RW, Sterns RH. Hyponatremia treatment guidelines 2007: expert panel recommendations. Am J Med. 2007;120:S1\u201321.","journal-title":"Am J Med"},{"key":"9509_CR54","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0002-9343(87)90649-8","volume":"83","author":"HM Chung","year":"1987","unstructured":"Chung HM, Kluge R, Schrier RW, Anderson RJ. Clinical assessment of extracellular fluid volume in hyponatremia. Am J Med. 1987;83:905\u20138.","journal-title":"Am J Med"},{"key":"9509_CR55","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.amjmed.2013.07.006","volume":"126","author":"JG Verbalis","year":"2013","unstructured":"Verbalis JG, et al. Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations. Am J Med. 2013;126:S1\u201342.","journal-title":"Am J Med"},{"key":"9509_CR56","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1056\/NEJMoa065181","volume":"355","author":"RW Schrier","year":"2006","unstructured":"Schrier RW, et al. Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia. N Engl J Med. 2006;355:2099\u2013112.","journal-title":"N Engl J Med"},{"key":"9509_CR57","doi-asserted-by":"crossref","first-page":"71.e1","DOI":"10.1016\/j.amjmed.2005.09.026","volume":"119","author":"B Renneboog","year":"2006","unstructured":"Renneboog B, Musch W, Vandemergel X, Manto MU, Decaux G. Mild chronic hyponatremia is associated with falls, unsteadiness, and attention deficits. Am J Med. 2006;119:71.e1\u20138.","journal-title":"Am J Med"},{"key":"9509_CR58","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1359\/jbmr.090827","volume":"25","author":"JG Verbalis","year":"2010","unstructured":"Verbalis JG, et al. Hyponatremia-induced osteoporosis. J Bone Miner Res. 2010;25:554\u201363.","journal-title":"J Bone Miner Res"},{"key":"9509_CR59","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.amjmed.2010.01.013","volume":"123","author":"W Fenske","year":"2010","unstructured":"Fenske W, Maier SK, Blechschmidt A, Allolio B, Stork S. Utility and limitations of the traditional diagnostic approach to hyponatremia: a diagnostic study. Am J Med. 2010;123:652\u20137.","journal-title":"Am J Med"},{"key":"9509_CR60","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/cen.13243","volume":"86","author":"N Nigro","year":"2017","unstructured":"Nigro N, et al. Evaluation of copeptin and commonly used laboratory parameters for the differential diagnosis of profound hyponatraemia in hospitalized patients: 'The Co-MED Study'. Clin Endocrinol. 2017;86:456\u201362.","journal-title":"Clin Endocrinol"},{"key":"9509_CR61","doi-asserted-by":"crossref","first-page":"537 e9","DOI":"10.1016\/j.amjmed.2015.11.005","volume":"129","author":"JG Verbalis","year":"2016","unstructured":"Verbalis JG, et al. Diagnosing and Treating the Syndrome of Inappropriate Antidiuretic Hormone Secretion. Am J Med. 2016;129:537 e9\u2013537 e23.","journal-title":"Am J Med"},{"key":"9509_CR62","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0002-9343(57)90224-3","volume":"23","author":"WB Schwartz","year":"1957","unstructured":"Schwartz WB, Bennett W, Curelop S, Bartter FC. A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone. Am J Med. 1957;23:529\u201342.","journal-title":"Am J Med"},{"key":"9509_CR63","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1146\/annurev.me.31.020180.001531","volume":"31","author":"R Zerbe","year":"1980","unstructured":"Zerbe R, Stropes L, Robertson G. Vasopressin function in the syndrome of inappropriate antidiuresis. Annu Rev Med. 1980;31:315\u201327.","journal-title":"Annu Rev Med"},{"key":"9509_CR64","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1681\/ASN.2013080895","volume":"25","author":"WK Fenske","year":"2014","unstructured":"Fenske WK, et al. A copeptin-based classification of the osmoregulatory defects in the syndrome of inappropriate antidiuresis. J Am Soc Nephrol. 2014;25:2376\u201383.","journal-title":"J Am Soc Nephrol"},{"key":"9509_CR65","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1002\/1097-0142(197612)38:6<2575::AID-CNCR2820380651>3.0.CO;2-B","volume":"38","author":"Y Hirata","year":"1976","unstructured":"Hirata Y, Matsukura S, Imura H, Yakura T, Ihjima S. Two cases of multiple hormone-producing small cell carcinoma of the lung: coexistence of tumor ADH, ACTH, and beta-MSH. Cancer. 1976;38:2575\u201382.","journal-title":"Cancer"},{"key":"9509_CR66","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1200\/JCO.1986.4.8.1191","volume":"4","author":"AF List","year":"1986","unstructured":"List AF, et al. The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in small-cell lung cancer. J Clin Oncol. 1986;4:1191\u20138.","journal-title":"J Clin Oncol"},{"key":"9509_CR67","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1365-2796.1995.tb00907.x","volume":"238","author":"JB Sorensen","year":"1995","unstructured":"Sorensen JB, Andersen MK, Hansen HH. Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in malignant disease. J Intern Med. 1995;238:97\u2013110.","journal-title":"J Intern Med"},{"key":"9509_CR68","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1007\/s00520-017-3638-3","volume":"25","author":"V Burst","year":"2017","unstructured":"Burst V, et al. Euvolemic hyponatremia in cancer patients. Report of the Hyponatremia Registry: an observational multicenter international study. Support Care Cancer. 2017;25:2275\u201383.","journal-title":"Support Care Cancer"},{"key":"9509_CR69","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/cc9055","volume":"14","author":"P Schuetz","year":"2010","unstructured":"Schuetz P, et al. Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections. Crit Care. 2010;14:R106.","journal-title":"Crit Care"},{"key":"9509_CR70","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/ana.21783","volume":"66","author":"M Katan","year":"2009","unstructured":"Katan M, et al. Copeptin: a novel, independent prognostic marker in patients with ischemic stroke. Ann Neurol. 2009;66:799\u2013808.","journal-title":"Ann Neurol"},{"key":"9509_CR71","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jacc.2009.01.076","volume":"54","author":"T Reichlin","year":"2009","unstructured":"Reichlin T, et al. Incremental value of copeptin for rapid rule out of acute myocardial infarction. J Am Coll Cardiol. 2009;54:60\u20138.","journal-title":"J Am Coll Cardiol"},{"key":"9509_CR72","first-page":"w13101","volume":"140","author":"M Katan","year":"2010","unstructured":"Katan M, Christ-Crain M. The stress hormone copeptin: a new prognostic biomarker in acute illness. Swiss Med Wkly. 2010;140:w13101.","journal-title":"Swiss Med Wkly"},{"key":"9509_CR73","doi-asserted-by":"crossref","unstructured":"Morgenthaler, N.G. et al. Copeptin, a Stable Peptide of the Arginine Vasopressin Precursor, Is Elevated in Hemorrhagic and Septic Shock. Shock (2007).","DOI":"10.1097\/SHK.0b013e318033e5da"},{"key":"9509_CR74","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1097\/00000542-199210000-00008","volume":"77","author":"KH Lindner","year":"1992","unstructured":"Lindner KH, et al. Stress hormone response during and after cardiopulmonary resuscitation. Anesthesiology. 1992;77:662\u20138.","journal-title":"Anesthesiology"},{"key":"9509_CR75","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1007\/s00134-014-3468-4","volume":"40","author":"Q Zhang","year":"2014","unstructured":"Zhang Q, Dong G, Zhao X, Wang M, Li CS. Prognostic significance of hypothalamic-pituitary-adrenal axis hormones in early sepsis: a study performed in the emergency department. Intensive Care Med. 2014;40:1499\u2013508.","journal-title":"Intensive Care Med"},{"key":"9509_CR76","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1365-2362.2007.01762.x","volume":"37","author":"B Muller","year":"2007","unstructured":"Muller B, et al. Circulating levels of copeptin, a novel biomarker, in lower respiratory tract infections. Eur J Clin Investig. 2007;37:145\u201352.","journal-title":"Eur J Clin Investig"},{"key":"9509_CR77","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1183\/09031936.00104412","volume":"41","author":"M Kolditz","year":"2013","unstructured":"Kolditz M, Ewig S, Hoffken G. Management-based risk prediction in community-acquired pneumonia by scores and biomarkers. Eur Respir J. 2013;41:974\u201384.","journal-title":"Eur Respir J"},{"key":"9509_CR78","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1378\/chest.06-2336","volume":"131","author":"D Stolz","year":"2007","unstructured":"Stolz D, et al. Copeptin, C-reactive protein, and procalcitonin as prognostic biomarkers in acute exacerbation of COPD. Chest. 2007;131:1058\u201367.","journal-title":"Chest"},{"key":"9509_CR79","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/j.1365-2362.2006.01724.x","volume":"36","author":"B Stoiser","year":"2006","unstructured":"Stoiser B, et al. Copeptin, a fragment of the vasopressin precursor, as a novel predictor of outcome in heart failure. Eur J Clin Investig. 2006;36:771\u20138.","journal-title":"Eur J Clin Investig"},{"key":"9509_CR80","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.cardfail.2006.09.004","volume":"13","author":"A Gegenhuber","year":"2007","unstructured":"Gegenhuber A, et al. Comparative evaluation of B-type natriuretic peptide, mid-regional pro-A-type natriuretic peptide, mid-regional pro-adrenomedullin, and Copeptin to predict 1-year mortality in patients with acute destabilized heart failure. J Card Fail. 2007;13:42\u20139.","journal-title":"J Card Fail"},{"key":"9509_CR81","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cca.2017.10.001","volume":"475","author":"Y Zhong","year":"2017","unstructured":"Zhong Y, et al. Copeptin in heart failure: Review and meta-analysis. Clin Chim Acta. 2017;475:36\u201343.","journal-title":"Clin Chim Acta"},{"key":"9509_CR82","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1161\/CIRCULATIONAHA.106.685503","volume":"115","author":"SQ Khan","year":"2007","unstructured":"Khan SQ, et al. C-terminal provasopressin (copeptin) as a novel and prognostic marker in acute myocardial infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) study. Circulation. 2007;115:2103\u201310.","journal-title":"Circulation"},{"key":"9509_CR83","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ijcard.2018.11.140","volume":"283","author":"K Wildi","year":"2019","unstructured":"Wildi K, et al. Comparison of fourteen rule-out strategies for acute myocardial infarction. Int J Cardiol. 2019;283:41\u20137.","journal-title":"Int J Cardiol"},{"key":"9509_CR84","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1161\/01.STR.25.6.1105","volume":"25","author":"K Fassbender","year":"1994","unstructured":"Fassbender K, Schmidt R, Mossner R. Daffertshofer, M. & Hennerici, M. Pattern of activation of the hypothalamic-pituitary-adrenal axis in acute stroke. Relation to acute confusional state, extent of brain damage, and clinical outcome. Stroke. 1994;25:1105\u20138.","journal-title":"Stroke"},{"key":"9509_CR85","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0022-510X(96)05308-7","volume":"147","author":"A Johansson","year":"1997","unstructured":"Johansson A, Olsson T, Carlberg B, Karlsson K, Fagerlund M. Hypercortisolism after stroke--partly cytokine-mediated? J Neurol Sci. 1997;147:43\u20137.","journal-title":"J Neurol Sci"},{"key":"9509_CR86","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0022-510X(02)00018-7","volume":"196","author":"A Slowik","year":"2002","unstructured":"Slowik A, et al. Hypercortisolemia in acute stroke is related to the inflammatory response. J Neurol Sci. 2002;196:27\u201332.","journal-title":"J Neurol Sci"},{"key":"9509_CR87","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1046\/j.1365-2796.2000.00600.x","volume":"247","author":"A Johansson","year":"2000","unstructured":"Johansson A, Ahren B, Nasman B, Carlstrom K, Olsson T. Cortisol axis abnormalities early after stroke--relationships to cytokines and leptin. J Intern Med. 2000;247:179\u201387.","journal-title":"J Intern Med"},{"key":"9509_CR88","doi-asserted-by":"crossref","first-page":"e1517","DOI":"10.1212\/WNL.0000000000007177","volume":"92","author":"GM De Marchis","year":"2019","unstructured":"De Marchis GM, et al. A novel biomarker-based prognostic score in acute ischemic stroke: The CoRisk score. Neurology. 2019;92:e1517\u201325.","journal-title":"Neurology"},{"key":"9509_CR89","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1530\/EJE-14-0405","volume":"171","author":"J Siegenthaler","year":"2014","unstructured":"Siegenthaler J, Walti C, Urwyler SA, Schuetz P, Christ-Crain M. Copeptin concentrations during psychological stress: the PsyCo study. Eur J Endocrinol. 2014;171:737\u201342.","journal-title":"Eur J Endocrinol"},{"key":"9509_CR90","doi-asserted-by":"crossref","unstructured":"Urwyler, S.A., Schuetz, P., Sailer, C. & Christ-Crain, M. Copeptin as a stress marker prior and after a written examination - the CoEXAM study. Stress, 1\u20134 (2015).","DOI":"10.3109\/10253890.2014.993966"},{"key":"9509_CR91","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0140-6736(07)60601-1","volume":"369","author":"VE Torres","year":"2007","unstructured":"Torres VE, Harris PC, Pirson Y. Autosomal dominant polycystic kidney disease. Lancet. 2007;369:1287\u2013301.","journal-title":"Lancet"},{"key":"9509_CR92","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1681\/ASN.2013111184","volume":"25","author":"RW Schrier","year":"2014","unstructured":"Schrier RW, et al. Predictors of autosomal dominant polycystic kidney disease progression. J Am Soc Nephrol. 2014;25:2399\u2013418.","journal-title":"J Am Soc Nephrol"},{"key":"9509_CR93","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2215\/CJN.04560510","volume":"6","author":"E Meijer","year":"2011","unstructured":"Meijer E, et al. Copeptin, a surrogate marker of vasopressin, is associated with disease severity in autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol. 2011;6:361\u20138.","journal-title":"Clin J Am Soc Nephrol"},{"key":"9509_CR94","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1053\/j.ajkd.2012.08.038","volume":"61","author":"WE Boertien","year":"2013","unstructured":"Boertien WE, et al. Relationship of copeptin, a surrogate marker for arginine vasopressin, with change in total kidney volume and GFR decline in autosomal dominant polycystic kidney disease: results from the CRISP cohort. Am J Kidney Dis. 2013;61:420\u20139.","journal-title":"Am J Kidney Dis"},{"key":"9509_CR95","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1161\/CIRCULATIONAHA.109.909663","volume":"121","author":"S Enhorning","year":"2010","unstructured":"Enhorning S, et al. Plasma copeptin and the risk of diabetes mellitus. Circulation. 2010;121:2102\u20138.","journal-title":"Circulation"},{"key":"9509_CR96","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1007\/s00125-013-2922-0","volume":"56","author":"WE Boertien","year":"2013","unstructured":"Boertien WE, et al. Copeptin, a surrogate marker for arginine vasopressin, is associated with declining glomerular filtration in patients with diabetes mellitus (ZODIAC-33). Diabetologia. 2013;56:1680\u20138.","journal-title":"Diabetologia"},{"key":"9509_CR97","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.jdiacomp.2015.07.006","volume":"29","author":"M Pikkemaat","year":"2015","unstructured":"Pikkemaat M, Melander O, Bengtsson Bostrom K. Association between copeptin and declining glomerular filtration rate in people with newly diagnosed diabetes. The Skaraborg Diabetes Register. J Diabetes Complicat. 2015;29:1062\u20135.","journal-title":"J Diabetes Complicat"},{"key":"9509_CR98","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.2337\/dc13-0683","volume":"36","author":"G Velho","year":"2013","unstructured":"Velho G, et al. Plasma copeptin and renal outcomes in patients with type 2 diabetes and albuminuria. Diabetes Care. 2013;36:3639\u201345.","journal-title":"Diabetes Care"},{"key":"9509_CR99","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s12020-018-1680-7","volume":"62","author":"G Muscogiuri","year":"2018","unstructured":"Muscogiuri G, et al. Water intake keeps type 2 diabetes away? Focus on copeptin. Endocrine. 2018;62:292\u20138.","journal-title":"Endocrine"}],"container-title":["Reviews in Endocrine and Metabolic Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11154-019-09509-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11154-019-09509-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11154-019-09509-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T19:47:49Z","timestamp":1664740069000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11154-019-09509-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":99,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["9509"],"URL":"https:\/\/doi.org\/10.1007\/s11154-019-09509-9","relation":{},"ISSN":["1389-9155","1573-2606"],"issn-type":[{"value":"1389-9155","type":"print"},{"value":"1573-2606","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"28 October 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"MCC received speaker honoraria from Thermofisher AG, the manufacturer of the copeptin assay.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All participants of the mentioned studies gave written informed consent to participate in the studies.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}