{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:32:35Z","timestamp":1792783955733,"version":"4.5.0"},"reference-count":168,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273294"],"award-info":[{"award-number":["82273294"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Science and Technology Department of Sichuan Province","award":["2022YFS0136"],"award-info":[{"award-number":["2022YFS0136"]}],"id":[{"id":"https:\/\/ror.org\/04323m874","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the Chengdu Bureau of Science and Technology","award":["2022-YF05-01316-SN"],"award-info":[{"award-number":["2022-YF05-01316-SN"]}]},{"name":"the Sichuan University","award":["2018SCUH0093"],"award-info":[{"award-number":["2018SCUH0093"]}],"id":[{"id":"https:\/\/ror.org\/011ashp19","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the 1.3.5 project for discipline of excellence, West China Hospital, Sichuan University","award":["2020HXFH008"],"award-info":[{"award-number":["2020HXFH008"]}]},{"name":"the 1.3.5 project for discipline of excellence, West China Hospital, Sichuan University","award":["ZYJC18003"],"award-info":[{"award-number":["ZYJC18003"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rev Endocr Metab Disord"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1007\/s11154-022-09778-x","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T23:31:55Z","timestamp":1670887915000},"page":"191-205","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["How does Hashimoto\u2019s thyroiditis affect bone metabolism?"],"prefix":"10.1007","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4468-956X","authenticated-orcid":false,"given":"Jialu","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2279-8418","authenticated-orcid":false,"given":"Hui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3504-7664","authenticated-orcid":false,"given":"Xijie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"9778_CR1","doi-asserted-by":"crossref","unstructured":"Delitala AP, Scuteri A, Doria C. Thyroid Hormone Diseases and Osteoporosis. J Clin Med, 2020. 9(4).","DOI":"10.3390\/jcm9041034"},{"key":"9778_CR2","doi-asserted-by":"crossref","unstructured":"Engblom C, et al., Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF(high) neutrophils. Science, 2017. 358(6367).","DOI":"10.1126\/science.aal5081"},{"issue":"12","key":"9778_CR3","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/nrendo.2010.190","volume":"6","author":"G Schett","year":"2010","unstructured":"Schett G, David JP. The multiple faces of autoimmune-mediated bone loss. Nat Rev Endocrinol. 2010;6(12):698\u2013706.","journal-title":"Nat Rev Endocrinol"},{"key":"9778_CR4","doi-asserted-by":"publisher","first-page":"116353","DOI":"10.1016\/j.bone.2022.116353","volume":"159","author":"N Takegahara","year":"2022","unstructured":"Takegahara N, Kim H, Choi Y. RANKL biology Bone. 2022;159:116353.","journal-title":"RANKL biology Bone"},{"issue":"12","key":"9778_CR5","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/s41573-020-0081-9","volume":"19","author":"NM Edner","year":"2020","unstructured":"Edner NM, et al. Targeting co-stimulatory molecules in autoimmune disease. Nat Rev Drug Discov. 2020;19(12):860\u201383.","journal-title":"Nat Rev Drug Discov"},{"key":"9778_CR6","first-page":"116466","volume":"162","author":"G Schett","year":"2022","unstructured":"Schett G, Takayanagi H. Editorial overview: Osteoimmunology Bone. 2022;162:116466.","journal-title":"Editorial overview: Osteoimmunology Bone"},{"issue":"6812","key":"9778_CR7","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/35046196","volume":"408","author":"JR Arron","year":"2000","unstructured":"Arron JR, Choi Y. Bone versus immune system. Nature. 2000;408(6812):535\u20136.","journal-title":"Nature"},{"key":"9778_CR8","doi-asserted-by":"publisher","first-page":"116375","DOI":"10.1016\/j.bone.2022.116375","volume":"159","author":"F Lademann","year":"2022","unstructured":"Lademann F, et al. Bone cell-specific deletion of thyroid hormone transporter Mct8 distinctly regulates bone volume in young versus adult male mice. Bone. 2022;159:116375.","journal-title":"Bone"},{"key":"9778_CR9","doi-asserted-by":"crossref","unstructured":"Groeneweg S, et al., Thyroid Hormone Transporters. Endocr Rev, 2020. 41(2).","DOI":"10.1210\/endrev\/bnz008"},{"issue":"1","key":"9778_CR10","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.bone.2008.03.019","volume":"43","author":"AJ Williams","year":"2008","unstructured":"Williams AJ, et al. Iodothyronine deiodinase enzyme activities in bone. Bone. 2008;43(1):126\u201334.","journal-title":"Bone"},{"issue":"2","key":"9778_CR11","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1089\/thy.2019.0271","volume":"30","author":"F Lademann","year":"2020","unstructured":"Lademann F, et al. Lack of the thyroid hormone transporter Mct8 in osteoblast and osteoclast progenitors increases trabecular bone in male mice. Thyroid. 2020;30(2):329\u201342.","journal-title":"Thyroid"},{"issue":"8","key":"9778_CR12","doi-asserted-by":"publisher","first-page":"4049","DOI":"10.1210\/en.2011-1713","volume":"153","author":"S Abe","year":"2012","unstructured":"Abe S, et al. Monocarboxylate transporter 10 functions as a thyroid hormone transporter in chondrocytes. Endocrinology. 2012;153(8):4049\u201358.","journal-title":"Endocrinology"},{"key":"9778_CR13","doi-asserted-by":"crossref","unstructured":"Lademann F, et al., The thyroid hormone transporter MCT10 is a Novel Regulator of Trabecular Bone Mass and bone turnover in male mice. Endocrinology, 2022. 163(1).","DOI":"10.1210\/endocr\/bqab218"},{"issue":"2","key":"9778_CR14","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1210\/er.2009-0007","volume":"31","author":"SY Cheng","year":"2010","unstructured":"Cheng SY, Leonard JL, Davis PJ. Molecular aspects of thyroid hormone actions. Endocr Rev. 2010;31(2):139\u201370.","journal-title":"Endocr Rev"},{"issue":"1","key":"9778_CR15","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1210\/en.2012-1727","volume":"154","author":"R Lavado-Autric","year":"2013","unstructured":"Lavado-Autric R, et al. Deiodinase activities in thyroids and tissues of iodine-deficient female rats. Endocrinology. 2013;154(1):529\u201336.","journal-title":"Endocrinology"},{"issue":"1","key":"9778_CR16","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1210\/en.2004-1043","volume":"146","author":"CH Gouveia","year":"2005","unstructured":"Gouveia CH, et al. Type 2 iodothyronine selenodeiodinase is expressed throughout the mouse skeleton and in the MC3T3-E1 mouse osteoblastic cell line during differentiation. Endocrinology. 2005;146(1):195\u2013200.","journal-title":"Endocrinology"},{"key":"9778_CR17","doi-asserted-by":"publisher","first-page":"300","DOI":"10.3389\/fendo.2019.00300","volume":"10","author":"CR Zaitune","year":"2019","unstructured":"Zaitune CR, et al. Abnormal thyroid hormone status differentially affects bone Mass Accrual and Bone Strength in C3H\/HeJ mice: a mouse model of type I deiodinase Deficiency. Front Endocrinol (Lausanne). 2019;10:300.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"16","key":"9778_CR18","doi-asserted-by":"publisher","first-page":"7604","DOI":"10.1073\/pnas.0911346107","volume":"107","author":"JH Bassett","year":"2010","unstructured":"Bassett JH, et al. Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts. Proc Natl Acad Sci U S A. 2010;107(16):7604\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"9778_CR19","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/ncb1272","volume":"7","author":"M Dentice","year":"2005","unstructured":"Dentice M, et al. The hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate. Nat Cell Biol. 2005;7(7):698\u2013705.","journal-title":"Nat Cell Biol"},{"issue":"3","key":"9778_CR20","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1089\/thy.2014.0476","volume":"25","author":"JA Waung","year":"2015","unstructured":"Waung JA, Bassett JH, Williams GR. Adult mice lacking the type 2 iodothyronine deiodinase have increased subchondral bone but normal articular cartilage. Thyroid. 2015;25(3):269\u201377.","journal-title":"Thyroid"},{"issue":"3","key":"9778_CR21","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1111\/cen.14206","volume":"93","author":"YE Kang","year":"2020","unstructured":"Kang YE, et al. Type 2 deiodinase Thr92Ala polymorphism is associated with a reduction in bone mineral density: a community-based korean genome and epidemiology study. Clin Endocrinol (Oxf). 2020;93(3):238\u201347.","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"7","key":"9778_CR22","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1093\/hmg\/ddt575","volume":"23","author":"L Zhang","year":"2014","unstructured":"Zhang L, et al. Multistage genome-wide association meta-analyses identified two new loci for bone mineral density. Hum Mol Genet. 2014;23(7):1923\u201333.","journal-title":"Hum Mol Genet"},{"issue":"4","key":"9778_CR23","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1530\/EJE-13-1009","volume":"170","author":"A Gogakos","year":"2014","unstructured":"Gogakos A, et al. THRA and DIO2 mutations are unlikely to be a common cause of increased bone mineral density in euthyroid post-menopausal women. Eur J Endocrinol. 2014;170(4):637\u201344.","journal-title":"Eur J Endocrinol"},{"key":"9778_CR24","doi-asserted-by":"crossref","unstructured":"Bassett JH, Williams GR, Critical role of the hypothalamic-pituitary-thyroid axis in bone Bone, 2008. 43(3): p.\u00a0418 \u2013 26.","DOI":"10.1016\/j.bone.2008.05.007"},{"issue":"2","key":"9778_CR25","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/S8756-3282(97)00097-5","volume":"21","author":"EO Abu","year":"1997","unstructured":"Abu EO, et al. The expression of thyroid hormone receptors in human bone. Bone. 1997;21(2):137\u201342.","journal-title":"Bone"},{"issue":"10","key":"9778_CR26","doi-asserted-by":"publisher","first-page":"2058","DOI":"10.1002\/jbmr.4092","volume":"35","author":"F Lademann","year":"2020","unstructured":"Lademann F, et al. Disruption of BMP Signaling prevents Hyperthyroidism-Induced Bone loss in male mice. J Bone Miner Res. 2020;35(10):2058\u201369.","journal-title":"J Bone Miner Res"},{"issue":"1","key":"9778_CR27","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/S8756-3282(01)00631-7","volume":"30","author":"T Siebler","year":"2002","unstructured":"Siebler T, et al. Thyroid status affects number and localization of thyroid hormone receptor expressing mast cells in bone marrow. Bone. 2002;30(1):259\u201366.","journal-title":"Bone"},{"issue":"3","key":"9778_CR28","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1530\/JOE-12-0059","volume":"213","author":"JJ Nicholls","year":"2012","unstructured":"Nicholls JJ, et al. The skeletal consequences of thyrotoxicosis. J Endocrinol. 2012;213(3):209\u201321.","journal-title":"J Endocrinol"},{"issue":"5","key":"9778_CR29","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1210\/me.2007-0033","volume":"21","author":"JH Bassett","year":"2007","unstructured":"Bassett JH, et al. Thyroid hormone excess rather than thyrotropin deficiency induces osteoporosis in hyperthyroidism. Mol Endocrinol. 2007;21(5):1095\u2013107.","journal-title":"Mol Endocrinol"},{"issue":"9","key":"9778_CR30","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.1002\/jbmr.432","volume":"26","author":"LE Monfoulet","year":"2011","unstructured":"Monfoulet LE, et al. Thyroid hormone receptor \u03b2 mediates thyroid hormone effects on bone remodeling and bone mass. J Bone Miner Res. 2011;26(9):2036\u201344.","journal-title":"J Bone Miner Res"},{"issue":"8","key":"9778_CR31","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1210\/me.2007-0157","volume":"21","author":"JH Bassett","year":"2007","unstructured":"Bassett JH, et al. Thyroid status during skeletal development determines adult bone structure and mineralization. Mol Endocrinol. 2007;21(8):1893\u2013904.","journal-title":"Mol Endocrinol"},{"issue":"24","key":"9778_CR32","doi-asserted-by":"publisher","first-page":"13209","DOI":"10.1073\/pnas.230285997","volume":"97","author":"M Kaneshige","year":"2000","unstructured":"Kaneshige M, et al. Mice with a targeted mutation in the thyroid hormone beta receptor gene exhibit impaired growth and resistance to thyroid hormone. Proc Natl Acad Sci U S A. 2000;97(24):13209\u201314.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"21","key":"9778_CR33","doi-asserted-by":"publisher","first-page":"17812","DOI":"10.1074\/jbc.M111.311464","volume":"287","author":"PJ O\u2019Shea","year":"2012","unstructured":"O\u2019Shea PJ, et al. Advanced bone formation in mice with a dominant-negative mutation in the thyroid hormone receptor \u03b2 gene due to activation of Wnt\/\u03b2-catenin protein signaling. J Biol Chem. 2012;287(21):17812\u201322.","journal-title":"J Biol Chem"},{"issue":"1","key":"9778_CR34","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s12020-017-1265-x","volume":"56","author":"RC Lindsey","year":"2017","unstructured":"Lindsey RC, Mohan S. Thyroid hormone acting via TR\u03b2 induces expression of browning genes in mouse bone marrow adipose tissue. Endocrine. 2017;56(1):109\u201320.","journal-title":"Endocrine"},{"issue":"2","key":"9778_CR35","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1210\/er.2015-1106","volume":"37","author":"JH Bassett","year":"2016","unstructured":"Bassett JH, Williams GR. Role of thyroid hormones in skeletal development and bone maintenance. Endocr Rev. 2016;37(2):135\u201387.","journal-title":"Endocr Rev"},{"issue":"9","key":"9778_CR36","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1210\/me.2003-0137","volume":"17","author":"DA Stevens","year":"2003","unstructured":"Stevens DA, et al. Thyroid hormone activates fibroblast growth factor receptor-1 in bone. Mol Endocrinol. 2003;17(9):1751\u201366.","journal-title":"Mol Endocrinol"},{"issue":"3","key":"9778_CR37","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1172\/JCI108497","volume":"58","author":"GR Mundy","year":"1976","unstructured":"Mundy GR, et al. Direct stimulation of bone resorption by thyroid hormones. J Clin Invest. 1976;58(3):529\u201334.","journal-title":"J Clin Invest"},{"issue":"3","key":"9778_CR38","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1677\/joe.0.1330327","volume":"133","author":"TJ Allain","year":"1992","unstructured":"Allain TJ, et al. Tri-iodothyronine stimulates rat osteoclastic bone resorption by an indirect effect. J Endocrinol. 1992;133(3):327\u201331.","journal-title":"J Endocrinol"},{"issue":"2","key":"9778_CR39","first-page":"435","volume":"84","author":"A Siddiqi","year":"1999","unstructured":"Siddiqi A, et al. Serum cytokines in thyrotoxicosis. J Clin Endocrinol Metab. 1999;84(2):435\u20139.","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"9778_CR40","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s00774-016-0752-0","volume":"35","author":"I Lambrinoudaki","year":"2017","unstructured":"Lambrinoudaki I, et al. Thyroid function and autoimmunity are associated with the risk of vertebral fractures in postmenopausal women. J Bone Miner Metab. 2017;35(2):227\u201333.","journal-title":"J Bone Miner Metab"},{"issue":"3","key":"9778_CR41","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.bone.2009.10.031","volume":"46","author":"G Mazziotti","year":"2010","unstructured":"Mazziotti G, et al. Serum TSH values and risk of vertebral fractures in euthyroid post-menopausal women with low bone mineral density. Bone. 2010;46(3):747\u201351.","journal-title":"Bone"},{"issue":"8","key":"9778_CR42","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.1210\/jc.2013-2474","volume":"99","author":"A Leader","year":"2014","unstructured":"Leader A, et al. Thyrotropin levels within the lower normal range are associated with an increased risk of hip fractures in euthyroid women, but not men, over the age of 65 years. J Clin Endocrinol Metab. 2014;99(8):2665\u201373.","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"9778_CR43","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.1002\/jbmr.2244","volume":"29","author":"B Abrahamsen","year":"2014","unstructured":"Abrahamsen B, et al. Low serum thyrotropin level and duration of suppression as a predictor of major osteoporotic fractures-the OPENTHYRO register cohort. J Bone Miner Res. 2014;29(9):2040\u201350.","journal-title":"J Bone Miner Res"},{"issue":"6","key":"9778_CR44","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1159\/000518058","volume":"10","author":"E Soto-Pedre","year":"2021","unstructured":"Soto-Pedre E, et al. Evidence of a causal relationship between serum thyroid-stimulating hormone and osteoporotic bone fractures. Eur Thyroid J. 2021;10(6):439\u201346.","journal-title":"Eur Thyroid J"},{"issue":"1","key":"9778_CR45","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s12902-021-00715-8","volume":"21","author":"T Deng","year":"2021","unstructured":"Deng T, et al. Thyroid-stimulating hormone decreases the risk of osteoporosis by regulating osteoblast proliferation and differentiation. BMC Endocr Disord. 2021;21(1):49.","journal-title":"BMC Endocr Disord"},{"issue":"4","key":"9778_CR46","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s00223-016-0163-1","volume":"99","author":"C Konca Degertekin","year":"2016","unstructured":"Konca Degertekin C, et al. RANKL\/Osteoprotegerin system and bone turnover in Hashimoto Thyroiditis. Calcif Tissue Int. 2016;99(4):365\u201372.","journal-title":"Calcif Tissue Int"},{"issue":"11","key":"9778_CR47","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1089\/thy.2008.0158","volume":"18","author":"G Grimnes","year":"2008","unstructured":"Grimnes G, et al. The relationship between serum TSH and bone mineral density in men and postmenopausal women: the Troms\u00f8 study. Thyroid. 2008;18(11):1147\u201355.","journal-title":"Thyroid"},{"issue":"11","key":"9778_CR48","doi-asserted-by":"publisher","first-page":"4289","DOI":"10.1073\/pnas.0712395105","volume":"105","author":"L Sun","year":"2008","unstructured":"Sun L, et al. Intermittent recombinant TSH injections prevent ovariectomy-induced bone loss. Proc Natl Acad Sci U S A. 2008;105(11):4289\u201394.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"9778_CR49","doi-asserted-by":"publisher","first-page":"3737","DOI":"10.1172\/JCI63948","volume":"122","author":"R Baliram","year":"2012","unstructured":"Baliram R, et al. Hyperthyroid-associated osteoporosis is exacerbated by the loss of TSH signaling. J Clin Invest. 2012;122(10):3737\u201341.","journal-title":"J Clin Invest"},{"issue":"2","key":"9778_CR50","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0092-8674(03)00771-2","volume":"115","author":"E Abe","year":"2003","unstructured":"Abe E, et al. TSH is a negative regulator of skeletal remodeling. Cell. 2003;115(2):151\u201362.","journal-title":"Cell"},{"issue":"34","key":"9778_CR51","doi-asserted-by":"publisher","first-page":"12849","DOI":"10.1073\/pnas.0600427103","volume":"103","author":"H Hase","year":"2006","unstructured":"Hase H, et al. TNFalpha mediates the skeletal effects of thyroid-stimulating hormone. Proc Natl Acad Sci U S A. 2006;103(34):12849\u201354.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"39","key":"9778_CR52","doi-asserted-by":"publisher","first-page":"16277","DOI":"10.1073\/pnas.1110286108","volume":"108","author":"R Baliram","year":"2011","unstructured":"Baliram R, et al. Thyroid-stimulating hormone induces a Wnt-dependent, feed-forward loop for osteoblastogenesis in embryonic stem cell cultures. Proc Natl Acad Sci U S A. 2011;108(39):16277\u201382.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"9778_CR53","doi-asserted-by":"publisher","first-page":"4919","DOI":"10.1210\/en.2012-2234","volume":"154","author":"R Baliram","year":"2013","unstructured":"Baliram R, et al. Thyroid and bone: macrophage-derived TSH-\u03b2 splice variant increases murine osteoblastogenesis. Endocrinology. 2013;154(12):4919\u201326.","journal-title":"Endocrinology"},{"issue":"8","key":"9778_CR54","doi-asserted-by":"publisher","first-page":"3446","DOI":"10.1096\/fj.14-251124","volume":"28","author":"A Boutin","year":"2014","unstructured":"Boutin A, et al. \u03b2-Arrestin-1 mediates thyrotropin-enhanced osteoblast differentiation. Faseb j. 2014;28(8):3446\u201355.","journal-title":"Faseb j"},{"key":"9778_CR55","doi-asserted-by":"publisher","first-page":"509764","DOI":"10.1155\/2013\/509764","volume":"2013","author":"MA Iddah","year":"2013","unstructured":"Iddah MA, Macharia BN. Autoimmune thyroid disorders. ISRN Endocrinol. 2013;2013:509764.","journal-title":"ISRN Endocrinol"},{"key":"9778_CR56","first-page":"749576","volume":"2014","author":"C Dunne","year":"2014","unstructured":"Dunne C, De Luca F. Long-term Follow-Up of a child with autoimmune thyroiditis and recurrent hyperthyroidism in the absence of TSH receptor antibodies. Case Rep Endocrinol. 2014;2014:749576.","journal-title":"Case Rep Endocrinol"},{"issue":"6","key":"9778_CR57","first-page":"e2804","volume":"10","author":"A Shahbaz","year":"2018","unstructured":"Shahbaz A, et al. Prolonged duration of hashitoxicosis in a patient with Hashimoto\u2019s Thyroiditis: a Case Report and Review of Literature. Cureus. 2018;10(6):e2804.","journal-title":"Cureus"},{"issue":"1","key":"9778_CR58","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s12325-020-01537-1","volume":"38","author":"JV Hennessey","year":"2021","unstructured":"Hennessey JV, et al. The Association between switching from Synthroid(\u00ae) and clinical outcomes: US evidence from a retrospective database analysis. Adv Ther. 2021;38(1):337\u201349.","journal-title":"Adv Ther"},{"issue":"2","key":"9778_CR59","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/8756-3282(86)90681-2","volume":"7","author":"EF Eriksen","year":"1986","unstructured":"Eriksen EF, Mosekilde L, Melsen F. Kinetics of trabecular bone resorption and formation in hypothyroidism: evidence for a positive balance per remodeling cycle. Bone. 1986;7(2):101\u20138.","journal-title":"Bone"},{"issue":"5","key":"9778_CR60","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1089\/105072502760043503","volume":"12","author":"P Vestergaard","year":"2002","unstructured":"Vestergaard P, Mosekilde L. Fractures in patients with hyperthyroidism and hypothyroidism: a nationwide follow-up study in 16,249 patients. Thyroid. 2002;12(5):411\u20139.","journal-title":"Thyroid"},{"issue":"2","key":"9778_CR61","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1210\/me.2007-0221","volume":"22","author":"JH Bassett","year":"2008","unstructured":"Bassett JH, et al. A lack of thyroid hormones rather than excess thyrotropin causes abnormal skeletal development in hypothyroidism. Mol Endocrinol. 2008;22(2):501\u201312.","journal-title":"Mol Endocrinol"},{"issue":"2","key":"9778_CR62","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s12020-020-02398-y","volume":"71","author":"ML Obling","year":"2021","unstructured":"Obling ML, et al. Restoration of euthyroidism in women with Hashimoto\u2019s thyroiditis changes bone microarchitecture but not estimated bone strength. Endocrine. 2021;71(2):397\u2013406.","journal-title":"Endocrine"},{"issue":"1","key":"9778_CR63","first-page":"40","volume":"64","author":"D Tuchendler","year":"2013","unstructured":"Tuchendler D, Bolanowski M. Assessment of bone metabolism in premenopausal females with hyperthyroidism and hypothyroidism. Endokrynol Pol. 2013;64(1):40\u20134.","journal-title":"Endokrynol Pol"},{"issue":"20","key":"9778_CR64","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1001\/jama.2015.5161","volume":"313","author":"MR Blum","year":"2015","unstructured":"Blum MR, et al. Subclinical thyroid dysfunction and fracture risk: a meta-analysis. JAMA. 2015;313(20):2055\u201365.","journal-title":"JAMA"},{"issue":"1","key":"9778_CR65","first-page":"83","volume":"45","author":"LB Liang","year":"2014","unstructured":"Liang LB, et al. Changes of bone mineral density and bone metabolic marker in patients with subclinical hypothyroidism. Sichuan Da Xue Xue Bao Yi Xue Ban. 2014;45(1):83. 66 \u2013 9,, , ( : p.","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"issue":"3","key":"9778_CR66","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/BF03401309","volume":"12","author":"S Polovina","year":"2013","unstructured":"Polovina S, et al. Frax score calculations in postmenopausal women with subclinical hypothyroidism. Horm (Athens). 2013;12(3):439\u201348.","journal-title":"Horm (Athens)"},{"issue":"4","key":"9778_CR67","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1507\/endocrj.K06-201","volume":"54","author":"M Nagata","year":"2007","unstructured":"Nagata M, et al. Subclinical hypothyroidism is related to lower heel QUS in postmenopausal women. Endocr J. 2007;54(4):625\u201330.","journal-title":"Endocr J"},{"issue":"1","key":"9778_CR68","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0889-8529(18)30338-4","volume":"19","author":"L Mosekilde","year":"1990","unstructured":"Mosekilde L, Eriksen EF, Charles P. Effects of thyroid hormones on bone and mineral metabolism. Endocrinol Metab Clin North Am. 1990;19(1):35\u201363.","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"4","key":"9778_CR69","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1677\/erc.1.01072","volume":"12","author":"JL Reverter","year":"2005","unstructured":"Reverter JL, et al. Lack of deleterious effect on bone mineral density of long-term thyroxine suppressive therapy for differentiated thyroid carcinoma. Endocr Relat Cancer. 2005;12(4):973\u201381.","journal-title":"Endocr Relat Cancer"},{"issue":"6","key":"9778_CR70","first-page":"293","volume":"64","author":"M Appetecchia","year":"2005","unstructured":"Appetecchia M. Effects on bone mineral density by treatment of benign nodular goiter with mildly suppressive doses of L-thyroxine in a cohort women study. Horm Res. 2005;64(6):293\u20138.","journal-title":"Horm Res"},{"issue":"4","key":"9778_CR71","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s00774-015-0680-4","volume":"34","author":"M Mendon\u00e7a","year":"2016","unstructured":"Mendon\u00e7a M, de Barros G, et al. Bone mineral density and bone microarchitecture after long-term suppressive levothyroxine treatment of differentiated thyroid carcinoma in young adult patients. J Bone Miner Metab. 2016;34(4):417\u201321.","journal-title":"J Bone Miner Metab"},{"issue":"1","key":"9778_CR72","doi-asserted-by":"publisher","first-page":"51","DOI":"10.11005\/jbm.2019.26.1.51","volume":"26","author":"BH Yoon","year":"2019","unstructured":"Yoon BH, et al. Influence of thyroid-stimulating hormone suppression therapy on bone Mineral density in patients with differentiated thyroid Cancer: a Meta-analysis. J Bone Metab. 2019;26(1):51\u201360.","journal-title":"J Bone Metab"},{"issue":"12","key":"9778_CR73","first-page":"3655","volume":"106","author":"EJ Ku","year":"2021","unstructured":"Ku EJ, et al. Effect of TSH suppression therapy on bone Mineral density in differentiated thyroid Cancer: a systematic review and Meta-analysis. J Clin Endocrinol Metab. 2021;106(12):3655\u201367.","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"9778_CR74","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1056\/NEJM200108023450506","volume":"345","author":"A Davidson","year":"2001","unstructured":"Davidson A, Diamond B. Autoimmune diseases. N Engl J Med. 2001;345(5):340\u201350.","journal-title":"N Engl J Med"},{"issue":"10","key":"9778_CR75","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1089\/jir.2011.0049","volume":"31","author":"BB Ganesh","year":"2011","unstructured":"Ganesh BB, et al. Role of cytokines in the pathogenesis and suppression of thyroid autoimmunity. J Interferon Cytokine Res. 2011;31(10):721\u201331.","journal-title":"J Interferon Cytokine Res"},{"issue":"2","key":"9778_CR76","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1615\/CritRevImmunol.v25.i2.10","volume":"25","author":"IJ Crane","year":"2005","unstructured":"Crane IJ, Forrester JV. Th1 and Th2 lymphocytes in autoimmune disease. Crit Rev Immunol. 2005;25(2):75\u2013102.","journal-title":"Crit Rev Immunol"},{"issue":"5","key":"9778_CR77","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1507\/endocrj.EJ18-0396","volume":"66","author":"T Zake","year":"2019","unstructured":"Zake T, et al. Upregulated tissue expression of T helper (th) 17 pathogenic interleukin (IL)-23 and IL-1\u03b2 in Hashimoto\u2019s thyroiditis but not in Graves\u2019 disease. Endocr J. 2019;66(5):423\u201330.","journal-title":"Endocr J"},{"key":"9778_CR78","unstructured":"Huifang S. Study on the correlation between Hashimoto\u2019s thyroiditis and bone mineral density in postmenopausal women. Qingdao University; 2021."},{"issue":"1","key":"9778_CR79","first-page":"54","volume":"16","author":"SP Polovina","year":"2017","unstructured":"Polovina SP, et al. The impact of thyroid autoimmunity (TPOAb) on bone density and fracture risk in postmenopausal women. Horm (Athens). 2017;16(1):54\u201361.","journal-title":"Horm (Athens)"},{"issue":"1","key":"9778_CR80","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3810\/pgm.2010.01.2102","volume":"122","author":"ES Siris","year":"2010","unstructured":"Siris ES, Baim S, Nattiv A. Primary care use of FRAX: absolute fracture risk assessment in postmenopausal women and older men. Postgrad Med. 2010;122(1):82\u201390.","journal-title":"Postgrad Med"},{"issue":"12","key":"9778_CR81","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1055\/a-1023-4181","volume":"51","author":"VF Koehler","year":"2019","unstructured":"Koehler VF, Filmann N, Mann WA. Vitamin D status and thyroid autoantibodies in Autoimmune Thyroiditis. Horm Metab Res. 2019;51(12):792\u20137.","journal-title":"Horm Metab Res"},{"key":"9778_CR82","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3389\/fphys.2014.00137","volume":"5","author":"J van de Peppel","year":"2014","unstructured":"van de Peppel J, van Leeuwen JP. Vitamin D and gene networks in human osteoblasts. Front Physiol. 2014;5:137.","journal-title":"Front Physiol"},{"issue":"2","key":"9778_CR83","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1210\/endo.140.2.6673","volume":"140","author":"S Takeda","year":"1999","unstructured":"Takeda S, et al. Stimulation of osteoclast formation by 1,25-dihydroxyvitamin D requires its binding to vitamin D receptor (VDR) in osteoblastic cells: studies using VDR knockout mice. Endocrinology. 1999;140(2):1005\u20138.","journal-title":"Endocrinology"},{"issue":"1","key":"9778_CR84","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1210\/jc.2008-1454","volume":"94","author":"D Bikle","year":"2009","unstructured":"Bikle D. Nonclassic actions of vitamin D. J Clin Endocrinol Metab. 2009;94(1):26\u201334.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"9778_CR85","doi-asserted-by":"publisher","first-page":"e58725","DOI":"10.1371\/journal.pone.0058725","volume":"8","author":"A Hossein-nezhad","year":"2013","unstructured":"Hossein-nezhad A, Spira A, Holick MF. Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial. PLoS ONE. 2013;8(3):e58725.","journal-title":"PLoS ONE"},{"key":"9778_CR86","doi-asserted-by":"publisher","first-page":"155","DOI":"10.2147\/IJGM.S152873","volume":"11","author":"J Lechner","year":"2018","unstructured":"Lechner J, Aschoff J, Rudi T. The vitamin D receptor and the etiology of RANTES\/CCL-expressive fatty-degenerative osteolysis of the jawbone: an interface between osteoimmunology and bone metabolism. Int J Gen Med. 2018;11:155\u201366.","journal-title":"Int J Gen Med"},{"key":"9778_CR87","doi-asserted-by":"crossref","unstructured":"Chahardoli R, et al., Can Supplementation with Vitamin D Modify Thyroid Autoantibodies (Anti-TPO Ab, Anti-Tg Ab) and Thyroid Profile (T3, T4, TSH) in Hashimoto\u2019s Thyroiditis? A Double Blind, Randomized Clinical Trial Horm Metab Res, 2019. 51(5): p.\u00a0296\u2013301.","DOI":"10.1055\/a-0856-1044"},{"issue":"2","key":"9778_CR88","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s12020-021-02688-z","volume":"73","author":"F Fang","year":"2021","unstructured":"Fang F, et al. Vitamin D deficiency is associated with thyroid autoimmunity: results from an epidemiological survey in Tianjin, China. Endocrine. 2021;73(2):447\u201354.","journal-title":"Endocrine"},{"issue":"6","key":"9778_CR89","first-page":"e25869","volume":"14","author":"SA Khozam","year":"2022","unstructured":"Khozam SA, et al. Association between vitamin D Deficiency and Autoimmune thyroid disorder: a systematic review. Cureus. 2022;14(6):e25869.","journal-title":"Cureus"},{"issue":"6","key":"9778_CR90","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1111\/jcpt.13605","volume":"47","author":"H Jiang","year":"2022","unstructured":"Jiang H, et al. Effects of vitamin D treatment on thyroid function and autoimmunity markers in patients with Hashimoto\u2019s thyroiditis-A meta-analysis of randomized controlled trials. J Clin Pharm Ther. 2022;47(6):767\u201375.","journal-title":"J Clin Pharm Ther"},{"issue":"9","key":"9778_CR91","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1038\/s41430-019-0395-z","volume":"73","author":"M Nodehi","year":"2019","unstructured":"Nodehi M, et al. Effects of vitamin D supplements on frequency of CD4(+) T-cell subsets in women with Hashimoto\u2019s thyroiditis: a double-blind placebo-controlled study. Eur J Clin Nutr. 2019;73(9):1236\u201343.","journal-title":"Eur J Clin Nutr"},{"issue":"3","key":"9778_CR92","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s11154-016-9405-9","volume":"18","author":"B Altieri","year":"2017","unstructured":"Altieri B, et al. Does vitamin D play a role in autoimmune endocrine disorders? A proof of concept. Rev Endocr Metab Disord. 2017;18(3):335\u201346.","journal-title":"Rev Endocr Metab Disord"},{"issue":"3","key":"9778_CR93","first-page":"161","volume":"79","author":"MP Sarmiento-Ram\u00f3n","year":"2022","unstructured":"Sarmiento-Ram\u00f3n MP, et al. Characterization of serum vitamin D levels in pediatric patients with chronic lymphocytic thyroiditis. Bol Med Hosp Infant Mex. 2022;79(3):161\u20139.","journal-title":"Bol Med Hosp Infant Mex"},{"issue":"4","key":"9778_CR94","first-page":"510","volume":"55","author":"M Kaan Demircioglu","year":"2021","unstructured":"Kaan Demircioglu M, et al. Is vitamin D Deficiency Associated with chronic lymphocytic thyroiditis? Sisli Etfal Hastan Tip Bul. 2021;55(4):510\u20135.","journal-title":"Sisli Etfal Hastan Tip Bul"},{"key":"9778_CR95","doi-asserted-by":"publisher","first-page":"8197580","DOI":"10.1155\/2019\/8197580","volume":"2019","author":"A Maciejewski","year":"2019","unstructured":"Maciejewski A, et al. Vitamin D receptor gene polymorphisms and autoimmune thyroiditis: are they Associated with Disease occurrence and its features? Biomed Res Int. 2019;2019:8197580.","journal-title":"Biomed Res Int"},{"issue":"5","key":"9778_CR96","doi-asserted-by":"publisher","first-page":"237","DOI":"10.4103\/nmj.NMJ_200_20","volume":"61","author":"KK Behera","year":"2020","unstructured":"Behera KK, et al. Effect of vitamin D supplementation on thyroid autoimmunity among subjects of autoimmune thyroid disease in a Coastal Province of India: a Randomized Open-label trial. Niger Med J. 2020;61(5):237\u201340.","journal-title":"Niger Med J"},{"issue":"5","key":"9778_CR97","first-page":"640","volume":"8","author":"Azam","year":"2017","unstructured":"Azam, Amini, et al. The effect of vitamin D replacement on Musculoskeletal Pain in hypothyroid patients with vitamin D Deficiency. Int J Sci Eng Res. 2017;8(5):640\u20132.","journal-title":"Int J Sci Eng Res"},{"key":"9778_CR98","doi-asserted-by":"crossref","unstructured":"Wang H, et al., Associations between dynamic vitamin D level and thyroid function during pregnancy. Nutrients, 2022. 14(18).","DOI":"10.3390\/nu14183780"},{"key":"9778_CR99","doi-asserted-by":"publisher","first-page":"953745","DOI":"10.3389\/fnut.2022.953745","volume":"9","author":"Y Chen","year":"2022","unstructured":"Chen Y, et al. Vitamin D categories and postpartum thyroid function in women with hypothyroidism. Front Nutr. 2022;9:953745.","journal-title":"Front Nutr"},{"key":"9778_CR100","doi-asserted-by":"publisher","first-page":"14570","DOI":"10.1038\/ncomms14570","volume":"8","author":"Z Xu","year":"2017","unstructured":"Xu Z, et al. SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts. Nat Commun. 2017;8:14570.","journal-title":"Nat Commun"},{"issue":"4","key":"9778_CR101","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1002\/jcb.10242","volume":"86","author":"LC Hofbauer","year":"2002","unstructured":"Hofbauer LC, et al. Detection and characterization of RANK ligand and osteoprotegerin in the thyroid gland. J Cell Biochem. 2002;86(4):642\u201350.","journal-title":"J Cell Biochem"},{"issue":"3","key":"9778_CR102","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1530\/eje.1.01870","volume":"152","author":"T Nagasaki","year":"2005","unstructured":"Nagasaki T, et al. Increased levels of serum osteoprotegerin in hypothyroid patients and its normalization with restoration of normal thyroid function. Eur J Endocrinol. 2005;152(3):347\u201353.","journal-title":"Eur J Endocrinol"},{"issue":"10","key":"9778_CR103","doi-asserted-by":"publisher","first-page":"5765","DOI":"10.1210\/jc.2005-0562","volume":"90","author":"X Guang-da","year":"2005","unstructured":"Guang-da X, et al. Changes in plasma concentrations of osteoprotegerin before and after levothyroxine replacement therapy in hypothyroid patients. J Clin Endocrinol Metab. 2005;90(10):5765\u20138.","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"9778_CR104","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.metabol.2007.01.004","volume":"56","author":"M Giusti","year":"2007","unstructured":"Giusti M, et al. Serum osteoprotegerin and soluble receptor activator of nuclear factor kappaB ligand levels in patients with a history of differentiated thyroid carcinoma: a case-controlled cohort study. Metabolism. 2007;56(5):699\u2013707.","journal-title":"Metabolism"},{"issue":"4","key":"9778_CR105","doi-asserted-by":"publisher","first-page":"304","DOI":"10.14310\/horm.2002.1111026","volume":"6","author":"M Giusti","year":"2007","unstructured":"Giusti M, et al. Recombinant human thyroid stimulating hormone does not acutely change serum osteoprotegerin and soluble receptor activator of nuclear factor-kappabeta ligand in patients under evaluation for differentiated thyroid carcinoma. Horm (Athens). 2007;6(4):304\u201313.","journal-title":"Horm (Athens)"},{"issue":"33","key":"9778_CR106","doi-asserted-by":"publisher","first-page":"3754","DOI":"10.2174\/0929867323666160907162546","volume":"23","author":"L Ginaldi","year":"2016","unstructured":"Ginaldi L, De Martinis M. Osteoimmunology and Beyond. Curr Med Chem. 2016;23(33):3754\u201374.","journal-title":"Curr Med Chem"},{"issue":"4","key":"9778_CR107","first-page":"391","volume":"66","author":"SD Brincat","year":"2014","unstructured":"Brincat SD, et al. The role of cytokines in postmenopausal osteoporosis. Minerva Ginecol. 2014;66(4):391\u2013407.","journal-title":"Minerva Ginecol"},{"issue":"1","key":"9778_CR108","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1186\/s12891-020-03334-x","volume":"21","author":"B Chen","year":"2020","unstructured":"Chen B, Li HZ. Association of IL-6 174G\/C (rs1800795) and 572\u00a0C\/G (rs1800796) polymorphisms with risk of osteoporosis: a meta-analysis. BMC Musculoskelet Disord. 2020;21(1):330.","journal-title":"BMC Musculoskelet Disord"},{"issue":"5","key":"9778_CR109","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1002\/j.1460-2075.1994.tb06368.x","volume":"13","author":"V Poli","year":"1994","unstructured":"Poli V, et al. Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. Embo j. 1994;13(5):1189\u201396.","journal-title":"Embo j"},{"issue":"3","key":"9778_CR110","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1172\/JCI19872","volume":"113","author":"NA Sims","year":"2004","unstructured":"Sims NA, et al. Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways. J Clin Invest. 2004;113(3):379\u201389.","journal-title":"J Clin Invest"},{"key":"9778_CR111","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1196\/annals.1346.047","volume":"1068","author":"XH Liu","year":"2006","unstructured":"Liu XH, et al. Interactive effect of interleukin-6 and prostaglandin E2 on osteoclastogenesis via the OPG\/RANKL\/RANK system. Ann N Y Acad Sci. 2006;1068:225\u201333.","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"9778_CR112","doi-asserted-by":"publisher","first-page":"87","DOI":"10.2334\/josnusd.53.87","volume":"53","author":"K Honda","year":"2011","unstructured":"Honda K. Interleukin-6 and soluble interleukin-6 receptor suppress osteoclastic differentiation by inducing PGE(2) production in chondrocytes. J Oral Sci. 2011;53(1):87\u201396.","journal-title":"J Oral Sci"},{"issue":"1","key":"9778_CR113","first-page":"78","volume":"82","author":"P Lakatos","year":"1997","unstructured":"Lakatos P, et al. Serum interleukin-6 and bone metabolism in patients with thyroid function disorders. J Clin Endocrinol Metab. 1997;82(1):78\u201381.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"9778_CR114","doi-asserted-by":"publisher","first-page":"74","DOI":"10.4183\/aeb.2019.74","volume":"-5","author":"J Gerenova","year":"2019","unstructured":"Gerenova J, Manolova I, Stanilova S. SERUM LEVELS OF INTERLEUKIN \u2013 23 AND INTERLEUKIN \u2013 17 IN HASHIMOTO\u2019S THYROIDITIS. Acta Endocrinol (Buchar). 2019;-5(1):74\u20139.","journal-title":"Acta Endocrinol (Buchar)"},{"issue":"3","key":"9778_CR115","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1002\/jcp.27180","volume":"234","author":"Q Li","year":"2019","unstructured":"Li Q, et al. The pathogenesis of thyroid autoimmune diseases: new T lymphocytes - cytokines circuits beyond the Th1-Th2 paradigm. J Cell Physiol. 2019;234(3):2204\u201316.","journal-title":"J Cell Physiol"},{"key":"9778_CR116","doi-asserted-by":"publisher","first-page":"794568","DOI":"10.3389\/fendo.2021.794568","volume":"12","author":"Y Pan","year":"2021","unstructured":"Pan Y, et al. A chinese patent Medicine JiaYanKangTai alleviates inflammatory lesions of experimental autoimmune thyroiditis by regulating Interleukin-17 signaling. Front Endocrinol (Lausanne). 2021;12:794568.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"9","key":"9778_CR117","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1089\/thy.2019.0552","volume":"30","author":"Y Liu","year":"2020","unstructured":"Liu Y, et al. Elevated MicroRNA-326 levels regulate the IL-23\/IL-23R\/Th17 cell Axis in Hashimoto\u2019s Thyroiditis by targeting a disintegrin and metalloprotease 17. Thyroid. 2020;30(9):1327\u201337.","journal-title":"Thyroid"},{"issue":"2","key":"9778_CR118","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1210\/jc.2009-1719","volume":"95","author":"N Figueroa-Vega","year":"2010","unstructured":"Figueroa-Vega N, et al. Increased circulating pro-inflammatory cytokines and Th17 lymphocytes in Hashimoto\u2019s thyroiditis. J Clin Endocrinol Metab. 2010;95(2):953\u201362.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"9778_CR119","doi-asserted-by":"publisher","first-page":"16155","DOI":"10.1038\/s41598-021-95640-0","volume":"11","author":"H Bhadricha","year":"2021","unstructured":"Bhadricha H, et al. Increased frequency of Th17 cells and IL-17 levels are associated with low bone mineral density in postmenopausal women. Sci Rep. 2021;11(1):16155.","journal-title":"Sci Rep"},{"key":"9778_CR120","doi-asserted-by":"crossref","unstructured":"Ikeuchi T, Moutsopoulos NM. Osteoimmunology in periodontitis; a paradigm for Th17\/IL-17 inflammatory bone loss. Bone, 2022: p.\u00a0116500.","DOI":"10.1016\/j.bone.2022.116500"},{"issue":"9","key":"9778_CR121","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/j.archoralbio.2014.05.009","volume":"59","author":"YG Kim","year":"2014","unstructured":"Kim YG, et al. IL-17 inhibits osteoblast differentiation and bone regeneration in rat. Arch Oral Biol. 2014;59(9):897\u2013905.","journal-title":"Arch Oral Biol"},{"key":"9778_CR122","doi-asserted-by":"publisher","first-page":"5950395","DOI":"10.1155\/2017\/5950395","volume":"2017","author":"JR Zhang","year":"2017","unstructured":"Zhang JR, et al. Different Modulatory Effects of IL-17, IL-22, and IL-23 on osteoblast differentiation. Mediators Inflamm. 2017;2017:5950395.","journal-title":"Mediators Inflamm"},{"issue":"4","key":"9778_CR123","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/j.bbrc.2020.02.054","volume":"524","author":"HJ Kim","year":"2020","unstructured":"Kim HJ, et al. IL-17 promotes osteoblast differentiation, bone regeneration, and remodeling in mice. Biochem Biophys Res Commun. 2020;524(4):1044\u201350.","journal-title":"Biochem Biophys Res Commun"},{"issue":"330","key":"9778_CR124","doi-asserted-by":"publisher","first-page":"330ra37","DOI":"10.1126\/scitranslmed.aad8996","volume":"8","author":"\u00d6 Ulu\u00e7kan","year":"2016","unstructured":"Ulu\u00e7kan \u00d6, et al. Chronic skin inflammation leads to bone loss by IL-17-mediated inhibition of wnt signaling in osteoblasts. Sci Transl Med. 2016;8(330):330ra37.","journal-title":"Sci Transl Med"},{"issue":"9","key":"9778_CR125","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/nri3707","volume":"14","author":"SL Gaffen","year":"2014","unstructured":"Gaffen SL, et al. The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing. Nat Rev Immunol. 2014;14(9):585\u2013600.","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"9778_CR126","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1507\/endocrj.EJ13-0484","volume":"61","author":"RM Ruggeri","year":"2014","unstructured":"Ruggeri RM, et al. Serum interleukin-23 (IL-23) is increased in Hashimoto\u2019s thyroiditis. Endocr J. 2014;61(4):359\u201363.","journal-title":"Endocr J"},{"key":"9778_CR127","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.bone.2018.01.027","volume":"110","author":"P Shukla","year":"2018","unstructured":"Shukla P, Mansoori MN, Singh D. Efficacy of anti-IL-23 monotherapy versus combination therapy with anti-IL-17 in estrogen deficiency induced bone loss conditions. Bone. 2018;110:84\u201395.","journal-title":"Bone"},{"issue":"2","key":"9778_CR128","doi-asserted-by":"publisher","first-page":"951","DOI":"10.4049\/jimmunol.1003986","volume":"187","author":"IE Adamopoulos","year":"2011","unstructured":"Adamopoulos IE, et al. IL-23 is critical for induction of arthritis, osteoclast formation, and maintenance of bone mass. J Immunol. 2011;187(2):951\u20139.","journal-title":"J Immunol"},{"issue":"2","key":"9778_CR129","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.4049\/jimmunol.181.2.1507","volume":"181","author":"JH Ju","year":"2008","unstructured":"Ju JH, et al. IL-23 induces receptor activator of NF-kappaB ligand expression on CD4 + T cells and promotes osteoclastogenesis in an autoimmune arthritis model. J Immunol. 2008;181(2):1507\u201318.","journal-title":"J Immunol"},{"issue":"2","key":"9778_CR130","doi-asserted-by":"publisher","first-page":"4673","DOI":"10.4238\/2014.June.18.10","volume":"13","author":"YK Kang","year":"2014","unstructured":"Kang YK, Zhang MC. IL-23 promotes osteoclastogenesis in osteoblast-osteoclast co-culture system. Genet Mol Res. 2014;13(2):4673\u20139.","journal-title":"Genet Mol Res"},{"issue":"1","key":"9778_CR131","doi-asserted-by":"publisher","first-page":"10244","DOI":"10.1038\/s41598-021-89625-2","volume":"11","author":"W Razawy","year":"2021","unstructured":"Razawy W, et al. IL-23 receptor deficiency results in lower bone mass via indirect regulation of bone formation. Sci Rep. 2021;11(1):10244.","journal-title":"Sci Rep"},{"issue":"5","key":"9778_CR132","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s00774-007-0766-8","volume":"25","author":"S Kamiya","year":"2007","unstructured":"Kamiya S, et al. Effects of IL-23 and IL-27 on osteoblasts and osteoclasts: inhibitory effects on osteoclast differentiation. J Bone Miner Metab. 2007;25(5):277\u201385.","journal-title":"J Bone Miner Metab"},{"issue":"7","key":"9778_CR133","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.2174\/1871530319666190226164309","volume":"19","author":"X Wang","year":"2019","unstructured":"Wang X, et al. Dysregulated interleukin \u2013 33\/ST2 pathway perpetuates chronic inflammation in Hashimoto\u2019s Thyroiditis. Endocr Metab Immune Disord Drug Targets. 2019;19(7):1012\u201321.","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"issue":"22","key":"9778_CR134","doi-asserted-by":"publisher","first-page":"3883","DOI":"10.1007\/s00018-010-0410-y","volume":"67","author":"SH Mun","year":"2010","unstructured":"Mun SH, et al. Interleukin-33 stimulates formation of functional osteoclasts from human CD14(+) monocytes. Cell Mol Life Sci. 2010;67(22):3883\u201392.","journal-title":"Cell Mol Life Sci"},{"issue":"7","key":"9778_CR135","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1177\/0022034515577815","volume":"94","author":"J Malcolm","year":"2015","unstructured":"Malcolm J, et al. IL-33 exacerbates Periodontal Disease through induction of RANKL. J Dent Res. 2015;94(7):968\u201375.","journal-title":"J Dent Res"},{"issue":"11","key":"9778_CR136","doi-asserted-by":"publisher","first-page":"6097","DOI":"10.4049\/jimmunol.1003487","volume":"186","author":"MM Zaiss","year":"2011","unstructured":"Zaiss MM, et al. IL-33 shifts the balance from osteoclast to alternatively activated macrophage differentiation and protects from TNF-alpha-mediated bone loss. J Immunol. 2011;186(11):6097\u2013105.","journal-title":"J Immunol"},{"key":"9778_CR137","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s41232-019-0101-5","volume":"39","author":"N Kaneko","year":"2019","unstructured":"Kaneko N, et al. The role of interleukin-1 in general pathology. Inflamm Regen. 2019;39:12.","journal-title":"Inflamm Regen"},{"issue":"3","key":"9778_CR138","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1210\/endo-120-3-1212","volume":"120","author":"M Mine","year":"1987","unstructured":"Mine M, et al. Interleukin-1 stimulates thyroid cell growth and increases the concentration of the c-myc proto-oncogene mRNA in thyroid follicular cells in culture. Endocrinology. 1987;120(3):1212\u20134.","journal-title":"Endocrinology"},{"issue":"5","key":"9778_CR139","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.1210\/endo-127-5-2322","volume":"127","author":"T Enomoto","year":"1990","unstructured":"Enomoto T, et al. Prolonged effects of recombinant human interleukin-1 alpha on mouse thyroid function. Endocrinology. 1990;127(5):2322\u20137.","journal-title":"Endocrinology"},{"issue":"3","key":"9778_CR140","first-page":"945","volume":"83","author":"M Nilsson","year":"1998","unstructured":"Nilsson M, et al. Cytokines and thyroid epithelial integrity: interleukin-1alpha induces dissociation of the junctional complex and paracellular leakage in filter-cultured human thyrocytes. J Clin Endocrinol Metab. 1998;83(3):945\u201352.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"9778_CR141","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1677\/joe.0.1220177","volume":"122","author":"S Yamashita","year":"1989","unstructured":"Yamashita S, et al. Interleukin-1 inhibits thyrotrophin-induced human thyroglobulin gene expression. J Endocrinol. 1989;122(1):177\u201383.","journal-title":"J Endocrinol"},{"issue":"4","key":"9778_CR142","first-page":"465","volume":"121","author":"K Ashizawa","year":"1989","unstructured":"Ashizawa K, et al. Inhibition of human thyroid peroxidase gene expression by interleukin 1. Acta Endocrinol (Copenh). 1989;121(4):465\u20139.","journal-title":"Acta Endocrinol (Copenh)"},{"issue":"3","key":"9778_CR143","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/j.intimp.2013.08.012","volume":"17","author":"R Zhao","year":"2013","unstructured":"Zhao R, Zhou H, Su SB. A critical role for interleukin-1\u03b2 in the progression of autoimmune diseases. Int Immunopharmacol. 2013;17(3):658\u201369.","journal-title":"Int Immunopharmacol"},{"issue":"3","key":"9778_CR144","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3109\/07435800.2015.1124439","volume":"41","author":"L Sun","year":"2016","unstructured":"Sun L, et al. Elevated interleukin-1\u03b2 in peripheral blood mononuclear cells contributes to the pathogenesis of autoimmune thyroid diseases, especially of Hashimoto thyroiditis. Endocr Res. 2016;41(3):185\u201392.","journal-title":"Endocr Res"},{"key":"9778_CR145","doi-asserted-by":"crossref","unstructured":"Levescot A, et al., IL-1\u03b2-driven osteoclastogenic Tregs accelerate bone erosion in arthritis. J Clin Invest, 2021. 131(18).","DOI":"10.1172\/JCI141008"},{"issue":"1","key":"9778_CR146","doi-asserted-by":"publisher","first-page":"36","DOI":"10.2119\/molmed.2012.00058","volume":"19","author":"NE Hengartner","year":"2013","unstructured":"Hengartner NE, et al. IL-1\u03b2 inhibits human osteoblast migration. Mol Med. 2013;19(1):36\u201342.","journal-title":"Mol Med"},{"issue":"4","key":"9778_CR147","doi-asserted-by":"publisher","first-page":"e12792","DOI":"10.1111\/eos.12792","volume":"129","author":"Y Ebe","year":"2021","unstructured":"Ebe Y, et al. Effect of interleukin-1\u03b2 on bone morphogenetic protein-9-induced osteoblastic differentiation of human periodontal ligament fibroblasts. Eur J Oral Sci. 2021;129(4):e12792.","journal-title":"Eur J Oral Sci"},{"key":"9778_CR148","doi-asserted-by":"crossref","unstructured":"Huang J, Chen L. IL-1\u03b2 inhibits osteogenesis of human bone marrow-derived mesenchymal stem cells by activating FoxD3\/microRNA-496 to repress wnt signaling. Genesis, 2017. 55(7).","DOI":"10.1002\/dvg.23040"},{"issue":"3","key":"9778_CR149","first-page":"890","volume":"25","author":"W Ye","year":"2017","unstructured":"Ye W, et al. IL-1\u03b2-Treated bone marrow mesenchymal stem cells enhances osteogenetic potential via NF-\u03baB pathway. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017;25(3):890\u20135.","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"issue":"3","key":"9778_CR150","doi-asserted-by":"publisher","first-page":"897","DOI":"10.4049\/jimmunol.1301628","volume":"192","author":"SH Hong","year":"2014","unstructured":"Hong SH, Braley-Mullen H. Follicular B cells in thyroids of mice with spontaneous autoimmune thyroiditis contribute to disease pathogenesis and are targets of anti-CD20 antibody therapy. J Immunol. 2014;192(3):897\u2013905.","journal-title":"J Immunol"},{"issue":"1 Pt 2","key":"9778_CR151","doi-asserted-by":"publisher","first-page":"S73","DOI":"10.1016\/0090-1229(89)90114-1","volume":"50","author":"S Mariotti","year":"1989","unstructured":"Mariotti S, et al. Recent advances in the understanding of humoral and cellular mechanisms implicated in thyroid autoimmune disorders. Clin Immunol Immunopathol. 1989;50(1 Pt 2):S73\u201384.","journal-title":"Clin Immunol Immunopathol"},{"key":"9778_CR152","first-page":"425","volume":"16","author":"WQ Yongshuang Xie","year":"2009","unstructured":"Yongshuang Xie WQ. Researching on the relation between autoimmune thyroid disesae and tumor necrosis factors-alpha\/interleukin-6 ratio. J Practical Med Techniques. 2009;16:425\u20136.","journal-title":"J Practical Med Techniques"},{"key":"9778_CR153","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.ai.2014.11.001","volume":"126","author":"H Braley-Mullen","year":"2015","unstructured":"Braley-Mullen H, Yu S. NOD.H-2h4 mice: an important and underutilized animal model of autoimmune thyroiditis and Sjogren\u2019s syndrome. Adv Immunol. 2015;126:1\u201343.","journal-title":"Adv Immunol"},{"issue":"11","key":"9778_CR154","doi-asserted-by":"publisher","first-page":"3537","DOI":"10.1172\/JCI36389","volume":"118","author":"FM Brennan","year":"2008","unstructured":"Brennan FM, McInnes IB. Evidence that cytokines play a role in rheumatoid arthritis. J Clin Invest. 2008;118(11):3537\u201345.","journal-title":"J Clin Invest"},{"key":"9778_CR155","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1146\/annurev.immunol.15.1.749","volume":"15","author":"U Boehm","year":"1997","unstructured":"Boehm U, et al. Cellular responses to interferon-gamma. Annu Rev Immunol. 1997;15:749\u201395.","journal-title":"Annu Rev Immunol"},{"issue":"7","key":"9778_CR156","doi-asserted-by":"publisher","first-page":"3999","DOI":"10.4049\/jimmunol.169.7.3999","volume":"169","author":"S Yu","year":"2002","unstructured":"Yu S, Sharp GC, Braley-Mullen H. Dual roles for IFN-gamma, but not for IL-4, in spontaneous autoimmune thyroiditis in NOD.H-2h4 mice. J Immunol. 2002;169(7):3999\u20134007.","journal-title":"J Immunol"},{"issue":"2","key":"9778_CR157","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.4049\/jimmunol.176.2.1259","volume":"176","author":"S Yu","year":"2006","unstructured":"Yu S, Sharp GC, Braley-Mullen H. Thyrocytes responding to IFN-gamma are essential for development of lymphocytic spontaneous autoimmune thyroiditis and inhibition of thyrocyte hyperplasia. J Immunol. 2006;176(2):1259\u201365.","journal-title":"J Immunol"},{"key":"9778_CR158","unstructured":"Zhang X, Zhu L, Sun L, IFN-y mediates thyroid injury by upregulating Fas expression in Hashimoto thyroiditis Acta Universitatis Medicinalis Anhui, 2017. 52(06): p.\u00a0806\u2013809."},{"issue":"1","key":"9778_CR159","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1172\/JCI30074","volume":"117","author":"Y Gao","year":"2007","unstructured":"Gao Y, et al. IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation. J Clin Invest. 2007;117(1):122\u201332.","journal-title":"J Clin Invest"},{"issue":"6812","key":"9778_CR160","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1038\/35046102","volume":"408","author":"H Takayanagi","year":"2000","unstructured":"Takayanagi H, et al. T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. Nature. 2000;408(6812):600\u20135.","journal-title":"Nature"},{"issue":"12","key":"9778_CR161","doi-asserted-by":"publisher","first-page":"5681","DOI":"10.4049\/jimmunol.1500273","volume":"194","author":"T Maruhashi","year":"2015","unstructured":"Maruhashi T, et al. DCIR maintains bone homeostasis by regulating IFN-\u03b3 production in T cells. J Immunol. 2015;194(12):5681\u201391.","journal-title":"J Immunol"},{"issue":"4","key":"9778_CR162","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1111\/cts.12993","volume":"14","author":"Y Hu","year":"2021","unstructured":"Hu Y, et al. Effect of selenium on thyroid autoimmunity and regulatory T cells in patients with Hashimoto\u2019s thyroiditis: a prospective randomized-controlled trial. Clin Transl Sci. 2021;14(4):1390\u2013402.","journal-title":"Clin Transl Sci"},{"key":"9778_CR163","doi-asserted-by":"crossref","unstructured":"Kryczyk-Kozio\u0142 J, et al., Assessment of the Effect of Selenium supplementation on production of selected cytokines in women with Hashimoto\u2019s Thyroiditis. Nutrients, 2022. 14(14).","DOI":"10.3390\/nu14142869"},{"issue":"9","key":"9778_CR164","doi-asserted-by":"publisher","first-page":"607","DOI":"10.2217\/nnm-2021-0401","volume":"17","author":"S Poleboina","year":"2022","unstructured":"Poleboina S, et al. Selenium nanoparticles stimulate osteoblast differentiation via BMP-2\/MAPKs\/\u03b2-catenin pathway in diabetic osteoporosis. Nanomed (Lond). 2022;17(9):607\u201325.","journal-title":"Nanomed (Lond)"},{"key":"9778_CR165","doi-asserted-by":"publisher","first-page":"126989","DOI":"10.1016\/j.jtemb.2022.126989","volume":"72","author":"M Wei","year":"2022","unstructured":"Wei M, et al. Manganese, iron, copper, and selenium co-exposure and osteoporosis risk in chinese adults. J Trace Elem Med Biol. 2022;72:126989.","journal-title":"J Trace Elem Med Biol"},{"issue":"4","key":"9778_CR166","doi-asserted-by":"publisher","first-page":"e0152748","DOI":"10.1371\/journal.pone.0152748","volume":"11","author":"CM Beukhof","year":"2016","unstructured":"Beukhof CM, et al. Selenium Status is positively Associated with Bone Mineral density in healthy aging european men. PLoS ONE. 2016;11(4):e0152748.","journal-title":"PLoS ONE"},{"issue":"11","key":"9778_CR167","doi-asserted-by":"publisher","first-page":"4061","DOI":"10.1210\/jc.2012-2121","volume":"97","author":"A Hoeg","year":"2012","unstructured":"Hoeg A, et al. Bone turnover and bone mineral density are independently related to selenium status in healthy euthyroid postmenopausal women. J Clin Endocrinol Metab. 2012;97(11):4061\u201370.","journal-title":"J Clin Endocrinol Metab"},{"key":"9778_CR168","doi-asserted-by":"publisher","first-page":"115631","DOI":"10.1016\/j.bone.2020.115631","volume":"143","author":"CC Wu","year":"2021","unstructured":"Wu CC, et al. Selenium status is independently related to bone mineral density, FRAX score, and bone fracture history: NHANES, 2013 to 2014. Bone. 2021;143:115631.","journal-title":"Bone"}],"container-title":["Reviews in Endocrine and Metabolic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11154-022-09778-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11154-022-09778-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11154-022-09778-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T23:17:53Z","timestamp":1679095073000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11154-022-09778-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,13]]},"references-count":168,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["9778"],"URL":"https:\/\/doi.org\/10.1007\/s11154-022-09778-x","relation":{},"ISSN":["1389-9155","1573-2606"],"issn-type":[{"value":"1389-9155","type":"print"},{"value":"1573-2606","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,13]]},"assertion":[{"value":"7 December 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Funding.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statements and declarations"}},{"value":"This work was supported by grants from the National Natural Science Foundation of China [No. 82273294]; the Science and Technology Department of Sichuan Province (2022YFS0136); the Chengdu Bureau of Science and Technology (2022-YF05-01316-SN); the Sichuan University [No. 2018SCUH0093]; and the 1.3.5 project for discipline of excellence, West China Hospital, Sichuan University [No. 2020HXFH008, No. ZYJC18003].","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statements and declarations"}},{"value":"The authors declare no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}