{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T18:58:22Z","timestamp":1780945102318,"version":"3.54.1"},"reference-count":117,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"European Research Council","award":["810331"],"award-info":[{"award-number":["810331"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Rev Endocr Metab Disord"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s11154-025-10010-9","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T07:23:33Z","timestamp":1766993013000},"page":"457-468","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The role of tanycytes in the regulation of energy balance"],"prefix":"10.1007","volume":"27","author":[{"given":"Sara","family":"Martinez-Martinez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Iglesias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Dieguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sowmyalakshmi","family":"Rasika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Schwaninger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7185-3615","authenticated-orcid":false,"given":"Vincent","family":"Prevot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Nogueiras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"issue":"7","key":"10010_CR1","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.tips.2022.04.007","volume":"43","author":"M Lopez","year":"2022","unstructured":"Lopez M. Hypothalamic AMPK as a possible target for energy balance-related diseases. Trends Pharmacol Sci. 2022;43(7):546\u201356.","journal-title":"Trends Pharmacol Sci"},{"issue":"10","key":"10010_CR2","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1038\/s42255-022-00657-y","volume":"4","author":"L Steuernagel","year":"2022","unstructured":"Steuernagel L, et al. HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus. Nat Metab. 2022;4(10):1402\u201319.","journal-title":"Nat Metab"},{"key":"10010_CR3","doi-asserted-by":"crossref","unstructured":"van Santen HM. The central control of energy metabolism: hypothalamic obesity is not one disease. Horm Res Paediatr. 2025;1\u201310.","DOI":"10.1159\/000543544"},{"issue":"2","key":"10010_CR4","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1002\/j.2040-4603.2016.tb00697.x","volume":"6","author":"S Burbridge","year":"2016","unstructured":"Burbridge S, Stewart I, Placzek M. Development Neuroendocrine Hypothalamus Compr Physiol. 2016;6(2):623\u201343.","journal-title":"Development Neuroendocrine Hypothalamus Compr Physiol"},{"issue":"1","key":"10010_CR5","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/nrendo.2017.124","volume":"14","author":"J Clasadonte","year":"2018","unstructured":"Clasadonte J, Prevot V. The special relationship: glia-neuron interactions in the neuroendocrine hypothalamus. Nat Rev Endocrinol. 2018;14(1):25\u201344.","journal-title":"Nat Rev Endocrinol"},{"issue":"8","key":"10010_CR6","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1038\/s42255-021-00432-5","volume":"3","author":"M Duquenne","year":"2021","unstructured":"Duquenne M, et al. Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function. Nat Metab. 2021;3(8):1071\u201390.","journal-title":"Nat Metab"},{"issue":"1","key":"10010_CR7","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/s41593-018-0286-y","volume":"22","author":"C Garcia-Caceres","year":"2019","unstructured":"Garcia-Caceres C, et al. Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism. Nat Neurosci. 2019;22(1):7\u201314.","journal-title":"Nat Neurosci"},{"issue":"1","key":"10010_CR8","doi-asserted-by":"publisher","first-page":"6701","DOI":"10.1038\/s41467-024-50798-9","volume":"15","author":"L Kuczynski-Noyau","year":"2024","unstructured":"Kuczynski-Noyau L, et al. A plastic Aggrecan barrier modulated by peripheral energy state gates metabolic signal access to arcuate neurons. Nat Commun. 2024;15(1):6701.","journal-title":"Nat Commun"},{"issue":"3","key":"10010_CR9","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1210\/er.2017-00235","volume":"39","author":"V Prevot","year":"2018","unstructured":"Prevot V, et al. The versatile tanycyte: A hypothalamic integrator of reproduction and energy metabolism. Endocr Rev. 2018;39(3):333\u201368.","journal-title":"Endocr Rev"},{"key":"10010_CR10","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/B978-0-12-820107-7.00016-1","volume":"180","author":"V Prevot","year":"2021","unstructured":"Prevot V, Nogueiras R, Schwaninger M. Tanycytes in the infundibular nucleus and median eminence and their role in the blood-brain barrier. Handb Clin Neurol. 2021;180:253\u201373.","journal-title":"Handb Clin Neurol"},{"key":"10010_CR11","doi-asserted-by":"publisher","first-page":"1129414","DOI":"10.3389\/fnins.2022.1129414","volume":"16","author":"H Fong","year":"2022","unstructured":"Fong H, Kurrasch DM. Developmental and functional relationships between hypothalamic tanycytes and embryonic radial glia. Front Neurosci. 2022;16:1129414.","journal-title":"Front Neurosci"},{"issue":"9","key":"10010_CR12","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1111\/j.1365-2826.2007.01576.x","volume":"19","author":"M Baroncini","year":"2007","unstructured":"Baroncini M, et al. Morphological evidence for direct interaction between gonadotrophin-releasing hormone neurones and astroglial cells in the human hypothalamus. J Neuroendocrinol. 2007;19(9):691\u2013702.","journal-title":"J Neuroendocrinol"},{"issue":"3","key":"10010_CR13","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1111\/j.1600-079X.2010.00750.x","volume":"48","author":"A Sidibe","year":"2010","unstructured":"Sidibe A, et al. Expression of the orphan GPR50 protein in rodent and human dorsomedial hypothalamus, tanycytes and median eminence. J Pineal Res. 2010;48(3):263\u20139.","journal-title":"J Pineal Res"},{"issue":"9","key":"10010_CR14","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1002\/cne.24376","volume":"526","author":"G Pellegrino","year":"2018","unstructured":"Pellegrino G, et al. A comparative study of the neural stem cell niche in the adult hypothalamus of human, mouse, rat and Gray mouse Lemur (Microcebus murinus). J Comp Neurol. 2018;526(9):1419\u201343.","journal-title":"J Comp Neurol"},{"issue":"1","key":"10010_CR15","doi-asserted-by":"publisher","first-page":"15384","DOI":"10.1038\/s41598-024-66044-7","volume":"14","author":"Y Bai","year":"2024","unstructured":"Bai Y, Chen Q, Li Y. A single-cell transcriptomic study of heterogeneity in human embryonic tanycytes. Sci Rep. 2024;14(1):15384.","journal-title":"Sci Rep"},{"key":"10010_CR16","doi-asserted-by":"publisher","first-page":"1073759","DOI":"10.3389\/fendo.2022.1073759","volume":"13","author":"D Lopez-Rodriguez","year":"2022","unstructured":"Lopez-Rodriguez D, et al. Ontogeny of ependymoglial cells lining the third ventricle in mice. Front Endocrinol (Lausanne). 2022;13:1073759.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10010_CR17","doi-asserted-by":"publisher","first-page":"p2049","DOI":"10.1038\/ncomms3049","volume":"4","author":"SC Robins","year":"2013","unstructured":"Robins SC, et al. alpha-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors. Nat Commun. 2013;4:p2049.","journal-title":"Nat Commun"},{"issue":"7","key":"10010_CR18","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1038\/s42255-022-00610-z","volume":"4","author":"S Nampoothiri","year":"2022","unstructured":"Nampoothiri S, et al. Glial cells as integrators of peripheral and central signals in the regulation of energy homeostasis. Nat Metab. 2022;4(7):813\u201325.","journal-title":"Nat Metab"},{"key":"10010_CR19","doi-asserted-by":"crossref","unstructured":"Rodriguez-Cortes B, et al. Tanycytes: bloodhounds of the metabolic brain. Trends Endocrinol Metab. 2025.","DOI":"10.1016\/j.tem.2025.10.005"},{"issue":"3","key":"10010_CR20","doi-asserted-by":"publisher","first-page":"e13239","DOI":"10.1111\/jne.13239","volume":"35","author":"A Coutteau-Robles","year":"2023","unstructured":"Coutteau-Robles A, Prevot V, Sharif A. Cell proliferation and glial cell marker expression in the wall of the third ventricle in the tuberal region of the male mouse hypothalamus during postnatal development. J Neuroendocrinol. 2023;35(3):e13239.","journal-title":"J Neuroendocrinol"},{"key":"10010_CR21","doi-asserted-by":"publisher","first-page":"101154","DOI":"10.1016\/j.yfrne.2024.101154","volume":"75","author":"A Sharif","year":"2024","unstructured":"Sharif A, Prevot V. Astrogenesis in the hypothalamus: A life-long process contributing to the development and plasticity of neuroendocrine networks. Front Neuroendocrinol. 2024;75:101154.","journal-title":"Front Neuroendocrinol"},{"key":"10010_CR22","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/B978-0-12-819975-6.00006-6","volume":"179","author":"A Sharif","year":"2021","unstructured":"Sharif A, Fitzsimons CP, Lucassen PJ. Neurogenesis in the adult hypothalamus: A distinct form of structural plasticity involved in metabolic and circadian regulation, with potential relevance for human pathophysiology. Handb Clin Neurol. 2021;179:125\u201340.","journal-title":"Handb Clin Neurol"},{"issue":"7","key":"10010_CR23","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1210\/en.2019-00105","volume":"160","author":"M Kano","year":"2019","unstructured":"Kano M, et al. Tanycyte-Like cells derived from mouse embryonic stem culture show hypothalamic neural stem\/Progenitor cell functions. Endocrinology. 2019;160(7):1701\u201318.","journal-title":"Endocrinology"},{"key":"10010_CR24","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0074-7696(05)47003-5","volume":"247","author":"EM Rodriguez","year":"2005","unstructured":"Rodriguez EM, et al. Hypothalamic tanycytes: a key component of brain-endocrine interaction. Int Rev Cytol. 2005;247:89\u2013164.","journal-title":"Int Rev Cytol"},{"key":"10010_CR25","doi-asserted-by":"publisher","first-page":"286","DOI":"10.3389\/fendo.2019.00286","volume":"10","author":"F Langlet","year":"2019","unstructured":"Langlet F. Tanycyte gene expression dynamics in the regulation of energy homeostasis. Front Endocrinol (Lausanne). 2019;10:286.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10010_CR26","doi-asserted-by":"publisher","first-page":"869019","DOI":"10.3389\/fendo.2022.869019","volume":"13","author":"L Butruille","year":"2022","unstructured":"Butruille L, et al. Selective depletion of adult GFAP-Expressing tanycytes leads to hypogonadotropic hypogonadism in males. Front Endocrinol (Lausanne). 2022;13:869019.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10010_CR27","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.mce.2016.08.020","volume":"445","author":"K Rizzoti","year":"2017","unstructured":"Rizzoti K, Lovell-Badge R. Pivotal role of median eminence tanycytes for hypothalamic function and neurogenesis. Mol Cell Endocrinol. 2017;445:7\u201313.","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"10010_CR28","doi-asserted-by":"publisher","first-page":"6604","DOI":"10.1038\/s41467-024-50913-w","volume":"15","author":"M Brunner","year":"2024","unstructured":"Brunner M, et al. Fasting induces metabolic switches and Spatial redistributions of lipid processing and neuronal interactions in tanycytes. Nat Commun. 2024;15(1):6604.","journal-title":"Nat Commun"},{"issue":"8","key":"10010_CR29","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/s41574-019-0213-7","volume":"15","author":"WA Banks","year":"2019","unstructured":"Banks WA. The blood-brain barrier as an endocrine tissue. Nat Rev Endocrinol. 2019;15(8):444\u201355.","journal-title":"Nat Rev Endocrinol"},{"key":"10010_CR30","doi-asserted-by":"publisher","first-page":"390","DOI":"10.3389\/fnins.2015.00390","volume":"9","author":"S Miyata","year":"2015","unstructured":"Miyata S. New aspects in fenestrated capillary and tissue dynamics in the sensory circumventricular organs of adult brains. Front Neurosci. 2015;9:390.","journal-title":"Front Neurosci"},{"issue":"15","key":"10010_CR31","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1002\/cne.23355","volume":"521","author":"F Langlet","year":"2013","unstructured":"Langlet F, et al. Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brain. J Comp Neurol. 2013;521(15):3389\u2013405.","journal-title":"J Comp Neurol"},{"issue":"4","key":"10010_CR32","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.cmet.2013.03.004","volume":"17","author":"F Langlet","year":"2013","unstructured":"Langlet F, et al. Tanycytic VEGF-A boosts blood-hypothalamus barrier plasticity and access of metabolic signals to the arcuate nucleus in response to fasting. Cell Metab. 2013;17(4):607\u201317.","journal-title":"Cell Metab"},{"issue":"2","key":"10010_CR33","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.neuron.2020.04.020","volume":"107","author":"H Jiang","year":"2020","unstructured":"Jiang H, et al. MCH neurons regulate permeability of the median eminence barrier. Neuron. 2020;107(2):306\u2013e3199.","journal-title":"Neuron"},{"issue":"3","key":"10010_CR34","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/S0306-4522(99)00383-8","volume":"94","author":"V Prevot","year":"1999","unstructured":"Prevot V, et al. Definitive evidence for the existence of morphological plasticity in the external zone of the median eminence during the rat estrous cycle: implication of neuro-glio-endothelial interactions in gonadotropin-releasing hormone release. Neuroscience. 1999;94(3):809\u201319.","journal-title":"Neuroscience"},{"issue":"4","key":"10010_CR35","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1073\/pnas.1212137110","volume":"110","author":"M Schaeffer","year":"2013","unstructured":"Schaeffer M, et al. Rapid sensing of Circulating Ghrelin by hypothalamic appetite-modifying neurons. Proc Natl Acad Sci U S A. 2013;110(4):1512\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10010_CR36","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/s41467-017-00604-6","volume":"8","author":"H Muller-Fielitz","year":"2017","unstructured":"Muller-Fielitz H, et al. Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis. Nat Commun. 2017;8(1):484.","journal-title":"Nat Commun"},{"key":"10010_CR37","doi-asserted-by":"publisher","first-page":"155976","DOI":"10.1016\/j.metabol.2024.155976","volume":"158","author":"D Fernandois","year":"2024","unstructured":"Fernandois D, et al. Estrogen receptor-alpha signaling in tanycytes Lies at the crossroads of fertility and metabolism. Metabolism. 2024;158:155976.","journal-title":"Metabolism"},{"issue":"6","key":"10010_CR38","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.1210\/en.2016-1014","volume":"157","author":"DW Kim","year":"2016","unstructured":"Kim DW, et al. Maternal obesity in the mouse compromises the Blood-Brain barrier in the arcuate nucleus of offspring. Endocrinology. 2016;157(6):2229\u201342.","journal-title":"Endocrinology"},{"key":"10010_CR39","doi-asserted-by":"publisher","first-page":"101022","DOI":"10.1016\/j.molmet.2020.101022","volume":"39","author":"M Bottcher","year":"2020","unstructured":"Bottcher M, et al. NF-kappaB signaling in tanycytes mediates inflammation-induced anorexia. Mol Metab. 2020;39:101022.","journal-title":"Mol Metab"},{"key":"10010_CR40","doi-asserted-by":"publisher","first-page":"111449","DOI":"10.1016\/j.mce.2021.111449","volume":"538","author":"M Uriarte","year":"2021","unstructured":"Uriarte M, et al. Circulating Ghrelin crosses the blood-cerebrospinal fluid barrier via growth hormone secretagogue receptor dependent and independent mechanisms. Mol Cell Endocrinol. 2021;538:111449.","journal-title":"Mol Cell Endocrinol"},{"issue":"7","key":"10010_CR41","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1038\/s42255-022-00602-z","volume":"4","author":"V Pena-Leon","year":"2022","unstructured":"Pena-Leon V, et al. Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21. Nat Metab. 2022;4(7):901\u201317.","journal-title":"Nat Metab"},{"issue":"6","key":"10010_CR42","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1002\/oby.22465","volume":"27","author":"A Chmielewski","year":"2019","unstructured":"Chmielewski A, et al. Preclinical assessment of leptin transport into the cerebrospinal fluid in Diet-Induced obese minipigs. Obes (Silver Spring). 2019;27(6):950\u20136.","journal-title":"Obes (Silver Spring)"},{"issue":"2","key":"10010_CR43","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.cmet.2013.12.015","volume":"19","author":"E Balland","year":"2014","unstructured":"Balland E, et al. Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain. Cell Metab. 2014;19(2):293\u2013301.","journal-title":"Cell Metab"},{"issue":"7","key":"10010_CR44","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/j.cmet.2022.06.002","volume":"34","author":"M Imbernon","year":"2022","unstructured":"Imbernon M, et al. Tanycytes control hypothalamic liraglutide uptake and its anti-obesity actions. Cell Metab. 2022;34(7):1054\u2013e10637.","journal-title":"Cell Metab"},{"issue":"2","key":"10010_CR45","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1210\/endrev\/bnab025","volume":"43","author":"A Jais","year":"2022","unstructured":"Jais A, Bruning JC. Arcuate Nucleus-Dependent regulation of Metabolism-Pathways to obesity and diabetes mellitus. Endocr Rev. 2022;43(2):314\u201328.","journal-title":"Endocr Rev"},{"key":"10010_CR46","doi-asserted-by":"publisher","first-page":"101996","DOI":"10.1016\/j.molmet.2024.101996","volume":"87","author":"M Duquenne","year":"2024","unstructured":"Duquenne M, et al. Tanycytic transcytosis Inhibition disrupts energy balance, glucose homeostasis and cognitive function in male mice. Mol Metab. 2024;87:101996.","journal-title":"Mol Metab"},{"issue":"1","key":"10010_CR47","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.molmet.2014.10.003","volume":"4","author":"G Collden","year":"2015","unstructured":"Collden G, et al. Neonatal overnutrition causes early alterations in the central response to peripheral Ghrelin. Mol Metab. 2015;4(1):15\u201324.","journal-title":"Mol Metab"},{"issue":"2","key":"10010_CR48","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/s41574-023-00919-z","volume":"20","author":"GM Anderson","year":"2024","unstructured":"Anderson GM, et al. Metabolic control of puberty: 60 years in the footsteps of Kennedy and mitra\u2019s seminal work. Nat Rev Endocrinol. 2024;20(2):111\u201323.","journal-title":"Nat Rev Endocrinol"},{"issue":"8","key":"10010_CR49","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/s42255-019-0095-y","volume":"1","author":"JM Friedman","year":"2019","unstructured":"Friedman JM. Leptin and the endocrine control of energy balance. Nat Metab. 2019;1(8):754\u201364.","journal-title":"Nat Metab"},{"key":"10010_CR50","doi-asserted-by":"publisher","first-page":"156026","DOI":"10.1016\/j.metabol.2024.156026","volume":"161","author":"H Munzberg","year":"2024","unstructured":"Munzberg H, et al. History and future of leptin: Discovery, regulation and signaling. Metabolism. 2024;161:156026.","journal-title":"Metabolism"},{"issue":"5","key":"10010_CR51","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/nm0596-589","volume":"2","author":"MW Schwartz","year":"1996","unstructured":"Schwartz MW, et al. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat Med. 1996;2(5):589\u201393.","journal-title":"Nat Med"},{"issue":"9021","key":"10010_CR52","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S0140-6736(96)03173-X","volume":"348","author":"JF Caro","year":"1996","unstructured":"Caro JF, et al. Decreased cerebrospinal-fluid\/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet. 1996;348(9021):159\u201361.","journal-title":"Lancet"},{"key":"10010_CR53","doi-asserted-by":"publisher","unstructured":"Uner AA et al. LRP1 mediates leptin transport by coupling with the short-form leptin receptor in the choroid plexus. BioRxiv. 2023. https:\/\/doi.org\/10.1101\/2023.07.03.547520.","DOI":"10.1101\/2023.07.03.547520"},{"key":"10010_CR54","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.molmet.2017.12.001","volume":"8","author":"A Di Spiezio","year":"2018","unstructured":"Di Spiezio A, et al. The LepR-mediated leptin transport across brain barriers controls food reward. Mol Metab. 2018;8:13\u201322.","journal-title":"Mol Metab"},{"issue":"3","key":"10010_CR55","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/nn.4495","volume":"20","author":"JN Campbell","year":"2017","unstructured":"Campbell JN, et al. A molecular census of arcuate hypothalamus and median eminence cell types. Nat Neurosci. 2017;20(3):484\u201396.","journal-title":"Nat Neurosci"},{"key":"10010_CR56","doi-asserted-by":"publisher","first-page":"240","DOI":"10.3389\/fnins.2019.00240","volume":"13","author":"S Yoo","year":"2019","unstructured":"Yoo S, et al. Tanycyte-Independent control of hypothalamic leptin signaling. Front Neurosci. 2019;13:240.","journal-title":"Front Neurosci"},{"issue":"8","key":"10010_CR57","doi-asserted-by":"publisher","first-page":"111239","DOI":"10.1016\/j.celrep.2022.111239","volume":"40","author":"B Zhou","year":"2022","unstructured":"Zhou B, et al. Central FGF21 production regulates memory but not peripheral metabolism. Cell Rep. 2022;40(8):111239.","journal-title":"Cell Rep"},{"issue":"2","key":"10010_CR58","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/0196-9781(96)00025-3","volume":"17","author":"WA Banks","year":"1996","unstructured":"Banks WA, et al. Leptin enters the brain by a saturable system independent of insulin. Peptides. 1996;17(2):305\u201311.","journal-title":"Peptides"},{"issue":"1","key":"10010_CR59","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1038\/s41467-019-09320-9","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, et al. Temporal dynamic reorganization of 3D chromatin architecture in hormone-induced breast cancer and endocrine resistance. Nat Commun. 2019;10(1):1522.","journal-title":"Nat Commun"},{"issue":"19","key":"10010_CR60","doi-asserted-by":"publisher","first-page":"3305","DOI":"10.1002\/1873-3468.13240","volume":"592","author":"Z Liu","year":"2018","unstructured":"Liu Z, et al. Short-term Tamoxifen treatment has long-term effects on metabolism in high-fat diet-fed mice with involvement of Nmnat2 in POMC neurons. FEBS Lett. 2018;592(19):3305\u201316.","journal-title":"FEBS Lett"},{"issue":"1","key":"10010_CR61","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.cmet.2018.05.001","volume":"28","author":"EE Noble","year":"2018","unstructured":"Noble EE, et al. Control of feeding behavior by cerebral ventricular volume transmission of Melanin-Concentrating hormone. Cell Metab. 2018;28(1):55\u2013e687.","journal-title":"Cell Metab"},{"issue":"7","key":"10010_CR62","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1038\/nn.3401","volume":"16","author":"G Conductier","year":"2013","unstructured":"Conductier G, et al. Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume. Nat Neurosci. 2013;16(7):845\u20137.","journal-title":"Nat Neurosci"},{"issue":"8","key":"10010_CR63","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.1007\/s12035-020-01944-z","volume":"57","author":"F Guillebaud","year":"2020","unstructured":"Guillebaud F, et al. Glial endozepines reverse High-Fat Diet-Induced obesity by enhancing hypothalamic response to peripheral leptin. Mol Neurobiol. 2020;57(8):3307\u201333.","journal-title":"Mol Neurobiol"},{"issue":"6","key":"10010_CR64","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.molmet.2015.03.005","volume":"4","author":"TD Muller","year":"2015","unstructured":"Muller TD, et al. Ghrelin Mol Metab. 2015;4(6):437\u201360.","journal-title":"Ghrelin Mol Metab"},{"key":"10010_CR65","doi-asserted-by":"publisher","first-page":"171367","DOI":"10.1016\/j.peptides.2025.171367","volume":"186","author":"K Skoracka","year":"2025","unstructured":"Skoracka K, et al. The role of leptin and Ghrelin in the regulation of appetite in obesity. Peptides. 2025;186:171367.","journal-title":"Peptides"},{"issue":"5","key":"10010_CR66","doi-asserted-by":"publisher","first-page":"e405","DOI":"10.1016\/j.orcp.2013.10.002","volume":"8","author":"T Sato","year":"2014","unstructured":"Sato T, et al. Physiological roles of Ghrelin on obesity. Obes Res Clin Pract. 2014;8(5):e405\u201313.","journal-title":"Obes Res Clin Pract"},{"key":"10010_CR67","doi-asserted-by":"publisher","first-page":"102046","DOI":"10.1016\/j.molmet.2024.102046","volume":"90","author":"IM Gomez","year":"2024","unstructured":"Gomez IM, et al. Hypothalamic tanycytes internalize Ghrelin from the cerebrospinal fluid: molecular mechanisms and functional implications. Mol Metab. 2024;90:102046.","journal-title":"Mol Metab"},{"issue":"2","key":"10010_CR68","doi-asserted-by":"publisher","first-page":"bqaf011","DOI":"10.1210\/endocr\/bqaf011","volume":"166","author":"M Perello","year":"2025","unstructured":"Perello M. Critical insights into LEAP2 biology and physiological functions: potential roles beyond Ghrelin antagonism. Endocrinology. 2025;166(2):bqaf011.","journal-title":"Endocrinology"},{"issue":"12","key":"10010_CR69","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1038\/s42255-021-00499-0","volume":"3","author":"M Porniece Kumar","year":"2021","unstructured":"Porniece Kumar M, et al. Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity. Nat Metab. 2021;3(12):1662\u201379.","journal-title":"Nat Metab"},{"issue":"8","key":"10010_CR70","doi-asserted-by":"publisher","first-page":"111698","DOI":"10.1016\/j.celrep.2022.111698","volume":"41","author":"W Bakker","year":"2022","unstructured":"Bakker W, et al. Acute changes in systemic glycemia gate access and action of GLP-1R agonist on brain structures controlling energy homeostasis. Cell Rep. 2022;41(8):111698.","journal-title":"Cell Rep"},{"issue":"5","key":"10010_CR71","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.2337\/diabetes.53.5.1230","volume":"53","author":"NM Sanders","year":"2004","unstructured":"Sanders NM, Dunn-Meynell AA, Levin BE. Third ventricular Alloxan reversibly impairs glucose counterregulatory responses. Diabetes. 2004;53(5):1230\u20136.","journal-title":"Diabetes"},{"key":"10010_CR72","doi-asserted-by":"publisher","first-page":"101311","DOI":"10.1016\/j.molmet.2021.101311","volume":"53","author":"A Rohrbach","year":"2021","unstructured":"Rohrbach A, et al. Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice. Mol Metab. 2021;53:101311.","journal-title":"Mol Metab"},{"issue":"10","key":"10010_CR73","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1002\/glia.23817","volume":"68","author":"S Yoo","year":"2020","unstructured":"Yoo S, et al. Tanycyte ablation in the arcuate nucleus and median eminence increases obesity susceptibility by increasing body fat content in male mice. Glia. 2020;68(10):1987\u20132000.","journal-title":"Glia"},{"issue":"7","key":"10010_CR74","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1111\/jcmm.12590","volume":"19","author":"R Elizondo-Vega","year":"2015","unstructured":"Elizondo-Vega R, et al. The role of tanycytes in hypothalamic glucosensing. J Cell Mol Med. 2015;19(7):1471\u201382.","journal-title":"J Cell Mol Med"},{"issue":"Pt 9","key":"10010_CR75","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1113\/jphysiol.2010.202051","volume":"589","author":"C Frayling","year":"2011","unstructured":"Frayling C, Britton R, Dale N. ATP-mediated glucosensing by hypothalamic tanycytes. J Physiol. 2011;589(Pt 9):2275\u201386.","journal-title":"J Physiol"},{"issue":"18","key":"10010_CR76","doi-asserted-by":"publisher","first-page":"e140521","DOI":"10.1172\/JCI140521","volume":"131","author":"T Lhomme","year":"2021","unstructured":"Lhomme T, et al. Tanycytic networks mediate energy balance by feeding lactate to glucose-insensitive POMC neurons. J Clin Invest. 2021;131(18):e140521.","journal-title":"J Clin Invest"},{"issue":"4","key":"10010_CR77","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.cub.2021.12.039","volume":"32","author":"B Rodriguez-Cortes","year":"2022","unstructured":"Rodriguez-Cortes B, et al. Suprachiasmatic nucleus-mediated glucose entry into the arcuate nucleus determines the daily rhythm in blood glycemia. Curr Biol. 2022;32(4):796\u2013805. e4.","journal-title":"Curr Biol"},{"issue":"4","key":"10010_CR78","doi-asserted-by":"publisher","first-page":"R173","DOI":"10.1016\/j.cub.2022.01.038","volume":"32","author":"M Imbernon","year":"2022","unstructured":"Imbernon M, Dehouck B, Prevot V. Glycemic control: tanycytes March to the beat of the Suprachiasmatic drummer. Curr Biol. 2022;32(4):R173\u20136.","journal-title":"Curr Biol"},{"issue":"21","key":"10010_CR79","doi-asserted-by":"publisher","first-page":"3481","DOI":"10.1016\/j.cub.2018.08.060","volume":"28","author":"MS Muller","year":"2018","unstructured":"Muller MS, Fouyssac M, Taylor CW. Effective glucose uptake by human astrocytes requires its sequestration in the Endoplasmic reticulum by glucose-6-Phosphatase-beta. Curr Biol. 2018;28(21):3481\u20136. e4.","journal-title":"Curr Biol"},{"key":"10010_CR80","doi-asserted-by":"crossref","unstructured":"Forsyth RJ et al. Astrocytic glucose-6-phosphatase and the permeability of brain microsomes to glucose 6-phosphate. Biochem J. 1993;294 (Pt 1)(Pt 1): 145\u2009\u2013\u200951.","DOI":"10.1042\/bj2940145"},{"key":"10010_CR81","doi-asserted-by":"publisher","first-page":"101940","DOI":"10.1016\/j.molmet.2024.101940","volume":"84","author":"MJ Barahona","year":"2024","unstructured":"Barahona MJ, et al. Tanycytes release glucose using the glucose-6-phosphatase system during hypoglycemia to control hypothalamic energy balance. Mol Metab. 2024;84:101940.","journal-title":"Mol Metab"},{"key":"10010_CR82","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.brainres.2017.08.010","volume":"1673","author":"A Szilvasy-Szabo","year":"2017","unstructured":"Szilvasy-Szabo A, et al. Localization of connexin 43 gap junctions and hemichannels in tanycytes of adult mice. Brain Res. 2017;1673:64\u201371.","journal-title":"Brain Res"},{"issue":"5","key":"10010_CR83","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1038\/s12276-025-01449-6","volume":"57","author":"N Kim","year":"2025","unstructured":"Kim N, et al. Adenosine transmission from hypothalamic tanycytes to AGRP\/NPY neurons regulates energy homeostasis. Exp Mol Med. 2025;57(5):1047\u201363.","journal-title":"Exp Mol Med"},{"issue":"11","key":"10010_CR84","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1016\/j.molmet.2017.08.015","volume":"6","author":"G Lazutkaite","year":"2017","unstructured":"Lazutkaite G, et al. Amino acid sensing in hypothalamic tanycytes via Umami taste receptors. Mol Metab. 2017;6(11):1480\u201392.","journal-title":"Mol Metab"},{"issue":"1","key":"10010_CR85","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1038\/s41467-023-37099-3","volume":"14","author":"Q Yu","year":"2023","unstructured":"Yu Q, et al. Bitter taste cells in the ventricular walls of the murine brain regulate glucose homeostasis. Nat Commun. 2023;14(1):1588.","journal-title":"Nat Commun"},{"issue":"4","key":"10010_CR86","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.cmet.2019.08.004","volume":"30","author":"S Geller","year":"2019","unstructured":"Geller S, et al. Tanycytes regulate lipid homeostasis by sensing free fatty acids and signaling to key hypothalamic neuronal populations via FGF21 secretion. Cell Metab. 2019;30(4):833\u2013e8447.","journal-title":"Cell Metab"},{"issue":"6","key":"10010_CR87","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1177\/0271678X231219115","volume":"44","author":"D Liu","year":"2024","unstructured":"Liu D, et al. Saturated fatty acids stimulate cytokine production in tanycytes via the PP2Ac-dependent signaling pathway. J Cereb Blood Flow Metab. 2024;44(6):985\u201399.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"9","key":"10010_CR88","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1016\/j.cmet.2023.07.010","volume":"35","author":"JE Campbell","year":"2023","unstructured":"Campbell JE, et al. GIPR\/GLP-1R dual agonist therapies for diabetes and weight loss-chemistry, physiology, and clinical applications. Cell Metab. 2023;35(9):1519\u201329.","journal-title":"Cell Metab"},{"issue":"6","key":"10010_CR89","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1038\/s42255-023-00812-z","volume":"5","author":"R Nogueiras","year":"2023","unstructured":"Nogueiras R, Nauck MA, Tschop MH. Gut hormone co-agonists for the treatment of obesity: from bench to bedside. Nat Metab. 2023;5(6):933\u201344.","journal-title":"Nat Metab"},{"issue":"6","key":"10010_CR90","doi-asserted-by":"publisher","first-page":"e133429","DOI":"10.1172\/jci.insight.133429","volume":"5","author":"S Gabery","year":"2020","unstructured":"Gabery S, et al. Semaglutide lowers body weight in rodents via distributed neural pathways. JCI Insight. 2020;5(6):e133429.","journal-title":"JCI Insight"},{"issue":"10","key":"10010_CR91","doi-asserted-by":"publisher","first-page":"e13387","DOI":"10.1111\/jne.13387","volume":"36","author":"K Chachlaki","year":"2024","unstructured":"Chachlaki K, et al. Novel insights into minipuberty and gnrh: implications on neurodevelopment, cognition, and COVID-19 therapeutics. J Neuroendocrinol. 2024;36(10):e13387.","journal-title":"J Neuroendocrinol"},{"issue":"7","key":"10010_CR92","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1111\/j.1365-2826.2010.02033.x","volume":"22","author":"V Prevot","year":"2010","unstructured":"Prevot V, et al. Gonadotrophin-releasing hormone nerve terminals, tanycytes and neurohaemal junction remodelling in the adult median eminence: functional consequences for reproduction and dynamic role of vascular endothelial cells. J Neuroendocrinol. 2010;22(7):639\u201349.","journal-title":"J Neuroendocrinol"},{"issue":"6\u201307","key":"10010_CR93","first-page":"388","volume":"128","author":"H Muller-Fielitz","year":"2020","unstructured":"Muller-Fielitz H, Schwaninger M. The role of tanycytes in the Hypothalamus-Pituitary-Thyroid axis and the possibilities for their genetic manipulation. Exp Clin Endocrinol Diabetes. 2020;128(6\u201307):388\u201394.","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"2","key":"10010_CR94","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1089\/thy.2023.0375","volume":"34","author":"A Chandrasekar","year":"2024","unstructured":"Chandrasekar A, et al. Regulation of thyroid hormone gatekeepers by Thyrotropin in tanycytes. Thyroid. 2024;34(2):261\u201373.","journal-title":"Thyroid"},{"issue":"11","key":"10010_CR95","doi-asserted-by":"publisher","first-page":"e70093","DOI":"10.1111\/jne.70093","volume":"37","author":"J Liu","year":"2025","unstructured":"Liu J, et al. Annual rhythms of thyroid hormone signaling: environmental influences on thyroid function and disease implications. J Neuroendocrinol. 2025;37(11):e70093.","journal-title":"J Neuroendocrinol"},{"issue":"3","key":"10010_CR96","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.cub.2023.12.042","volume":"34","author":"VJ Melum","year":"2024","unstructured":"Melum VJ, et al. Hypothalamic tanycytes as mediators of maternally programmed seasonal plasticity. Curr Biol. 2024;34(3):632\u2013e6406.","journal-title":"Curr Biol"},{"issue":"5","key":"10010_CR97","doi-asserted-by":"publisher","first-page":"R209","DOI":"10.1016\/j.cub.2024.01.055","volume":"34","author":"M Rivagorda","year":"2024","unstructured":"Rivagorda M, Prevot V, Schwaninger M. Seasonal biology: tanycytes give the hypothalamus a spring makeover. Curr Biol. 2024;34(5):R209\u201311.","journal-title":"Curr Biol"},{"issue":"1","key":"10010_CR98","doi-asserted-by":"publisher","first-page":"5803","DOI":"10.1038\/s41467-024-49996-2","volume":"15","author":"SM Mohr","year":"2024","unstructured":"Mohr SM, et al. Hypothalamic hormone deficiency enables physiological anorexia in ground squirrels during hibernation. Nat Commun. 2024;15(1):5803.","journal-title":"Nat Commun"},{"issue":"7","key":"10010_CR99","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1038\/s42255-024-01079-8","volume":"6","author":"O Le Thuc","year":"2024","unstructured":"Le Thuc O, Garcia-Caceres C. Obesity-induced inflammation: connecting the periphery to the brain. Nat Metab. 2024;6(7):1237\u201352.","journal-title":"Nat Metab"},{"key":"10010_CR100","doi-asserted-by":"publisher","first-page":"114917","DOI":"10.1016\/j.physbeh.2025.114917","volume":"296","author":"R Dali","year":"2025","unstructured":"Dali R, Langlet F. Tanycytes in the nexus of hypothalamic inflammation, appetite control, and obesity. Physiol Behav. 2025;296:114917.","journal-title":"Physiol Behav"},{"key":"10010_CR101","doi-asserted-by":"publisher","first-page":"387","DOI":"10.3389\/fnins.2015.00387","volume":"9","author":"T Goodman","year":"2015","unstructured":"Goodman T, Hajihosseini MK. Hypothalamic tanycytes-masters and servants of metabolic, neuroendocrine, and neurogenic functions. Front Neurosci. 2015;9:387.","journal-title":"Front Neurosci"},{"key":"10010_CR102","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.pneurobio.2018.04.001","volume":"170","author":"S Yoo","year":"2018","unstructured":"Yoo S, Blackshaw S. Regulation and function of neurogenesis in the adult mammalian hypothalamus. Prog Neurobiol. 2018;170:53\u201366.","journal-title":"Prog Neurobiol"},{"issue":"23","key":"10010_CR103","doi-asserted-by":"publisher","first-page":"7599","DOI":"10.1523\/JNEUROSCI.16-23-07599.1996","volume":"16","author":"S Weiss","year":"1996","unstructured":"Weiss S, et al. Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis. J Neurosci. 1996;16(23):7599\u2013609.","journal-title":"J Neurosci"},{"issue":"10","key":"10010_CR104","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1038\/ncb2562","volume":"14","author":"J Li","year":"2012","unstructured":"Li J, Tang Y, Cai D. IKKbeta\/NF-kappaB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes. Nat Cell Biol. 2012;14(10):999\u20131012.","journal-title":"Nat Cell Biol"},{"issue":"13","key":"10010_CR105","doi-asserted-by":"publisher","first-page":"dev180950","DOI":"10.1242\/dev.180950","volume":"147","author":"T Goodman","year":"2020","unstructured":"Goodman T, et al. Fibroblast growth factor 10 is a negative regulator of postnatal neurogenesis in the mouse hypothalamus. Development. 2020;147(13):dev180950.","journal-title":"Development"},{"issue":"2","key":"10010_CR106","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1111\/jnc.15188","volume":"156","author":"A Recabal","year":"2021","unstructured":"Recabal A, et al. The FGF2-induced tanycyte proliferation involves a connexin 43 hemichannel\/purinergic-dependent pathway. J Neurochem. 2021;156(2):182\u201399.","journal-title":"J Neurochem"},{"issue":"1","key":"10010_CR107","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/glia.21246","volume":"60","author":"JA Orellana","year":"2012","unstructured":"Orellana JA, et al. Glucose increases intracellular free Ca(2+) in tanycytes via ATP released through connexin 43 hemichannels. Glia. 2012;60(1):53\u201368.","journal-title":"Glia"},{"key":"10010_CR108","doi-asserted-by":"publisher","first-page":"157","DOI":"10.3389\/fnins.2014.00157","volume":"8","author":"DA Lee","year":"2014","unstructured":"Lee DA, et al. Dietary and sex-specific factors regulate hypothalamic neurogenesis in young adult mice. Front Neurosci. 2014;8:157.","journal-title":"Front Neurosci"},{"issue":"5","key":"10010_CR109","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1038\/nn.3079","volume":"15","author":"DA Lee","year":"2012","unstructured":"Lee DA, et al. Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche. Nat Neurosci. 2012;15(5):700\u20132.","journal-title":"Nat Neurosci"},{"issue":"4","key":"10010_CR110","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.molmet.2017.01.010","volume":"6","author":"JD Douglass","year":"2017","unstructured":"Douglass JD, et al. Astrocyte IKKbeta\/NF-kappaB signaling is required for diet-induced obesity and hypothalamic inflammation. Mol Metab. 2017;6(4):366\u201373.","journal-title":"Mol Metab"},{"issue":"22","key":"10010_CR111","doi-asserted-by":"publisher","first-page":"eabg3777","DOI":"10.1126\/sciadv.abg3777","volume":"7","author":"S Yoo","year":"2021","unstructured":"Yoo S, et al. Control of neurogenic competence in mammalian hypothalamic tanycytes. Sci Adv. 2021;7(22):eabg3777.","journal-title":"Sci Adv"},{"issue":"1","key":"10010_CR112","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.1038\/s41467-021-22640-z","volume":"12","author":"W Mu","year":"2021","unstructured":"Mu W, et al. Hypothalamic Rax(+) tanycytes contribute to tissue repair and tumorigenesis upon oncogene activation in mice. Nat Commun. 2021;12(1):2288.","journal-title":"Nat Commun"},{"key":"10010_CR113","doi-asserted-by":"publisher","first-page":"101312","DOI":"10.1016\/j.molmet.2021.101312","volume":"53","author":"Surbhi","year":"2021","unstructured":"Surbhi, et al. Adult-born Proopiomelanocortin neurons derived from Rax-expressing precursors mitigate the metabolic effects of congenital hypothalamic Proopiomelanocortin deficiency. Mol Metab. 2021;53:101312.","journal-title":"Mol Metab"},{"issue":"5","key":"10010_CR114","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/s42255-021-00382-y","volume":"3","author":"JE Son","year":"2021","unstructured":"Son JE, et al. Irx3 and Irx5 in Ins2-Cre(+) cells regulate hypothalamic postnatal neurogenesis and leptin response. Nat Metab. 2021;3(5):701\u201313.","journal-title":"Nat Metab"},{"key":"10010_CR115","doi-asserted-by":"publisher","first-page":"763856","DOI":"10.3389\/fnins.2021.763856","volume":"15","author":"Z Dou","year":"2021","unstructured":"Dou Z, Son JE, Hui CC. Irx3 and Irx5 - Novel regulatory factors of postnatal hypothalamic neurogenesis. Front Neurosci. 2021;15:763856.","journal-title":"Front Neurosci"},{"issue":"2","key":"10010_CR116","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.cmet.2024.01.003","volume":"36","author":"Y Lei","year":"2024","unstructured":"Lei Y, et al. Region-specific transcriptomic responses to obesity and diabetes in macaque hypothalamus. Cell Metab. 2024;36(2):438\u2013e4536.","journal-title":"Cell Metab"},{"key":"10010_CR117","doi-asserted-by":"publisher","DOI":"10.1101\/2022.05.04.22274181","author":"F Sauv\u00e9","year":"2022","unstructured":"Sauv\u00e9 F, et al. Tanycytes are degraded in alzheimer\u2019s Disease, disrupting the brain-to-blood efflux of Tau. MedRxiv. 2022. https:\/\/doi.org\/10.1101\/2022.05.04.22274181.","journal-title":"MedRxiv"}],"container-title":["Reviews in Endocrine and Metabolic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11154-025-10010-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11154-025-10010-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11154-025-10010-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T18:02:43Z","timestamp":1780941763000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11154-025-10010-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,29]]},"references-count":117,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10010"],"URL":"https:\/\/doi.org\/10.1007\/s11154-025-10010-9","relation":{},"ISSN":["1389-9155","1573-2606"],"issn-type":[{"value":"1389-9155","type":"print"},{"value":"1573-2606","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,29]]},"assertion":[{"value":"4 December 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}